| JCEG ID |
Family |
Name |
Locus Tag |
Human Ortholog Name |
OMIM |
GWAS Catalog |
|
|
JCEG001
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-1 |
T26A5.4 |
ALG1
|
605907
608540
|
|
|
|
JCEG002
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-2 |
F09E5.2 |
ALG2
|
607905
607906
|
|
|
|
JCEG003
*
=
|
Asparagine-linked glycosylation (ALG) genes |
bus-8 |
T23F2.1 |
ALG2
|
|
|
|
|
JCEG004
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
K09E4.2 |
ALG3
|
601110
608750
|
|
|
|
JCEG005
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
H43I07.3 |
ALG5
|
604565
|
|
|
|
JCEG006
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
C08B11.8 |
ALG6
|
603147
604566
|
|
|
|
JCEG007
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-7 |
Y60A3A.14 |
DPAGT1
|
191350
608093
614750
|
|
|
|
JCEG008
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
T08D2.2 |
DPAGT1
|
191350
608093
614750
|
|
|
|
JCEG009
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
C08H9.3 |
ALG8
|
608103
608104
|
|
|
|
JCEG010
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
C14A4.3 |
ALG9
|
606941
608776
|
|
|
|
JCEG011
*
=
|
Asparagine-linked glycosylation (ALG) genes |
tag-179 |
T24D1.4 |
ALG10
|
603313
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000008
(WRAT)
|
|
|
|
17903297
|
|
Seshadri S 2007-09-19 BMC Med Genet
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
|
|
|
|
JCEG012
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-11 |
B0361.8 |
ALG11
|
613661
613666
|
|
|
|
JCEG013
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
ZC513.5 |
ALG12
|
607143
607144
|
|
|
|
JCEG014
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-13 |
R10D12.12 |
ALG13
|
|
|
|
|
JCEG015
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-14 |
M02B7.4 |
ALG14
|
612866
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.00000005
(proportions)
|
|
0.7
(% increase)
|
[NR] |
22359512
|
|
Demirkan A 2012-02-16 PLoS Genet
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
|
| MAPPED |
0.49 |
0.000000000000000002
|
|
0.1651
(unit decrease)
|
[0.128-0.202] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
| MAPPED |
0.451 |
0.00000000003
|
|
0.178
(unit incease)
|
[0.125-0.23] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG016
*
=
|
Asparagine-linked glycosylation (ALG) genes |
dpm-1 |
Y66H1A.2 |
DPM1
|
603503
608799
|
|
|
|
JCEG017
*
=
|
Core 1 GalT |
|
T09E11.12 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG018
*
=
|
Core 1 GalT |
|
C38H2.2 |
C1GALT1
|
300611
300622
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG019
*
=
|
Core 1 GalT |
|
C16D9.6 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG020
*
=
|
Core 1 GalT |
|
F56H6.1 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG021
*
=
|
Core 1 GalT |
|
T09E11.6 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG022
*
=
|
Core 1 GalT |
|
E03H4.3 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG023
*
=
|
Core 1 GalT |
|
C17A2.3 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG024
*
=
|
Core 1 GalT |
bus-4 |
T22B11.2 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG025
*
=
|
Core 1 GalT |
|
C02H6.1 |
C1GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG026
*
|
Fucosyltransferases |
|
T28F2.1 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG027
*
|
Fucosyltransferases |
|
F41D3.6 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG028
*
|
Fucosyltransferases |
|
F08A8.5 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG029
*
|
Fucosyltransferases |
|
C14C6.3 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG030
*
|
Fucosyltransferases |
|
EGAP9.3 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG031
*
|
Fucosyltransferases |
|
T26H5.8 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG032
*
|
Fucosyltransferases |
|
T26E4.4 |
FUT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG033
*
|
Fucosyltransferases |
fut-2 |
EGAP9.2 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG034
*
=
|
Fucosyltransferases |
|
B0205.4 |
FUT2 FUT1
|
182100
182100
211100
211100
612542
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG035
*
|
Fucosyltransferases |
|
F17B5.4 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG036
*
|
Fucosyltransferases |
|
C17A2.4 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG037
*
|
Fucosyltransferases |
|
Y71H2AM.14 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG038
*
|
Fucosyltransferases |
|
C06E1.7 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG039
*
|
Fucosyltransferases |
|
K06H6.6 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG040
*
|
Fucosyltransferases |
|
F31F4.17 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG041
*
|
Fucosyltransferases |
|
F31F4.11 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG042
*
|
Fucosyltransferases |
|
Y5H2B.1 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG043
*
|
Fucosyltransferases |
|
C18G1.8 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG044
*
|
Fucosyltransferases |
|
W07G4.2 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG045
*
|
Fucosyltransferases |
|
F11A5.5 |
FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG046
*
=
|
Fucosyltransferases |
pad-2 |
K10G9.3 |
POFUT2
|
610249
|
|
|
|
JCEG047
*
|
Fucosyltransferases |
|
Y39F10A.2 |
FUT2
|
251450
613165
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG048
*
|
Fucosyltransferases |
|
F17B5.6 |
FUT1 FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG049
*
=
|
Fucosyltransferases |
fut-3 |
F59E12.13 |
FUT5 FUT1 FUT10 FUT11
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
|
JCEG050
*
=
|
Fucosyltransferases |
fut-1 |
K08F8.3 |
FUT5 FUT3 FUT4 FUT6
|
104230
111100
111100
136835
136836
602030
606865
613852
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000004
(EA)
|
|
|
|
22566498
|
|
Turner ST 2012-05-07 Hypertension
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
| DOWNSTREAM |
|
0.0000009
(EA)
|
|
1.4
(unit increase)
|
[0.79-2.01] |
22566498
|
|
Turner ST 2012-05-07 Hypertension
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
| MAPPED |
|
0.00000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
|
0.0000000000004
|
|
49.78
(pg/ml increase)
|
[36.41-63.15] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.0000000000000000008
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.38 |
(CA19-9)
|
|
0.282
(U/ml increase)
|
[0.20-0.37] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.33 |
0.00000000000000000000000000000000001
(CEA)
|
|
0.073
(ng/ml increase)
|
[0.048-0.098] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.33 |
(CA19-9)
|
|
0.481
(U/ml decrease)
|
[0.44-0.52] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.2 |
