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JCEG ID Family Name Locus Tag Human Ortholog Name OMIM GWAS Catalog
JCEG001 * = Asparagine-linked glycosylation (ALG) genes algn-1 T26A5.4 ALG1 605907
608540
JCEG002 * = Asparagine-linked glycosylation (ALG) genes algn-2 F09E5.2 ALG2 607905
607906
JCEG003 * = Asparagine-linked glycosylation (ALG) genes bus-8 T23F2.1 ALG2
JCEG004 * = Asparagine-linked glycosylation (ALG) genes K09E4.2 ALG3 601110
608750
JCEG005 * = Asparagine-linked glycosylation (ALG) genes H43I07.3 ALG5 604565
JCEG006 * = Asparagine-linked glycosylation (ALG) genes C08B11.8 ALG6 603147
604566
JCEG007 * = Asparagine-linked glycosylation (ALG) genes algn-7 Y60A3A.14 DPAGT1 191350
608093
614750
JCEG008 * = Asparagine-linked glycosylation (ALG) genes T08D2.2 DPAGT1 191350
608093
614750
JCEG009 * = Asparagine-linked glycosylation (ALG) genes C08H9.3 ALG8 608103
608104
JCEG010 * = Asparagine-linked glycosylation (ALG) genes C14A4.3 ALG9 606941
608776
JCEG011 * = Asparagine-linked glycosylation (ALG) genes tag-179 T24D1.4 ALG10 603313
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 8.0E-6 (WRAT) 17903297
JCEG012 * = Asparagine-linked glycosylation (ALG) genes algn-11 B0361.8 ALG11 613661
613666
JCEG013 * = Asparagine-linked glycosylation (ALG) genes ZC513.5 ALG12 607143
607144
JCEG014 * = Asparagine-linked glycosylation (ALG) genes algn-13 R10D12.12 ALG13
JCEG015 * = Asparagine-linked glycosylation (ALG) genes algn-14 M02B7.4 ALG14 612866
STREAMRAFp-valueORBETACIStudy
UPSTREAM 5.0E-8 (proportions) 0.7 (% increase) [NR] 22359512
MAPPED 0.49 2.0E-18 0.1651 (unit decrease) [0.128-0.202] 23362303
MAPPED 0.451 3.0E-11 0.178 (unit incease) [0.125-0.23] 23362303
JCEG016 * = Asparagine-linked glycosylation (ALG) genes dpm-1 Y66H1A.2 DPM1 603503
608799
JCEG017 * = Core 1 GalT T09E11.12 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG018 * = Core 1 GalT C38H2.2 C1GALT1 300611
300622
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG019 * = Core 1 GalT C16D9.6 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG020 * = Core 1 GalT F56H6.1 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG021 * = Core 1 GalT T09E11.6 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG022 * = Core 1 GalT E03H4.3 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG023 * = Core 1 GalT C17A2.3 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG024 * = Core 1 GalT bus-4 T22B11.2 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG025 * = Core 1 GalT C02H6.1 C1GALT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 2.0E-7 (PCB105) 1.32 (unit decrease) [0.83-1.81] 25839716
MAPPED 0.46 4.0E-6 [NR] 19010793
MAPPED 0.444 1.0E-6 0.099 (unit decrease) [0.06-0.138] 24159190
MAPPED 0.444 6.0E-7 0.101 (unit increase) [0.062-0.14] 24159190
JCEG026 * Fucosyltransferases T28F2.1 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG027 * Fucosyltransferases F41D3.6 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG028 * Fucosyltransferases F08A8.5 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG029 * Fucosyltransferases C14C6.3 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG030 * Fucosyltransferases EGAP9.3 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG031 * Fucosyltransferases T26H5.8 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG032 * Fucosyltransferases T26E4.4 FUT1
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG033 * Fucosyltransferases fut-2 EGAP9.2 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG034 * = Fucosyltransferases B0205.4 FUT2 FUT1 182100
182100
211100
211100
612542
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 3.0E-10 24941225
