JCEG ID JCEG164
Name uggt-2      WormBase    NCBI Gene
Human Ortholog

GGDB:UGGT1 

OMIM: 605897 605898

OrthoList :   UGGT1   UGGT2  (Ensembl Compara)

GGDB Score E-val
UGGT2 (UGCGL2) 724 0.0
UGGT1 (UGCGL1) 611 e-176
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name UGCGL1
Locus Tag F26H9.8
RNAi phenotype
phenotype Emb
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
gg_motif:M1, M2, M3, M4, M5, M6
tm:Detected
dxd:Detected
Sequence CDS
Protein
References

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Buzzi LI, Simonetta SH, Parodi AJ, Castro OA PLoS ONE (2011) 6 (11) :e27025 [PMID : 22073243] The two Caenorhabditis elegans UDP-glucose:glycoprotein glucosyltransferase homologues have distinct biological functions.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions uggt-2

uggt-2 encodes one of two C. elegans homologs of UDP-Glc:glycoprotein glucosyltransferase (UGGT), an endoplasmic reticulum enzyme involved in quality control of glycoprotein folding; loss of uggt-2 activity via RNAi indicates that uggt-2 is an essential embryonic gene that is also required for regulating the rate of larval developmental; uggt-2 interacts genetically with ire-1 with respect to basal unfolded protein response during larval development; uggt-2 is expressed throughout larval development, with peak levels seen at the L2/L3 stages.
Deletion Mutants tm2318 gk1680 ok2510
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0004574

Z4 "Somatic gonad precursor cell" [ISBN:0-87969-307-X] Enriched WBPaper00048690 : male-Z1-Z4_enriched
WBPaper00048690
WB WBbt:0004577

Z1 "Somatic gonad precursor cell" [ISBN:0-87969-307-X] Enriched WBPaper00048690 : male-Z1-Z4_enriched
WBPaper00048690
WB WBbt:0005784

germ line "cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] Enriched WBPaper00044760 : germline_specific
WBPaper00044760

WBGene00009178
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
developmental delay

"The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557]
RNAi: WBRNAi00093464   WBPaper00040397   Observed
Allele: WBVar00093646   WBPaper00040397   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
Allele: WBVar00093646   WBPaper00040397   Observed
organism hypersensitive desication

"Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021]
Allele: WBVar00251220   WBPaper00044578   Observed
tunicamycin hypersensitive

"Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557]
RNAi: WBRNAi00093466   WBPaper00040397   Observed
RNAi: WBRNAi00093471   WBPaper00040397   Observed


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