0.00000000000000000000000000000000000000000000000000000002
(CA19-9)
|
|
0.169
(U/ml decrease)
|
[0.11-0.22] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.11 |
0.0000000009
(DG12)
|
|
0.3
(unit decrease)
|
[0.20-0.40] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.000000000003
(DG7)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.000000000001
(FUC-A)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.00000000000000004
(DG9)
|
|
0.41
(unit decrease)
|
[0.31-0.51] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
|
|
|
JCEG051
*
=
|
Fucosyltransferases |
fut-4 |
K12H6.3 |
FUT6 FUT7
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000000004
|
|
49.78
(pg/ml increase)
|
[36.41-63.15] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.0000000000000000008
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.38 |
(CA19-9)
|
|
0.282
(U/ml increase)
|
[0.20-0.37] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.33 |
0.00000000000000000000000000000000001
(CEA)
|
|
0.073
(ng/ml increase)
|
[0.048-0.098] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.33 |
(CA19-9)
|
|
0.481
(U/ml decrease)
|
[0.44-0.52] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.2 |
0.00000000000000000000000000000000000000000000000000000002
(CA19-9)
|
|
0.169
(U/ml decrease)
|
[0.11-0.22] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.11 |
0.0000000009
(DG12)
|
|
0.3
(unit decrease)
|
[0.20-0.40] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.000000000003
(DG7)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.000000000001
(FUC-A)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.00000000000000004
(DG9)
|
|
0.41
(unit decrease)
|
[0.31-0.51] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
|
|
|
JCEG052
*
=
|
Fucosyltransferases |
fut-6 |
T05A7.5 |
FUT6 FUT7
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000000000004
|
|
49.78
(pg/ml increase)
|
[36.41-63.15] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.0000000000000000008
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.38 |
(CA19-9)
|
|
0.282
(U/ml increase)
|
[0.20-0.37] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.33 |
0.00000000000000000000000000000000001
(CEA)
|
|
0.073
(ng/ml increase)
|
[0.048-0.098] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.33 |
(CA19-9)
|
|
0.481
(U/ml decrease)
|
[0.44-0.52] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.2 |
0.00000000000000000000000000000000000000000000000000000002
(CA19-9)
|
|
0.169
(U/ml decrease)
|
[0.11-0.22] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.11 |
0.0000000009
(DG12)
|
|
0.3
(unit decrease)
|
[0.20-0.40] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.000000000003
(DG7)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.000000000001
(FUC-A)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
| MAPPED |
0.11 |
0.00000000000000004
(DG9)
|
|
0.41
(unit decrease)
|
[0.31-0.51] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
|
|
|
JCEG053
*
=
|
Fucosyltransferases |
fut-8 |
C10F3.6 |
FUT8
|
602589
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.59 |
0.00000004
|
|
0.03
(unit increase)
|
[0.02-0.04] |
25231870
|
|
Perry JR 2014-07-23 Nature
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
|
| MAPPED |
0.21 |
0.00000001
(DG6)
|
|
0.22
(unit decrease)
|
[0.14-0.30] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
|
|
|
JCEG054
*
=
|
Fukutin |
|
T07D3.4 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
|
JCEG055
*
=
|
Fukutin |
|
T07A5.1 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
|
JCEG056
*
=
|
Fukutin |
|
F28A10.9 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
|
JCEG057
*
=
|
Fukutin |
|
T07D3.6 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
|
JCEG058
*
=
|
Fukutin |
|
W02B3.4 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
|
JCEG059
*
=
|
GPI-anchor synthesis |
hpo-3 |
F33D11.9 |
GPAA1
|
603048
|
|
|
|
JCEG060
*
=
|
GPI-anchor synthesis |
|
F38E1.9 |
MPDU1
|
604041
609180
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.29 |
0.00000001
(Testosterone)
|
|
0.28
(unit decrease)
|
[0.18-0.38] |
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
| MAPPED |
0.29 |
0.0000000000000000005
(SHBG)
|
|
0.09
(unit decrease)
|
[0.070-0.110] |
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
| MAPPED |
0.21 |
0.0000000004
|
1.23
|
|
[1.16-1.32] |
22197929
|
|
Yu XQ 2011-12-25 Nat Genet
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
|
|
|
|
JCEG061
*
=
|
GPI-anchor synthesis |
|
R01B10.4 |
PGAP3
|
611801
615716
|
|
|
|
JCEG062
*
=
|
GPI-anchor synthesis |
|
T19B10.8 |
PGAP1
|
611655
|
|
|
|
JCEG063
*
=
|
GPI-anchor synthesis |
tag-189 |
T04A8.12 |
PGAP2
|
614207
615187
|
|
|
|
JCEG064
*
=
|
GPI-anchor synthesis |
piga-1 |
D2085.6 |
PIGA
|
300818
300868
311770
|
|
|
|
JCEG065
*
=
|
GPI-anchor synthesis |
|
T27F7.4 |
PIGB
|
604122
|
|
|
|
JCEG066
*
=
|
GPI-anchor synthesis |
|
T20D3.8 |
PIGC
|
601730
|
|
|
|
JCEG067
*
=
|
GPI-anchor synthesis |
|
F28C6.4 |
PIGG
|
|
|
|
|
JCEG068
*
=
|
GPI-anchor synthesis |
hpo-4 |
T05E11.6 |
PIGK
|
605087
|
|
|
|
JCEG069
*
=
|
GPI-anchor synthesis |
|
B0491.1 |
PIGM
|
610273
610293
|
|
|
|
JCEG070
*
=
|
GPI-anchor synthesis |
|
Y54E10BR.1 |
PIGN
|
606097
614080
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000009
(phenotype 3)
|
3.57
|
|
[NR] |
25461247
|
|
Lehmann DS 2015-02-01 Pharmacogenet Genomics
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
|
| MAPPED |
|
0.000009
(phenotype 1)
|
3.57
|
|
[NR] |
25461247
|
|
Lehmann DS 2015-02-01 Pharmacogenet Genomics
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
|
|
|
|
JCEG071
*
=
|
GPI-anchor synthesis |
|
C27A12.9 |
PIGO
|
614730
614749
|
|
|
|
JCEG072
*
=
|
GPI-anchor synthesis |
|
Y48E1B.2 |
PIGP
|
614919
|
|
|
|
JCEG073
*
=
|
GPI-anchor synthesis |
|
F01G4.5 |
PIGQ
|
605754
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
0.42 |
0.000009
|
|
0.1
(unit increase)
|
[0.059-0.141] |
22993228
|
|
Williams FM 2012-09-19 Ann Rheum Dis
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
|
| MAPPED |
0.42 |
0.000004
|
|
0.11
(unit increase)
|
[0.065-0.155] |
22993228
|
|
Williams FM 2012-09-19 Ann Rheum Dis
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
|
|
|
|
JCEG074
*
=
|
GPI-anchor synthesis |
hpo-5 |
T14G10.7 |
PIGS
|
610271
|
|
|
|
JCEG075
*
=
|
GPI-anchor synthesis |
|
F17C11.7 |
PIGT
|
610272
615398
615399
|
|
|
|
JCEG076
*
=
|
GPI-anchor synthesis |
|
T22C1.3 |
PIGU
|
608528
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.09 |
0.000000000000001
|
1.75
|
|
[1.53-2.01] |
18488026
|
|
Brown KM 2008-05-18 Nat Genet
Common sequence variants on 20q11.22 confer melanoma susceptibility.
