JCEG ID JCEG221
Name gly-7      WormBase    NCBI Gene
Human Ortholog

GGDB:GALNT7 

OMIM: 605005

OrthoList :   GALNT7  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.3308 0.000005 (Primary) 0.2278 (unit decrease) [0.11-0.35] 25188341
MAPPED 0.0458 0.000000006 (Case/control) 1.1474 (unit decrease) [0.76-1.53] 25188341
GGDB Score E-val
GALNT7 464 e-132
GALNT10 419 e-118
GALNT1 394 e-111
GALNT13 379 e-107
GALNT3 342 1e-95
GALNT6 336 5e-94
GALNT4 332 7e-93
GALNT11 319 1e-88
GALNT2 310 4e-86
GALNT12 309 9e-86
GALNT5 308 2e-85
GALNT9 287 4e-79
GALNT14 280 5e-77
GALNT19 266 6e-73
GALNT8 254 4e-69
GALNT15 244 3e-66
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name ppGalNAcT
Locus Tag Y46H3A.6
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Hagen FK, Nehrke K J. Biol. Chem. (1998) 273 (14) :8268-77 [PMID : 9525933] cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.

Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H J. Biol. Chem. (2002) 277 (25) :22623-38 [PMID : 11925450] Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK Mol. Biol. Cell (2005) 16 (9) :4202-13 [PMID : 15987734] The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA Glycobiology (2012) 22 (6) :736-56 [PMID : 22183981] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

WormBase (WS254)

Functional Descriptions gly-7

gly-7 encodes an N-acetylgalactosaminyltransferase that exhibits activity when expressed in COS7 cells.
Deletion Mutants gk374
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00040985 : AIN-2_L4_intestine, AIN-2_asynchronous_intestine
 WBPaper00040985 WormAtlas

WBGene00001632
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele


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