JCEG ID |
JCEG161 |
Name |
hst-1
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:NDST1
OMIM:
600853
603268
603950
615039
OrthoList :
NDST1
NDST2
NDST4
NDST3
ENSG00000175818
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Sulfotransferase and sulfation-related genes |
Locus Tag |
F08B4.6
|
RNAi phenotype |
phenotype
|
Emb
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
|
Sequence |
CDS
atgataataaccccctacctcaatcgtaaaattacaagaccgctaaaatg gattttagcgttaattttcttatatttgatttatatatgcttattttcca acaattcgaagccaccaaaaccaagaaaaaagccaaaacttgtggaaaat tacacgtgtccgtttgcaagaacagagggcactgccagtgaaaatctatt tttccacactaacaatggaaccgatgcacgaattttagtaattctggact cacttttttcgagacatggaaaaacgataattcaaattttgaactctcaa aaactacagttcaaggcagaagctgtttcaaaaaatctcccagtgctaac tacatcacgaagagggagatattcgcttataataattgagaattattata aatatttgaatatggcacaatggaatcgccaattattggataaatattgc aaagaatatcgagttcccatgttttcattcatgtcgagtaaaccgaatga ccaactcaagcggataaaaatcaagggaagttcactttggatgtggcaaa atcaacgaattcaacgactcgccgtcactccatccataattcacagaatc tctaaaataggaaactatcggcaattttcttcatcagatccagccgattg gatattatttgaaacatccgaaaagttcgaatcagttctatctggaacag taaagagtggttatgagagagcagtagttgttagagacaaaggattagaa gatggcgttgaaagaataatttttggaagaaatttgacagattttcaagt taaaatcacatttctggatgctttatggtgggcaatgggtaaccagaaaa gcttcacactggatagatttgtacaagtagacatcgatgatgtattcgta ggtgcccagggaactcggatagtagaagaagatgtgcgaaaattaatttc aactcaaaaagaatttcgaaattatgttcaaaatttcacatttatgctag gattctcggggagttattttcgaaatggagatgatttggaggatcgtgga gacgagtttctcgttgaaaatgctgaaaagttcgtgtggttcccacatat gtggaggcacaatcatgctcatgaacataatttcacgtatctagaagcta taatggctcagaataaactctttgcgcagaatatgcaccttcctgttgac tatccgtatgcgattgctccgcaacatgatggtgtatttccagttcacga gcaattatttagagcgtggagaaaagtttggaatgtttctgtaactgcaa ctgaagaatatccacacttcaaaccagcaacagctcgaaaaggttttatt catgctggaatacatgttttaccccggcaaacatgtggattgtacactca tactcaactgtttgatgaatatccagaaggatttgataaagttcaaaaaa gtattgaaggaggagatcttttctttacgattctattaaatccgatttcg atcttcatgacccatcaacaaaattatgcttatgatcgtctggctctgta tacttttgaaaatctatttcgattcataaagtgctggacgaatattaaac ttaaatggcaagatcctctgacgtcatctcagctgtactttcaaaagttt cctgatgaaagaactcctctgtggacgaatccttgcaccgatccacgtca tcatgcgattcttcctccatctatcaactgcactaagaaatcattgcctg atttgttgattattggacctcagaaaactggttctaccgcgttggcaagt tttctatctcttcatccaaatacttcacaaaatacgccagtccctggtag ttttgaagaagttcaatttttcggtggtcaaaattatttgaaaggcgttg aatggtatatgtcaaactttcccagctcgtctacagtaacctttgaaaaa agtgcaacatatttcgataatccatcggcgccgaaacaagccgcttccct tgttccacatgcaaaaatagtgataattcttcaaaatcctgcacaaagag cttattcgtggtttcagcacatccttgcccacgaagatccagtagccatt actgctggttcattggaagttattcttgattcaaattccacttcatcgaa aaaagtacgacagaggtgtatatctggtggacgatatgttcatcatctga caaagtggctcgaacatttctctttacaacaaatgatttttgtagactct gatgagttgaagatgaagccaccaacggtactcaactctttatcaaaatg gcttgatctaccggaatttccatttgaaacctacatacgctatagtcctt caaaaggatttcattgccgtttgttggatggaaaaaccaaatgtttggga gaaagtaaaggtcgaaagtatccggaaatgcctgaaaatctccgtcgcaa actggataaaatcttctcgctagacaactcggcactttataaatttttac gaaaaaacagactgaaaattcccacgtggcttgaggaatcggttagaatt cgtgcataa
|
Protein