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG035 * Fucosyltransferases F17B5.4 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG036 * Fucosyltransferases C17A2.4 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG037 * Fucosyltransferases Y71H2AM.14 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG038 * Fucosyltransferases C06E1.7 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG039 * Fucosyltransferases K06H6.6 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG040 * Fucosyltransferases F31F4.17 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG041 * Fucosyltransferases F31F4.11 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG042 * Fucosyltransferases Y5H2B.1 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG043 * Fucosyltransferases C18G1.8 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG044 * Fucosyltransferases W07G4.2 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG045 * Fucosyltransferases F11A5.5 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG046 * = Fucosyltransferases pad-2 K10G9.3 POFUT2 610249
JCEG047 * Fucosyltransferases Y39F10A.2 FUT2 251450
613165
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG048 * Fucosyltransferases F17B5.6 FUT1 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 3.0E-10 24941225
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG049 * = Fucosyltransferases fut-3 F59E12.13 FUT5 FUT1 FUT10 FUT11
STREAMRAFp-valueORBETACIStudy
MAPPED 3.0E-10 24941225
JCEG050 * = Fucosyltransferases fut-1 K08F8.3 FUT5 FUT3 FUT4 FUT6 104230
111100
111100
136835
136836
602030
606865
613852
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-6 (EA) 22566498
DOWNSTREAM 9.0E-7 (EA) 1.4 (unit increase) [0.79-2.01] 22566498
MAPPED 3.0E-8 24941225
MAPPED 4.0E-13 49.78 (pg/ml increase) [36.41-63.15] 22367966
MAPPED 8.0E-19 24941225
MAPPED 0.38 (CA19-9) 0.282 (U/ml increase) [0.20-0.37] 23300138
MAPPED 0.33 1.0E-35 (CEA) 0.073 (ng/ml increase) [0.048-0.098] 23300138
MAPPED 0.33 (CA19-9) 0.481 (U/ml decrease) [0.44-0.52] 23300138
MAPPED 0.2 2.0E-56 (CA19-9) 0.169 (U/ml decrease) [0.11-0.22] 23300138
MAPPED 0.11 9.0E-10 (DG12) 0.3 (unit decrease) [0.20-0.40] 21203500
MAPPED 0.11 3.0E-12 (DG7) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 1.0E-12 (FUC-A) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 4.0E-17 (DG9) 0.41 (unit decrease) [0.31-0.51] 21203500
JCEG051 * = Fucosyltransferases fut-4 K12H6.3 FUT6 FUT7
STREAMRAFp-valueORBETACIStudy
MAPPED 4.0E-13 49.78 (pg/ml increase) [36.41-63.15] 22367966
MAPPED 8.0E-19 24941225
MAPPED 0.38 (CA19-9) 0.282 (U/ml increase) [0.20-0.37] 23300138
MAPPED 0.33 1.0E-35 (CEA) 0.073 (ng/ml increase) [0.048-0.098] 23300138
MAPPED 0.33 (CA19-9) 0.481 (U/ml decrease) [0.44-0.52] 23300138
MAPPED 0.2 2.0E-56 (CA19-9) 0.169 (U/ml decrease) [0.11-0.22] 23300138
MAPPED 0.11 9.0E-10 (DG12) 0.3 (unit decrease) [0.20-0.40] 21203500
MAPPED 0.11 3.0E-12 (DG7) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 1.0E-12 (FUC-A) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 4.0E-17 (DG9) 0.41 (unit decrease) [0.31-0.51] 21203500
JCEG052 * = Fucosyltransferases fut-6 T05A7.5 FUT6 FUT7
STREAMRAFp-valueORBETACIStudy
MAPPED 4.0E-13 49.78 (pg/ml increase) [36.41-63.15] 22367966
MAPPED 8.0E-19 24941225
MAPPED 0.38 (CA19-9) 0.282 (U/ml increase) [0.20-0.37] 23300138
MAPPED 0.33 1.0E-35 (CEA) 0.073 (ng/ml increase) [0.048-0.098] 23300138
MAPPED 0.33 (CA19-9) 0.481 (U/ml decrease) [0.44-0.52] 23300138
MAPPED 0.2 2.0E-56 (CA19-9) 0.169 (U/ml decrease) [0.11-0.22] 23300138
MAPPED 0.11 9.0E-10 (DG12) 0.3 (unit decrease) [0.20-0.40] 21203500
MAPPED 0.11 3.0E-12 (DG7) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 1.0E-12 (FUC-A) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 4.0E-17 (DG9) 0.41 (unit decrease) [0.31-0.51] 21203500
JCEG053 * = Fucosyltransferases fut-8 C10F3.6 FUT8 602589
STREAMRAFp-valueORBETACIStudy
MAPPED 0.59 4.0E-8 0.03 (unit increase) [0.02-0.04] 25231870
MAPPED 0.21 1.0E-8 (DG6) 0.22 (unit decrease) [0.14-0.30] 21203500
JCEG054 * = Fukutin T07D3.4 FCMD 253800
607440
611588
611615
613152
JCEG055 * = Fukutin T07A5.1 FCMD 253800
607440
611588
611615
613152
JCEG056 * = Fukutin F28A10.9 FCMD 253800
607440
611588
611615
613152
JCEG057 * = Fukutin T07D3.6 FCMD 253800
607440
611588
611615
613152
JCEG058 * = Fukutin W02B3.4 FCMD 253800
