WBGene00011638
Phenotype
Homology_paralog
| Observed | Observed and NOT Observed |
| JCEG ID | JCEG139 | ||||||||
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| Name | ostb-1 WormBase NCBI Gene | ||||||||
| Human Ortholog |
GGDB:DDOST OrthoList : DDOST (Ensembl Compara) |
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| Family Name | Oligosaccharyltransferase complex | ||||||||
| Locus Tag | T09A5.11 | ||||||||
| RNAi phenotype |
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| Sequence Features | |||||||||
| Sequence | CDS |
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| Protein |
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| References |
Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH PLoS Biol. (2003) 1 (1) :E12 [PMID : 14551910] Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M Genome Res. (2004) 14 (10B) :2162-8 [PMID : 15489339] Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA Proc. Natl. Acad. Sci. U.S.A. (2008) 105 (2) :728-33 [PMID : 18182484] Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K Cell (2011) 145 (3) :470-82 [PMID : 21529718] A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Winter JF, Hopfner S, Korn K, Farnung BO, Bradshaw CR, Marsico G, Volkmer M, Habermann B, Zerial M Nat. Cell Biol. (2012) 14 (7) :666-76 [PMID : 22634595] Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. |
| Functional Descriptions |
ostb-1 |
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| Deletion Mutants | ||||
| In Situ | ||||
| Expression | Expression | |||
WBGene00011638 Phenotype Homology_paralog |
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| Phenotype | Definition | RNAi / Allele | ||
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apoptosis fails to occur
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"Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712] |
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apoptosis reduced
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"Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021] |
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cell membrane organization biogenesis variant
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"Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
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chromosome condensation variant
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"Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557] |
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diplotene absent during oogenesis
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"The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557] |
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embryo osmotic integrity defective early emb
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"Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141] |
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] |
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germ cell compartment expansion absent
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"The compartments of the germline do not increase in size." [WB:WBPaper00038381, WB:WBPerson557] |
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germ cell compartment expansion variant
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"Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557] |
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germ cell partition morphology variant
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"Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. " [WB:WBPaper00038381, WB:WBPerson557] |
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germline nuclear positioning variant
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"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
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gonad small
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"A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPaper00038381, WB:WBPerson557] |
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larval arrest
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"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021] |
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712] |
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lethal
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"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021] |
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locomotion variant
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"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712] |
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long
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"Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
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membrane trafficking variant
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"Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control." [GO:0005215, WB:WBPaper00025137, WB:WBPerson2021] |
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no oocytes
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"Hermaphrodites lack fully specialized female gametes that are competent for fertilization." [WB:WBPerson2021] |
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nuclear fallout
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"Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557] |
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nuclei small
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"Nuclei of specific cells are smaller compared to control animals." [WB:WBPerson557] |
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oocyte number decreased
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"A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557] |
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pachytene progression during oogenesis variant
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"Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GO:0000239, WB:WBPaper00038381, WB:WBPerson557] |
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pachytene region organization variant
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"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas)." [WB:WBPaper00038381, WB:WBPerson557] |
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RAB-11 recycling endosome morphology variant
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"Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] |
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rachis narrow
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"The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557] |
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reduced brood size
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"The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557] |
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] |
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sterile
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"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712] |
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transgene subcellular localization variant
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"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] |
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