MIITPYLNRKITRPLKWILALIFLYLIYICLFSNNSKPPKPRKKPKLVENYTCPFARTEG TASENLFFHTNNGTDARILVILDSLFSRHGKTIIQILNSQKLQFKAEAVSKNLPVLTTSR RGRYSLIIIENYYKYLNMAQWNRQLLDKYCKEYRVPMFSFMSSKPNDQLKRIKIKGSSLW MWQNQRIQRLAVTPSIIHRISKIGNYRQFSSSDPADWILFETSEKFESVLSGTVKSGYER AVVVRDKGLEDGVERIIFGRNLTDFQVKITFLDALWWAMGNQKSFTLDRFVQVDIDDVFV GAQGTRIVEEDVRKLISTQKEFRNYVQNFTFMLGFSGSYFRNGDDLEDRGDEFLVENAEK FVWFPHMWRHNHAHEHNFTYLEAIMAQNKLFAQNMHLPVDYPYAIAPQHDGVFPVHEQLF RAWRKVWNVSVTATEEYPHFKPATARKGFIHAGIHVLPRQTCGLYTHTQLFDEYPEGFDK VQKSIEGGDLFFTILLNPISIFMTHQQNYAYDRLALYTFENLFRFIKCWTNIKLKWQDPL TSSQLYFQKFPDERTPLWTNPCTDPRHHAILPPSINCTKKSLPDLLIIGPQKTGSTALAS FLSLHPNTSQNTPVPGSFEEVQFFGGQNYLKGVEWYMSNFPSSSTVTFEKSATYFDNPSA PKQAASLVPHAKIVIILQNPAQRAYSWFQHILAHEDPVAITAGSLEVILDSNSTSSKKVR QRCISGGRYVHHLTKWLEHFSLQQMIFVDSDELKMKPPTVLNSLSKWLDLPEFPFETYIR YSPSKGFHCRLLDGKTKCLGESKGRKYPEMPENLRRKLDKIFSLDNSALYKFLRKNRLKI PTWLEESVRIRA
|
References |
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K
Cell
(2011)
145
(3)
:470-82
[PMID : 21529718]
A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.
Berninsone PM, Hirschberg CB
Glycoconj. J.
19
(4-5)
:325-30
[PMID : 12975612]
The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans.
|
Functional Descriptions |
hst-1
hst-1 encodes the C. elegans ortholog of N-deacetylase/N-sulfotransferase (NDST), a bifunctional enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate; loss of hst-1 activity has been reported to result in embryonic lethality at various stages of development, defects in ventral neuroblast migrations during epidermal enclosure, and cessation of egg production in injected hermaphrodites.
|
Deletion Mutants |
tm626
ok1068
|
In Situ |
In Situ
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Embryo_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00031532 : Larva_Pan_Neuronal_Enriched
|
WBPaper00031532
|
WormAtlas
|
WB |
WBbt:0004740
|
I5 neuron |
"Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005278
|
DA neuron |
"Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005278
|
DA neuron |
"Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] |
Enriched |
WBPaper00030839 : Embryo_A_Class
|
WBPaper00030839
|
|
WB |
WBbt:0005396
|
SAB |
"Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
|
WB |
WBbt:0005656
|
retrovesicular ganglion |
"ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] |
Enriched |
WBPaper00025141 : unc-4
|
WBPaper00025141
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00040985 : AIN-2_L4_intestine
|
WBPaper00040985
|
WormAtlas
|
WB |
WBbt:0005784
|
germ line |
"cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] |
Enriched |
WBPaper00044760 : germline_specific
|
WBPaper00044760
|
|
|
WBGene00002028
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
germ cell compartment morphology variant
|
"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
|
|
germ cell partition morphology variant
|
"Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. " [WB:WBPaper00038381, WB:WBPerson557]
|
|
germline nuclear positioning variant
|
"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
nuclear fallout
|
"Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557]
|
|
oocyte accumulation
|
"An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. " [WB:WBPaper00006281, WB:WBPaper00030855]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
rachis wide
|
"The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals." [WB:WBPaper00038381, WB:WBPerson557]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|