607440
611588
611615
613152
JCEG059 * = GPI-anchor synthesis hpo-3 F33D11.9 GPAA1 603048
JCEG060 * = GPI-anchor synthesis F38E1.9 MPDU1 604041
609180
STREAMRAFp-valueORBETACIStudy
MAPPED 0.29 1.0E-8 (Testosterone) 0.28 (unit decrease) [0.18-0.38] 24049095
MAPPED 0.29 5.0E-19 (SHBG) 0.09 (unit decrease) [0.070-0.110] 24049095
MAPPED 0.21 4.0E-10 1.23 [1.16-1.32] 22197929
JCEG061 * = GPI-anchor synthesis R01B10.4 PGAP3 611801
615716
JCEG062 * = GPI-anchor synthesis T19B10.8 PGAP1 611655
JCEG063 * = GPI-anchor synthesis tag-189 T04A8.12 PGAP2 614207
615187
JCEG064 * = GPI-anchor synthesis piga-1 D2085.6 PIGA 300818
300868
311770
JCEG065 * = GPI-anchor synthesis T27F7.4 PIGB 604122
JCEG066 * = GPI-anchor synthesis T20D3.8 PIGC 601730
JCEG067 * = GPI-anchor synthesis F28C6.4 PIGG
JCEG068 * = GPI-anchor synthesis hpo-4 T05E11.6 PIGK 605087
JCEG069 * = GPI-anchor synthesis B0491.1 PIGM 610273
610293
JCEG070 * = GPI-anchor synthesis Y54E10BR.1 PIGN 606097
614080
STREAMRAFp-valueORBETACIStudy
MAPPED 9.0E-6 (phenotype 3) 3.57 [NR] 25461247
MAPPED 9.0E-6 (phenotype 1) 3.57 [NR] 25461247
JCEG071 * = GPI-anchor synthesis C27A12.9 PIGO 614730
614749
JCEG072 * = GPI-anchor synthesis Y48E1B.2 PIGP 614919
JCEG073 * = GPI-anchor synthesis F01G4.5 PIGQ 605754
STREAMRAFp-valueORBETACIStudy
UPSTREAM 0.42 9.0E-6 0.1 (unit increase) [0.059-0.141] 22993228
MAPPED 0.42 4.0E-6 0.11 (unit increase) [0.065-0.155] 22993228
JCEG074 * = GPI-anchor synthesis hpo-5 T14G10.7 PIGS 610271
JCEG075 * = GPI-anchor synthesis F17C11.7 PIGT 610272
615398
615399
JCEG076 * = GPI-anchor synthesis T22C1.3 PIGU 608528
STREAMRAFp-valueORBETACIStudy
MAPPED 0.09 1.0E-15 1.75 [1.53-2.01] 18488026
JCEG077 * = GPI-anchor synthesis pigv-1 T09B4.1 PIGV 239300
610274
STREAMRAFp-valueORBETACIStudy
UPSTREAM 0.09 1.0E-9 0.037 (mg/dL increase) [NR] 24097068
UPSTREAM 0.09 3.0E-12 0.05 (unit increase) [NR] 24097068
UPSTREAM 0.09 1.0E-15 0.051 (unit decrease) [NR] 24097068
JCEG078 * = GPI-anchor synthesis hpo-20 Y110A2AL.12 PIGW 610275
JCEG079 * GPI-anchor synthesis F49E7.2 PIGX
JCEG080 * = GPI-anchor synthesis dpm-3 F28D1.11 DPM3
JCEG081 * = GlcNAcT(GnT) gly-14 M01F1.1 MGAT1 160995
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.85 6.0E-6 (females) 0.16 (kg decrease) [NR] 19851299
DOWNSTREAM 0.85 7.0E-8 (females) 2.96 (kg decrease) [NR] 19851299
MAPPED 0.47 5.0E-6 (HDL-C) 0.23 (mg/dL increase) [NR] 19197348
DOWNSTREAM 0.14 8.0E-6 (EA-glucose response) 3.67 (mg/dL increase) [2.06-5.28] 23400010
JCEG082 * = GlcNAcT(GnT) gly-13 B0416.6 MGAT1 160995
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.85 6.0E-6 (females) 0.16 (kg decrease) [NR] 19851299
DOWNSTREAM 0.85 7.0E-8 (females) 2.96 (kg decrease) [NR] 19851299
MAPPED 0.47 5.0E-6 (HDL-C) 0.23 (mg/dL increase) [NR] 19197348
DOWNSTREAM 0.14 8.0E-6 (EA-glucose response) 3.67 (mg/dL increase) [2.06-5.28] 23400010
JCEG083 * = GlcNAcT(GnT) gly-12 F48E3.1 MGAT1 160995
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.85 6.0E-6 (females) 0.16 (kg decrease) [NR] 19851299
DOWNSTREAM 0.85 7.0E-8 (females) 2.96 (kg decrease) [NR] 19851299
MAPPED 0.47 5.0E-6 (HDL-C) 0.23 (mg/dL increase) [NR] 19197348
DOWNSTREAM 0.14 8.0E-6 (EA-glucose response) 3.67 (mg/dL increase) [2.06-5.28] 23400010
JCEG084 * = GlcNAcT(GnT) gly-20 C03E10.4 MGAT2 212066
602616
JCEG085 * = GlcNAcT(GnT) gly-2 C55B7.2 MGAT5 MGAT5B 601774
612441
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 8.0E-6 (M) 17.78 (unit decrease) [10.16-25.4] 25524916
DOWNSTREAM 0.9858 7.0E-6 (Ordinal I) 2.5604 (unit increase) [1.45-3.68] 25188341
UPSTREAM 0.974 3.0E-8 (Chinese) 0.328 (unit decrease) [0.21-0.44] 24383474
UPSTREAM 0.917 3.0E-6 1.61 [1.32-2.0] 22683750
DOWNSTREAM 0.8 2.0E-12 0.032 (unit decrease) [NR] 20881960
MAPPED 0.64 7.0E-6 (overall) 22589738
MAPPED 0.36 2.0E-7 20117844
DOWNSTREAM 0.2 3.0E-6 (Recessive) 34.0 [4.29-269.48] 22293537
UPSTREAM 0.08 5.0E-6 0.069 (unit decrease)] 22823124
DOWNSTREAM 0.023 4.0E-8 0.048 (unit decrease) [0.031-0.065] 23362303
