CGGDB

> expression > hypodermis

Definition: "epidermal layer" [WB:pws]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG024 ^* ⁼

Core 1 GalT

bus-4

T22B11.2

C1GALT1

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM		0.0000002 (PCB105)	1.32 (unit decrease)	[0.83-1.81]	25839716
	Ng E 2015-04-02 Environ Res Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.
MAPPED	0.46	0.000004		[NR]	19010793
	Baranzini SE 2008-11-14 Hum Mol Genet Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
MAPPED	0.444	0.000001	0.099 (unit decrease)	[0.06-0.138]	24159190
	Seppala I 2013-10-24 Eur Heart J Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
MAPPED	0.444	0.0000006	0.101 (unit increase)	[0.062-0.14]	24159190
	Seppala I 2013-10-24 Eur Heart J Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

JCEG045 ^*

Fucosyltransferases

F11A5.5

FUT2

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000002 (Conditioned on rs2303759)	1.08		[1.07-1.09]	21833088
	Sawcer S 2011-08-11 Nature Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
MAPPED		0.00000004	1.183432		[1.15-1.22]	25574825
	Baurecht H 2015-01-08 Am J Hum Genet Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
MAPPED		0.000000000000000000000000000000000004		70.21 (pg/ml increase)	[59.37-81.05]	22367966
	Lin X 2012-02-24 Hum Mol Genet Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
MAPPED		0.00000000000000000000000000000000000000000000000000000001				24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED	0.53	0.0000000000001 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)		0.045 (unit increase)	[0.033-0.057]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.53	0.00000000000000000003 (vitamin B12)		49.77 (pg/ml increase)	[37.09-62.45]	19303062
	Tanaka T 2009-03-18 Am J Hum Genet Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
UPSTREAM	0.52	0.00000005 (Single Height-males)		0.07 (unit increase)	[0.043-0.097]	23449627
	Cousminer DL 2013-02-27 Hum Mol Genet Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
MAPPED	0.49	0.0000000002		1.27 (mg/dL increase)	[0.86-1.68]	20686565
	Teslovich TM 2010-08-05 Nature Biological, clinical and population relevance of 95 loci for blood lipids.
MAPPED	0.49	0.00000000000000005		0.09 (pg/ml decrease)	[0.07-0.11]	18776911
	Hazra A 2008-09-07 Nat Genet Common variants of FUT2 are associated with plasma vitamin B12 levels.
UPSTREAM	0.487	0.000000000007	1.07		[1.04-1.11]	21102463
	Franke A 2010-11-21 Nat Genet Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
MAPPED	0.483	0.000000000000001	1.107		[1.071-1.143]	23128233
	Jostins L 2012-11-01 Nature Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
MAPPED	0.482	0.0000002 (Vitamin B12)		0.143 (unit increase)	[NR]	25147783
	Keene KL 2014-08-06 Front Public Health Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
MAPPED	0.47	0.0000000008		2.3 (% increase)	[1.80-2.90]	22001757
	Chambers JC 2011-10-16 Nat Genet Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
MAPPED	0.47	0.0000000000000001		0.031 (unit increase)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
MAPPED	0.464	0.00000000000000000004 (SM-11 + 2 other traits)		0.129 (unit increase)	[NR]	21886157
	Suhre K 2011-08-31 Nature Human metabolic individuality in biomedical and pharmaceutical research.
MAPPED	0.46	(CA19-9)		0.444 (U/ml increase)	[0.41-0.48]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.46	(CEA)		0.238 (ng/ml increase)	[0.21-0.26]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.44	0.000000000000002 (Plasma Vitamin B12)		0.07 (unit decrease)	[0.050-0.090]	19744961
	Hazra A 2009-09-10 Hum Mol Genet Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
MAPPED	0.431	0.00000002				20570966
	McGovern DP 2010-06-22 Hum Mol Genet Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
MAPPED	0.43	0.000000006		0.04 (unit increase)	[0.026-0.054]	25028398
	Weiss FU 2014-07-15 Gut Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
MAPPED	0.43	0.00000000003 (ADpSGEGDFXAEGGGVR)		0.041 (unit increase)	[0.029-0.053]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.43	0.000000000000001		1.8 (% increase)	[0.80-2.80]	22001757
	Chambers JC 2011-10-16 Nat Genet Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
MAPPED	0.43	0.00000000000000000002 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)		0.055 (unit decrease)	[0.043-0.067]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.272	0.000002 (Vitamin B12 )		0.03 (pmol/L increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

JCEG046 ^* ⁼

Fucosyltransferases

pad-2

K10G9.3

POFUT2

610249

JCEG055 ^* ⁼

Fukutin

T07A5.1

FCMD

253800
607440
611588
611615
613152

JCEG077 ^* ⁼

GPI-anchor synthesis

pigv-1

T09B4.1

PIGV

239300
610274

STREAM	RAF	p-value	BETA	CI	Study
UPSTREAM	0.09	0.000000001	0.037 (mg/dL increase)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
UPSTREAM	0.09	0.000000000003	0.05 (unit increase)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
UPSTREAM	0.09	0.000000000000001	0.051 (unit decrease)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.

JCEG083 ^* ⁼

GlcNAcT(GnT)

gly-12

F48E3.1

MGAT1

160995

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM	0.85	0.000006 (females)	0.16 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
DOWNSTREAM	0.85	0.00000007 (females)	2.96 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
MAPPED	0.47	0.000005 (HDL-C)	0.23 (mg/dL increase)	[NR]	19197348
	Lowe JK 2009-02-06 PLoS Genet Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
DOWNSTREAM	0.14	0.000008 (EA-glucose response)	3.67 (mg/dL increase)	[2.06-5.28]	23400010
	Del-Aguila JL 2013-02-12 Pharmacogenomics J Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.

