JCEG ID |
Family |
Name |
Locus Tag |
Human Ortholog Name |
OMIM |
GWAS Catalog |
|
JCEG005
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
H43I07.3 |
ALG5
|
604565
|
|
|
JCEG013
*
=
|
Asparagine-linked glycosylation (ALG) genes |
|
ZC513.5 |
ALG12
|
607143
607144
|
|
|
JCEG014
*
=
|
Asparagine-linked glycosylation (ALG) genes |
algn-13 |
R10D12.12 |
ALG13
|
|
|
|
JCEG024
*
=
|
Core 1 GalT |
bus-4 |
T22B11.2 |
C1GALT1
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
JCEG018
*
=
|
Core 1 GalT |
|
C38H2.2 |
C1GALT1
|
300611
300622
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
|
0.0000002
(PCB105)
|
|
1.32
(unit decrease)
|
[0.83-1.81] |
25839716
|
|
Ng E 2015-04-02 Environ Res
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
|
MAPPED |
0.46 |
0.000004
|
|
|
[NR] |
19010793
|
|
Baranzini SE 2008-11-14 Hum Mol Genet
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
|
MAPPED |
0.444 |
0.000001
|
|
0.099
(unit decrease)
|
[0.06-0.138] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
MAPPED |
0.444 |
0.0000006
|
|
0.101
(unit increase)
|
[0.062-0.14] |
24159190
|
|
Seppala I 2013-10-24 Eur Heart J
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
|
|
|
JCEG033
*
|
Fucosyltransferases |
fut-2 |
EGAP9.2 |
FUT2
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
JCEG037
*
|
Fucosyltransferases |
|
Y71H2AM.14 |
FUT2
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
JCEG038
*
|
Fucosyltransferases |
|
C06E1.7 |
FUT2
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000002
(Conditioned on rs2303759)
|
1.08
|
|
[1.07-1.09] |
21833088
|
|
Sawcer S 2011-08-11 Nature
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
MAPPED |
|
0.00000004
|
1.183432
|
|
[1.15-1.22] |
25574825
|
|
Baurecht H 2015-01-08 Am J Hum Genet
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
|
MAPPED |
|
0.000000000000000000000000000000000004
|
|
70.21
(pg/ml increase)
|
[59.37-81.05] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
MAPPED |
|
0.00000000000000000000000000000000000000000000000000000001
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
0.53 |
0.0000000000001
(DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.045
(unit increase)
|
[0.033-0.057] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.53 |
0.00000000000000000003
(vitamin B12)
|
|
49.77
(pg/ml increase)
|
[37.09-62.45] |
19303062
|
|
Tanaka T 2009-03-18 Am J Hum Genet
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
UPSTREAM |
0.52 |
0.00000005
(Single Height-males)
|
|
0.07
(unit increase)
|
[0.043-0.097] |
23449627
|
|
Cousminer DL 2013-02-27 Hum Mol Genet
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
|
MAPPED |
0.49 |
0.0000000002
|
|
1.27
(mg/dL increase)
|
[0.86-1.68] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
MAPPED |
0.49 |
0.00000000000000005
|
|
0.09
(pg/ml decrease)
|
[0.07-0.11] |
18776911
|
|
Hazra A 2008-09-07 Nat Genet
Common variants of FUT2 are associated with plasma vitamin B12 levels.
|
UPSTREAM |
0.487 |
0.000000000007
|
1.07
|
|
[1.04-1.11] |
21102463
|
|
Franke A 2010-11-21 Nat Genet
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
MAPPED |
0.483 |
0.000000000000001
|
1.107
|
|
[1.071-1.143] |
23128233
|
|
Jostins L 2012-11-01 Nature
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
MAPPED |
0.482 |
0.0000002
(Vitamin B12)
|
|
0.143
(unit increase)
|
[NR] |
25147783
|
|
Keene KL 2014-08-06 Front Public Health
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
|
MAPPED |
0.47 |
0.0000000008
|
|
2.3
(% increase)
|
[1.80-2.90] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
MAPPED |
0.47 |
0.0000000000000001
|
|
0.031
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
MAPPED |
0.464 |
0.00000000000000000004
(SM-11 + 2 other traits)
|
|
0.129
(unit increase)
|
[NR] |
21886157
|
|
Suhre K 2011-08-31 Nature
Human metabolic individuality in biomedical and pharmaceutical research.
