JCEG ID JCEG085
Name gly-2      WormBase    NCBI Gene
Human Ortholog

GGDB:MGAT5 MGAT5B 

OMIM: 601774 612441

OrthoList :   MGAT5   MGAT5B   CCDC126  (Ensembl Compara)

GWAS Catalog
STREAMRAFp-valueORBETACIStudy
DOWNSTREAM 0.000008 (M) 17.78 (unit decrease) [10.16-25.4] 25524916
DOWNSTREAM 0.9858 0.000007 (Ordinal I) 2.5604 (unit increase) [1.45-3.68] 25188341
UPSTREAM 0.974 0.00000003 (Chinese) 0.328 (unit decrease) [0.21-0.44] 24383474
UPSTREAM 0.917 0.000003 1.61 [1.32-2.0] 22683750
DOWNSTREAM 0.8 0.000000000002 0.032 (unit decrease) [NR] 20881960
MAPPED 0.64 0.000007 (overall) 22589738
MAPPED 0.36 0.0000002 20117844
DOWNSTREAM 0.2 0.000003 (Recessive) 34 [4.29-269.48] 22293537
UPSTREAM 0.08 0.000005 0.069 (unit decrease)] 22823124
DOWNSTREAM 0.023 0.00000004 0.048 (unit decrease) [0.031-0.065] 23362303
GGDB Score E-val
MGAT5 385 e-109
MGAT5B 351 2e-98
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name GlcNAcT(GnT)
Locus Tag C55B7.2
RNAi phenotype
phenotype Emb
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
tm:Detected
gg_motif:M1, M2, M3, M4, M6
Sequence CDS
Protein
References

Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M, Ahringer J Nature (2000) 408 (6810) :325-30 [PMID : 11099033] Functional genomic analysis of C. elegans chromosome I by systematic RNA interference.

Warren CE, Krizus A, Roy PJ, Culotti JG, Dennis JW J. Biol. Chem. (2002) 277 (25) :22829-38 [PMID : 11937505] The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shen X, Valencia CA, Gao W, Cotten SW, Dong B, Huang BC, Liu R Cell Calcium (2007) 43 (5) :444-56 [PMID : 17854888] Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

WormBase (WS254)

Functional Descriptions gly-2

gly-2 encodes a functional homolog of mammalian UDP-N-acetylglucosamine alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-TV) which regulates polylactosamine-containing N-glycans; gly-2 is functionally interchangeable with the mammalian gene; GLY-2 is expressed in late embryos and in a subset of neurons in larvae, spermathecal and pharyngeal-intestinal valves and in specific vulval cells of adults; GLY-2 binds bovine calmodulin in vitro in a calcium-dependent manner.
Deletion Mutants gk204 qa700 tm839 gk205 qa703
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003675

muscle cell "contractile cell that makes up muscle tissue." [WB:rynl] Enriched WBPaper00031003 : 0hr_muscle_enriched, total_muscle_enriched
 WBPaper00031003 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Larval_Pan_Neuronal
 WBPaper00030839 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00031532 : Larva_Pan_Neuronal_Enriched
 WBPaper00031532 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00037950 : all-neurons_larva_enriched
 WBPaper00037950 WormAtlas
WB WBbt:0003966

R9BR "Male sensory rays, neuron, darkly staining tip, open to outside" [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003968

R9BL "Post-embryonic cell of pedigree TL.appapapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003970

R9AR "Male sensory rays, neuron, striated rootlet" [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003971

R9AL "Male sensory rays, neuron, striated rootlet" [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003988

R8BR "Male sensory rays, neuron, darkly staining tip, open to outside" [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003990

R8BL "Post-embryonic cell of pedigree TL.appaaapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003992

R8AR "Male sensory rays, neuron, striated rootlet" [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0003994

R8AL "Post-embryonic cell of pedigree TL.appaaaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004012

R6BR "Post-embryonic cell of pedigree V6R.pppppapa, male sensory rays, neuron, not darkly staining nor open to outside." [ISBN:0-87969-307-X, WB:Paper00000462] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004014

R6BL "Post-embryonic cell of pedigree V6L.pppppapa, male sensory rays, neuron, not darkly staining nor open to outside." [ISBN:0-87969-307-X, WB:Paper00000462] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004016

R6AR "Post-embryonic cell of pedigree V6R.pppppaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004018

R6AL "Post-embryonic cell of pedigree V6L.pppppaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004021

R5BR "Post-embryonic cell of pedigree V6R.ppppaapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X, WB:Paper00000462] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004022

R5BL "Post-embryonic cell of pedigree V6L.ppppaapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X, WB:Paper00000462] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004023

R5AR "Post-embryonic cell of pedigree V6R.ppppaaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X, WB:Paper00000462] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004024

R5AL "Post-embryonic cell of pedigree V6L.ppppaaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X, WB:Paper00000462] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004033

R3BR "Post-embryonic cell of pedigree V6R.papppapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004034

R3BL "Post-embryonic cell of pedigree V6L.papppapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004035

R3AR "Post-embryonic cell of pedigree V6R.papppaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004036

R3AL "Post-embryonic cell of pedigree V6L.papppaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004039

R2BR "Post-embryonic cell of pedigree V6R.papapapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004040

R2BL "Post-embryonic cell of pedigree V6L.papapapa, male sensory rays, neuron, darkly staining tip, open to outside." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004041

R2AR "Post-embryonic cell of pedigree V6R.papapaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004042

