| JCEG ID | JCEG016 | |||||||||
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| Name | dpm-1 WormBase NCBI Gene | |||||||||
| Human Ortholog |
GGDB:DPM1 OrthoList : DPM1 (Ensembl Compara)
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| Family Name | Asparagine-linked glycosylation (ALG) genes | |||||||||
| Locus Tag | Y66H1A.2 | |||||||||
| RNAi phenotype |
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| Sequence Features |
tm:soluble |
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| Sequence | CDS |
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| Protein |
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| References |
Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Arur S, Ohmachi M, Nayak S, Hayes M, Miranda A, Hay A, Golden A, Schedl T Proc. Natl. Acad. Sci. U.S.A. (2009) 106 (12) :4776-81 [PMID : 19264959] Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. |
| Functional Descriptions |
dpm-1 dpm-1 encodes a putative catalytic subunit of dolichol phosphate mannosyltransferase, orthologous to budding yeast and human DPM1 (OMIM:603503, mutated in congenital disorder of glycosylation type Ie); in mass RNAi assays, DPM-1 is required for embryonic viability and proper cortical motion in the early embryo. |
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| Deletion Mutants | ||||
| In Situ | ||||
| Expression | Expression | |||
WBGene00022044 Phenotype Homology_paralog |
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| Phenotype | Definition | RNAi / Allele | ||
cortical dynamics defective early emb
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"Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141] |
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] |
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