JCEG ID |
JCEG051 |
Name |
fut-4
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:FUT6 FUT7
OMIM:
OrthoList :
FUT7
FUT3
FUT5
FUT4
FUT6
FUT9
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.0000000000004
|
|
49.78
(pg/ml increase)
|
[36.41-63.15] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
MAPPED |
|
0.0000000000000000008
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
0.38 |
(CA19-9)
|
|
0.282
(U/ml increase)
|
[0.20-0.37] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.33 |
0.00000000000000000000000000000000001
(CEA)
|
|
0.073
(ng/ml increase)
|
[0.048-0.098] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.33 |
(CA19-9)
|
|
0.481
(U/ml decrease)
|
[0.44-0.52] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.2 |
0.00000000000000000000000000000000000000000000000000000002
(CA19-9)
|
|
0.169
(U/ml decrease)
|
[0.11-0.22] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.11 |
0.0000000009
(DG12)
|
|
0.3
(unit decrease)
|
[0.20-0.40] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.000000000003
(DG7)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.000000000001
(FUC-A)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.00000000000000004
(DG9)
|
|
0.41
(unit decrease)
|
[0.31-0.51] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Fucosyltransferases |
Locus Tag |
K12H6.3
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
kr:Detected
tm:Detected
gg_motif:M1,M2,M3,M5
|
Sequence |
CDS
atgtcttcgacaagtggcaatttctggaaatttctggttatttttggagt ttacgctgtagttatactgactttttggcaatttttttattcggccgatt ttctctccaaattcctccaactcagcggcccctcggaattctctgtaccg cgcaaaaatgtgaccatctacgtggcaaccacttattatggagaccccat agacgcagaaatggcatttctgacttgcccggagctgaaaaaattttgta gagttacacggaatttttccgaggcttcaacttctgatgcgctgcttttt catagtaggaacttttttgaagcagtcaaaattctcccaaatctcaaaaa attgcgaaaacccaatgttccatggattttatggaacattgagagcccga gccatgagcagcttccaaccgaaaaaaatttgttcaattggacaatgacg tatcgccgggatgcagatctatgggcaccatatgggtacatggagaagat ggatgtgccagccaaaatcgacgtcaactcaatctggagcctcaaaacaa agactgccacgtggctcggctccaactgcaacaccccgaacaatcgaatc caactgatcgggaaaatgatccagaaaggcctggaagccgacgtttgggg agcctgtggagccccgccgggagcctgtatgggagtacaaaaacggacgg agccctgtgtccgggagctcattgagccctacaagttttatttagcactg gaaaattcgaattgtgtggattatgtcactgaaaagttctggaaatcgct gggcgatcgaatggctgtgccaattgtgctccagcgggaagttgtgcgac agctcggagtcccggatcccgcgtacatttctgtggacgattttcagaat ctggaggagtttgtggattttgtggaaaaggtcgggagtgaaaaggattt ttatttgaaatttcacgagtggaggaaggattatagggtaatattcgaca acgggttctcaggatggtgccgtttatgtgaacgacttcaggatgaaaat ttaattttagaaaatcgtaaattttataaaaatgcaaatgaaaattggca ggcagcaggagtgtgtaataattcaattggaatgaagtatttgatatag
|
Protein
MSSTSGNFWKFLVIFGVYAVVILTFWQFFYSADFLSKFLQLSGPSEFSVPRKNVTIYVAT TYYGDPIDAEMAFLTCPELKKFCRVTRNFSEASTSDALLFHSRNFFEAVKILPNLKKLRK PNVPWILWNIESPSHEQLPTEKNLFNWTMTYRRDADLWAPYGYMEKMDVPAKIDVNSIWS LKTKTATWLGSNCNTPNNRIQLIGKMIQKGLEADVWGACGAPPGACMGVQKRTEPCVREL IEPYKFYLALENSNCVDYVTEKFWKSLGDRMAVPIVLQREVVRQLGVPDPAYISVDDFQN LEEFVDFVEKVGSEKDFYLKFHEWRKDYRVIFDNGFSGWCRLCERLQDENLILENRKFYK NANENWQAAGVCNNSIGMKYLI
|
References |
Paschinger K, Rendic D, Lochnit G, Jantsch V, Wilson IB
J. Biol. Chem.
(2004)
279
(48)
:49588-98
[PMID : 15364955]
Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Nguyen K, van Die I, Grundahl KM, Kawar ZS, Cummings RD
Glycobiology
(2007)
17
(6)
:586-99
[PMID : 17369288]
Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.
Wang J, Farr GW, Hall DH, Li F, Furtak K, Dreier L, Horwich AL
PLoS Genet.
(2009)
5
(1)
:e1000350
[PMID : 19165329]
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
fut-4
fut-4 encodes a member of the glycosyltransferase 10 family.
|
Deletion Mutants |
gk111
|
In Situ |
|
Expression |
Expression
|
WBGene00001507
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
protein aggregation variant
|
"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|