CGGDB

> expression > coelomocyte

Definition: "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG006 ^* ⁼

Asparagine-linked glycosylation (ALG) genes

C08B11.8

ALG6

603147
604566

JCEG053 ^* ⁼

Fucosyltransferases

fut-8

C10F3.6

FUT8

602589

STREAM	RAF	p-value	BETA	CI	Study
MAPPED	0.59	0.00000004	0.03 (unit increase)	[0.02-0.04]	25231870
	Perry JR 2014-07-23 Nature Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
MAPPED	0.21	0.00000001 (DG6)	0.22 (unit decrease)	[0.14-0.30]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

JCEG058 ^* ⁼

Fukutin

W02B3.4

FCMD

253800
607440
611588
611615
613152

JCEG070 ^* ⁼

GPI-anchor synthesis

Y54E10BR.1

PIGN

606097
614080

STREAM	RAF	p-value	OR	CI	Study
MAPPED		0.000009 (phenotype 3)	3.57	[NR]	25461247
	Lehmann DS 2015-02-01 Pharmacogenet Genomics Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
MAPPED		0.000009 (phenotype 1)	3.57	[NR]	25461247
	Lehmann DS 2015-02-01 Pharmacogenet Genomics Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.

JCEG084 ^* ⁼

GlcNAcT(GnT)

gly-20

C03E10.4

MGAT2

212066
602616

JCEG085 ^* ⁼

GlcNAcT(GnT)

gly-2

C55B7.2

MGAT5 MGAT5B

601774
612441

STREAM	RAF	p-value	OR	BETA	CI	Study
DOWNSTREAM		0.000008 (M)		17.78 (unit decrease)	[10.16-25.4]	25524916
	Palmer ND 2014-12-18 Diabetes Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
DOWNSTREAM	0.9858	0.000007 (Ordinal I)		2.5604 (unit increase)	[1.45-3.68]	25188341
	Beecham GW 2014-09-04 PLoS Genet Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
UPSTREAM	0.974	0.00000003 (Chinese)		0.328 (unit decrease)	[0.21-0.44]	24383474
	Manichaikul A 2014-01-02 Am J Respir Crit Care Med Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
UPSTREAM	0.917	0.000003	1.61		[1.32-2.0]	22683750
	Sinner MF 2012-06-06 Heart Rhythm A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
DOWNSTREAM	0.8	0.000000000002		0.032 (unit decrease)	[NR]	20881960
	Lango Allen H 2010-09-29 Nature Hundreds of variants clustered in genomic loci and biological pathways affect human height.
MAPPED	0.64	0.000007 (overall)				22589738
	Fox CS 2012-05-10 PLoS Genet Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
MAPPED	0.36	0.0000002				20117844
	Brynedal B 2010-02-01 J Neuroimmunol MGAT5 alters the severity of multiple sclerosis.
DOWNSTREAM	0.2	0.000003 (Recessive)	34		[4.29-269.48]	22293537
	Kiyotani K 2012-01-29 Pharmacogenet Genomics A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
UPSTREAM	0.08	0.000005	0.069		(unit decrease)]	22823124
	Verweij KJ 2012-07-24 Addict Biol The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
DOWNSTREAM	0.023	0.00000004		0.048 (unit decrease)	[0.031-0.065]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

JCEG088 ^* ⁼

GlcT

cgt-1

T06C12.10

UGCG

602874

JCEG096 ^* ⁼

Glucuronyltransferase(GlcAT)

glct-6

W07G9.2

B3GAT1

151290
245600
606374
607497

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000008	4.35		[2.28-8.30]	24172245
	Haga S 2013-10-31 J Hum Genet A genome-wide association study of third molar agenesis in Japanese and Korean populations.
MAPPED		0.000003	0.701		(unit decrease)]	24277619
	Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
UPSTREAM		0.000002		0.64 (unit increase)	[0.39-0.89]	25562672
	Byrne EM 2014-12-09 J Clin Psychiatry Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
UPSTREAM	0.889723713	0.000009 (IGP36)		0.227 (unit decrease)	[0.13-0.33]	23382691
	Lauc G 2013-01-31 PLoS Genet Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
UPSTREAM	0.871	0.000002			[NR]	23049088
	Meng W 2012-10-09 Invest Ophthalmol Vis Sci A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
DOWNSTREAM	0.53	0.000005 (CERAD-dr)		0.2826 (unit decrease)	[0.16-0.4]	25648963
	Debette S 2014-11-25 Biol Psychiatry Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
UPSTREAM	0.143	0.0000007			[NR]	23049088
	Meng W 2012-10-09 Invest Ophthalmol Vis Sci A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.