|
|
|
|
JCEG077
*
=
|
GPI-anchor synthesis |
pigv-1 |
T09B4.1 |
PIGV
|
239300
610274
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
0.09 |
0.000000001
|
|
0.037
(mg/dL increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| UPSTREAM |
0.09 |
0.000000000003
|
|
0.05
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| UPSTREAM |
0.09 |
0.000000000000001
|
|
0.051
(unit decrease)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
|
|
|
JCEG078
*
=
|
GPI-anchor synthesis |
hpo-20 |
Y110A2AL.12 |
PIGW
|
610275
|
|
|
|
JCEG079
*
|
GPI-anchor synthesis |
|
F49E7.2 |
PIGX
|
|
|
|
|
JCEG080
*
=
|
GPI-anchor synthesis |
dpm-3 |
F28D1.11 |
DPM3
|
|
|
|
|
JCEG081
*
=
|
GlcNAcT(GnT) |
gly-14 |
M01F1.1 |
MGAT1
|
160995
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
| DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
|
JCEG082
*
=
|
GlcNAcT(GnT) |
gly-13 |
B0416.6 |
MGAT1
|
160995
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
| DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
|
JCEG083
*
=
|
GlcNAcT(GnT) |
gly-12 |
F48E3.1 |
MGAT1
|
160995
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
| DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
|
JCEG084
*
=
|
GlcNAcT(GnT) |
gly-20 |
C03E10.4 |
MGAT2
|
212066
602616
|
|
|
|
JCEG085
*
=
|
GlcNAcT(GnT) |
gly-2 |
C55B7.2 |
MGAT5 MGAT5B
|
601774
612441
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000008
(M)
|
|
17.78
(unit decrease)
|
[10.16-25.4] |
25524916
|
|
Palmer ND 2014-12-18 Diabetes
Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
|
| DOWNSTREAM |
0.9858 |
0.000007
(Ordinal I)
|
|
2.5604
(unit increase)
|
[1.45-3.68] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
| UPSTREAM |
0.974 |
0.00000003
(Chinese)
|
|
0.328
(unit decrease)
|
[0.21-0.44] |
24383474
|
|
Manichaikul A 2014-01-02 Am J Respir Crit Care Med
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
|
| UPSTREAM |
0.917 |
0.000003
|
1.61
|
|
[1.32-2.0] |
22683750
|
|
Sinner MF 2012-06-06 Heart Rhythm
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
|
| DOWNSTREAM |
0.8 |
0.000000000002
|
|
0.032
(unit decrease)
|
[NR] |
20881960
|
|
Lango Allen H 2010-09-29 Nature
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
| MAPPED |
0.64 |
0.000007
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.36 |
0.0000002
|
|
|
|
20117844
|
|
Brynedal B 2010-02-01 J Neuroimmunol
MGAT5 alters the severity of multiple sclerosis.
|
| DOWNSTREAM |
0.2 |
0.000003
(Recessive)
|
34
|
|
[4.29-269.48] |
22293537
|
|
Kiyotani K 2012-01-29 Pharmacogenet Genomics
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
| UPSTREAM |
0.08 |
0.000005
|
0.069
|
|
(unit decrease)] |
22823124
|
|
Verweij KJ 2012-07-24 Addict Biol
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
|
| DOWNSTREAM |
0.023 |
0.00000004
|
|
0.048
(unit decrease)
|
[0.031-0.065] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG086
*
=
|
GlcNAcT(GnT) |
|
M70.4 |
POMGNT1
|
300492
608617
608618
608619
|
|
|
|
JCEG087
*
=
|
GlcT |
|
ZC250.2 |
B3GLCT
|
261540
610308
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.44 |
0.00000002
|
1.1
|
|
[1.07-1.14] |
23455636
|
|
Fritsche LG 2013-03-03 Nat Genet
Seven new loci associated with age-related macular degeneration.
|
|
|
|
JCEG088
*
=
|
GlcT |
cgt-1 |
T06C12.10 |
UGCG
|
602874
|
|
|
|
JCEG089
*
=
|
GlcT |
cgt-2 |
F20B4.6 |
UGCG
|
602874
|
|
|
|
JCEG090
*
=
|
GlcT |
cgt-3 |
F59G1.1 |
UGCG
|
602874
|
|
|
|
JCEG091
*
=
|
Glucuronyltransferase(GlcAT) |
glct-4 |
C47F8.4 |
B3GAT1
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
| MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
| UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
| UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
| UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
| DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
| UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
|
JCEG092
*
=
|
Glucuronyltransferase(GlcAT) |
glct-1 |
T09E11.1 |
B3GAT1
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
| MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
| UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
| UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
| UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
| DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
| UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
|
JCEG093
*
=
|
Glucuronyltransferase(GlcAT) |
glct-3 |
T15D6.7 |
B3GAT1
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
| MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
| UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
| UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
| UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
| DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
| UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
|
JCEG094
*
=
|
Glucuronyltransferase(GlcAT) |
glct-2 |
E03H4.12 |
B3GAT1
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
| MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
| UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
| UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
| UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
| DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
| UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
|
JCEG095
*
=
|
Glucuronyltransferase(GlcAT) |
glct-5 |
C54C8.5 |
B3GAT1
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
| MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
| UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
| UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
| UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
| DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
| UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
|
JCEG096
*
=
|
Glucuronyltransferase(GlcAT) |
glct-6 |
W07G9.2 |
B3GAT1
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
| MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
| UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
| UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
| UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
| DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
| UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
|
JCEG097
*
=
|
Glucuronyltransferase(GlcAT) |
sqv-8 |
ZK1307.5 |
B3GAT3 B3GAT2
|
151290
245600
606374
607497
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000005
|
0.2918
|
|
(unit increase)] |
23319000
|
|
Luykx JJ 2013-01-15 Mol Psychiatry
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
|
| MAPPED |
0.219 |
0.000007
(ALT/AST)
|
|
0.03
(unit increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| UPSTREAM |
0.16 |
0.0000009
|
|
1.17
(unit decrease)
|
[0.70-1.64] |
21326311
|
|
Bhatnagar P 2011-02-17 J Hum Genet
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.