JCEG086 * = GlcNAcT(GnT) M70.4 POMGNT1 300492
608617
608618
608619
JCEG087 * = GlcT ZC250.2 B3GLCT 261540
610308
STREAMRAFp-valueORBETACIStudy
MAPPED 0.44 2.0E-8 1.1 [1.07-1.14] 23455636
JCEG088 * = GlcT cgt-1 T06C12.10 UGCG 602874
JCEG089 * = GlcT cgt-2 F20B4.6 UGCG 602874
JCEG090 * = GlcT cgt-3 F59G1.1 UGCG 602874
JCEG091 * = Glucuronyltransferase(GlcAT) glct-4 C47F8.4 B3GAT1 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 8.0E-6 4.35 [2.28-8.30] 24172245
MAPPED 3.0E-6 0.701 (unit decrease)] 24277619
UPSTREAM 2.0E-6 0.64 (unit increase) [0.39-0.89] 25562672
UPSTREAM 0.889723713 9.0E-6 (IGP36) 0.227 (unit decrease) [0.13-0.33] 23382691
UPSTREAM 0.871 2.0E-6 [NR] 23049088
DOWNSTREAM 0.53 5.0E-6 (CERAD-dr) 0.2826 (unit decrease) [0.16-0.4] 25648963
UPSTREAM 0.143 7.0E-7 [NR] 23049088
JCEG092 * = Glucuronyltransferase(GlcAT) glct-1 T09E11.1 B3GAT1 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 8.0E-6 4.35 [2.28-8.30] 24172245
MAPPED 3.0E-6 0.701 (unit decrease)] 24277619
UPSTREAM 2.0E-6 0.64 (unit increase) [0.39-0.89] 25562672
UPSTREAM 0.889723713 9.0E-6 (IGP36) 0.227 (unit decrease) [0.13-0.33] 23382691
UPSTREAM 0.871 2.0E-6 [NR] 23049088
DOWNSTREAM 0.53 5.0E-6 (CERAD-dr) 0.2826 (unit decrease) [0.16-0.4] 25648963
UPSTREAM 0.143 7.0E-7 [NR] 23049088
JCEG093 * = Glucuronyltransferase(GlcAT) glct-3 T15D6.7 B3GAT1 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 8.0E-6 4.35 [2.28-8.30] 24172245
MAPPED 3.0E-6 0.701 (unit decrease)] 24277619
UPSTREAM 2.0E-6 0.64 (unit increase) [0.39-0.89] 25562672
UPSTREAM 0.889723713 9.0E-6 (IGP36) 0.227 (unit decrease) [0.13-0.33] 23382691
UPSTREAM 0.871 2.0E-6 [NR] 23049088
DOWNSTREAM 0.53 5.0E-6 (CERAD-dr) 0.2826 (unit decrease) [0.16-0.4] 25648963
UPSTREAM 0.143 7.0E-7 [NR] 23049088
JCEG094 * = Glucuronyltransferase(GlcAT) glct-2 E03H4.12 B3GAT1 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 8.0E-6 4.35 [2.28-8.30] 24172245
MAPPED 3.0E-6 0.701 (unit decrease)] 24277619
UPSTREAM 2.0E-6 0.64 (unit increase) [0.39-0.89] 25562672
UPSTREAM 0.889723713 9.0E-6 (IGP36) 0.227 (unit decrease) [0.13-0.33] 23382691
UPSTREAM 0.871 2.0E-6 [NR] 23049088
DOWNSTREAM 0.53 5.0E-6 (CERAD-dr) 0.2826 (unit decrease) [0.16-0.4] 25648963
UPSTREAM 0.143 7.0E-7 [NR] 23049088
JCEG095 * = Glucuronyltransferase(GlcAT) glct-5 C54C8.5 B3GAT1 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 8.0E-6 4.35 [2.28-8.30] 24172245
MAPPED 3.0E-6 0.701 (unit decrease)] 24277619
UPSTREAM 2.0E-6 0.64 (unit increase) [0.39-0.89] 25562672
UPSTREAM 0.889723713 9.0E-6 (IGP36) 0.227 (unit decrease) [0.13-0.33] 23382691
UPSTREAM 0.871 2.0E-6 [NR] 23049088
DOWNSTREAM 0.53 5.0E-6 (CERAD-dr) 0.2826 (unit decrease) [0.16-0.4] 25648963
UPSTREAM 0.143 7.0E-7 [NR] 23049088
JCEG096 * = Glucuronyltransferase(GlcAT) glct-6 W07G9.2 B3GAT1 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 8.0E-6 4.35 [2.28-8.30] 24172245
MAPPED 3.0E-6 0.701 (unit decrease)] 24277619
UPSTREAM 2.0E-6 0.64 (unit increase) [0.39-0.89] 25562672
UPSTREAM 0.889723713 9.0E-6 (IGP36) 0.227 (unit decrease) [0.13-0.33] 23382691
UPSTREAM 0.871 2.0E-6 [NR] 23049088
DOWNSTREAM 0.53 5.0E-6 (CERAD-dr) 0.2826 (unit decrease) [0.16-0.4] 25648963
UPSTREAM 0.143 7.0E-7 [NR] 23049088
JCEG097 * = Glucuronyltransferase(GlcAT) sqv-8 ZK1307.5 B3GAT3 B3GAT2 151290
245600
606374
607497
STREAMRAFp-valueORBETACIStudy
UPSTREAM 5.0E-6 0.2918 (unit increase)] 23319000
MAPPED 0.219 7.0E-6 (ALT/AST) 0.03 (unit increase) [NR] 23251661
UPSTREAM 0.16 9.0E-7 1.17 (unit decrease) [0.70-1.64] 21326311
JCEG098 Glyco_transf_92 C05C8.8
JCEG099 Glyco_transf_92 C14C6.8
JCEG100 Glyco_transf_92 ZK488.5
JCEG101 Glyco_transf_92 C14C6.6
JCEG102 Glyco_transf_92 D1014.7
JCEG103 Glyco_transf_92 F28H7.7
JCEG104 Glyco_transf_92 R05A10.6
JCEG105 Glyco_transf_92 C31B8.7
JCEG106 Glyco_transf_92 D1014.6
JCEG107 Glyco_transf_92 K06H6.4
JCEG108 Glyco_transf_92 ZK488.6
JCEG109 Glyco_transf_92 C01G5.9
JCEG110 Glyco_transf_92 C14C6.7
JCEG111 Glyco_transf_92 T06A1.5
JCEG112 Glyco_transf_92 C08B6.3
JCEG113 Glyco_transf_92 K08D9.2
