JCEG ID JCEG051
Name fut-4      WormBase    NCBI Gene
Human Ortholog

GGDB:FUT6 FUT7 

OMIM:

OrthoList :   FUT7   FUT3   FUT5   FUT4   FUT6   FUT9  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
MAPPED 0.0000000000004 49.78 (pg/ml increase) [36.41-63.15] 22367966
MAPPED 0.0000000000000000008 24941225
MAPPED 0.38 (CA19-9) 0.282 (U/ml increase) [0.20-0.37] 23300138
MAPPED 0.33 0.00000000000000000000000000000000001 (CEA) 0.073 (ng/ml increase) [0.048-0.098] 23300138
MAPPED 0.33 (CA19-9) 0.481 (U/ml decrease) [0.44-0.52] 23300138
MAPPED 0.2 0.00000000000000000000000000000000000000000000000000000002 (CA19-9) 0.169 (U/ml decrease) [0.11-0.22] 23300138
MAPPED 0.11 0.0000000009 (DG12) 0.3 (unit decrease) [0.20-0.40] 21203500
MAPPED 0.11 0.000000000003 (DG7) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 0.000000000001 (FUC-A) 0.34 (unit decrease) [0.24-0.44] 21203500
MAPPED 0.11 0.00000000000000004 (DG9) 0.41 (unit decrease) [0.31-0.51] 21203500
GGDB Score E-val
FUT7 124 3e-30
FUT6 122 7e-30
FUT5 115 2e-27
FUT3 108 1e-25
FUT4 107 3e-25
FUT9 107 4e-25
FUT11 76 8e-16
FUT10 70 6e-14
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Fucosyltransferases
Locus Tag K12H6.3
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
tm:Detected
gg_motif:M1,M2,M3,M5
Sequence CDS
Protein
References

Paschinger K, Rendic D, Lochnit G, Jantsch V, Wilson IB J. Biol. Chem. (2004) 279 (48) :49588-98 [PMID : 15364955] Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Nguyen K, van Die I, Grundahl KM, Kawar ZS, Cummings RD Glycobiology (2007) 17 (6) :586-99 [PMID : 17369288] Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.

Wang J, Farr GW, Hall DH, Li F, Furtak K, Dreier L, Horwich AL PLoS Genet. (2009) 5 (1) :e1000350 [PMID : 19165329] An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions fut-4

fut-4 encodes a member of the glycosyltransferase 10 family.
Deletion Mutants gk111
In Situ
Expression Expression

WBGene00001507
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
protein aggregation variant

"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
RNAi: WBRNAi00081638   WBPaper00034765   Observed


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