|
MAPPED |
0.46 |
(CA19-9)
|
|
0.444
(U/ml increase)
|
[0.41-0.48] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.46 |
(CEA)
|
|
0.238
(ng/ml increase)
|
[0.21-0.26] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.44 |
0.000000000000002
(Plasma Vitamin B12)
|
|
0.07
(unit decrease)
|
[0.050-0.090] |
19744961
|
|
Hazra A 2009-09-10 Hum Mol Genet
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
|
MAPPED |
0.431 |
0.00000002
|
|
|
|
20570966
|
|
McGovern DP 2010-06-22 Hum Mol Genet
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|
MAPPED |
0.43 |
0.000000006
|
|
0.04
(unit increase)
|
[0.026-0.054] |
25028398
|
|
Weiss FU 2014-07-15 Gut
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
|
MAPPED |
0.43 |
0.00000000003
(ADpSGEGDFXAEGGGVR)
|
|
0.041
(unit increase)
|
[0.029-0.053] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.43 |
0.000000000000001
|
|
1.8
(% increase)
|
[0.80-2.80] |
22001757
|
|
Chambers JC 2011-10-16 Nat Genet
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
MAPPED |
0.43 |
0.00000000000000000002
(ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)
|
|
0.055
(unit decrease)
|
[0.043-0.067] |
24816252
|
|
Shin SY 2014-05-11 Nat Genet
An atlas of genetic influences on human blood metabolites.
|
MAPPED |
0.272 |
0.000002
(Vitamin B12 )
|
|
0.03
(pmol/L increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
|
|
JCEG030
*
|
Fucosyltransferases |
|
EGAP9.3 |
FUT1
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.0000000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
|
|
JCEG052
*
=
|
Fucosyltransferases |
fut-6 |
T05A7.5 |
FUT6 FUT7
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.0000000000004
|
|
49.78
(pg/ml increase)
|
[36.41-63.15] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
MAPPED |
|
0.0000000000000000008
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
0.38 |
(CA19-9)
|
|
0.282
(U/ml increase)
|
[0.20-0.37] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.33 |
0.00000000000000000000000000000000001
(CEA)
|
|
0.073
(ng/ml increase)
|
[0.048-0.098] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.33 |
(CA19-9)
|
|
0.481
(U/ml decrease)
|
[0.44-0.52] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.2 |
0.00000000000000000000000000000000000000000000000000000002
(CA19-9)
|
|
0.169
(U/ml decrease)
|
[0.11-0.22] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.11 |
0.0000000009
(DG12)
|
|
0.3
(unit decrease)
|
[0.20-0.40] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.000000000003
(DG7)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.000000000001
(FUC-A)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.00000000000000004
(DG9)
|
|
0.41
(unit decrease)
|
[0.31-0.51] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
|
|
JCEG046
*
=
|
Fucosyltransferases |
pad-2 |
K10G9.3 |
POFUT2
|
610249
|
|
|
JCEG050
*
=
|
Fucosyltransferases |
fut-1 |
K08F8.3 |
FUT5 FUT3 FUT4 FUT6
|
104230
111100
111100
136835
136836
602030
606865
613852
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
|
0.000004
(EA)
|
|
|
|
22566498
|
|
Turner ST 2012-05-07 Hypertension
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
DOWNSTREAM |
|
0.0000009
(EA)
|
|
1.4
(unit increase)
|
[0.79-2.01] |
22566498
|
|
Turner ST 2012-05-07 Hypertension
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
MAPPED |
|
0.00000003
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
|
0.0000000000004
|
|
49.78
(pg/ml increase)
|
[36.41-63.15] |
22367966
|
|
Lin X 2012-02-24 Hum Mol Genet
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
|
MAPPED |
|
0.0000000000000000008
|
|
|
|
24941225
|
|
Liang Y 2014-06-18 PLoS One
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
