WBGene00017282
Phenotype
Homology_paralog
| Observed | Observed and NOT Observed |
| JCEG ID | JCEG002 | |||||||||
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| Name | algn-2 WormBase NCBI Gene | |||||||||
| Human Ortholog |
GGDB:ALG2 OrthoList : ALG2 (Ensembl Compara)
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| Family Name | Asparagine-linked glycosylation (ALG) genes | |||||||||
| Locus Tag | F09E5.2 | |||||||||
| RNAi phenotype |
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| Sequence Features |
dxd:N.D. tm:soluble gg_motif:M1,M2,M3,M4 |
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| Sequence | CDS |
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| Protein |
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| References |
Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH PLoS Biol. (2003) 1 (1) :E12 [PMID : 14551910] Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K Cell (2011) 145 (3) :470-82 [PMID : 21529718] A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. |
| Functional Descriptions |
algn-2 |
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| Deletion Mutants | ||||
| In Situ | In Situ | |||
| Expression | Expression | |||
WBGene00017282 Phenotype Homology_paralog |
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| Phenotype | Definition | RNAi / Allele | ||
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accumulated germline cell corpses
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"Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] |
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age associated fluorescence increased
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"Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021] |
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apoptosis reduced
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"Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021] |
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apoptosis variant
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"Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021] |
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clear
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"Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654] |
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embryo osmotic integrity defective early emb
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"Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141] |
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] |
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foraging behavior variant
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"Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [GO:0060756, WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712] |
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germ cell compartment expansion variant
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"Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557] |
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germ cell compartment morphology variant
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"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557] |
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germ cell compartment size variant
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"Any variation in germ cell compartment size compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
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germline nuclear positioning variant
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"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021] |
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long
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"Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
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oocyte morphology variant
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"Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021] |
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oocyte number decreased
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"A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
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oocyte septum formation variant
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"Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947] |
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oogenesis variant
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"Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals." [GO:0048477, WB:WBPerson2021] |
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paraquat hypersensitive
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"Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
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rachis morphology variant
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"Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557] |
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rachis narrow
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"The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557] |
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shortened life span
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"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712] |
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sick
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"Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] |
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] |
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