CGGDB

> expression > SAB

Definition: "Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG003 ^* ⁼

Asparagine-linked glycosylation (ALG) genes

bus-8

T23F2.1

ALG2

JCEG015 ^* ⁼

Asparagine-linked glycosylation (ALG) genes

algn-14

M02B7.4

ALG14

612866

STREAM	RAF	p-value	BETA	CI	Study
UPSTREAM		0.00000005 (proportions)	0.7 (% increase)	[NR]	22359512
	Demirkan A 2012-02-16 PLoS Genet Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
MAPPED	0.49	0.000000000000000002	0.1651 (unit decrease)	[0.128-0.202]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
MAPPED	0.451	0.00000000003	0.178 (unit incease)	[0.125-0.23]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

JCEG079 ^*

GPI-anchor synthesis

F49E7.2

PIGX

JCEG071 ^* ⁼

GPI-anchor synthesis

C27A12.9

PIGO

614730
614749

JCEG083 ^* ⁼

GlcNAcT(GnT)

gly-12

F48E3.1

MGAT1

160995

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM	0.85	0.000006 (females)	0.16 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
DOWNSTREAM	0.85	0.00000007 (females)	2.96 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
MAPPED	0.47	0.000005 (HDL-C)	0.23 (mg/dL increase)	[NR]	19197348
	Lowe JK 2009-02-06 PLoS Genet Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
DOWNSTREAM	0.14	0.000008 (EA-glucose response)	3.67 (mg/dL increase)	[2.06-5.28]	23400010
	Del-Aguila JL 2013-02-12 Pharmacogenomics J Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.

JCEG085 ^* ⁼

GlcNAcT(GnT)

gly-2

C55B7.2

MGAT5 MGAT5B

601774
612441

STREAM	RAF	p-value	OR	BETA	CI	Study
DOWNSTREAM		0.000008 (M)		17.78 (unit decrease)	[10.16-25.4]	25524916
	Palmer ND 2014-12-18 Diabetes Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
DOWNSTREAM	0.9858	0.000007 (Ordinal I)		2.5604 (unit increase)	[1.45-3.68]	25188341
	Beecham GW 2014-09-04 PLoS Genet Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
UPSTREAM	0.974	0.00000003 (Chinese)		0.328 (unit decrease)	[0.21-0.44]	24383474
	Manichaikul A 2014-01-02 Am J Respir Crit Care Med Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
UPSTREAM	0.917	0.000003	1.61		[1.32-2.0]	22683750
	Sinner MF 2012-06-06 Heart Rhythm A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
DOWNSTREAM	0.8	0.000000000002		0.032 (unit decrease)	[NR]	20881960
	Lango Allen H 2010-09-29 Nature Hundreds of variants clustered in genomic loci and biological pathways affect human height.
MAPPED	0.64	0.000007 (overall)				22589738
	Fox CS 2012-05-10 PLoS Genet Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
MAPPED	0.36	0.0000002				20117844
	Brynedal B 2010-02-01 J Neuroimmunol MGAT5 alters the severity of multiple sclerosis.
DOWNSTREAM	0.2	0.000003 (Recessive)	34		[4.29-269.48]	22293537
	Kiyotani K 2012-01-29 Pharmacogenet Genomics A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
UPSTREAM	0.08	0.000005	0.069		(unit decrease)]	22823124
	Verweij KJ 2012-07-24 Addict Biol The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
DOWNSTREAM	0.023	0.00000004		0.048 (unit decrease)	[0.031-0.065]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

JCEG086 ^* ⁼

GlcNAcT(GnT)

M70.4

POMGNT1

300492
608617
608618
608619

JCEG117

Glyco_transf_92

Y105C5B.25

JCEG161 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-1

F08B4.6

NDST1

600853
603268
603950
615039

JCEG162 ^*

UDP-glucuronosyltransferases

ugt-46

B0310.5

CGT

JCEG165 ^* ⁼

UGCGL1

uggt-1

F48E3.3

UGGT1 UGGT2

605897
605898

JCEG167 ^* ⁼

a-N-acetylglucosaminidase

K09E4.4

NAGLU

252920
609701

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