|
MAPPED |
0.38 |
(CA19-9)
|
|
0.282
(U/ml increase)
|
[0.20-0.37] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.33 |
0.00000000000000000000000000000000001
(CEA)
|
|
0.073
(ng/ml increase)
|
[0.048-0.098] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.33 |
(CA19-9)
|
|
0.481
(U/ml decrease)
|
[0.44-0.52] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.2 |
0.00000000000000000000000000000000000000000000000000000002
(CA19-9)
|
|
0.169
(U/ml decrease)
|
[0.11-0.22] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
MAPPED |
0.11 |
0.0000000009
(DG12)
|
|
0.3
(unit decrease)
|
[0.20-0.40] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.000000000003
(DG7)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.000000000001
(FUC-A)
|
|
0.34
(unit decrease)
|
[0.24-0.44] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
MAPPED |
0.11 |
0.00000000000000004
(DG9)
|
|
0.41
(unit decrease)
|
[0.31-0.51] |
21203500
|
|
Lauc G 2010-12-23 PLoS Genet
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
|
|
|
JCEG058
*
=
|
Fukutin |
|
W02B3.4 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
JCEG054
*
=
|
Fukutin |
|
T07D3.4 |
FCMD
|
253800
607440
611588
611615
613152
|
|
|
JCEG077
*
=
|
GPI-anchor synthesis |
pigv-1 |
T09B4.1 |
PIGV
|
239300
610274
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
0.09 |
0.000000001
|
|
0.037
(mg/dL increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
UPSTREAM |
0.09 |
0.000000000003
|
|
0.05
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
UPSTREAM |
0.09 |
0.000000000000001
|
|
0.051
(unit decrease)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
|
|
JCEG066
*
=
|
GPI-anchor synthesis |
|
T20D3.8 |
PIGC
|
601730
|
|
|
JCEG072
*
=
|
GPI-anchor synthesis |
|
Y48E1B.2 |
PIGP
|
614919
|
|
|
JCEG079
*
|
GPI-anchor synthesis |
|
F49E7.2 |
PIGX
|
|
|
|
JCEG059
*
=
|
GPI-anchor synthesis |
hpo-3 |
F33D11.9 |
GPAA1
|
603048
|
|
|
JCEG062
*
=
|
GPI-anchor synthesis |
|
T19B10.8 |
PGAP1
|
611655
|
|
|
JCEG063
*
=
|
GPI-anchor synthesis |
tag-189 |
T04A8.12 |
PGAP2
|
614207
615187
|
|
|
JCEG080
*
=
|
GPI-anchor synthesis |
dpm-3 |
F28D1.11 |
DPM3
|
|
|
|
JCEG060
*
=
|
GPI-anchor synthesis |
|
F38E1.9 |
MPDU1
|
604041
609180
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.29 |
0.00000001
(Testosterone)
|
|
0.28
(unit decrease)
|
[0.18-0.38] |
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
MAPPED |
0.29 |
0.0000000000000000005
(SHBG)
|
|
0.09
(unit decrease)
|
[0.070-0.110] |
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
MAPPED |
0.21 |
0.0000000004
|
1.23
|
|
[1.16-1.32] |
22197929
|
|
Yu XQ 2011-12-25 Nat Genet
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
|
|
|
JCEG073
*
=
|
GPI-anchor synthesis |
|
F01G4.5 |
PIGQ
|
605754
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
0.42 |
0.000009
|
|
0.1
(unit increase)
|
[0.059-0.141] |
22993228
|
|
Williams FM 2012-09-19 Ann Rheum Dis
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
|
MAPPED |
0.42 |
0.000004
|
|
0.11
(unit increase)
|
[0.065-0.155] |
22993228
|
|
Williams FM 2012-09-19 Ann Rheum Dis
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
|
|
|
JCEG083
*
=
|
GlcNAcT(GnT) |
gly-12 |
F48E3.1 |
MGAT1
|
160995
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
JCEG081
*
=
|
GlcNAcT(GnT) |
gly-14 |
M01F1.1 |
MGAT1
|
160995
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
JCEG082
*
=
|
GlcNAcT(GnT) |
gly-13 |
B0416.6 |
MGAT1
|
160995
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
0.85 |
0.000006
(females)
|
|
0.16
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
DOWNSTREAM |
0.85 |
0.00000007
(females)
|
|
2.96
(kg decrease)
|
[NR] |