JCEG114 Glyco_transf_92 T15D6.10
JCEG115 Glyco_transf_92 galt-1 M03F8.4
JCEG116 Glyco_transf_92 F54D10.8
JCEG117 Glyco_transf_92 Y105C5B.25
JCEG118 Glyco_transf_92 T06A1.1
JCEG119 Glyco_transf_92 C17A2.2
JCEG120 Glyco_transf_92 F46F5.7
JCEG121 Glyco_transf_92 D1014.5
JCEG122 Glyco_transf_92 C13A2.2
JCEG123 Glyco_transf_92 R08C7.4
JCEG124 * = Glycogen synthase gsy-1 Y46G5A.31 GYS1 GYS2 138570
138571
240600
611556
STREAMRAFp-valueORBETACIStudy
MAPPED 0.08 4.0E-8 (FSH) 24049095
JCEG125 * = Glycosaminoglycan (GAG ) and Chitin synthesis genes sqv-5 T24D1.1 CHSY1 CHPF CHSY3 CHPF2 CSGALNACT1 CSGALNACT2 605282
608183
609963
STREAMRAFp-valueORBETACIStudy
MAPPED 7.0E-6 0.226 (unit increase) [NR] 23322567
MAPPED 2.0E-7 2.14 [1.53-2.99] 23726668
MAPPED 0.66 2.0E-9 0.08 (unit decrease) [0.06-0.1] 23291589
MAPPED 0.601 1.0E-6 0.022 (unit increase) [NR] 25201988
UPSTREAM 0.31 2.0E-6 (ETV6-RUNX1 positive) 1.19 [1.07 - 1.33] 22076464
UPSTREAM 0.31 6.0E-9 (ETV6-RUNX1 positive, Northern European) 22076464
JCEG126 * = Glycosaminoglycan (GAG ) and Chitin synthesis genes mig-22 PAR2.4 CHPF 608037
610405
JCEG127 * = Glycosaminoglycan (GAG ) and Chitin synthesis genes rib-1 F12F6.3 EXT1 EXTL1 133700
150230
215300
601738
608177
STREAMRAFp-valueORBETACIStudy
MAPPED 0.48 6.0E-6 0.36 (cm decrease) [NR] 19893584
MAPPED 0.093 2.0E-6 (Cortisol ) 0.03 (ng/mL increase) [NR] 23251661
DOWNSTREAM 0.07 8.0E-6 (men) 0.18 (kg/m2 decrease) [0.1-0.26] 25811787
JCEG128 * = Glycosaminoglycan (GAG ) and Chitin synthesis genes rib-2 K01G5.6 EXTL3 EXTL2 EXT2 133700
133701
602411
605744
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-8 (Conditioned on rs11581062) 1.09 [1.08-1.11] 21833088
DOWNSTREAM 4.0E-8 1.09 [1.08-1.11] 21833088
MAPPED 0.68 2.0E-8 0.023 (unit increase) [0.0093-0.0367] 25429064
JCEG129 * Glycosaminoglycan (GAG ) and Chitin synthesis genes chs-2 F48A11.1 HAS2
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.63 6.0E-6 1.59 [1.30-1.92] 21546767
DOWNSTREAM 0.047 5.0E-6 (Folate ) 0.03 (nmol/L increase) [NR] 23251661
JCEG130 * Glycosaminoglycan (GAG ) and Chitin synthesis genes chs-1 T25G3.2 HAS3 HAS1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-6 (binary) 18821565
JCEG131 * = Glycosyltransferase like (GTL) D2045.9 LHL1
JCEG132 * = HS C5 epimerase hse-5 B0285.5 GLCE 612134
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.26 2.0E-6 (percent change) 1.7 (percent increase) [0.92-2.48] 23118302
JCEG133 * = LARGE lge-1 K09C8.4 LARGE 603590
605517
608840
609709
613154
615287
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.56 6.0E-6 (women) 22589738
DOWNSTREAM 0.54 6.0E-7 (women) 22589738
MAPPED 0.28 8.0E-6 (overall) 22589738
MAPPED 0.11 8.0E-6 1.44 [1.28-1.60] 24962325
JCEG134 * = O-GlcNAcT H12D21.10 EOGT 614789
615297
JCEG135 * = O-GlcNAcT ogt-1 K04G7.3 OGT 300255
JCEG136 * = Oligosaccharyltransferase complex stt-3 T12A2.2 STT3 608605
615597
STREAMRAFp-valueORBETACIStudy
MAPPED 0.884 9.0E-7 (Modelling analysis) 23453885
MAPPED 0.88 1.0E-6 1.1 [1.06-1.14] 21926974
JCEG137 * = Oligosaccharyltransferase complex dad-1 F57B10.10 DAD1 600243
JCEG138 * = Oligosaccharyltransferase complex ZK686.3 MAGT1 TUSC3 300715
300853
601385
611093
JCEG139 * = Oligosaccharyltransferase complex ostb-1 T09A5.11 DDOST 602202
614507
JCEG140 * = Oligosaccharyltransferase complex ribo-1 T22D1.4 RPN1 180470
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 6.0E-13 (Monocytes) 0.028 (unit decrease) [0.020-0.036] 21738480
DOWNSTREAM 4.0E-13 (Basophils) 0.01 (unit increase) [0.0073-0.0127] 21738480
DOWNSTREAM 0.66 3.0E-17 (eosinophil count) 0.103 (unit increase) [0.08-0.12] 21738478
DOWNSTREAM 0.66 5.0E-40 (basophil count) 0.161 (unit increase) [0.14-0.18] 21738478
DOWNSTREAM 0.441 1.0E-8 (EA) 0.028 (unit decrease) [0.018-0.038] 25096241
MAPPED 0.4 2.0E-16 0.23 (unit decrease)] 23314186
JCEG141 * = Oligosaccharyltransferase complex ostd-1 M01A10.3 RPN2 180490
STREAMRAFp-valueORBETACIStudy
MAPPED 6.0E-6 19668339
JCEG142 Oligosaccharyltransferase complex T07A5.5
