WBGene00011776
Phenotype
Homology_paralog
| Observed | Observed and NOT Observed |
| JCEG ID | JCEG074 | ||||||||
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| Name | hpo-5 WormBase | ||||||||
| Human Ortholog |
GGDB:PIGS OMIM: 610271 OrthoList : PIGS (Ensembl Compara) |
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| Family Name | GPI-anchor synthesis | ||||||||
| Locus Tag | T14G10.7 | ||||||||
| RNAi phenotype |
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| Sequence Features | |||||||||
| Sequence | CDS |
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| Protein |
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| References |
Balklava Z, Pant S, Fares H, Grant BD Nat. Cell Biol. (2007) 9 (9) :1066-73 [PMID : 17704769] Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV PLoS Pathog. (2011) 7 (3) :e1001314 [PMID : 21408619] Global functional analyses of cellular responses to pore-forming toxins. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Winter JF, Hopfner S, Korn K, Farnung BO, Bradshaw CR, Marsico G, Volkmer M, Habermann B, Zerial M Nat. Cell Biol. (2012) 14 (7) :666-76 [PMID : 22634595] Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. |
| Functional Descriptions |
hpo-5 |
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| Deletion Mutants | ||||
| In Situ | ||||
| Expression | Expression | |||
WBGene00011776 Phenotype Homology_paralog |
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| Phenotype | Definition | RNAi / Allele | ||
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Bacillus thuringiensis toxin hypersensitive
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"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] |
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lysosome-related organelle morphology variant
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"Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] |
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pattern of transgene expression variant
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"Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
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pore forming toxin hypersensitive
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"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557] |
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receptor mediated endocytosis defective
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"Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes." [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021] |
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transgene expression reduced
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"Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
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transgene subcellular localization variant
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"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
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