JCEG115

Glyco_transf_92

galt-1

M03F8.4

JCEG125 ^* ⁼

Glycosaminoglycan (GAG ) and Chitin synthesis genes

sqv-5

T24D1.1

CHSY1 CHPF CHSY3 CHPF2 CSGALNACT1 CSGALNACT2

605282
608183
609963

STREAM	RAF	p-value	OR	BETA	CI	Study
MAPPED		0.000007		0.226 (unit increase)	[NR]	23322567
	Lopes MC 2013-01-15 Invest Ophthalmol Vis Sci Identification of a candidate gene for astigmatism.
MAPPED		0.0000002	2.14		[1.53-2.99]	23726668
	Hunter AM 2013-05-30 J Psychiatr Res A genome-wide association study of a sustained pattern of antidepressant response.
MAPPED	0.66	0.000000002		0.08 (unit decrease)	[0.06-0.1]	23291589
	Lu Y 2013-01-06 Nat Genet Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
MAPPED	0.601	0.000001		0.022 (unit increase)	[NR]	25201988
	Rietveld CA 2014-09-08 Proc Natl Acad Sci U S A Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
UPSTREAM	0.31	0.000002 (ETV6-RUNX1 positive)	1.19		[1.07 - 1.33]	22076464
	Ellinghaus E 2011-11-11 Leukemia Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
UPSTREAM	0.31	0.000000006 (ETV6-RUNX1 positive, Northern European)				22076464
	Ellinghaus E 2011-11-11 Leukemia Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.

JCEG126 ^* ⁼

Glycosaminoglycan (GAG ) and Chitin synthesis genes

mig-22

PAR2.4

CHPF

608037
610405

JCEG152 ^* ⁼

POFUT

C15C7.7

POFUT1

607491
615327

JCEG158 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-3.1

F40H3.5

HS3ST1

JCEG173 ^* ⁼

b3GalT1/b3GnT orthologs

bre-2

Y39E4B.9

B3GALT1

603018

STREAM	RAF	p-value	BETA	CI	Study
MAPPED	0.103	0.000002 (Amylin )	0.03 (pM increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
MAPPED	0.083	0.000008 (Diet fat )	0.04 (%energy increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
DOWNSTREAM	0.04	0.000000002 (KvDMR 21)			23725790
	Renteria ME 2013-06-03 Twin Res Hum Genet GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.

JCEG193 ^* ⁼

b6GnT

gly-18

F22D6.11

GCNT3

JCEG200 ^* ⁼

b6GnT

T28F3.9

GCNT3

JCEG220 ^* ⁼

ppGalNAcT

gly-4

Y116F11B.12

GALNT2

602274

STREAM	RAF	p-value	BETA	CI	Study
MAPPED	0.6	0.000000004	0.02 (unit increase)	[0.01-0.03]	20864672
	Waterworth DM 2010-09-23 Arterioscler Thromb Vasc Biol Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
MAPPED	0.6	0.00000000000003	1.11 (mg/dl higher)	[NR]	18193043
	Willer CJ 2008-01-13 Nat Genet Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
MAPPED	0.44	0.000000001			22916037
	Inouye M 2012-08-16 PLoS Genet Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
MAPPED	0.41	0.0000000000000000000000000000007000000000000001	0.04 (mg/dL increase)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
MAPPED	0.41	0.00000000000000000000000000000000000000004	0.048 (unit decrease)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
MAPPED	0.4	0.0000008	4.25 (mg/dl higher)	[NR]	18193043
	Willer CJ 2008-01-13 Nat Genet Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
MAPPED	0.4	0.00000004	0.05 (s.d. decrease)	[0.01-0.09]	19060906
	Kathiresan S 2008-12-07 Nat Genet Common variants at 30 loci contribute to polygenic dyslipidemia.
MAPPED	0.4	0.0000000000002	0.07 (% SD lower)	[0.05-0.09]	18193044
	Kathiresan S 2008-01-13 Nat Genet Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
MAPPED	0.4	0.000000000000007	0.08 (% SD higher)	[0.06-0.10]	18193044
	Kathiresan S 2008-01-13 Nat Genet Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
MAPPED	0.4	0.000000000000000000004	0.61 (mg/dL decrease)	[0.47-0.75]	20686565
	Teslovich TM 2010-08-05 Nature Biological, clinical and population relevance of 95 loci for blood lipids.
MAPPED	0.39	0.000003	0.05 (unit decrease)	[0.030-0.070]	23620142
	Reiner AP 2013-04-24 Hum Mol Genet Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
MAPPED	0.39	0.00000004 (HDL)	0.08 (mmol/l decrease)	[NR]	22399527
	Kristiansson K 2012-03-07 Circ Cardiovasc Genet Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
MAPPED	0.39	0.00000000000002	2.76 (mg/dL increase)	[2.02-3.5]	20686565
	Teslovich TM 2010-08-05 Nature Biological, clinical and population relevance of 95 loci for blood lipids.
MAPPED	0.224	0.000008 (ALB/GLB)	0.016 (unit increase)	[0.0082-0.0238]	23303382
	Hong KW 2013-01-10 J Hum Genet Genome-wide association study of serum albumin:globulin ratio in Korean populations.
MAPPED	0.1984	0.000004 (Complete)	0.4595 (unit decrease)	[0.26-0.66]	25188341
	Beecham GW 2014-09-04 PLoS Genet Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
MAPPED	0.1959	0.000002 (Primary)	0.3966 (unit decrease)	[0.23-0.56]	25188341
	Beecham GW 2014-09-04 PLoS Genet Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.

JCEG219 ^* ⁼

ppGalNAcT

gly-5

Y39E4B.12

GALNT1

Insert title here