JCEG ID |
JCEG059 |
Name |
hpo-3
WormBase
|
Human Ortholog |
GGDB:GPAA1
OMIM:
603048
OrthoList :
GPAA1
(Ensembl Compara)
|
Family Name |
GPI-anchor synthesis |
Locus Tag |
F33D11.9
|
RNAi phenotype |
phenotype
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Microscope observation (Image)
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COPAS (Image)
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hsp-4::GFP (Image)
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Sequence Features |
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Sequence |
CDS
ATGTATATTATACCGCTCACAATTCTTGTGAGCCCACTTGTCATCTCGGCCTACTTCGAATGGACCAAAA TTCAAGAATTCCAATTTCCAGTGGTCCATTTGGCATTCCACGTGCTCGGATTCTTCTACTACATTGCAAC TACATATGTATTTCAAACAATTGGAACAACATTTGTTCTTCAATGGATGCAATGGCCATTTGTTGGTATT GATGGATGTGATGGACAGTTTACACCATCATGGTCTCTAATCAACAGTTTTCTCATATTCTTCATGATTC CATTAGGACCATATGTTTTCTTGAAAGAACCAGTTCGTTGTGTCCCAAGTATGCGAATCGTGTGTCTCCT TGAAACATCCCTAGTTCTCTATGGTATTTGTCTCACCAATTTCGGGCTCGCCATTCTCTGTACAGCATTT GTCGTTCCAATCGTTTTTCTTATGACGTACGAATCATCGGATAGAACTCGCAGTATCTTCCGATCTTCAG TCCTTGCCATCCTCAATCCAATCTCCGTGCTTGCATTTGTGGCGATTAACATTCCGGGAATGTTCGGACA ACTATTCCCAACTATTTCTCAAGATTCATGGCTCGCCGCTGCTCAAAGCATTGCACTCACAGCTATCAGA GAAGACGTGGAATTTAAAGTGAATCATTTCTTCCTTTTGTGCTGCTTTGGTTATCCTATCTGGAATATGC TTTTTGCCTGTTCGATGCGATATGGTCCAGAACCACAAGGAAGTTTGGGAATTTTTGGAAATGGAAGCGA TGACGATGATGGTGATGATGATGATGGGCCACAAAAAACCAATCGGGGCCATTCAACAAAGAAGAATAAG AGAGAGTGA
ATGGAGAATCTTTTAAAATTCACAAACAAAAAATTAAAACTTCTAGAAATGGCACTAGAAATATCAAAAG ATGGAGGAACAACGCGGCCGAAAATTCTCGACAAAATACTAAAATTTCGGAAAGTTGCCCTGATTATCGC ATATATTGGAGCATATTTAAGTGCACAATGGTTATTTGATCCAGTGAATATGGAAGTTACAAGGATATCT GAACACTCTTTGATGCCAGGATTAGTGACTCCAAAATTCGATAAAAGTGGAATAGCAATTCAGTTGTATC GAAGATTCAGTGATCTACCAAAATCCAAGTCTCAACAAGAATTAATTCACACCATATTTTCTGATCTTGG CCTCGAATGTTTCACTCATAAATGGAGATCAAAAGTGGCGGGAAATCCAATGAATGGAGAAAATGTGTAT GGATTTATTAGAGGACCACGAAATGATGGAGCAGAAGCACAAATGATTGTTGTACAACTTGGAAGATCAG AGAAATCACGTAGAATGATGTCAAGAATGTTAGCATTTGTTGATTATGCAAAAGATCAAGTTTATTGGGC AAGAGATATTGTTATTGTTTTTGTTGATGGAGGAGAAAAAAATGATTCAATTGAAAAAGCTGCATTTGCA TTGGATGCTTTTCTTCTGAAATATCAAAAAATTGAAGCTTTGAATTCGAAAAAATCAATAACAGTAGAAG CAGATGAAATCCAAGCCCAAACGGGAGCACTCATCGGTGGAGTAGTTTATGATTTATCTGGAATGGCTGT TAAAGGACAACATATTGTGAATATTCAAACAAATGGGCTCAATGGACAGCAAGTTAATTTAGACGTTTTC AATGGAATTACTAAAATTGCCGATTCCAAACATCATTCAAGAGTTGCTATTTTTGGAACTCTTCATAGAC ATTCGAATCCATATATGGAGTATTCCCCATTTATTGTTCCAATGAGAGCTCTCTACACACAAGCATTTAT TTCCATCGAAGGAATTCATAGTGTACTAGGAAAATATGGAGTTCAGGGTCTTACCGTTGGATTGAGTCAC GATTACAGTGAAAAACAGACAGGACAATTCATTGAAGAAGTGTCTCGTATGTTAAATAACGTATTGGAAA GGCTTCATCAAAGTTATTTCATGTACGTACTGGCGGACGATCTTCACTTCTCGTCAATTGCCATGTATAT TATACCGCTCACAATTCTTGTGAGCCCACTTGTCATCTCGGCCTACTTCGAATGGACCAAAATTCAAGAA TTCCAATTTCCAGTGGTCCATTTGGCATTCCACGTGCTCGGATTCTTCTACTACATTGCAACTACATATG TATTTCAAACAATTGGAACAACATTTGTTCTTCAATGGATGCAATGGCCATTTGTTGGTATTGATGGATG TGATGGACAGTTTACACCATCATGGTCTCTAATCAACAGTTTTCTCATATTCTTCATGATTCCATTAGGA CCATATGTTTTCTTGAAAGAACCAGTTCGTTGTGTCCCAAGTATGCGAATCGTGTGTCTCCTTGAAACAT CCCTAGTTCTCTATGGTATTTGTCTCACCAATTTCGGGCTCGCCATTCTCTGTACAGCATTTGTCGTTCC AATCGTTTTTCTTATGACGTACGAATCATCGGATAGAACTCGCAGTATCTTCCGATCTTCAGTCCTTGCC ATCCTCAATCCAATCTCCGTGCTTGCATTTGTGGCGATTAACATTCCGGGAATGTTCGGACAACTATTCC CAACTATTTCTCAAGATTCATGGCTCGCCGCTGCTCAAAGCATTGCACTCACAGCTATCAGAGAAGACGT GGAATTTAAAGTGAATCATTTCTTCCTTTTGTGCTGCTTTGGTTATCCTATCTGGAATATGCTTTTTGCC TGTTCGATGCGATATGGTCCAGAACCACAAGGAAGTTTGGGAATTTTTGGAAATGGAAGCGATGACGATG ATGGTGATGATGATGATGGGCCACAAAAAACCAATCGGGGCCATTCAACAAAGAAGAATAAGAGAGAGTG A
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Protein