19851299
|
|
Johansson A 2009-10-22 Obesity (Silver Spring)
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
|
MAPPED |
0.47 |
0.000005
(HDL-C)
|
|
0.23
(mg/dL increase)
|
[NR] |
19197348
|
|
Lowe JK 2009-02-06 PLoS Genet
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
DOWNSTREAM |
0.14 |
0.000008
(EA-glucose response)
|
|
3.67
(mg/dL increase)
|
[2.06-5.28] |
23400010
|
|
Del-Aguila JL 2013-02-12 Pharmacogenomics J
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
|
|
|
JCEG090
*
=
|
GlcT |
cgt-3 |
F59G1.1 |
UGCG
|
602874
|
|
|
JCEG088
*
=
|
GlcT |
cgt-1 |
T06C12.10 |
UGCG
|
602874
|
|
|
JCEG089
*
=
|
GlcT |
cgt-2 |
F20B4.6 |
UGCG
|
602874
|
|
|
JCEG096
*
=
|
Glucuronyltransferase(GlcAT) |
glct-6 |
W07G9.2 |
B3GAT1
|
151290
245600
606374
607497
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
|
|
JCEG105
|
Glyco_transf_92 |
|
C31B8.7 |
|
|
|
|
JCEG109
|
Glyco_transf_92 |
|
C01G5.9 |
|
|
|
|
JCEG111
|
Glyco_transf_92 |
|
T06A1.5 |
|
|
|
|
JCEG112
|
Glyco_transf_92 |
|
C08B6.3 |
|
|
|
|
JCEG115
|
Glyco_transf_92 |
galt-1 |
M03F8.4 |
|
|
|
|
JCEG099
|
Glyco_transf_92 |
|
C14C6.8 |
|
|
|
|
JCEG132
*
=
|
HS C5 epimerase |
hse-5 |
B0285.5 |
GLCE
|
612134
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
0.26 |
0.000002
(percent change)
|
|
1.7
(percent increase)
|
[0.92-2.48] |
23118302
|
|
Chu AY 2012-11-01 Circ Cardiovasc Genet
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
|
|
|
JCEG135
*
=
|
O-GlcNAcT |
ogt-1 |
K04G7.3 |
OGT
|
300255
|
|
|
JCEG134
*
=
|
O-GlcNAcT |
|
H12D21.10 |
EOGT
|
614789
615297
|
|
|
JCEG141
*
=
|
Oligosaccharyltransferase complex |
ostd-1 |
M01A10.3 |
RPN2
|
180490
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.000006
|
|
|
|
19668339
|
|
Potkin SG 2009-08-07 PLoS One
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
|
|
|
JCEG138
*
=
|
Oligosaccharyltransferase complex |
|
ZK686.3 |
MAGT1 TUSC3
|
300715
300853
601385
611093
|
|
|
JCEG137
*
=
|
Oligosaccharyltransferase complex |
dad-1 |
F57B10.10 |
DAD1
|
600243
|
|
|
JCEG151
*
=
|
PAPS synthase and PAPS transporters |
pps-1 |
T14G10.1 |
PAPSS1 PAPSS2
|
603005
603262
612847
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.000004
|
1.32
|
|
[1.17-1.49] |
19727025
|
|
De Moor MH 2009-09-02 Med Sci Sports Exerc
Genome-wide association study of exercise behavior in Dutch and American adults.
|
DOWNSTREAM |
|
0.000002
(EA)
|
0.02742
|
|
(0.01614-0.03871) (mg/dl increase)] |
25886283
|
|
Chang X 2015-04-17 PLoS One
Genome-wide association study of serum minerals levels in children of different ethnic background.
|
DOWNSTREAM |
|
0.0000004
|
|
0.0243
(mg/dl increase)
|
[NR] |
25886283
|
|
Chang X 2015-04-17 PLoS One
Genome-wide association study of serum minerals levels in children of different ethnic background.
|
DOWNSTREAM |
0.029 |
0.00000005
|
|
|
[NR] |
24478790
|
|
Lee JH 2014-01-17 Front Genet
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
|
|
|
JCEG149
*
=
|
PAPS synthase and PAPS transporters |
pst-1 |
M03F8.2 |
SLC35B2
|
610788
|
|
|
JCEG150
*
=
|
PAPS synthase and PAPS transporters |
pst-2 |
F54E7.1 |
SLC35B3
|
610845
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
DOWNSTREAM |
|
0.000008
|
|
|
|
24324551
|
|
Deng X 2013-11-20 PLoS One
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
|
DOWNSTREAM |
0.49 |
0.000003
(AA)
|
|
0.17
(unit decrease)
|
[0.092-0.248] |
23870195
|
|
Wojczynski MK 2013-07-19 BMC Med Genet
Genetics of coronary artery calcification among African Americans, a meta-analysis.
|
DOWNSTREAM |
0.48 |
0.000000000000000003
|
|
0.046
(unit increase)
|
[0.035-0.056] |
25628336
|
|
Hromatka BS 2015-01-26 Hum Mol Genet
Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.