|
|
|
|
JCEG098
|
Glyco_transf_92 |
|
C05C8.8 |
|
|
|
|
|
JCEG099
|
Glyco_transf_92 |
|
C14C6.8 |
|
|
|
|
|
JCEG100
|
Glyco_transf_92 |
|
ZK488.5 |
|
|
|
|
|
JCEG101
|
Glyco_transf_92 |
|
C14C6.6 |
|
|
|
|
|
JCEG102
|
Glyco_transf_92 |
|
D1014.7 |
|
|
|
|
|
JCEG103
|
Glyco_transf_92 |
|
F28H7.7 |
|
|
|
|
|
JCEG104
|
Glyco_transf_92 |
|
R05A10.6 |
|
|
|
|
|
JCEG105
|
Glyco_transf_92 |
|
C31B8.7 |
|
|
|
|
|
JCEG106
|
Glyco_transf_92 |
|
D1014.6 |
|
|
|
|
|
JCEG107
|
Glyco_transf_92 |
|
K06H6.4 |
|
|
|
|
|
JCEG108
|
Glyco_transf_92 |
|
ZK488.6 |
|
|
|
|
|
JCEG109
|
Glyco_transf_92 |
|
C01G5.9 |
|
|
|
|
|
JCEG110
|
Glyco_transf_92 |
|
C14C6.7 |
|
|
|
|
|
JCEG111
|
Glyco_transf_92 |
|
T06A1.5 |
|
|
|
|
|
JCEG112
|
Glyco_transf_92 |
|
C08B6.3 |
|
|
|
|
|
JCEG113
|
Glyco_transf_92 |
|
K08D9.2 |
|
|
|
|
|
JCEG114
|
Glyco_transf_92 |
|
T15D6.10 |
|
|
|
|
|
JCEG115
|
Glyco_transf_92 |
galt-1 |
M03F8.4 |
|
|
|
|
|
JCEG116
|
Glyco_transf_92 |
|
F54D10.8 |
|
|
|
|
|
JCEG117
|
Glyco_transf_92 |
|
Y105C5B.25 |
|
|
|
|
|
JCEG118
|
Glyco_transf_92 |
|
T06A1.1 |
|
|
|
|
|
JCEG119
|
Glyco_transf_92 |
|
C17A2.2 |
|
|
|
|
|
JCEG120
|
Glyco_transf_92 |
|
F46F5.7 |
|
|
|
|
|
JCEG121
|
Glyco_transf_92 |
|
D1014.5 |
|
|
|
|
|
JCEG122
|
Glyco_transf_92 |
|
C13A2.2 |
|
|
|
|
|
JCEG123
|
Glyco_transf_92 |
|
R08C7.4 |
|
|
|
|
|
JCEG124
*
=
|
Glycogen synthase |
gsy-1 |
Y46G5A.31 |
GYS1 GYS2
|
138570
138571
240600
611556
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.08 |
0.00000004
(FSH)
|
|
|
|
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
|
|
|
JCEG125
*
=
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
sqv-5 |
T24D1.1 |
CHSY1 CHPF CHSY3 CHPF2 CSGALNACT1 CSGALNACT2
|
605282
608183
609963
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000007
|
|
0.226
(unit increase)
|
[NR] |
23322567
|
|
Lopes MC 2013-01-15 Invest Ophthalmol Vis Sci
Identification of a candidate gene for astigmatism.
|
| MAPPED |
|
0.0000002
|
2.14
|
|
[1.53-2.99] |
23726668
|
|
Hunter AM 2013-05-30 J Psychiatr Res
A genome-wide association study of a sustained pattern of antidepressant response.
|
| MAPPED |
0.66 |
0.000000002
|
|
0.08
(unit decrease)
|
[0.06-0.1] |
23291589
|
|
Lu Y 2013-01-06 Nat Genet
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
|
| MAPPED |
0.601 |
0.000001
|
|
0.022
(unit increase)
|
[NR] |
25201988
|
|
Rietveld CA 2014-09-08 Proc Natl Acad Sci U S A
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
|
| UPSTREAM |
0.31 |
0.000002
(ETV6-RUNX1 positive)
|
1.19
|
|
[1.07 - 1.33] |
22076464
|
|
Ellinghaus E 2011-11-11 Leukemia
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
|
| UPSTREAM |
0.31 |
0.000000006
(ETV6-RUNX1 positive, Northern European)
|
|
|
|
22076464
|
|
Ellinghaus E 2011-11-11 Leukemia
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
|
|
|
|
JCEG126
*
=
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
mig-22 |
PAR2.4 |
CHPF
|
608037
610405
|
|
|
|
JCEG127
*
=
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
rib-1 |
F12F6.3 |
EXT1 EXTL1
|
133700
150230
215300
601738
608177
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.48 |
0.000006
|
|
0.36
(cm decrease)
|
[NR] |
19893584
|
|
Kim JJ 2009-11-06 J Hum Genet
Identification of 15 loci influencing height in a Korean population.
|
| MAPPED |
0.093 |
0.000002
(Cortisol )
|
|
0.03
(ng/mL increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.07 |
0.000008
(men)
|
|
0.18
(kg/m2 decrease)
|
[0.1-0.26] |
25811787
|
|
Huffman JE 2015-03-26 PLoS One
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans.
|
|
|
|
JCEG128
*
=
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
rib-2 |
K01G5.6 |
EXTL3 EXTL2 EXT2
|
133700
133701
602411
605744
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.00000004
(Conditioned on rs11581062)
|
1.09
|
|
[1.08-1.11] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| DOWNSTREAM |
|
0.00000004
|
1.09
|
|
[1.08-1.11] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
0.68 |
0.00000002
|
|
0.023
(unit increase)
|
[0.0093-0.0367] |
25429064
|
|
He M 2014-11-26 Hum Mol Genet
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
|
|
|
JCEG129
*
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
chs-2 |
F48A11.1 |
HAS2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.63 |
0.000006
|
1.59
|
|
[1.30-1.92] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
| DOWNSTREAM |
0.047 |
0.000005
(Folate )
|
|
0.03
(nmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG130
*
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
chs-1 |
T25G3.2 |
HAS3 HAS1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000004
(binary)
|
|
|
|
18821565
|
|
Lasky-Su J 2008-12-05 Am J Med Genet B Neuropsychiatr Genet
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
|
|
|
|
JCEG131
*
=
|
Glycosyltransferase like (GTL) |
|
D2045.9 |
LHL1
|
|
|
|
|
JCEG132
*
=
|
HS C5 epimerase |
hse-5 |
B0285.5 |
GLCE
|
612134
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.26 |
0.000002
(percent change)
|
|
1.7
(percent increase)
|
[0.92-2.48] |
23118302
|
|
Chu AY 2012-11-01 Circ Cardiovasc Genet
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
|
|
|
|
JCEG133
*
=
|
LARGE |
lge-1 |
K09C8.4 |
LARGE
|
603590
605517
608840
609709
613154
615287
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.56 |
0.000006
(women)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| DOWNSTREAM |
0.54 |
0.0000006
(women)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.28 |
0.000008
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.11 |
0.000008
|
1.44
|
|
[1.28-1.60] |
24962325
|
|
Kapoor M 2014-06-11 Drug Alcohol Depend
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
|
|
|
JCEG134
*
=
|
O-GlcNAcT |
|
H12D21.10 |
EOGT
|
614789
615297
|
|
|
|
JCEG135
*
=
|
O-GlcNAcT |
ogt-1 |
K04G7.3 |
OGT
|
300255
|
|
|
|
JCEG136
*
=
|
Oligosaccharyltransferase complex |
stt-3 |
T12A2.2 |
STT3
|
608605
615597
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.884 |
0.0000009
(Modelling analysis)
|
|
|
|
23453885
|
|
Smoller JW 2013-02-27 Lancet
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
| MAPPED |
0.88 |
0.000001
|
1.1
|
|
[1.06-1.14] |
21926974
|
|
Ripke S 2011-09-18 Nat Genet
Genome-wide association study identifies five new schizophrenia loci.
