| JCEG ID |
Family |
Name |
Locus Tag |
Human Ortholog Name |
OMIM |
GWAS Catalog |
|
|
JCEG070
*
=
|
GPI-anchor synthesis |
|
Y54E10BR.1 |
PIGN
|
606097
614080
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000009
(phenotype 3)
|
3.57
|
|
[NR] |
25461247
|
|
Lehmann DS 2015-02-01 Pharmacogenet Genomics
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
|
| MAPPED |
|
0.000009
(phenotype 1)
|
3.57
|
|
[NR] |
25461247
|
|
Lehmann DS 2015-02-01 Pharmacogenet Genomics
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
|
|
|
|
JCEG082
*
=
|
GlcNAcT(GnT) |
gly-13 |
B0416.6 |
MGAT1
|
160995
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
| DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
|
JCEG085
*
=
|
GlcNAcT(GnT) |
gly-2 |
C55B7.2 |
MGAT5 MGAT5B
|
601774
612441
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000008
(M)
|
|
17.78
(unit decrease)
|
[10.16-25.4] |
25524916
|
|
Palmer ND 2014-12-18 Diabetes
Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
|
| DOWNSTREAM |
0.9858 |
0.000007
(Ordinal I)
|
|
2.5604
(unit increase)
|
[1.45-3.68] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
| UPSTREAM |
0.974 |
0.00000003
(Chinese)
|
|
0.328
(unit decrease)
|
[0.21-0.44] |
24383474
|
|
Manichaikul A 2014-01-02 Am J Respir Crit Care Med
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
|
| UPSTREAM |
0.917 |
0.000003
|
1.61
|
|
[1.32-2.0] |
22683750
|
|
Sinner MF 2012-06-06 Heart Rhythm
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
|
| DOWNSTREAM |
0.8 |
0.000000000002
|
|
0.032
(unit decrease)
|
[NR] |
20881960
|
|
Lango Allen H 2010-09-29 Nature
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
| MAPPED |
0.64 |
0.000007
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.36 |
0.0000002
|
|
|
|
20117844
|
|
Brynedal B 2010-02-01 J Neuroimmunol
MGAT5 alters the severity of multiple sclerosis.
|
| DOWNSTREAM |
0.2 |
0.000003
(Recessive)
|
34
|
|
[4.29-269.48] |
22293537
|
|
Kiyotani K 2012-01-29 Pharmacogenet Genomics
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
| UPSTREAM |
0.08 |
0.000005
|
0.069
|
|
(unit decrease)] |
22823124
|
|
Verweij KJ 2012-07-24 Addict Biol
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
|
| DOWNSTREAM |
0.023 |
0.00000004
|
|
0.048
(unit decrease)
|
[0.031-0.065] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG122
|
Glyco_transf_92 |
|
C13A2.2 |
|
|
|
|
|
JCEG124
*
=
|
Glycogen synthase |
gsy-1 |
Y46G5A.31 |
GYS1 GYS2
|
138570
138571
240600
611556
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.08 |
0.00000004
(FSH)
|
|
|
|
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
|
|
|
JCEG127
*
=
|
Glycosaminoglycan (GAG ) and Chitin synthesis genes |
rib-1 |
F12F6.3 |
EXT1 EXTL1
|
133700
150230
215300
601738
608177
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.48 |
0.000006
|
|
0.36
(cm decrease)
|
[NR] |
19893584
|
|
Kim JJ 2009-11-06 J Hum Genet
Identification of 15 loci influencing height in a Korean population.
|
| MAPPED |
0.093 |
0.000002
(Cortisol )
|
|
0.03
(ng/mL increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
| DOWNSTREAM |
0.07 |
0.000008
(men)
|
|
0.18
(kg/m2 decrease)
|
[0.1-0.26] |
25811787
|
|
Huffman JE 2015-03-26 PLoS One
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans.
|
|
|
|
JCEG158
*
=
|
Sulfotransferase and sulfation-related genes |
hst-3.1 |
F40H3.5 |
HS3ST1
|
|
|
|
|
JCEG157
*
=
|
Sulfotransferase and sulfation-related genes |
hst-2 |
C34F6.4 |
HS2ST1
|
604844
|
|
|
|
JCEG191
*
=
|
b6GnT |
gly-16 |
T15D6.2 |
GCNT1 GCNT2
|
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.71 |
0.000007
|
1.56
|
|
[1.28-1.89] |
21546767
|
|
Murea M 2011-05-05 Am J Nephrol
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
|
|
|
|
JCEG193
*
=
|
b6GnT |
gly-18 |
F22D6.11 |
GCNT3
|
|
|
|