JCEG143 * = Other glycogenes Y38C1AB.5 C1GALT1C1
STREAMRAFp-valueORBETACIStudy
UPSTREAM 6.0E-6 (Alpha peak frequency, occipital 0.051 (unit increase) [0.029-0.073] 25387704
UPSTREAM 1.0000000000000001E-24 1.28 [NR] 22808956
JCEG144 * Other glycogenes T28A8.2 FUT1 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 3.0E-10 24941225
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG145 * Other glycogenes T26E4.3 FUT1 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 3.0E-10 24941225
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG146 * Other glycogenes T26E4.5 FUT1 FUT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 2.0E-6 (Conditioned on rs2303759) 1.08 [1.07-1.09] 21833088
MAPPED 4.0E-8 1.183432 [1.15-1.22] 25574825
MAPPED 3.0E-10 24941225
MAPPED 4.0E-36 70.21 (pg/ml increase) [59.37-81.05] 22367966
MAPPED 1.0E-56 24941225
MAPPED 0.53 1.0E-13 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.045 (unit increase) [0.033-0.057] 24816252
MAPPED 0.53 3.0E-20 (vitamin B12) 49.77 (pg/ml increase) [37.09-62.45] 19303062
UPSTREAM 0.52 5.0E-8 (Single Height-males) 0.07 (unit increase) [0.043-0.097] 23449627
MAPPED 0.49 2.0E-10 1.27 (mg/dL increase) [0.86-1.68] 20686565
MAPPED 0.49 5.0E-17 0.09 (pg/ml decrease) [0.07-0.11] 18776911
UPSTREAM 0.487 7.0E-12 1.07 [1.04-1.11] 21102463
MAPPED 0.483 1.0E-15 1.107 [1.071-1.143] 23128233
MAPPED 0.482 2.0E-7 (Vitamin B12) 0.143 (unit increase) [NR] 25147783
MAPPED 0.47 8.0E-10 2.3 (% increase) [1.80-2.90] 22001757
MAPPED 0.47 1.0E-16 0.031 (unit increase) [NR] 24097068
MAPPED 0.464 4.0E-20 (SM-11 + 2 other traits) 0.129 (unit increase) [NR] 21886157
MAPPED 0.46 (CA19-9) 0.444 (U/ml increase) [0.41-0.48] 23300138
MAPPED 0.46 (CEA) 0.238 (ng/ml increase) [0.21-0.26] 23300138
MAPPED 0.44 2.0E-15 (Plasma Vitamin B12) 0.07 (unit decrease) [0.050-0.090] 19744961
MAPPED 0.431 2.0E-8 20570966
MAPPED 0.43 6.0E-9 0.04 (unit increase) [0.026-0.054] 25028398
MAPPED 0.43 3.0E-11 (ADpSGEGDFXAEGGGVR) 0.041 (unit increase) [0.029-0.053] 24816252
MAPPED 0.43 1.0E-15 1.8 (% increase) [0.80-2.80] 22001757
MAPPED 0.43 2.0E-20 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR) 0.055 (unit decrease) [0.043-0.067] 24816252
MAPPED 0.272 2.0E-6 (Vitamin B12 ) 0.03 (pmol/L increase) [NR] 23251661
JCEG147 * = Other glycogenes fut-5 T05A7.10 FUT4 FUT7 FUT10
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-6 (EA) 22566498
DOWNSTREAM 9.0E-7 (EA) 1.4 (unit increase) [0.79-2.01] 22566498
JCEG148 * = Other glycogenes Y38C1AB.1 C1GALT1C1
STREAMRAFp-valueORBETACIStudy
UPSTREAM 6.0E-6 (Alpha peak frequency, occipital 0.051 (unit increase) [0.029-0.073] 25387704
UPSTREAM 1.0000000000000001E-24 1.28 [NR] 22808956
JCEG149 * = PAPS synthase and PAPS transporters pst-1 M03F8.2 SLC35B2 610788
JCEG150 * = PAPS synthase and PAPS transporters pst-2 F54E7.1 SLC35B3 610845
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 8.0E-6 24324551
DOWNSTREAM 0.49 3.0E-6 (AA) 0.17 (unit decrease) [0.092-0.248] 23870195
DOWNSTREAM 0.48 3.0E-18 0.046 (unit increase) [0.035-0.056] 25628336
JCEG151 * = PAPS synthase and PAPS transporters pps-1 T14G10.1 PAPSS1 PAPSS2 603005
603262
612847
STREAMRAFp-valueORBETACIStudy
MAPPED 4.0E-6 1.32 [1.17-1.49] 19727025
DOWNSTREAM 2.0E-6 (EA) 0.02742 (0.01614-0.03871) (mg/dl increase)] 25886283
DOWNSTREAM 4.0E-7 0.0243 (mg/dl increase) [NR] 25886283
DOWNSTREAM 0.029 5.0E-8 [NR] 24478790
JCEG152 * = POFUT C15C7.7 POFUT1 607491
615327
JCEG153 * POFUT F58D5.3 F58D5.3 POFUT1
JCEG154 * = POMGnT Y73B3A.3 POMGNT1 300492
608617
608618
608619
JCEG155 * = POMT R12E2.13 POMT2 602934
607551
JCEG156 * Sulfotransferase and sulfation-related genes Y48G1BL.7 CHST10 CHST8
STREAMRAFp-valueORBETACIStudy
MAPPED 4.0E-7 (Shared) 25574825
MAPPED 0.02 6.0E-7 (olanzapine) 21107309
JCEG157 * = Sulfotransferase and sulfation-related genes hst-2 C34F6.4 HS2ST1 604844
JCEG158 * = Sulfotransferase and sulfation-related genes hst-3.1 F40H3.5 HS3ST1