|
|
|
|
JCEG137
*
=
|
Oligosaccharyltransferase complex |
dad-1 |
F57B10.10 |
DAD1
|
600243
|
|
|
|
JCEG138
*
=
|
Oligosaccharyltransferase complex |
|
ZK686.3 |
MAGT1 TUSC3
|
300715
300853
601385
611093
|
|
|
|
JCEG139
*
=
|
Oligosaccharyltransferase complex |
ostb-1 |
T09A5.11 |
DDOST
|
602202
614507
|
|
|
|
JCEG140
*
=
|
Oligosaccharyltransferase complex |
ribo-1 |
T22D1.4 |
RPN1
|
180470
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000000000006
(Monocytes)
|
|
0.028
(unit decrease)
|
[0.020-0.036] |
21738480
|
|
Nalls MA 2011-07-01 PLoS Genet
Multiple loci are associated with white blood cell phenotypes.
|
| DOWNSTREAM |
|
0.0000000000004
(Basophils)
|
|
0.01
(unit increase)
|
[0.0073-0.0127] |
21738480
|
|
Nalls MA 2011-07-01 PLoS Genet
Multiple loci are associated with white blood cell phenotypes.
|
| DOWNSTREAM |
0.66 |
0.00000000000000003
(eosinophil count)
|
|
0.103
(unit increase)
|
[0.08-0.12] |
21738478
|
|
Okada Y 2011-06-30 PLoS Genet
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
|
| DOWNSTREAM |
0.66 |
0.0000000000000000000000000000000000000005
(basophil count)
|
|
0.161
(unit increase)
|
[0.14-0.18] |
21738478
|
|
Okada Y 2011-06-30 PLoS Genet
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
|
| DOWNSTREAM |
0.441 |
0.00000001
(EA)
|
|
0.028
(unit decrease)
|
[0.018-0.038] |
25096241
|
|
Keller MF 2014-08-05 Hum Mol Genet
Trans-ethnic meta-analysis of white blood cell phenotypes.
|
| MAPPED |
0.4 |
0.0000000000000002
|
0.23
|
|
(unit decrease)] |
23314186
|
|
Crosslin DR 2013-03-03 Hum Mol Genet
Genetic variation associated with circulating monocyte count in the eMERGE Network.
|
|
|
|
JCEG141
*
=
|
Oligosaccharyltransferase complex |
ostd-1 |
M01A10.3 |
RPN2
|
180490
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000006
|
|
|
|
19668339
|
|
Potkin SG 2009-08-07 PLoS One
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
|
|
|
|
JCEG142
|
Oligosaccharyltransferase complex |
|
T07A5.5 |
|
|
|
|
|
JCEG143
*
=
|
Other glycogenes |
|
Y38C1AB.5 |
C1GALT1C1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000006
(Alpha peak frequency, occipital
|
|
0.051
(unit increase)
|
[0.029-0.073] |
25387704
|
|
Malone SM 2014-12-01 Psychophysiology
Heritability and molecular-genetic basis of resting EEG activity: A genome-wide association study.
|
| UPSTREAM |
|
0.0000000000000000000000010000000000000001
|
1.28
|
|
[NR] |
22808956
|
|
Lyons PA 2012-07-19 N Engl J Med
Genetically distinct subsets within ANCA-associated vasculitis.
|
|
|
|
JCEG144
*
|
Other glycogenes |
|
T28A8.2 |
FUT1 FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG145
*
|
Other glycogenes |
|
T26E4.3 |
FUT1 FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG146
*
|
Other glycogenes |
|
T26E4.5 |
FUT1 FUT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
| MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
| MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
| UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
| MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
| UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
| MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
| MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
| MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
| MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
| MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
| MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
| MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
| MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
| MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
| MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG147
*
=
|
Other glycogenes |
fut-5 |
T05A7.10 |
FUT4 FUT7 FUT10
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000004
(EA)
|
|
|
|
22566498
|
|
Turner ST 2012-05-07 Hypertension
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
| DOWNSTREAM |
|
0.0000009
(EA)
|
|
1.4
(unit increase)
|
[0.79-2.01] |
22566498
|
|
Turner ST 2012-05-07 Hypertension
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
|
|
|
JCEG148
*
=
|
Other glycogenes |
|
Y38C1AB.1 |
C1GALT1C1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000006
(Alpha peak frequency, occipital
|
|
0.051
(unit increase)
|
[0.029-0.073] |
25387704
|
|
Malone SM 2014-12-01 Psychophysiology
Heritability and molecular-genetic basis of resting EEG activity: A genome-wide association study.
|
| UPSTREAM |
|
0.0000000000000000000000010000000000000001
|
1.28
|
|
[NR] |
22808956
|
|
Lyons PA 2012-07-19 N Engl J Med
Genetically distinct subsets within ANCA-associated vasculitis.
|
|
|
|
JCEG149
*
=
|
PAPS synthase and PAPS transporters |
pst-1 |
M03F8.2 |
SLC35B2
|
610788
|
|
|
|
JCEG150
*
=
|
PAPS synthase and PAPS transporters |
pst-2 |
F54E7.1 |
SLC35B3
|
610845
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000008
|
|
|
|
24324551
|
|
Deng X 2013-11-20 PLoS One
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
|
| DOWNSTREAM |
0.49 |
0.000003
(AA)
|
|
0.17
(unit decrease)
|
[0.092-0.248] |
23870195
|
|
Wojczynski MK 2013-07-19 BMC Med Genet
Genetics of coronary artery calcification among African Americans, a meta-analysis.
|
| DOWNSTREAM |
0.48 |
0.000000000000000003
|
|
0.046
(unit increase)
|
[0.035-0.056] |
25628336
|
|
Hromatka BS 2015-01-26 Hum Mol Genet
Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.