|
|
|
JCEG152
*
=
|
POFUT |
|
C15C7.7 |
POFUT1
|
607491
615327
|
|
|
JCEG155
*
=
|
POMT |
|
R12E2.13 |
POMT2
|
602934
607551
|
|
|
JCEG161
*
=
|
Sulfotransferase and sulfation-related genes |
hst-1 |
F08B4.6 |
NDST1
|
600853
603268
603950
615039
|
|
|
JCEG162
*
|
UDP-glucuronosyltransferases |
ugt-46 |
B0310.5 |
CGT
|
|
|
|
JCEG165
*
=
|
UGCGL1 |
uggt-1 |
F48E3.3 |
UGGT1 UGGT2
|
605897
605898
|
|
|
JCEG180
*
=
|
b3GalT1/b3GnT orthologs |
sqv-2 |
Y110A2AL.14 |
B3GALT6
|
271640
615291
615349
|
|
|
JCEG175
*
=
|
b3GalT1/b3GnT orthologs |
|
B0024.15 |
B3GALT1 B3GNT2 B3GNT5
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.103 |
0.000002
(Amylin )
|
|
0.03
(pM increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
MAPPED |
0.083 |
0.000008
(Diet fat )
|
|
0.04
(%energy increase)
|
[NR] |
23251661
|
|
Comuzzie AG 2012-12-04 PLoS One
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
DOWNSTREAM |
0.04 |
0.000000002
(KvDMR 21)
|
|
|
|
23725790
|
|
Renteria ME 2013-06-03 Twin Res Hum Genet
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
|
|
|
JCEG177
*
=
|
b3GalT1/b3GnT orthologs |
|
F14B6.6 |
B3GALNT1
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.43 |
0.000002
(AA)
|
|
4.21
(unit decrease)
|
[2.49-5.93] |
23599027
|
|
Demerath EW 2013-04-17 Hum Mol Genet
Genome-wide association study of age at menarche in African-American women.
|
|
|
JCEG182
*
|
b3GalT1/b3GnT orthologs |
bus-2 |
K08D12.5 |
B3GNT5 G26
|
|
|
|
JCEG178
*
=
|
b3GalT1/b3GnT orthologs |
bre-5 |
T12G3.8 |
B3GALNT1 B3GALT4 B3GALT5 B3GNT3 B3GNT4 B3GNT6 B3GNT7
|
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.000006
|
1.178
|
|
|
21041247
|
|
Perlis RH 2010-11-01 Am J Psychiatry
Genome-wide association study of suicide attempts in mood disorder patients.
|
UPSTREAM |
|
0.00000006
|
|
0.031
(unit increase)
|
[0.019-0.043] |
25387707
|
|
Vaidyanathan U 2014-12-01 Psychophysiology
Heritability and molecular genetic basis of antisaccade eye tracking error rate: A genome-wide association study.
|
UPSTREAM |
0.733 |
0.0000000001
|
|
0.3
(unit increase)
|
[0.20-0.40] |
23583979
|
|
den Hoed M 2013-04-14 Nat Genet
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
UPSTREAM |
0.543 |
0.0000007
|
|
0.108
(unit increase)
|
[0.065-0.151] |
23568457
|
|
Wade TD 2013-04-09 Int J Eat Disord
Genetic variants associated with disordered eating.
|
MAPPED |
0.43 |
0.000002
(AA)
|
|
4.21
(unit decrease)
|
[2.49-5.93] |
23599027
|
|
Demerath EW 2013-04-17 Hum Mol Genet
Genome-wide association study of age at menarche in African-American women.
|
DOWNSTREAM |
0.26 |
0.0000000000001
(CA19-9)
|
|
0.072
(U/ml decrease)
|
[0.029-0.115] |
23300138
|
|
He M 2013-01-07 Gut
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
|
|
|
JCEG186
*
=
|
b4GalT |
|
W02B12.1 |
B4GALT5
|
610179
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000004
|
0.298
|
|
(unit decrease)] |
23362303
|
|
Wu JH 2013-01-29 Circ Cardiovasc Genet
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
|
MAPPED |
0.11 |
0.000006
|
|
0.108
(kg/m2 increase)
|
[0.061-0.155] |
25811787
|
|
Huffman JE 2015-03-26 PLoS One
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans.
