| JCEG ID |
Family |
Name |
Locus Tag |
Human Ortholog Name |
OMIM |
GWAS Catalog |
|
|
JCEG003
*
=
|
Asparagine-linked glycosylation (ALG) genes |
bus-8 |
T23F2.1 |
ALG2
|
|
|
|
|
JCEG015
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-14 |
M02B7.4 |
ALG14
|
612866
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| UPSTREAM |
|
0.00000005
(proportions)
|
|
0.7
(% increase)
|
[NR] |
22359512
|
|
Demirkan A 2012-02-16 PLoS Genet
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
|
| MAPPED |
0.49 |
0.000000000000000002
|
|
0.1651
(unit decrease)
|
[0.128-0.202] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
| MAPPED |
0.451 |
0.00000000003
|
|
0.178
(unit incease)
|
[0.125-0.23] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG079
*
|
GPI-anchor synthesis |
|
F49E7.2 |
PIGX
|
|
|
|
|
JCEG071
*
=
|
GPI-anchor synthesis |
|
C27A12.9 |
PIGO
|
614730
614749
|
|
|
|
JCEG083
*
=
|
GlcNAcT(GnT) |
gly-12 |
F48E3.1 |
MGAT1
|
160995
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
| MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
| DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
|
JCEG085
*
=
|
GlcNAcT(GnT) |
gly-2 |
C55B7.2 |
MGAT5 MGAT5B
|
601774
612441
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| DOWNSTREAM |
|
0.000008
(M)
|
|
17.78
(unit decrease)
|
[10.16-25.4] |
25524916
|
|
Palmer ND 2014-12-18 Diabetes
Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
|
| DOWNSTREAM |
0.9858 |
0.000007
(Ordinal I)
|
|
2.5604
(unit increase)
|
[1.45-3.68] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
| UPSTREAM |
0.974 |
0.00000003
(Chinese)
|
|
0.328
(unit decrease)
|
[0.21-0.44] |
24383474
|
|
Manichaikul A 2014-01-02 Am J Respir Crit Care Med
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
|
| UPSTREAM |
0.917 |
0.000003
|
1.61
|
|
[1.32-2.0] |
22683750
|
|
Sinner MF 2012-06-06 Heart Rhythm
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
|
| DOWNSTREAM |
0.8 |
0.000000000002
|
|
0.032
(unit decrease)
|
[NR] |
20881960
|
|
Lango Allen H 2010-09-29 Nature
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
| MAPPED |
0.64 |
0.000007
(overall)
|
|
|
|
22589738
|
|
Fox CS 2012-05-10 PLoS Genet
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
|
| MAPPED |
0.36 |
0.0000002
|
|
|
|
20117844
|
|
Brynedal B 2010-02-01 J Neuroimmunol
MGAT5 alters the severity of multiple sclerosis.
|
| DOWNSTREAM |
0.2 |
0.000003
(Recessive)
|
34
|
|
[4.29-269.48] |
22293537
|
|
Kiyotani K 2012-01-29 Pharmacogenet Genomics
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
| UPSTREAM |
0.08 |
0.000005
|
0.069
|
|
(unit decrease)] |
22823124
|
|
Verweij KJ 2012-07-24 Addict Biol
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
|
| DOWNSTREAM |
0.023 |
0.00000004
|
|
0.048
(unit decrease)
|
[0.031-0.065] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
|
|
|
JCEG086
*
=
|
GlcNAcT(GnT) |
|
M70.4 |
POMGNT1
|
300492
608617
608618
608619
|
|
|
|
JCEG117
|
Glyco_transf_92 |
|
Y105C5B.25 |
|
|
|
|
|
JCEG161
*
=
|
Sulfotransferase and sulfation-related genes |
hst-1 |
F08B4.6 |
NDST1
|
600853
603268
603950
615039
|
|
|
|
JCEG159
*
=
|
Sulfotransferase and sulfation-related genes |
hst-3.2 |
F52B10.2 |
HS3ST3A1 HS3ST3B1 HS3ST2 HS3ST4 HS3ST5 HS3ST6
|
604056
604057
604058
604059
|
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
|
0.000002
|
|
|
|
24324551
|
|
Deng X 2013-11-20 PLoS One
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
|
| MAPPED |
|
0.0000007
|
|
0.0437
(unit increase)
|
[NR] |
24086445
|
|
Wang Q 2013-09-24 PLoS One
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
|
| MAPPED |
0.381 |
0.000004
(Dominant model)
|
1.647
|
|
[1.264-2.146] |
23648065
|
|
Low SK 2013-05-04 Cancer Sci
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
|
| UPSTREAM |
0.2 |
0.000001
|
1.19
|
|
[NR] |
19525955
|
|
Bahlo 2009-06-14 Nat Genet
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
|
| DOWNSTREAM |
0.04 |
0.000002
|
0.082
|
|
(unit increase)] |
22823124
|
|
Verweij KJ 2012-07-24 Addict Biol
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
|
|
|
|
JCEG162
*
|
UDP-glucuronosyltransferases |
ugt-46 |
B0310.5 |
CGT
|
|
|
|
|
JCEG165
*
=
|
UGCGL1 |
uggt-1 |
F48E3.3 |
UGGT1 UGGT2
|
605897
605898
|
|
|
|
JCEG167
*
=
|
a-N-acetylglucosaminidase |
|
K09E4.4 |
NAGLU
|
252920
609701
|
|
|
|
JCEG180
*
=
|
b3GalT1/b3GnT orthologs |
sqv-2 |
Y110A2AL.14 |
B3GALT6
|
271640
615291
615349
|
|
|