|
|
|
|
JCEG151
*
=
|
PAPS synthase and PAPS transporters |
pps-1 |
T14G10.1 |
PAPSS1 PAPSS2
|
603005
603262
612847
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000004
|
1.32
|
|
[1.17-1.49] |
19727025
|
|
De Moor MH 2009-09-02 Med Sci Sports Exerc
Genome-wide association study of exercise behavior in Dutch and American adults.
|
| DOWNSTREAM |
|
0.000002
(EA)
|
0.02742
|
|
(0.01614-0.03871) (mg/dl increase)] |
25886283
|
|
Chang X 2015-04-17 PLoS One
Genome-wide association study of serum minerals levels in children of different ethnic background.
|
| DOWNSTREAM |
|
0.0000004
|
|
0.0243
(mg/dl increase)
|
[NR] |
25886283
|
|
Chang X 2015-04-17 PLoS One
Genome-wide association study of serum minerals levels in children of different ethnic background.
|
| DOWNSTREAM |
0.029 |
0.00000005
|
|
|
[NR] |
24478790
|
|
Lee JH 2014-01-17 Front Genet
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
|
|
|
|
JCEG152
*
=
|
POFUT |
|
C15C7.7 |
POFUT1
|
607491
615327
|
|
|
|
JCEG153
*
|
POFUT |
F58D5.3 |
F58D5.3 |
POFUT1
|
|
|
|
|
JCEG154
*
=
|
POMGnT |
|
Y73B3A.3 |
POMGNT1
|
300492
608617
608618
608619
|
|
|
|
JCEG155
*
=
|
POMT |
|
R12E2.13 |
POMT2
|
602934
607551
|
|
|
|
JCEG156
*
|
Sulfotransferase and sulfation-related genes |
|
Y48G1BL.7 |
CHST10 CHST8
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.0000004
(Shared)
|
|
|
|
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
| MAPPED |
0.02 |
0.0000006
(olanzapine)
|
|
|
|
21107309
|
|
McClay JL 2010-11-24 Neuropsychopharmacology
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
|
|
|
|
JCEG157
*
=
|
Sulfotransferase and sulfation-related genes |
hst-2 |
C34F6.4 |
HS2ST1
|
604844
|
|
|
|
JCEG158
*
=
|
Sulfotransferase and sulfation-related genes |
hst-3.1 |
F40H3.5 |
HS3ST1
|
|
|
|
|
JCEG159
*
=
|
Sulfotransferase and sulfation-related genes |
hst-3.2 |
F52B10.2 |
HS3ST3A1 HS3ST3B1 HS3ST2 HS3ST4 HS3ST5 HS3ST6
|
604056
604057
604058
604059
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000002
|
|
|
|
24324551
|
|
Deng X 2013-11-20 PLoS One
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
|
| MAPPED |
|
0.0000007
|
|
0.0437
(unit increase)
|
[NR] |
24086445
|
|
Wang Q 2013-09-24 PLoS One
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
|
| MAPPED |
0.381 |
0.000004
(Dominant model)
|
1.647
|
|
[1.264-2.146] |
23648065
|
|
Low SK 2013-05-04 Cancer Sci
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
|
| UPSTREAM |
0.2 |
0.000001
|
1.19
|
|
[NR] |
19525955
|
|
Bahlo 2009-06-14 Nat Genet
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
| DOWNSTREAM |
0.04 |
0.000002
|
0.082
|
|
(unit increase)] |
22823124
|
|
Verweij KJ 2012-07-24 Addict Biol
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
|
|
|
|
JCEG160
*
=
|
Sulfotransferase and sulfation-related genes |
hst-6 |
Y34B4A.3 |
HS6ST1
|
300545
604846
609401
614880
|
|
|
|
JCEG161
*
=
|
Sulfotransferase and sulfation-related genes |
hst-1 |
F08B4.6 |
NDST1
|
600853
603268
603950
615039
|
|
|
|
JCEG162
*
|
UDP-glucuronosyltransferases |
ugt-46 |
B0310.5 |
CGT
|
|
|
|
|
JCEG163
|
UDP-glucuronosyltransferases |
ugt-65 |
F08G5.5 |
|
|
|
|
|
JCEG164
*
=
|
UGCGL1 |
uggt-2 |
F26H9.8 |
UGGT1
|
605897
605898
|
|
|
|
JCEG165
*
=
|
UGCGL1 |
uggt-1 |
F48E3.3 |
UGGT1 UGGT2
|
605897
605898
|
|
|
|
JCEG166
*
=
|
XylT |
sqv-6 |
Y50D4C.4 |
XYLT1 XYLT2
|
608124
608125
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000004
(Additive model)
|
2.5
|
|
[1.70-3.50] |
23478653
|
|
Han JY 2013-03-12 Pharmacogenomics J
A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy.
|
| UPSTREAM |
0.09 |
0.000002
|
|
0.088
(unit decrease)
|
[NR] |
23322567
|
|
Lopes MC 2013-01-15 Invest Ophthalmol Vis Sci
Identification of a candidate gene for astigmatism.
|
| DOWNSTREAM |
0.015 |
0.0000008
(ALT )
|
|
0.04
(U/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| UPSTREAM |
0.006 |
0.000009
(ALT )
|
|
0.02
(U/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
|
JCEG167
*
=
|
a-N-acetylglucosaminidase |
|
K09E4.4 |
NAGLU
|
252920
609701
|
|
|
|
JCEG168
*
|
b3GalT1/b3GnT orthologs |
|
F48F7.3 |
B3GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG169
*
=
|
b3GalT1/b3GnT orthologs |
|
F14B6.4 |
B3GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG170
*
=
|
b3GalT1/b3GnT orthologs |
|
C47F8.3 |
B3GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG171
*
=
|
b3GalT1/b3GnT orthologs |
|
C47F8.6 |
B3GALT1
|
603095
604066
605863
615313
615315
615357
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG172
*
=
|
b3GalT1/b3GnT orthologs |
|
E03H4.11 |
B3GALT1
|
603095
604066
605863
615313
615315
615357
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG173
*
=
|
b3GalT1/b3GnT orthologs |
bre-2 |
Y39E4B.9 |
B3GALT1
|
603018
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG174
*
=
|
b3GalT1/b3GnT orthologs |
|
T09F5.1 |
B3GALT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG175
*
=
|
b3GalT1/b3GnT orthologs |
|
B0024.15 |
B3GALT1 B3GNT2 B3GNT5
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
|
JCEG176
*
|
b3GalT1/b3GnT orthologs |
bus-17 |
ZK678.8 |
B3GALT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
0.169 |
0.0000003
|
1.09
|
|
[1.05-1.13] |
24162737
|
|
European Alzheimer's Disease Initiative (EADI) 2013-10-27 Nat Genet
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
|
|
|
JCEG177
*
=
|
b3GalT1/b3GnT orthologs |
|
F14B6.6 |
B3GALNT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.43 |
0.000002
(AA)
|
|
4.21
(unit decrease)
|
[2.49-5.93] |
23599027
|
|
Demerath EW 2013-04-17 Hum Mol Genet
Genome-wide association study of age at menarche in African-American women.
