CGGDB

> expression > retrovesicular ganglion

Definition: "ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG003 ^* ⁼

Asparagine-linked glycosylation (ALG) genes

bus-8

T23F2.1

ALG2

JCEG015 ^* ⁼

Asparagine-linked glycosylation (ALG) genes

algn-14

M02B7.4

ALG14

612866

STREAM	RAF	p-value	BETA	CI	Study
UPSTREAM		0.00000005 (proportions)	0.7 (% increase)	[NR]	22359512
	Demirkan A 2012-02-16 PLoS Genet Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
MAPPED	0.49	0.000000000000000002	0.1651 (unit decrease)	[0.128-0.202]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
MAPPED	0.451	0.00000000003	0.178 (unit incease)	[0.125-0.23]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

JCEG050 ^* ⁼

Fucosyltransferases

fut-1

K08F8.3

FUT5 FUT3 FUT4 FUT6

104230
111100
111100
136835
136836
602030
606865
613852

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM		0.000004 (EA)			22566498
	Turner ST 2012-05-07 Hypertension Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
DOWNSTREAM		0.0000009 (EA)	1.4 (unit increase)	[0.79-2.01]	22566498
	Turner ST 2012-05-07 Hypertension Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
MAPPED		0.00000003			24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED		0.0000000000004	49.78 (pg/ml increase)	[36.41-63.15]	22367966
	Lin X 2012-02-24 Hum Mol Genet Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
MAPPED		0.0000000000000000008			24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED	0.38	(CA19-9)	0.282 (U/ml increase)	[0.20-0.37]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.33	0.00000000000000000000000000000000001 (CEA)	0.073 (ng/ml increase)	[0.048-0.098]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.33	(CA19-9)	0.481 (U/ml decrease)	[0.44-0.52]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.2	0.00000000000000000000000000000000000000000000000000000002 (CA19-9)	0.169 (U/ml decrease)	[0.11-0.22]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.11	0.0000000009 (DG12)	0.3 (unit decrease)	[0.20-0.40]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.000000000003 (DG7)	0.34 (unit decrease)	[0.24-0.44]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.000000000001 (FUC-A)	0.34 (unit decrease)	[0.24-0.44]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.00000000000000004 (DG9)	0.41 (unit decrease)	[0.31-0.51]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

JCEG079 ^*

GPI-anchor synthesis

F49E7.2

PIGX

JCEG071 ^* ⁼

GPI-anchor synthesis

C27A12.9

PIGO

614730
614749

JCEG083 ^* ⁼

GlcNAcT(GnT)

gly-12

F48E3.1

MGAT1

160995

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM	0.85	0.000006 (females)	0.16 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
DOWNSTREAM	0.85	0.00000007 (females)	2.96 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
MAPPED	0.47	0.000005 (HDL-C)	0.23 (mg/dL increase)	[NR]	19197348
	Lowe JK 2009-02-06 PLoS Genet Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
DOWNSTREAM	0.14	0.000008 (EA-glucose response)	3.67 (mg/dL increase)	[2.06-5.28]	23400010
	Del-Aguila JL 2013-02-12 Pharmacogenomics J Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.

JCEG085 ^* ⁼

GlcNAcT(GnT)

gly-2

C55B7.2

MGAT5 MGAT5B

601774
612441

STREAM	RAF	p-value	OR	BETA	CI	Study
DOWNSTREAM		0.000008 (M)		17.78 (unit decrease)	[10.16-25.4]	25524916
	Palmer ND 2014-12-18 Diabetes Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
DOWNSTREAM	0.9858	0.000007 (Ordinal I)		2.5604 (unit increase)	[1.45-3.68]	25188341
	Beecham GW 2014-09-04 PLoS Genet Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
UPSTREAM	0.974	0.00000003 (Chinese)		0.328 (unit decrease)	[0.21-0.44]	24383474
	Manichaikul A 2014-01-02 Am J Respir Crit Care Med Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
UPSTREAM	0.917	0.000003	1.61		[1.32-2.0]	22683750
	Sinner MF 2012-06-06 Heart Rhythm A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
DOWNSTREAM	0.8	0.000000000002		0.032 (unit decrease)	[NR]	20881960
	Lango Allen H 2010-09-29 Nature Hundreds of variants clustered in genomic loci and biological pathways affect human height.
MAPPED	0.64	0.000007 (overall)				22589738
	Fox CS 2012-05-10 PLoS Genet Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
MAPPED	0.36	0.0000002				20117844
	Brynedal B 2010-02-01 J Neuroimmunol MGAT5 alters the severity of multiple sclerosis.
DOWNSTREAM	0.2	0.000003 (Recessive)	34		[4.29-269.48]	22293537
	Kiyotani K 2012-01-29 Pharmacogenet Genomics A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
UPSTREAM	0.08	0.000005	0.069		(unit decrease)]	22823124
	Verweij KJ 2012-07-24 Addict Biol The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
DOWNSTREAM	0.023	0.00000004		0.048 (unit decrease)	[0.031-0.065]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

JCEG086 ^* ⁼

GlcNAcT(GnT)

M70.4

POMGNT1

300492
608617
608618
608619

JCEG117

Glyco_transf_92

Y105C5B.25

JCEG161 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-1

F08B4.6

NDST1

600853
603268
603950
615039

JCEG162 ^*

UDP-glucuronosyltransferases

ugt-46

B0310.5

CGT

JCEG165 ^* ⁼

UGCGL1

uggt-1

F48E3.3

UGGT1 UGGT2

605897
605898

JCEG167 ^* ⁼

a-N-acetylglucosaminidase

K09E4.4

NAGLU

252920
609701

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