MYIIPLTILVSPLVISAYFEWTKIQEFQFPVVHLAFHVLGFFYYIATTYVFQTIGTTFVLQWMQWPFVGI DGCDGQFTPSWSLINSFLIFFMIPLGPYVFLKEPVRCVPSMRIVCLLETSLVLYGICLTNFGLAILCTAF VVPIVFLMTYESSDRTRSIFRSSVLAILNPISVLAFVAINIPGMFGQLFPTISQDSWLAAAQSIALTAIR EDVEFKVNHFFLLCCFGYPIWNMLFACSMRYGPEPQGSLGIFGNGSDDDDGDDDDGPQKTNRGHSTKKNK RE
MENLLKFTNKKLKLLEMALEISKDGGTTRPKILDKILKFRKVALIIAYIGAYLSAQWLFDPVNMEVTRIS EHSLMPGLVTPKFDKSGIAIQLYRRFSDLPKSKSQQELIHTIFSDLGLECFTHKWRSKVAGNPMNGENVY GFIRGPRNDGAEAQMIVVQLGRSEKSRRMMSRMLAFVDYAKDQVYWARDIVIVFVDGGEKNDSIEKAAFA LDAFLLKYQKIEALNSKKSITVEADEIQAQTGALIGGVVYDLSGMAVKGQHIVNIQTNGLNGQQVNLDVF NGITKIADSKHHSRVAIFGTLHRHSNPYMEYSPFIVPMRALYTQAFISIEGIHSVLGKYGVQGLTVGLSH DYSEKQTGQFIEEVSRMLNNVLERLHQSYFMYVLADDLHFSSIAMYIIPLTILVSPLVISAYFEWTKIQE FQFPVVHLAFHVLGFFYYIATTYVFQTIGTTFVLQWMQWPFVGIDGCDGQFTPSWSLINSFLIFFMIPLG PYVFLKEPVRCVPSMRIVCLLETSLVLYGICLTNFGLAILCTAFVVPIVFLMTYESSDRTRSIFRSSVLA ILNPISVLAFVAINIPGMFGQLFPTISQDSWLAAAQSIALTAIREDVEFKVNHFFLLCCFGYPIWNMLFA CSMRYGPEPQGSLGIFGNGSDDDDGDDDDGPQKTNRGHSTKKNKRE
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References |
Barberan-Soler S, Zahler AM
PLoS Genet.
(2008)
4
(2)
:e1000001
[PMID : 18454200]
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets.
Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV
PLoS Pathog.
(2011)
7
(3)
:e1001314
[PMID : 21408619]
Global functional analyses of cellular responses to pore-forming toxins.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
hpo-3
|
Deletion Mutants |
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In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
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WBPaper00026980
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WormAtlas
|
WB |
WBbt:0005784
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germ line |
"cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] |
Enriched |
WBPaper00044760 : germline_specific
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WBPaper00044760
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WB |
WBbt:0006849
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germline precursor cell |
"member of a set of two cells that generate exclusively sperm and ovum." [WB:rynl] |
Enriched |
WBPaper00037950 : germline-precursors_embryo_enriched
|
WBPaper00037950
|
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WBGene00018006
Phenotype
Homology_paralog
|
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Phenotype |
Definition |
RNAi / Allele |
Bacillus thuringiensis toxin hypersensitive
|
"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
|
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embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
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maternal sterile
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" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
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pore forming toxin hypersensitive
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"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
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protein aggregation variant
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"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
|
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
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transgene subcellular localization variant
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"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
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Variant
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"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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