|
|
|
JCEG194
*
=
|
b6GnT |
gly-19 |
F22D6.12 |
GCNT3
|
|
|
|
JCEG193
*
=
|
b6GnT |
gly-18 |
F22D6.11 |
GCNT3
|
|
|
|
JCEG199
*
=
|
b6GnT |
|
Y51H4A.25 |
GCNT3
|
|
|
|
JCEG201
*
=
|
b6GnT |
|
R07B7.6 |
GCNT3
|
|
|
|
JCEG205
*
=
|
b6GnT |
|
H41C03.3 |
GCNT2
|
|
|
|
JCEG217
*
=
|
ppGalNAcT |
gly-3 |
ZK688.8 |
GALNT1
|
602273
608369
|
|
|
JCEG223
*
=
|
ppGalNAcT |
gly-8 |
Y66A7A.6 |
GALNT11
|
615130
615133
|
|
|
JCEG224
*
=
|
ppGalNAcT |
gly-11 |
Y75B8A.9 |
GALNT11
|
615130
615133
|
|
|
JCEG221
*
=
|
ppGalNAcT |
gly-7 |
Y46H3A.6 |
GALNT7
|
605005
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.3308 |
0.000005
(Primary)
|
|
0.2278
(unit decrease)
|
[0.11-0.35] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
MAPPED |
0.0458 |
0.000000006
(Case/control)
|
|
1.1474
(unit decrease)
|
[0.76-1.53] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
|
|
JCEG220
*
=
|
ppGalNAcT |
gly-4 |
Y116F11B.12 |
GALNT2
|
602274
|
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.6 |
0.000000004
|
|
0.02
(unit increase)
|
[0.01-0.03] |
20864672
|
|
Waterworth DM 2010-09-23 Arterioscler Thromb Vasc Biol
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
|
MAPPED |
0.6 |
0.00000000000003
|
|
1.11
(mg/dl higher)
|
[NR] |
18193043
|
|
Willer CJ 2008-01-13 Nat Genet
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
MAPPED |
0.44 |
0.000000001
|
|
|
|
22916037
|
|
Inouye M 2012-08-16 PLoS Genet
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
|
MAPPED |
0.41 |
0.0000000000000000000000000000007000000000000001
|
|
0.04
(mg/dL increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
MAPPED |
0.41 |
0.00000000000000000000000000000000000000004
|
|
0.048
(unit decrease)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
MAPPED |
0.4 |
0.0000008
|
|
4.25
(mg/dl higher)
|
[NR] |
18193043
|
|
Willer CJ 2008-01-13 Nat Genet
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
MAPPED |
0.4 |
0.00000004
|
|
0.05
(s.d. decrease)
|
[0.01-0.09] |
19060906
|
|
Kathiresan S 2008-12-07 Nat Genet
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
MAPPED |
0.4 |
0.0000000000002
|
|
0.07
(% SD lower)
|
[0.05-0.09] |
18193044
|
|
Kathiresan S 2008-01-13 Nat Genet
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
MAPPED |
0.4 |
0.000000000000007
|
|
0.08
(% SD higher)
|
[0.06-0.10] |
18193044
|
|
Kathiresan S 2008-01-13 Nat Genet
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
|
MAPPED |
0.4 |
0.000000000000000000004
|
|
0.61
(mg/dL decrease)
|
[0.47-0.75] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
MAPPED |
0.39 |
0.000003
|
|
0.05
(unit decrease)
|
[0.030-0.070] |
23620142
|
|
Reiner AP 2013-04-24 Hum Mol Genet
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
|
MAPPED |
0.39 |
0.00000004
(HDL)
|
|
0.08
(mmol/l decrease)
|
[NR] |
22399527
|
|
Kristiansson K 2012-03-07 Circ Cardiovasc Genet
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
MAPPED |
0.39 |
0.00000000000002
|
|
2.76
(mg/dL increase)
|
[2.02-3.5] |
20686565
|
|
Teslovich TM 2010-08-05 Nature
Biological, clinical and population relevance of 95 loci for blood lipids.
|
MAPPED |
0.224 |
0.000008
(ALB/GLB)
|
|
0.016
(unit increase)
|
[0.0082-0.0238] |
23303382
|
|
Hong KW 2013-01-10 J Hum Genet
Genome-wide association study of serum albumin:globulin ratio in Korean populations.
|
MAPPED |
0.1984 |
0.000004
(Complete)
|
|
0.4595
(unit decrease)
|
[0.26-0.66] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
MAPPED |
0.1959 |
0.000002
(Primary)
|
|
0.3966
(unit decrease)
|
[0.23-0.56] |
25188341
|
|
Beecham GW 2014-09-04 PLoS Genet
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias.
|
|
|