JCEG082 ^* ⁼

GlcNAcT(GnT)

gly-13

B0416.6

MGAT1

160995

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM	0.85	0.000006 (females)	0.16 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
DOWNSTREAM	0.85	0.00000007 (females)	2.96 (kg decrease)	[NR]	19851299
	Johansson A 2009-10-22 Obesity (Silver Spring) Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
MAPPED	0.47	0.000005 (HDL-C)	0.23 (mg/dL increase)	[NR]	19197348
	Lowe JK 2009-02-06 PLoS Genet Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
DOWNSTREAM	0.14	0.000008 (EA-glucose response)	3.67 (mg/dL increase)	[2.06-5.28]	23400010
	Del-Aguila JL 2013-02-12 Pharmacogenomics J Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.

JCEG090 ^* ⁼

GlcT

cgt-3

F59G1.1

UGCG

602874

JCEG097 ^* ⁼

Glucuronyltransferase(GlcAT)

sqv-8

ZK1307.5

B3GAT3 B3GAT2

151290
245600
606374
607497

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000005	0.2918		(unit increase)]	23319000
	Luykx JJ 2013-01-15 Mol Psychiatry Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
MAPPED	0.219	0.000007 (ALT/AST)		0.03 (unit increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
UPSTREAM	0.16	0.0000009		1.17 (unit decrease)	[0.70-1.64]	21326311
	Bhatnagar P 2011-02-17 J Hum Genet Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

JCEG118

Glyco_transf_92

T06A1.1

JCEG121

Glyco_transf_92

D1014.5

JCEG123

Glyco_transf_92

R08C7.4

JCEG132 ^* ⁼

HS C5 epimerase

hse-5

B0285.5

GLCE

612134

STREAM	RAF	p-value	OR	BETA	CI	Study
DOWNSTREAM	0.26	0.000002 (percent change)		1.7 (percent increase)	[0.92-2.48]	23118302
	Chu AY 2012-11-01 Circ Cardiovasc Genet Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

JCEG134 ^* ⁼

O-GlcNAcT

H12D21.10

EOGT

614789
615297

JCEG137 ^* ⁼

Oligosaccharyltransferase complex

dad-1

F57B10.10

DAD1

600243

JCEG142

Oligosaccharyltransferase complex

T07A5.5

JCEG149 ^* ⁼

PAPS synthase and PAPS transporters

pst-1

M03F8.2

SLC35B2

610788

JCEG150 ^* ⁼

PAPS synthase and PAPS transporters

pst-2

F54E7.1

SLC35B3

610845

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM		0.000008			24324551
	Deng X 2013-11-20 PLoS One Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
DOWNSTREAM	0.49	0.000003 (AA)	0.17 (unit decrease)	[0.092-0.248]	23870195
	Wojczynski MK 2013-07-19 BMC Med Genet Genetics of coronary artery calcification among African Americans, a meta-analysis.
DOWNSTREAM	0.48	0.000000000000000003	0.046 (unit increase)	[0.035-0.056]	25628336
	Hromatka BS 2015-01-26 Hum Mol Genet Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.

JCEG157 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-2

C34F6.4

HS2ST1

604844

JCEG160 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-6

Y34B4A.3

HS6ST1

300545
604846
609401
614880

JCEG159 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-3.2

F52B10.2

HS3ST3A1 HS3ST3B1 HS3ST2 HS3ST4 HS3ST5 HS3ST6

604056
604057
604058
604059

STREAM	RAF	p-value	OR	BETA	CI	Study
MAPPED		0.000002				24324551
	Deng X 2013-11-20 PLoS One Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
MAPPED		0.0000007		0.0437 (unit increase)	[NR]	24086445
	Wang Q 2013-09-24 PLoS One Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.
MAPPED	0.381	0.000004 (Dominant model)	1.647		[1.264-2.146]	23648065
	Low SK 2013-05-04 Cancer Sci Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
UPSTREAM	0.2	0.000001	1.19		[NR]	19525955
	Bahlo 2009-06-14 Nat Genet Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
DOWNSTREAM	0.04	0.000002	0.082		(unit increase)]	22823124
	Verweij KJ 2012-07-24 Addict Biol The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.

JCEG168 ^*

b3GalT1/b3GnT orthologs

F48F7.3

B3GALT1

STREAM	RAF	p-value	BETA	CI	Study
MAPPED	0.103	0.000002 (Amylin )	0.03 (pM increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
MAPPED	0.083	0.000008 (Diet fat )	0.04 (%energy increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
DOWNSTREAM	0.04	0.000000002 (KvDMR 21)			23725790
	Renteria ME 2013-06-03 Twin Res Hum Genet GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.

JCEG176 ^*

b3GalT1/b3GnT orthologs

bus-17

ZK678.8

B3GALT2

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM	0.169	0.0000003	1.09		[1.05-1.13]	24162737
	European Alzheimer's Disease Initiative (EADI) 2013-10-27 Nat Genet Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

JCEG207 ^*

b6GnT

H41C03.1

GCNT2

JCEG206 ^* ⁼

b6GnT

F35H8.2

GCNT2

JCEG210 ^* ⁼

iGnT orthologs

F21H7.10

GCNT2

JCEG209 ^* ⁼

iGnT orthologs

F22F7.6

GCNT2

JCEG216 ^*

ppGalNAcT

gly-6

H38K22.5

GALNT1

JCEG217 ^* ⁼

ppGalNAcT

gly-3

ZK688.8

GALNT1

602273
608369

JCEG223 ^* ⁼

ppGalNAcT

gly-8

Y66A7A.6

GALNT11

615130
615133

JCEG224 ^* ⁼

ppGalNAcT

gly-11

Y75B8A.9

GALNT11

615130
615133

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