JCEG ID JCEG064
Name piga-1      WormBase    NCBI Gene
Human Ortholog

GGDB:PIGA 

OMIM: 300818 300868 311770

OrthoList :   PIGA  (Ensembl Compara)

Family Name GPI-anchor synthesis
Locus Tag D2085.6
RNAi phenotype
phenotype
Microscope observation (Image)
COPAS (Image)
hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Piano F, Schetter AJ, Morton DG, Gunsalus KC, Reinke V, Kim SK, Kemphues KJ Curr. Biol. (2002) 12 (22) :1959-64 [PMID : 12445391] Gene clustering based on RNAi phenotypes of ovary-enriched genes in C. elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Murata D, Nomura KH, Dejima K, Mizuguchi S, Kawasaki N, Matsuishi-Nakajima Y, Ito S, Gengyo-Ando K, Kage-Nakadai E, Mitani S, Nomura K Mol Biol Cell. (2012) 23 (6) :982-95 [PMID : 22298425] GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans.

WormBase (WS254)

Functional Descriptions piga-1

D2085.6 is orthologous to the human gene CLASS A GLCNAC-INOSITOL PHOSPHOLIPID ASSEMBLY PROTEIN (PIGA; OMIM:311770), which when mutated leads to paroxysmal nocturnal hemoglobinuria.
Deletion Mutants
In Situ
Expression Expression

WBGene00008431
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
high incidence male progeny

"Higher numbers of male progeny occur in the population compared to control populations. In C. elegans, the high incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an increase in X chromosome nondisjunction." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712]
RNAi: WBRNAi00008101   WBPaper00005599   Observed


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