|
|
|
|
JCEG178
*
=
|
b3GalT1/b3GnT orthologs |
bre-5 |
T12G3.8 |
B3GALNT1 B3GALT4 B3GALT5 B3GNT3 B3GNT4 B3GNT6 B3GNT7
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000006
|
1.178
|
|
|
21041247
|
|
Perlis RH 2010-11-01 Am J Psychiatry
Genome-wide association study of suicide attempts in mood disorder patients.
|
| UPSTREAM |
|
0.00000006
|
|
0.031
(unit increase)
|
[0.019-0.043] |
25387707
|
|
Vaidyanathan U 2014-12-01 Psychophysiology
Heritability and molecular genetic basis of antisaccade eye tracking error rate: A genome-wide association study.
|
| UPSTREAM |
0.733 |
0.0000000001
|
|
0.3
(unit increase)
|
[0.20-0.40] |
23583979
|
|
den Hoed M 2013-04-14 Nat Genet
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
| UPSTREAM |
0.543 |
0.0000007
|
|
0.108
(unit increase)
|
[0.065-0.151] |
23568457
|
|
Wade TD 2013-04-09 Int J Eat Disord
Genetic variants associated with disordered eating.
|
| MAPPED |
0.43 |
0.000002
(AA)
|
|
4.21
(unit decrease)
|
[2.49-5.93] |
23599027
|
|
Demerath EW 2013-04-17 Hum Mol Genet
Genome-wide association study of age at menarche in African-American women.
|
| DOWNSTREAM |
0.26 |
0.0000000000001
(CA19-9)
|
|
0.072
(U/ml decrease)
|
[0.029-0.115] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
|
|
|
JCEG179
*
=
|
b3GalT1/b3GnT orthologs |
|
C54C8.3 |
B3GALT5
|
603095
604066
605863
615313
615315
615357
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000006
|
1.178
|
|
|
21041247
|
|
Perlis RH 2010-11-01 Am J Psychiatry
Genome-wide association study of suicide attempts in mood disorder patients.
|
|
|
|
JCEG180
*
=
|
b3GalT1/b3GnT orthologs |
sqv-2 |
Y110A2AL.14 |
B3GALT6
|
271640
615291
615349
|
|
|
|
JCEG181
*
=
|
b3GalT1/b3GnT orthologs |
|
T15D6.5 |
B3GNT3
|
603095
604066
605863
615313
615315
615357
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.26 |
0.0000000000001
(CA19-9)
|
|
0.072
(U/ml decrease)
|
[0.029-0.115] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
|
|
|
JCEG182
*
|
b3GalT1/b3GnT orthologs |
bus-2 |
K08D12.5 |
B3GNT5 G26
|
|
|
|
|
JCEG183
*
=
|
b3GalT1/b3GnT orthologs |
|
C47F8.5 |
B3GNT5 B3GALT2
|
605864
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
0.169 |
0.0000003
|
1.09
|
|
[1.05-1.13] |
24162737
|
|
European Alzheimer's Disease Initiative (EADI) 2013-10-27 Nat Genet
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
|
|
|
JCEG184
*
=
|
b3GalT1/b3GnT orthologs |
|
T09E11.10 |
B3GNT7
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.00000006
|
|
0.031
(unit increase)
|
[0.019-0.043] |
25387707
|
|
Vaidyanathan U 2014-12-01 Psychophysiology
Heritability and molecular genetic basis of antisaccade eye tracking error rate: A genome-wide association study.
|
| UPSTREAM |
0.733 |
0.0000000001
|
|
0.3
(unit increase)
|
[0.20-0.40] |
23583979
|
|
den Hoed M 2013-04-14 Nat Genet
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
| UPSTREAM |
0.543 |
0.0000007
|
|
0.108
(unit increase)
|
[0.065-0.151] |
23568457
|
|
Wade TD 2013-04-09 Int J Eat Disord
Genetic variants associated with disordered eating.
|
|
|
|
JCEG185
*
=
|
b4GalT |
bre-4 |
Y73E7A.7 |
B4GALT3
|
604016
604017
|
|
|
|
JCEG186
*
=
|
b4GalT |
|
W02B12.1 |
B4GALT5
|
610179
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.000004
|
0.298
|
|
(unit decrease)] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
| MAPPED |
0.11 |
0.000006
|
|
0.108
(kg/m2 increase)
|
[0.061-0.155] |
25811787
|
|
Huffman JE 2015-03-26 PLoS One
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans.
