| JCEG ID |
Family |
Name |
Locus Tag |
Human Ortholog Name |
OMIM |
GWAS Catalog |
|
|
JCEG005
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
H43I07.3 |
ALG5
|
604565
|
|
|
|
JCEG018
*
=
|
Core 1 GalT |
|
C38H2.2 |
C1GALT1
|
300611
300622
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
| MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
| MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
| MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
|
JCEG046
*
=
|
Fucosyltransferases |
pad-2 |
K10G9.3 |
POFUT2
|
610249
|
|
|
|
JCEG083
*
=
|
GlcNAcT(GnT) |
gly-12 |
F48E3.1 |
MGAT1
|
160995
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
| DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
|
JCEG084
*
=
|
GlcNAcT(GnT) |
gly-20 |
C03E10.4 |
MGAT2
|
212066
602616
|
|
|
|
JCEG085
*
=
|
GlcNAcT(GnT) |
gly-2 |
C55B7.2 |
MGAT5 MGAT5B
|
601774
612441
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000008
(M)
|
|
17.78
(unit decrease)
|
[10.16-25.4] |
25524916
|
|
Palmer ND 2014-12-18 Diabetes
Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
|
| DOWNSTREAM |
0.9858 |
0.000007
(Ordinal I)
|
|
2.5604
(unit increase)
|
[1.45-3.68] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
| UPSTREAM |
0.974 |
0.00000003
(Chinese)
|
|
0.328
(unit decrease)
|
[0.21-0.44] |
24383474
|
|
Manichaikul A 2014-01-02 Am J Respir Crit Care Med
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
|
| UPSTREAM |
0.917 |
0.000003
|
1.61
|
|
[1.32-2.0] |
22683750
|
|
Sinner MF 2012-06-06 Heart Rhythm
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
|
| DOWNSTREAM |
0.8 |
0.000000000002
|
|
0.032
(unit decrease)
|
[NR] |
20881960
|
|
Lango Allen H 2010-09-29 Nature
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
| MAPPED |
0.64 |
0.000007
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.36 |
0.0000002
|
|
|
|
20117844
|
|
Brynedal B 2010-02-01 J Neuroimmunol
MGAT5 alters the severity of multiple sclerosis.
|
| DOWNSTREAM |
0.2 |
0.000003
(Recessive)
|
34
|
|
[4.29-269.48] |
22293537
|
|
Kiyotani K 2012-01-29 Pharmacogenet Genomics
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
| UPSTREAM |
0.08 |
0.000005
|
0.069
|
|
(unit decrease)] |
22823124
|
|
Verweij KJ 2012-07-24 Addict Biol
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
|
| DOWNSTREAM |
0.023 |
0.00000004
|
|
0.048
(unit decrease)
|
[0.031-0.065] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG108
|
Glyco_transf_92 |
|
ZK488.6 |
|
|
|
|
|
JCEG128
*
=
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
rib-2 |
K01G5.6 |
EXTL3 EXTL2 EXT2
|
133700
133701
602411
605744
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.00000004
(Conditioned on rs11581062)
|
1.09
|
|
[1.08-1.11] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| DOWNSTREAM |
|
0.00000004
|
1.09
|
|
[1.08-1.11] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
| MAPPED |
0.68 |
0.00000002
|
|
0.023
(unit increase)
|
[0.0093-0.0367] |
25429064
|
|
He M 2014-11-26 Hum Mol Genet
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
|
|
|
|
JCEG131
*
=
|
Glycosyltransferase like (GTL) |
|
D2045.9 |
LHL1
|
|
|
|
|
JCEG133
*
=
|
LARGE |
lge-1 |
K09C8.4 |
LARGE
|
603590
605517
608840
609709
613154
615287
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.56 |
0.000006
(women)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| DOWNSTREAM |
0.54 |
0.0000006
(women)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.28 |
0.000008
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.11 |
0.000008
|
1.44
|
|
[1.28-1.60] |
24962325
|
|
Kapoor M 2014-06-11 Drug Alcohol Depend
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
|
|
|
JCEG141
*
=
|
Oligosaccharyltransferase complex |
ostd-1 |
M01A10.3 |
RPN2
|
180490
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000006
|
|
|
|
19668339
|
|
Potkin SG 2009-08-07 PLoS One
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
|
|
|
|
JCEG155
*
=
|
POMT |
|
R12E2.13 |
POMT2
|
602934
607551
|
|
|
|
JCEG158
*
=
|
Sulfotransferase and sulfation-related genes |
hst-3.1 |
F40H3.5 |
HS3ST1
|
|
|
|
|
JCEG165
*
=
|
UGCGL1 |
uggt-1 |
F48E3.3 |
UGGT1 UGGT2
|
605897
605898
|
|
|
|
JCEG178
*
=
|
b3GalT1/b3GnT orthologs |
bre-5 |
T12G3.8 |
B3GALNT1 B3GALT4 B3GALT5 B3GNT3 B3GNT4 B3GNT6 B3GNT7
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000006
|
1.178
|
|
|
21041247
|
|
Perlis RH 2010-11-01 Am J Psychiatry
Genome-wide association study of suicide attempts in mood disorder patients.
|
| UPSTREAM |
|
0.00000006
|
|
0.031
(unit increase)
|
[0.019-0.043] |
25387707
|
|
Vaidyanathan U 2014-12-01 Psychophysiology
Heritability and molecular genetic basis of antisaccade eye tracking error rate: A genome-wide association study.
|
| UPSTREAM |
0.733 |
0.0000000001
|
|
0.3
(unit increase)
|
[0.20-0.40] |
23583979
|
|
den Hoed M 2013-04-14 Nat Genet
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
| UPSTREAM |
0.543 |
0.0000007
|
|
0.108
(unit increase)
|
[0.065-0.151] |
23568457
|
|
Wade TD 2013-04-09 Int J Eat Disord
Genetic variants associated with disordered eating.
|
| MAPPED |
0.43 |
0.000002
(AA)
|
|
4.21
(unit decrease)
|
[2.49-5.93] |
23599027
|
|
Demerath EW 2013-04-17 Hum Mol Genet
Genome-wide association study of age at menarche in African-American women.
|
| DOWNSTREAM |
0.26 |
0.0000000000001
(CA19-9)
|
|
0.072
(U/ml decrease)
|
[0.029-0.115] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
|
|
|
JCEG193
*
=
|
b6GnT |
gly-18 |
F22D6.11 |
GCNT3
|
|
|
|