JCEG ID |
JCEG068 |
Name |
hpo-4
WormBase
|
Human Ortholog |
GGDB:PIGK
OMIM:
605087
OrthoList :
PIGK
(Ensembl Compara)
|
Family Name |
GPI-anchor synthesis |
Locus Tag |
T05E11.6
|
RNAi phenotype |
phenotype
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Microscope observation (Image)
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COPAS (Image)
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hsp-4::GFP (Image)
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Sequence Features |
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Sequence |
CDS
ATGCGTCATGTACTATTGATTTTCTGTGCAATAATTGCAACCGAAGCTCTTCTTAACACA GGTCTACAGCTGAAAATTGATGAATTATTCGACACCCCAGGTCACACAAATAACTGGGCC GTTCTCGTATGCACATCGAAATTTTGGTTCAACTATCGTCATGTCTCCAACGTTTTGGCT CTTTATCACTCAATCAAACGATTAGGTATTCCTGACAGTAATATTATAATGATGCTGGCA GAAGACGTACCATGTAATTCAAGAAATCCGCGGCCTGGAACGGTTTACGCCGCCAGAGCG GGAACAAATCTTTACGGAAGTGACGTGGAAGTTGACTATCGAGGAGAAGAAGTCACTGTT GAAAGCTTCATCCGCGTTTTGACAGGACGTCATCATCCGGCGACACCTCGTTCAAAAAGA CTGCTCACCGACCATCAGAGCAATGTTCTGATTTATCTCACTGGCCACGGAGGAGACAGT TTCATGAAATTCCAAGATTCTGAAGAGCTCACCAACGTTGATTTGGCGTATGCTATTCAA ACGATGTTCGAGGATAACCGGTATCACGAAATGCTTGTAATTGCTGATAGTTGCCGAAGT GCTTCAATGTATGAATGGATTGATTCACCAAATGTACTGAGTCTTTCTAGCAGTTTGACA CACGAAGAGAGCTATTCTTACGATGTGGATACAGATATCGGAGTTTACGTTATCGATAGA TACACCCATTACACTGTTAACTTCCTAACAAAAGAAGTGAAAGCATTGAATTCGTCTGCG AATATGCAAGATTATATTGATTCTTGTCCAGCTAGAAAATGTCTATCAAATACAGGCGTT CGAAAAGATCATTATCCGAAAGATGTGAAACGAGTTCGCGTGACCGACTTCTTTGGATCA TCAAGAATATTCCAACATCTCAGCGAAGAAATCGTGCTTGATGACGAGTTCTGGGCTTGA
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Protein
MRHVLLIFCAIIATEALLNTGLQLKIDELFDTPGHTNNWAVLVCTSKFWFNYRHVSNVLA LYHSIKRLGIPDSNIIMMLAEDVPCNSRNPRPGTVYAARAGTNLYGSDVEVDYRGEEVTV ESFIRVLTGRHHPATPRSKRLLTDHQSNVLIYLTGHGGDSFMKFQDSEELTNVDLAYAIQ TMFEDNRYHEMLVIADSCRSASMYEWIDSPNVLSLSSSLTHEESYSYDVDTDIGVYVIDR YTHYTVNFLTKEVKALNSSANMQDYIDSCPARKCLSNTGVRKDHYPKDVKRVRVTDFFGS SRIFQHLSEEIVLDDEFWA
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References |
Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, Chen L, Aroian RV
PLoS Pathog.
(2011)
7
(3)
:e1001314
[PMID : 21408619]
Global functional analyses of cellular responses to pore-forming toxins.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
hpo-4
|
Deletion Mutants |
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In Situ |
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Expression |
Expression
|
WBGene00011482
Phenotype
Homology_paralog
|
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Phenotype |
Definition |
RNAi / Allele |
Bacillus thuringiensis toxin hypersensitive
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"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
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basement membrane gap expansion variant
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"Animals display variations in the manner in which an opening in the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) expands to make way for intertissue connections, compared to control animals." [WB:WBPaper00038447, WB:WBPerson2987, WB:WBPerson557]
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
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maternal sterile
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" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
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pore forming toxin hypersensitive
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"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
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protein aggregation variant
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"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
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sterile progeny
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"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
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transgene subcellular localization variant
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"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
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Variant
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"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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