JCEG ID JCEG220
Name gly-4      WormBase    NCBI Gene
Human Ortholog

GGDB:GALNT2 

OMIM: 602274

OrthoList :   GALNT2   GALNT14   GALNT16  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.6 0.000000004 0.02 (unit increase) [0.01-0.03] 20864672
MAPPED 0.6 0.00000000000003 1.11 (mg/dl higher) [NR] 18193043
MAPPED 0.44 0.000000001 22916037
MAPPED 0.41 0.0000000000000000000000000000007000000000000001 0.04 (mg/dL increase) [NR] 24097068
MAPPED 0.41 0.00000000000000000000000000000000000000004 0.048 (unit decrease) [NR] 24097068
MAPPED 0.4 0.0000008 4.25 (mg/dl higher) [NR] 18193043
MAPPED 0.4 0.00000004 0.05 (s.d. decrease) [0.01-0.09] 19060906
MAPPED 0.4 0.0000000000002 0.07 (% SD lower) [0.05-0.09] 18193044
MAPPED 0.4 0.000000000000007 0.08 (% SD higher) [0.06-0.10] 18193044
MAPPED 0.4 0.000000000000000000004 0.61 (mg/dL decrease) [0.47-0.75] 20686565
MAPPED 0.39 0.000003 0.05 (unit decrease) [0.030-0.070] 23620142
MAPPED 0.39 0.00000004 (HDL) 0.08 (mmol/l decrease) [NR] 22399527
MAPPED 0.39 0.00000000000002 2.76 (mg/dL increase) [2.02-3.5] 20686565
MAPPED 0.224 0.000008 (ALB/GLB) 0.016 (unit increase) [0.0082-0.0238] 23303382
MAPPED 0.1984 0.000004 (Complete) 0.4595 (unit decrease) [0.26-0.66] 25188341
MAPPED 0.1959 0.000002 (Primary) 0.3966 (unit decrease) [0.23-0.56] 25188341
GGDB Score E-val
GALNT2 507 e-145
GALNT14 450 e-128
GALNT1 415 e-117
GALNT13 407 e-115
GALNT6 380 e-107
GALNT12 376 e-106
GALNT4 372 e-104
GALNT3 369 e-103
GALNT11 336 7e-94
GALNT10 330 5e-92
GALNT5 307 3e-85
GALNT9 295 1e-81
GALNT19 268 2e-73
GALNT15 267 4e-73
GALNT7 260 4e-71
GALNT8 246 7e-67
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name ppGalNAcT
Locus Tag Y116F11B.12
RNAi phenotype
phenotype Emb, oocyte morphology variant
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Hagen FK, Nehrke K J. Biol. Chem. (1998) 273 (14) :8268-77 [PMID : 9525933] cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.

Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H J. Biol. Chem. (2002) 277 (25) :22623-38 [PMID : 11925450] Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA Glycobiology (2012) 22 (6) :736-56 [PMID : 22183981] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

WormBase (WS254)

Functional Descriptions gly-4

gly-4 encodes a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase; GLY-4 exhibits UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity in vitro.
Deletion Mutants tm3849 ok2943
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Enriched WBPaper00037950 : coelomocytes_embryo_SelectivelyEnriched, coelomocytes_embryo_enriched
WBPaper00037950 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00037950 : intestine_larva_SelectivelyEnriched, intestine_larva_enriched
WBPaper00037950 WormAtlas

WBGene00001629
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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