|
|
|
|
JCEG187
*
=
|
b4GalT |
sqv-3 |
R10E11.4 |
B4GALT7
|
130070
137060
604013
604014
604015
607091
|
|
|
|
JCEG188
*
=
|
b6GnT |
gly-15 |
C54C8.11 |
GCNT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG189
*
=
|
b6GnT |
gly-1 |
F44F4.6 |
GCNT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG190
*
|
b6GnT |
|
ZK1225.5 |
GCNT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG191
*
=
|
b6GnT |
gly-16 |
T15D6.2 |
GCNT1 GCNT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG192
*
=
|
b6GnT |
gly-17 |
T15D6.3 |
GCNT1 G11
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG193
*
=
|
b6GnT |
gly-18 |
F22D6.11 |
GCNT3
|
|
|
|
|
JCEG194
*
=
|
b6GnT |
gly-19 |
F22D6.12 |
GCNT3
|
|
|
|
|
JCEG195
*
=
|
b6GnT |
|
T09E11.9 |
GCNT4
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000004
|
0.0888
|
|
(unit increase)] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG196
*
=
|
b6GnT |
|
T27F6.1 |
GCNT3
|
|
|
|
|
JCEG197
*
=
|
b6GnT |
|
R07C3.3 |
GCNT3
|
|
|
|
|
JCEG198
*
=
|
b6GnT |
|
T14B4.9 |
GCNT3
|
|
|
|
|
JCEG199
*
=
|
b6GnT |
|
Y51H4A.25 |
GCNT3
|
|
|
|
|
JCEG200
*
=
|
b6GnT |
|
T28F3.9 |
GCNT3
|
|
|
|
|
JCEG201
*
=
|
b6GnT |
|
R07B7.6 |
GCNT3
|
|
|
|
|
JCEG202
*
=
|
b6GnT |
|
F26D2.3 |
GCNT3
|
|
|
|
|
JCEG203
*
=
|
b6GnT |
|
F30A10.4 |
GCNT4
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000004
|
0.0888
|
|
(unit increase)] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG204
*
=
|
b6GnT |
|
ZK1225.2 |
GCNT1
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG205
*
=
|
b6GnT |
|
H41C03.3 |
GCNT2
|
|
|
|
|
JCEG206
*
=
|
b6GnT |
|
F35H8.2 |
GCNT2
|
|
|
|
|
JCEG207
*
|
b6GnT |
|
H41C03.1 |
GCNT2
|
|
|
|
|
JCEG208
*
=
|
iGnT orthologs |
|
F01D4.9 |
L2 GCNT2
|
|
|
|
|
JCEG209
*
=
|
iGnT orthologs |
|
F22F7.6 |
GCNT2
|
|
|
|
|
JCEG210
*
=
|
iGnT orthologs |
|
F21H7.10 |
GCNT2
|
|
|
|
|
JCEG211
*
=
|
iGnT orthologs |
|
C18G1.3 |
GCNT2
|
|
|
|
|
JCEG212
*
=
|
iGnT orthologs |
|
K08H2.9 |
GCNT2
|
|
|
|
|
JCEG213
*
=
|
iGnT orthologs |
|
C54C8.2 |
GCNT2
|
|
|
|
|
JCEG214
*
=
|
iGnT orthologs |
|
T15D6.4 |
GCNT2
|
|
|
|
|
JCEG215
*
=
|
iGnT orthologs |
|
F56H6.6 |
GCNT2
|
|
|
|
|
JCEG216
*
|
ppGalNAcT |
gly-6 |
H38K22.5 |
GALNT1
|
|
|
|
|
JCEG217
*
=
|
ppGalNAcT |
gly-3 |
ZK688.8 |
GALNT1
|
602273
608369
|
|
|
|
JCEG218
*
=
|
ppGalNAcT |
gly-9 |
Y47D3A.23 |
GALNT1
|
|
|
|
|
JCEG219
*
=
|
ppGalNAcT |
gly-5 |
Y39E4B.12 |
GALNT1
|
|
|
|
|
JCEG220
*
=
|
ppGalNAcT |
gly-4 |
Y116F11B.12 |
GALNT2
|
602274
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.6 |
0.000000004
|
|
0.02
(unit increase)
|
[0.01-0.03] |
20864672
|
|
Waterworth DM 2010-09-23 Arterioscler Thromb Vasc Biol
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
|
| MAPPED |
0.6 |
0.00000000000003
|
|
1.11
(mg/dl higher)
|
[NR] |
18193043
|
|
Willer CJ 2008-01-13 Nat Genet
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
| MAPPED |
0.44 |
0.000000001
|
|
|
|
22916037
|
|
Inouye M 2012-08-16 PLoS Genet
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
|
| MAPPED |
0.41 |
0.0000000000000000000000000000007000000000000001
|
|
0.04
(mg/dL increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.41 |
0.00000000000000000000000000000000000000004
|
|
0.048
(unit decrease)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
| MAPPED |
0.4 |
0.0000008
|
|
4.25
(mg/dl higher)
|
[NR] |
18193043
|
|
Willer CJ 2008-01-13 Nat Genet
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
| MAPPED |
0.4 |
0.00000004
|
|
0.05
(s.d. decrease)
|
[0.01-0.09] |
19060906
|
|
Kathiresan S 2008-12-07 Nat Genet
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
| MAPPED |
0.4 |
0.0000000000002
|
|
0.07
(% SD lower)
|
[0.05-0.09] |
18193044
|
|
Kathiresan S 2008-01-13 Nat Genet
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
| MAPPED |
0.4 |
0.000000000000007
|
|
0.08
(% SD higher)
|
[0.06-0.10] |
18193044
|
|
Kathiresan S 2008-01-13 Nat Genet
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
| MAPPED |
0.4 |
0.000000000000000000004
|
|
0.61
(mg/dL decrease)
|
[0.47-0.75] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.39 |
0.000003
|
|
0.05
(unit decrease)
|
[0.030-0.070] |
23620142
|
|
Reiner AP 2013-04-24 Hum Mol Genet
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
|
| MAPPED |
0.39 |
0.00000004
(HDL)
|
|
0.08
(mmol/l decrease)
|
[NR] |
22399527
|
|
Kristiansson K 2012-03-07 Circ Cardiovasc Genet
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
| MAPPED |
0.39 |
0.00000000000002
|
|
2.76
(mg/dL increase)
|
[2.02-3.5] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| MAPPED |
0.224 |
0.000008
(ALB/GLB)
|
|
0.016
(unit increase)
|
[0.0082-0.0238] |
23303382
|
|
Hong KW 2013-01-10 J Hum Genet
Genome-wide association study of serum albumin:globulin ratio in Korean populations.
|
| MAPPED |
0.1984 |
0.000004
(Complete)
|
|
0.4595
(unit decrease)
|
[0.26-0.66] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
| MAPPED |
0.1959 |
0.000002
(Primary)
|
|
0.3966
(unit decrease)
|
[0.23-0.56] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
|
|
|
JCEG221
*
=
|
ppGalNAcT |
gly-7 |
Y46H3A.6 |
GALNT7
|
605005
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.3308 |
0.000005
(Primary)
|
|
0.2278
(unit decrease)
|
[0.11-0.35] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
| MAPPED |
0.0458 |
0.000000006
(Case/control)
|
|
1.1474
(unit decrease)
|
[0.76-1.53] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
|
|
|
JCEG222
*
=
|
ppGalNAcT |
gly-10 |
Y45F10D.3 |
GALNT10
|
608043
615138
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.58 |
0.00000005
|
|
0.03
(unit increase)
|
[0.02-0.04] |
25231870
|
|
Perry JR 2014-07-23 Nature
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
|
| DOWNSTREAM |
0.42 |
0.00000000000005
|
|
0.021
(unit increase)
|
[0.012-0.030] |
23583978
|
|
Monda KL 2013-04-14 Nat Genet
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
|
| MAPPED |
0.379 |
0.00000003
|
1.0615711
|
|
[1.04-1.08] |
25056061
|
|
Ripke S 2014-07-22 Nature
Biological insights from 108 schizophrenia-associated genetic loci.
|
|
|
|
JCEG223
*
=
|
ppGalNAcT |
gly-8 |
Y66A7A.6 |
GALNT11
|
615130
615133
|
|
|
|
JCEG224
*
=
|
ppGalNAcT |
gly-11 |
Y75B8A.9 |
GALNT11
|
615130
615133
|
|
|