CGGDB

> expression > pharyngeal-intestinal valve

Definition: "A group of six equivalent cells forms a tightly constructed 'valve' that links the posterior bulb of the pharynx to the anterior four cells of the intestine. These six cells comprise a small epithelial channel with a cuticular lining in continuity with the pharyngeal cuticle and link the lumen of the pharynx to the large lumen of the anterior intestine." [WBPaper:00038216]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG050 ^* ⁼

Fucosyltransferases

fut-1

K08F8.3

FUT5 FUT3 FUT4 FUT6

104230
111100
111100
136835
136836
602030
606865
613852

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM		0.000004 (EA)			22566498
	Turner ST 2012-05-07 Hypertension Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
DOWNSTREAM		0.0000009 (EA)	1.4 (unit increase)	[0.79-2.01]	22566498
	Turner ST 2012-05-07 Hypertension Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
MAPPED		0.00000003			24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED		0.0000000000004	49.78 (pg/ml increase)	[36.41-63.15]	22367966
	Lin X 2012-02-24 Hum Mol Genet Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
MAPPED		0.0000000000000000008			24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED	0.38	(CA19-9)	0.282 (U/ml increase)	[0.20-0.37]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.33	0.00000000000000000000000000000000001 (CEA)	0.073 (ng/ml increase)	[0.048-0.098]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.33	(CA19-9)	0.481 (U/ml decrease)	[0.44-0.52]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.2	0.00000000000000000000000000000000000000000000000000000002 (CA19-9)	0.169 (U/ml decrease)	[0.11-0.22]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.11	0.0000000009 (DG12)	0.3 (unit decrease)	[0.20-0.40]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.000000000003 (DG7)	0.34 (unit decrease)	[0.24-0.44]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.000000000001 (FUC-A)	0.34 (unit decrease)	[0.24-0.44]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.00000000000000004 (DG9)	0.41 (unit decrease)	[0.31-0.51]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

JCEG085 ^* ⁼

GlcNAcT(GnT)

gly-2

C55B7.2

MGAT5 MGAT5B

601774
612441

STREAM	RAF	p-value	OR	BETA	CI	Study
DOWNSTREAM		0.000008 (M)		17.78 (unit decrease)	[10.16-25.4]	25524916
	Palmer ND 2014-12-18 Diabetes Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
DOWNSTREAM	0.9858	0.000007 (Ordinal I)		2.5604 (unit increase)	[1.45-3.68]	25188341
	Beecham GW 2014-09-04 PLoS Genet Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
UPSTREAM	0.974	0.00000003 (Chinese)		0.328 (unit decrease)	[0.21-0.44]	24383474
	Manichaikul A 2014-01-02 Am J Respir Crit Care Med Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
UPSTREAM	0.917	0.000003	1.61		[1.32-2.0]	22683750
	Sinner MF 2012-06-06 Heart Rhythm A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
DOWNSTREAM	0.8	0.000000000002		0.032 (unit decrease)	[NR]	20881960
	Lango Allen H 2010-09-29 Nature Hundreds of variants clustered in genomic loci and biological pathways affect human height.
MAPPED	0.64	0.000007 (overall)				22589738
	Fox CS 2012-05-10 PLoS Genet Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
MAPPED	0.36	0.0000002				20117844
	Brynedal B 2010-02-01 J Neuroimmunol MGAT5 alters the severity of multiple sclerosis.
DOWNSTREAM	0.2	0.000003 (Recessive)	34		[4.29-269.48]	22293537
	Kiyotani K 2012-01-29 Pharmacogenet Genomics A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
UPSTREAM	0.08	0.000005	0.069		(unit decrease)]	22823124
	Verweij KJ 2012-07-24 Addict Biol The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
DOWNSTREAM	0.023	0.00000004		0.048 (unit decrease)	[0.031-0.065]	23362303
	Wu JH 2013-01-29 Circ Cardiovasc Genet Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

JCEG090 ^* ⁼

GlcT

cgt-3

F59G1.1

UGCG

602874

JCEG088 ^* ⁼

GlcT

cgt-1

T06C12.10

UGCG

602874

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