JCEG159 * = Sulfotransferase and sulfation-related genes hst-3.2 F52B10.2 HS3ST3A1 HS3ST3B1 HS3ST2 HS3ST4 HS3ST5 HS3ST6 604056
604057
604058
604059
STREAMRAFp-valueORBETACIStudy
MAPPED 2.0E-6 24324551
MAPPED 7.0E-7 0.0437 (unit increase) [NR] 24086445
MAPPED 0.381 4.0E-6 (Dominant model) 1.647 [1.264-2.146] 23648065
UPSTREAM 0.2 1.0E-6 1.19 [NR] 19525955
DOWNSTREAM 0.04 2.0E-6 0.082 (unit increase)] 22823124
JCEG160 * = Sulfotransferase and sulfation-related genes hst-6 Y34B4A.3 HS6ST1 300545
604846
609401
614880
JCEG161 * = Sulfotransferase and sulfation-related genes hst-1 F08B4.6 NDST1 600853
603268
603950
615039
JCEG162 * UDP-glucuronosyltransferases ugt-46 B0310.5 CGT
JCEG163 UDP-glucuronosyltransferases ugt-65 F08G5.5
JCEG164 * = UGCGL1 uggt-2 F26H9.8 UGGT1 605897
605898
JCEG165 * = UGCGL1 uggt-1 F48E3.3 UGGT1 UGGT2 605897
605898
JCEG166 * = XylT sqv-6 Y50D4C.4 XYLT1 XYLT2 608124
608125
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-7 (Additive model) 2.5 [1.70-3.50] 23478653
UPSTREAM 0.09 2.0E-6 0.088 (unit decrease) [NR] 23322567
DOWNSTREAM 0.015 8.0E-7 (ALT ) 0.04 (U/L increase) [NR] 23251661
UPSTREAM 0.006 9.0E-6 (ALT ) 0.02 (U/L increase) [NR] 23251661
JCEG167 * = a-N-acetylglucosaminidase K09E4.4 NAGLU 252920
609701
JCEG168 * b3GalT1/b3GnT orthologs F48F7.3 B3GALT1
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG169 * = b3GalT1/b3GnT orthologs F14B6.4 B3GALT1
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG170 * = b3GalT1/b3GnT orthologs C47F8.3 B3GALT1
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG171 * = b3GalT1/b3GnT orthologs C47F8.6 B3GALT1 603095
604066
605863
615313
615315
615357
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG172 * = b3GalT1/b3GnT orthologs E03H4.11 B3GALT1 603095
604066
605863
615313
615315
615357
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG173 * = b3GalT1/b3GnT orthologs bre-2 Y39E4B.9 B3GALT1 603018
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG174 * = b3GalT1/b3GnT orthologs T09F5.1 B3GALT1
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG175 * = b3GalT1/b3GnT orthologs B0024.15 B3GALT1 B3GNT2 B3GNT5
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 2.0E-6 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 8.0E-6 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 2.0E-9 (KvDMR 21) 23725790
JCEG176 * b3GalT1/b3GnT orthologs bus-17 ZK678.8 B3GALT2
STREAMRAFp-valueORBETACIStudy
UPSTREAM 0.169 3.0E-7 1.09 [1.05-1.13] 24162737
JCEG177 * = b3GalT1/b3GnT orthologs F14B6.6 B3GALNT1
STREAMRAFp-valueORBETACIStudy
MAPPED 0.43 2.0E-6 (AA) 4.21 (unit decrease) [2.49-5.93] 23599027
JCEG178 * = b3GalT1/b3GnT orthologs bre-5 T12G3.8 B3GALNT1 B3GALT4 B3GALT5 B3GNT3 B3GNT4 B3GNT6 B3GNT7
STREAMRAFp-valueORBETACIStudy
MAPPED 6.0E-6 1.178 21041247
UPSTREAM 6.0E-8 0.031 (unit increase) [0.019-0.043] 25387707
UPSTREAM 0.733 1.0E-10 0.3 (unit increase) [0.20-0.40] 23583979
UPSTREAM 0.543 7.0E-7 0.108 (unit increase) [0.065-0.151] 23568457
MAPPED 0.43 2.0E-6 (AA) 4.21 (unit decrease) [2.49-5.93] 23599027
DOWNSTREAM 0.26 1.0E-13 (CA19-9) 0.072 (U/ml decrease) [0.029-0.115] 23300138
JCEG179 * = b3GalT1/b3GnT orthologs C54C8.3 B3GALT5 603095
604066
605863
615313
615315
615357
STREAMRAFp-valueORBETACIStudy
MAPPED 6.0E-6 1.178 21041247
JCEG180 * = b3GalT1/b3GnT orthologs sqv-2 Y110A2AL.14 B3GALT6 271640
615291
615349
JCEG181 * = b3GalT1/b3GnT orthologs T15D6.5 B3GNT3 603095
604066
605863
615313
615315
615357
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.26 1.0E-13 (CA19-9) 0.072 (U/ml decrease) [0.029-0.115] 23300138
JCEG182 * b3GalT1/b3GnT orthologs bus-2 K08D12.5 B3GNT5 G26
JCEG183 * = b3GalT1/b3GnT orthologs C47F8.5 B3GNT5 B3GALT2 605864
STREAMRAFp-valueORBETACIStudy
UPSTREAM 0.169 3.0E-7 1.09 [1.05-1.13] 24162737
JCEG184 * = b3GalT1/b3GnT orthologs T09E11.10 B3GNT7
STREAMRAFp-valueORBETACIStudy
UPSTREAM 6.0E-8 0.031 (unit increase) [0.019-0.043] 25387707
UPSTREAM 0.733 1.0E-10 0.3 (unit increase) [0.20-0.40] 23583979
UPSTREAM 0.543 7.0E-7 0.108 (unit increase) [0.065-0.151] 23568457
