JCEG ID JCEG009
Name C08H9.3      WormBase    NCBI Gene
Human Ortholog

GGDB:ALG8 

OMIM: 608103 608104

OrthoList :   ALG8  (Ensembl Compara)

GGDB Score E-val
ALG8 247 6e-67
ALG6 76 2e-15
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Asparagine-linked glycosylation (ALG) genes
Locus Tag C08H9.3
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)

Normal

Sequence Features kr:N.D.
tm:Detected
Sequence CDS
Protein
References

Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M Genome Res. (2004) 14 (10B) :2162-8 [PMID : 15489339] Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.

Ceron J, Rual JF, Chandra A, Dupuy D, Vidal M, van den Heuvel S BMC Dev. Biol. (2007) 7 :30 [PMID : 17417969] Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.

WormBase (WS254)

Functional Descriptions C08H9.3

none available
Deletion Mutants
In Situ In Situ   
Expression Expression

WBGene00007464
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00028703   WBPaper00024497   Observed
larval arrest

"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
RNAi: WBRNAi00028703   WBPaper00024497   Observed
RNAi: WBRNAi00072924   WBPaper00029258   Observed
RNAi: WBRNAi00072925   WBPaper00029258   Observed
RNAi: WBRNAi00072926   WBPaper00029258   Observed
protruding vulva

"Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021]
RNAi: WBRNAi00072926   WBPaper00029258   Observed
reduced brood size

"The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557]
RNAi: WBRNAi00028703   WBPaper00024497   Observed
sterile

"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
RNAi: WBRNAi00072924   WBPaper00029258   Observed
RNAi: WBRNAi00072926   WBPaper00029258   Observed


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