R2AL "Post-embryonic cell of pedigree V6L.papapaaa, male sensory rays, neuron, striated rootlet." [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004302

pm8 "eighth pharyngeal muscle cell layer (single cell)" [ISBN:0-87969-307-X] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0004740

I5 neuron "Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] Enriched WBPaper00025141 : unc-4
 WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00025141 : unc-4
 WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00030839 : Embryo_A_Class, Larval_A_Class
 WBPaper00030839
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00037950 : A-class-motor-neurons_larva_enriched
 WBPaper00037950
WB WBbt:0005339

VA neuron "Neuron class of twelve motoneurons, distributed along the ventral cord, which innervate ventral body muscles." [WB:Paper00000938] Enriched WBPaper00037950 : A-class-motor-neurons_larva_enriched
 WBPaper00037950
WB WBbt:0005396

SAB "Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] Enriched WBPaper00025141 : unc-4
 WBPaper00025141
WB WBbt:0005439

pharyngeal neuron "neuron of the pharyngeal nervous system." [WB:rynl] Partial WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0005447

preanal ganglion neuron "neuron with cell body in the preanal ganglion." [WB:rynl, WBPaper:00000938] Certain WB:Expr1901 WBPaper00005377
WB WBbt:0005656

retrovesicular ganglion "ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] Enriched WBPaper00025141 : unc-4
 WBPaper00025141 WormAtlas
WB WBbt:0005751

coelomocyte "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] Enriched WBPaper00037950 : coelomocytes_embryo_enriched
 WBPaper00037950 WormAtlas
WB WBbt:0005767

pharyngeal-intestinal valve "A group of six equivalent cells forms a tightly constructed 'valve' that links the posterior bulb of the pharynx to the anterior four cells of the intestine. These six cells comprise a small epithelial channel with a cuticular lining in continuity with the pharyngeal cuticle and link the lumen of the pharynx to the large lumen of the anterior intestine." [WBPaper:00038216] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0005801

dorsal-rectal ganglion neuron "neuron whose cell body is in the dorsal-rectal ganglion. " [WB:rynl] Certain WB:Expr1901 WBPaper00005377
WB WBbt:0005813

body wall musculature "Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion." [ISBN:0-87969-433-5] Enriched WBPaper00040985 : AIN-2_asynchronous_muscle
 WBPaper00040985 WormAtlas
WB WBbt:0005829

ventral nerve cord "a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring." [WB:Paper00000938] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0005829

ventral nerve cord "a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring." [WB:Paper00000938] Enriched WBPaper00037950 : glr-1(+)-neurons_larva_enriched
 WBPaper00037950 WormAtlas
WB WBbt:0006750

dorsal nerve cord "a bundle of nerve processes that runs along the dorsal mid-line of the animal." [WB:Paper00000938] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0006756

spermathecal-uterine junction "A valve tissue that connects the spermatheca and the uterus of a hermaphrodite gonad." [WB:rynl] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0006767

vulE "adult vulval toroid cell, E, formed by fusion of precursors of lineage names P6.paal, P6.paar, P6.pppl and P6.pppr." [WB:wjc] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0006768

vulF "adult vulval toroid cell, F, formed by fusion of precursors of lineage names P6.papl, P6.papr, P6.ppal and P6.ppar." [WB:wjc] Uncertain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0006791

uv1 "uterine-vulval cell proximal to the vulva." [WB:Paper00002608] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0006792

uv2 "uterine-vulval cell, medial position of three ut cells." [WB:Paper00002608] Certain WB:Expr1901 WBPaper00005377 WormAtlas
WB WBbt:0006802

lumbar neuron "neuron in lumbar ganglion." [WB:wjc] Certain WB:Expr1901 WBPaper00005377

WBGene00001627
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
amplitude of sinusoidal movement increased

"Animals exhibit an increase in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
backing decreased

"Animals spend less time backing compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
backward point velocity decreased

"Animals exhibit decreased velocity of backward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
body posture amplitude decreased

"Animals exhibit variations in body posture caused by a decrease in the extent of displacement measured from the mean position to an extreme position compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
body posture wavelength decreased

"Animals exhibit variations in body posture caused by a decrease in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
coiling frequency increased

"Animals spend more time with their body posture in a coil or they increase the frequency with which they form coils compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
embryonic lethal

"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
RNAi: WBRNAi00003240   WBPaper00004402   Observed
forward locomotion decreased

"Animals spend less time in forward locomotion, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
forward point velocity decreased

"Animals exhibit decreased velocity of forward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
frequency body bend reduced

"Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712]
Allele: WBVar00145611   WBPaper00043908   Observed
head bend angle variant

"Any variation in the extent of the maximum flex of the most anterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
nose movement increased

"Animals exhibit an increase in the movement of the extreme anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
path curvature increased

"Animals exhibit increases in the extent to which the overall path of movement is curved, producing tighter and more frequent curves compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
pausing variant

"Animals exhibit variations in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
roaming reduced

"Animals exhibit a decrease in their high-speed movement in the forward direction with brief backward movement compared to control. In C. elegans, Animals do not move more than a few body lengths from their starting position and searches occur locally with pivoting behavior." [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson712]
Allele: WBVar00145611   WBPaper00043908   Observed
short

"Animals exhibit a decreased body length compared to control animals of the same developmental stage." [WB:WBPerson712]
Allele: WBVar00145611   WBPaper00043908   Observed
tail bend angle increased

"Animals exhibit an increase in the extent of the maximum flex of the most posterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed
turning frequency variant

"Animals exhibit variations in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00145611   WBPaper00043908   Observed


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