JCEG185 * = b4GalT bre-4 Y73E7A.7 B4GALT3 604016
604017
JCEG186 * = b4GalT W02B12.1 B4GALT5 610179
STREAMRAFp-valueORBETACIStudy
UPSTREAM 4.0E-6 0.298 (unit decrease)] 23362303
MAPPED 0.11 6.0E-6 0.108 (kg/m2 increase) [0.061-0.155] 25811787
JCEG187 * = b4GalT sqv-3 R10E11.4 B4GALT7 130070
137060
604013
604014
604015
607091
JCEG188 * = b6GnT gly-15 C54C8.11 GCNT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.71 7.0E-6 1.56 [1.28-1.89] 21546767
JCEG189 * = b6GnT gly-1 F44F4.6 GCNT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.71 7.0E-6 1.56 [1.28-1.89] 21546767
JCEG190 * b6GnT ZK1225.5 GCNT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.71 7.0E-6 1.56 [1.28-1.89] 21546767
JCEG191 * = b6GnT gly-16 T15D6.2 GCNT1 GCNT2
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.71 7.0E-6 1.56 [1.28-1.89] 21546767
JCEG192 * = b6GnT gly-17 T15D6.3 GCNT1 G11
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.71 7.0E-6 1.56 [1.28-1.89] 21546767
JCEG193 * = b6GnT gly-18 F22D6.11 GCNT3
JCEG194 * = b6GnT gly-19 F22D6.12 GCNT3
JCEG195 * = b6GnT T09E11.9 GCNT4
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-6 0.0888 (unit increase)] 23362303
JCEG196 * = b6GnT T27F6.1 GCNT3
JCEG197 * = b6GnT R07C3.3 GCNT3
JCEG198 * = b6GnT T14B4.9 GCNT3
JCEG199 * = b6GnT Y51H4A.25 GCNT3
JCEG200 * = b6GnT T28F3.9 GCNT3
JCEG201 * = b6GnT R07B7.6 GCNT3
JCEG202 * = b6GnT F26D2.3 GCNT3
JCEG203 * = b6GnT F30A10.4 GCNT4
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 4.0E-6 0.0888 (unit increase)] 23362303
JCEG204 * = b6GnT ZK1225.2 GCNT1
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.71 7.0E-6 1.56 [1.28-1.89] 21546767
JCEG205 * = b6GnT H41C03.3 GCNT2
JCEG206 * = b6GnT F35H8.2 GCNT2
JCEG207 * b6GnT H41C03.1 GCNT2
JCEG208 * = iGnT orthologs F01D4.9 L2 GCNT2
JCEG209 * = iGnT orthologs F22F7.6 GCNT2
JCEG210 * = iGnT orthologs F21H7.10 GCNT2
JCEG211 * = iGnT orthologs C18G1.3 GCNT2
JCEG212 * = iGnT orthologs K08H2.9 GCNT2
JCEG213 * = iGnT orthologs C54C8.2 GCNT2
JCEG214 * = iGnT orthologs T15D6.4 GCNT2
JCEG215 * = iGnT orthologs F56H6.6 GCNT2
JCEG216 * ppGalNAcT gly-6 H38K22.5 GALNT1
JCEG217 * = ppGalNAcT gly-3 ZK688.8 GALNT1 602273
608369
JCEG218 * = ppGalNAcT gly-9 Y47D3A.23 GALNT1
JCEG219 * = ppGalNAcT gly-5 Y39E4B.12 GALNT1
JCEG220 * = ppGalNAcT gly-4 Y116F11B.12 GALNT2 602274
STREAMRAFp-valueORBETACIStudy
MAPPED 0.6 4.0E-9 0.02 (unit increase) [0.01-0.03] 20864672
MAPPED 0.6 3.0E-14 1.11 (mg/dl higher) [NR] 18193043
MAPPED 0.44 1.0E-9 22916037
MAPPED 0.41 7.000000000000001E-31 0.04 (mg/dL increase) [NR] 24097068
MAPPED 0.41 4.0E-41 0.048 (unit decrease) [NR] 24097068
MAPPED 0.4 8.0E-7 4.25 (mg/dl higher) [NR] 18193043
MAPPED 0.4 4.0E-8 0.05 (s.d. decrease) [0.01-0.09] 19060906
MAPPED 0.4 2.0E-13 0.07 (% SD lower) [0.05-0.09] 18193044
MAPPED 0.4 7.0E-15 0.08 (% SD higher) [0.06-0.10] 18193044
MAPPED 0.4 4.0E-21 0.61 (mg/dL decrease) [0.47-0.75] 20686565
MAPPED 0.39 3.0E-6 0.05 (unit decrease) [0.030-0.070] 23620142
MAPPED 0.39 4.0E-8 (HDL) 0.08 (mmol/l decrease) [NR] 22399527
MAPPED 0.39 2.0E-14 2.76 (mg/dL increase) [2.02-3.5] 20686565
MAPPED 0.224 8.0E-6 (ALB/GLB) 0.016 (unit increase) [0.0082-0.0238] 23303382
MAPPED 0.1984 4.0E-6 (Complete) 0.4595 (unit decrease) [0.26-0.66] 25188341
MAPPED 0.1959 2.0E-6 (Primary) 0.3966 (unit decrease) [0.23-0.56] 25188341
JCEG221 * = ppGalNAcT gly-7 Y46H3A.6 GALNT7 605005
STREAMRAFp-valueORBETACIStudy
MAPPED 0.3308 5.0E-6 (Primary) 0.2278 (unit decrease) [0.11-0.35] 25188341
MAPPED 0.0458 6.0E-9 (Case/control) 1.1474 (unit decrease) [0.76-1.53] 25188341
JCEG222 * = ppGalNAcT gly-10 Y45F10D.3 GALNT10 608043
615138
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.58 5.0E-8 0.03 (unit increase) [0.02-0.04] 25231870
DOWNSTREAM 0.42 5.0E-14 0.021 (unit increase) [0.012-0.030] 23583978
MAPPED 0.379 3.0E-8 1.0615711 [1.04-1.08] 25056061
JCEG223 * = ppGalNAcT gly-8 Y66A7A.6 GALNT11 615130
615133
JCEG224 * = ppGalNAcT gly-11 Y75B8A.9 GALNT11 615130
615133





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