JCEG ID |
JCEG175 |
Name |
B0024.15
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:B3GALT1 B3GNT2 B3GNT5
OMIM:
OrthoList :
B3GALT1
B3GALT2
B3GALT4
B3GALNT1
B3GALT5
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
b3GalT1/b3GnT orthologs |
Locus Tag |
B0024.15
|
RNAi phenotype |
phenotype
|
|
Microscope observation (Image)
|
|
COPAS (Image)
|
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
tm:soluble
dxd:Detected
gg_motif:M1,M2,M3
|
Sequence |
CDS
atgaatctttgtcgaaaactctggaaatatctactcggtctaattatttt atacgttacagtctttctgaatctcgatcgaattcgctcttattcaacag atgctcctatatttgaagtgacaaactctttttcttcaaaatctcattta tctaaagatgggtcaactaatcagttttaccatgctcagtttaaagacca aaatcatacttatcagttcatcacagtgccaaagaaacagtgctctaata acacaaaacttcaaatcacaattctttcaactgccggaaactttgatatt cggcaagcaattcgagagacatgggctaatccaaataattcggaacatgt cgctaacaatgatgttagaatttcatttattatttcaaaaacaagcaatg aatttttaaattttgctcttcaaaaagaaattgaaaaatttgacgatatg attgtaacggatttatatgaatcttatgaacttttgatattaaaagttca tgccatattaagctataaacagagtcactgtcaactggcggactttcaat tgaaaattgatgatgatatggcagtcgatatggatggattatacagaagt cttgaagataagaaacaagcaagtattaacggaattagtggaattatttg gaaaaattcaccaccagtgagagaaaaaaaacatagatggtatgtaccaa aaactctttattctgagaagtttttccctccatatattgatggcccaatt tatttaatcggaaaaaatgcagttccacgaatgttggaggaagctaagaa ctataatcaatggatcattgaggatgtcttctggactggagttattggca aagctttaaaaattaaacaaatcaactgggctaatcatcttcttcgttat gttattgagctcattccatctcgactcaaatgctcaaaaggaggagttcc tttgatctacgcagttcataatatgaaaggtccgcaaatgattcatgacg ggtatcaaaaactgaagggtgttaagtgtaaatga
|
Protein
MNLCRKLWKYLLGLIILYVTVFLNLDRIRSYSTDAPIFEVTNSFSSKSHLSKDGSTNQFY HAQFKDQNHTYQFITVPKKQCSNNTKLQITILSTAGNFDIRQAIRETWANPNNSEHVANN DVRISFIISKTSNEFLNFALQKEIEKFDDMIVTDLYESYELLILKVHAILSYKQSHCQLA DFQLKIDDDMAVDMDGLYRSLEDKKQASINGISGIIWKNSPPVREKKHRWYVPKTLYSEK FFPPYIDGPIYLIGKNAVPRMLEEAKNYNQWIIEDVFWTGVIGKALKIKQINWANHLLRY VIELIPSRLKCSKGGVPLIYAVHNMKGPQMIHDGYQKLKGVKCK
|
References |
|
Functional Descriptions |
B0024.15
none available
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Embryo_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00031532 : Larva_Pan_Neuronal_Enriched
|
WBPaper00031532
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00040985 : AIN-2_L4_intestine
|
WBPaper00040985
|
WormAtlas
|
|
WBGene00007104
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|