JCEG ID |
JCEG028 |
Name |
F08A8.5
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:FUT1
OMIM:
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
GGDB |
Score |
E-val |
FUT1
|
58 |
2e-10 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Fucosyltransferases |
Locus Tag |
F08A8.5
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
tm:Detected
kr:Detected
gg_motif:M1,M3 substitution(V->T)
|
Sequence |
CDS
atgaggtataattcgaattatttgatgtatttttgcttggttttaggaat atttgccaatatctatgttataatcaaaataactctgggatccagtcata ttttagaatattttcaaaaaaattcaaatttatcgccaaaatgtgagatc aataattcacaaaagtcccagccaaactatgaaaaaaccttgcaacttat gcttttcgccttcccttctggtggactaggaaacaagcttttcgagataa tttccctgcatggaattgctacctcattgcaacgaaaagcagtgataaat gctacaaatcccagttttattgaaactttaaacaggaatattcaaccgtt gttcccaaaattggcagatcaattcaccttgagaatcataccggactctt tggttacccaccagcaaacgaactggggaagatgttgtgtatacgatgat ccctcgagatttttgaaccgatccgaccaaaacttgattctagatggaca ctacttccagagtttcaaatatttccatcacattcgtcctcaagtgcgtg aatggttggctcccagcaaactacaagcgatgagagccgaaattctgctc ccagcaaagtttagggatgattttctaatctgcacccacgtcagacgggg agatttccagtatgatggacttcatcgaccatcggatgccacgtttacac gggcggccactgattttttggtggatttgtatcgaaaatctcatgaacgg gtcaatgtggtggttttaggcaatgatattcattttgcatatacggtttt tgaagatcgtgttgcccatttcacttttcttcaaaaaccagtcaacaatt cttatgactacagtttaccacaaatttctccaagttatacggcaattcta acaccaacattgacaccagaaatcgacttggcattttctagactattctg tgacgtcacactaataactgcgccatcttctacattcggatggtggttgt cgtacttggcaaaacgaactgcaactacatattatagggatattttggag tcaaaagatggggttgctggtgaaatgcacccggaagacttctacccgcc ggaatggataaagctgaaaacggatctaaacggaaagatcagcaaatatt ga
atgaggtataattcgaattatttgatgtatttttgcttggttttaggaat atttgccaatatctatgttataatcaaaataactctgggatccagtcata ttttagaatattttcaaaaaaattcaaatttatcgccaaaatgtgagatc aatgtgaacaacttgctaagttttattgaaaatcgacattttttggattt ggagcaaaaaaattcacaaaagtcccagccaaactatgaaaaaaccttgc aacttatgcttttcgccttcccttctggtggactaggaaacaagcttttc gagataatttccctgcatggaattgctacctcattgcaacgaaaagcagt gataaatgctacaaatcccagttttattgaaactttaaacaggaatattc aaccgttgttcccaaaattggcagatcaattcaccttgagaatcataccg gactctttggttacccaccagcaaacgaactggggaagatgttgtgtata cgatgatccctcgagatttttgaaccgatccgaccaaaacttgattctag atggacactacttccagagtttcaaatatttccatcacattcgtcctcaa gtgcgtgaatggttggctcccagcaaactacaagcgatgagagccgaaat tctgctcccagcaaagtttagggatgattttctaatctgcacccacgtca gacggggagatttccagtatgatggacttcatcgaccatcggatgccacg tttacacgggcggccactgattttttggtggatttgtatcgaaaatctca tgaacgggtcaatgtggtggttttaggcaatgatattcattttgcatata cggtttttgaagatcgtgttgcccatttcacttttcttcaaaaaccagtc aacaattcttatgactacagtttaccacaaatttctccaagttatacggc aattctaacaccaacattgacaccagaaatcgacttggcattttctagac tattctgtgacgtcacactaataactgcgccatcttctacattcggatgg tggttgtcgtacttggcaaaacgaactgcaactacatattatagggatat tttggagtcaaaagatggggttgctggtgaaatgcacccggaagacttct acccgccggaatggataaagctgaaaacggatctaaacggaaagatcagc aaatattga
|
Protein
MRYNSNYLMYFCLVLGIFANIYVIIKITLGSSHILEYFQKNSNLSPKCEINNSQKSQPNY EKTLQLMLFAFPSGGLGNKLFEIISLHGIATSLQRKAVINATNPSFIETLNRNIQPLFPK LADQFTLRIIPDSLVTHQQTNWGRCCVYDDPSRFLNRSDQNLILDGHYFQSFKYFHHIRP QVREWLAPSKLQAMRAEILLPAKFRDDFLICTHVRRGDFQYDGLHRPSDATFTRAATDFL VDLYRKSHERVNVVVLGNDIHFAYTVFEDRVAHFTFLQKPVNNSYDYSLPQISPSYTAIL TPTLTPEIDLAFSRLFCDVTLITAPSSTFGWWLSYLAKRTATTYYRDILESKDGVAGEMH PEDFYPPEWIKLKTDLNGKISKY
MRYNSNYLMYFCLVLGIFANIYVIIKITLGSSHILEYFQKNSNLSPKCEINVNNLLSFIE NRHFLDLEQKNSQKSQPNYEKTLQLMLFAFPSGGLGNKLFEIISLHGIATSLQRKAVINA TNPSFIETLNRNIQPLFPKLADQFTLRIIPDSLVTHQQTNWGRCCVYDDPSRFLNRSDQN LILDGHYFQSFKYFHHIRPQVREWLAPSKLQAMRAEILLPAKFRDDFLICTHVRRGDFQY DGLHRPSDATFTRAATDFLVDLYRKSHERVNVVVLGNDIHFAYTVFEDRVAHFTFLQKPV NNSYDYSLPQISPSYTAILTPTLTPEIDLAFSRLFCDVTLITAPSSTFGWWLSYLAKRTA TTYYRDILESKDGVAGEMHPEDFYPPEWIKLKTDLNGKISKY
|
References |
|
Functional Descriptions |
F08A8.5
F08A8.5 encodes, by alternative splicing, two isoforms of a putative alpha-1,2-fucosyltransferase (alpha1,2FT) that is required for biosynthesis of H-type 3 glycans; F08A8.5 is expressed pharyngeally from embryogenesis to adulthood; recombinant F08A8.5 protein has alpha1,2FT activity in vitro on a Gal[beta]1-3GalNAc[alpha]-O-pNP substrate, but not on Gal[beta]-O-phenyl; F08A8.5 has no obvious function in mass RNAi assays.
|
Deletion Mutants |
gk453
|
In Situ |
|
Expression |
Expression
|
WBGene00008568
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
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postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
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slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
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sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
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Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|
vulva development variant
|
"Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GO:0040025, WB:IA, WB:WBPerson2021]
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