JCEG ID JCEG078
Name hpo-20      WormBase
Human Ortholog

GGDB:PIGW 

OMIM: 610275

OrthoList :   ENSG00000184886  (Ensembl Compara)

Family Name GPI-anchor synthesis
Locus Tag Y110A2AL.12
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV PLoS Pathog. (2011) 7 (3) :e1001314 [PMID : 21408619] Global functional analyses of cellular responses to pore-forming toxins.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions hpo-20

Deletion Mutants
In Situ
Expression Expression

WBGene00022447
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
Bacillus thuringiensis toxin hypersensitive

"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
RNAi: WBRNAi00088646   WBPaper00038231   Observed
RNAi: WBRNAi00088753   WBPaper00038231   Observed
dauer lifespan extended

"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
RNAi: WBRNAi00103574   WBPaper00041478   Observed
pore forming toxin hypersensitive

"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
RNAi: WBRNAi00088646   WBPaper00038231   Observed
RNAi: WBRNAi00088753   WBPaper00038231   Observed


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