JCEG ID JCEG173
Name bre-2      WormBase    NCBI Gene
Human Ortholog

GGDB:B3GALT1 

OMIM: 603018

OrthoList :   B3GALT1   B3GALT2   B3GALT4   B3GALNT1   B3GALT5  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.103 0.000002 (Amylin ) 0.03 (pM increase) [NR] 23251661
MAPPED 0.083 0.000008 (Diet fat ) 0.04 (%energy increase) [NR] 23251661
DOWNSTREAM 0.04 0.000000002 (KvDMR 21) 23725790
GGDB Score E-val
B3GALT1 86 9e-19
B3GALT5 77 4e-16
B3GNT6 74 5e-15
B3GNT3 68 3e-13
B3GNT7 68 3e-13
B3GALNT1 63 8e-12
B3GNT4 59 1e-10
B3GALT2 57 6e-10
B3GNT2 54 4e-09
B3GNT8 51 4e-08
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name b3GalT1/b3GnT orthologs
Locus Tag Y39E4B.9
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
gg_motif:M1,M2,M3
tm:Detected
dxd:Detected
Sequence CDS
Protein
References

Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV Genetics (2000) 155 (4) :1693-9 [PMID : 10924467] Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.

Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Muller R, Brown JR, Hennet T, Esko JD, Aroian RV J. Biol. Chem. (2003) 278 (46) :45594-602 [PMID : 12944392] Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.

Darby C WormBook (2005) :1-15 [PMID : 18050390] Interactions with microbial pathogens.

Katic I, Vallier LG, Greenwald I Genetics (2005) 171 (4) :1605-15 [PMID : 16157663] New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV J. Biol. Chem. (2006) 282 (5) :3302-11 [PMID : 17135259] Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.

Ideo H, Fukushima K, Gengyo-Ando K, Mitani S, Dejima K, Nomura K, Yamashita K J. Biol. Chem. (2009) 284 (39) :26493-501 [PMID : 19635802] A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection.

Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions bre-2

bre-2 is required for Cry5B toxicity.
Deletion Mutants
In Situ
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00037950 : all-neurons_embryo_SelectivelyEnriched, all-neurons_embryo_enriched
 WBPaper00037950 WormAtlas
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Enriched WBPaper00037950 : coelomocytes_embryo_SelectivelyEnriched, coelomocytes_embryo_enriched
 WBPaper00037950 WormAtlas

WBGene00000267
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
Bacillus thuringiensis toxin resistant

"Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557]
RNAi: WBRNAi00091463   WBPaper00006229   Observed
Allele: WBVar00275395   WBPaper00034766   Observed
brood size variant

"The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557]
Allele: WBVar00275386   WBPaper00004264   Observed
Allele: WBVar00275395   WBPaper00004264   Observed
organism toxic chemical response variant

"Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557]
Allele: WBVar00275395   WBPaper00034766   Observed
pore forming toxin resistant

"Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00275386   WBPaper00004264   Observed
Allele: WBVar00275395   WBPaper00004264   Observed


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