| JCEG ID |
JCEG183 |
| Name |
C47F8.5
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:B3GNT5 B3GALT2
OMIM:
605864
OrthoList :
B3GALT1
B3GALT2
B3GALT4
B3GALNT1
B3GALT5
(Ensembl Compara)
GWAS Catalog
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
0.169 |
0.0000003
|
1.09
|
|
[1.05-1.13] |
24162737
|
|
European Alzheimer's Disease Initiative (EADI) 2013-10-27 Nat Genet
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
b3GalT1/b3GnT orthologs |
| Locus Tag |
C47F8.5
|
| RNAi phenotype |
|
phenotype
|
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
|
|
hsp-4::GFP (Image)
|
|
|
| Sequence Features |
dxd:Detected
gg_motif:M2,M3,M3,M4,M5,M6
tm:soluble
|
| Sequence |
CDS
atgcatttttcgaatttatttcaaatatttctctgggctcgcgtcgccgt
aattgcgtcgttttttattacttttttgttgttatggaattaccgaaatg
ttcaaaattcttcacaatatcatgcaaattcaaaaggaaaatttgttttc
gaagaaaattgcacgaggagcgggtggaatttaaatacaactgcggagcg
gaccatggactacggcaccagcttcatcatatccttcgcagacattcaaa
aaacctacaaatggctctacctacctgaaaccgacatcgtcttgcggagc
cctgacattctcatgatggtcgcctcgaggactgatagttttgccaggag
gaatgttttgaggaagacttggatgaataagaattatagtgaaattgtga
gggatggacggatgaaggcgctatttttggttggtatggtgtcggaggac
tatcgagtcaggaggattgtgatggaagaggcaaagttgtatggggatat
ggtggtcattgatttggaggatacttatgatgatttgccgtttaagtccc
tctccctgctgctctacgcagtgagcaaggctccagagttcaaagttatt
gggaaaatcgatgaagatgtcatgttcttccccgacaagctaatcccatt
gctcgatggaaaagttatcgatccggatgccgcggccttctacgggcagc
tcctgaaagagggggaacccgttattaagaaaaaggatgctcactggtac
gtacccgattacgcgtacaactgcacaggatacccagcatacgtcgccgg
cccattctacctggctactaggaaagccgccaagctggtgctgaaattca
caaagtttcagaattttatgacggttgaggactcccttatcaccggaatt
ctagccaatgacctagggataccgaggaaaaatttggagcatgtgtacag
gcatgattatgatatccaagataacgaggggaaggagattttggcgtggc
attcctttaaaaataatattccatatcgaaatttttttgtgaagcgagtt
gcaaggcatcgctacgagcagaatttgtccaatatgcttttggagattaa
tcgctaa
|
Protein
MHFSNLFQIFLWARVAVIASFFITFLLLWNYRNVQNSSQYHANSKGKFVFEENCTRSGWN
LNTTAERTMDYGTSFIISFADIQKTYKWLYLPETDIVLRSPDILMMVASRTDSFARRNVL
RKTWMNKNYSEIVRDGRMKALFLVGMVSEDYRVRRIVMEEAKLYGDMVVIDLEDTYDDLP
FKSLSLLLYAVSKAPEFKVIGKIDEDVMFFPDKLIPLLDGKVIDPDAAAFYGQLLKEGEP
VIKKKDAHWYVPDYAYNCTGYPAYVAGPFYLATRKAAKLVLKFTKFQNFMTVEDSLITGI
LANDLGIPRKNLEHVYRHDYDIQDNEGKEILAWHSFKNNIPYRNFFVKRVARHRYEQNLS
NMLLEINR
|
| References |
|
| Functional Descriptions |
C47F8.5
none available
|
| Deletion Mutants |
tm4388
|
| In Situ |
|
| Expression |
Expression
|
WBGene00019802
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|