JCEG ID | JCEG082 | |||||||||
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Name | gly-13 WormBase NCBI Gene | |||||||||
Human Ortholog |
GGDB:MGAT1 OMIM: 160995 OrthoList : POMGNT1 (Ensembl Compara)
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Family Name | GlcNAcT(GnT) | |||||||||
Locus Tag | B0416.6 | |||||||||
RNAi phenotype |
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Sequence Features |
kr:Detected tm:Detected dxd:EDD gg_motif:M1, M2, M3, M4, M5, M6 |
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Sequence | CDS |
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Protein |
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References |
Chen S, Zhou S, Sarkar M, Spence AM, Schachter H J. Biol. Chem. (1999) 274 (1) :288-97 [PMID : 9867843] Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development. Chen S, Tan J, Reinhold VN, Spence AM, Schachter H Biochim. Biophys. Acta (2002) 1573 (3) :271-9 [PMID : 12417409] UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II in Caenorhabditis elegans. Zhang W, Cao P, Chen S, Spence AM, Zhu S, Staudacher E, Schachter H Biochem. J. (2003) 372 (Pt 1) :53-64 [PMID : 12603202] Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase. Zhu S, Hanneman A, Reinhold VN, Spence AM, Schachter H Biochem. J. (2004) 382 (Pt 3) :995-1001 [PMID : 15228383] Caenorhabditis elegans triple null mutant lacking UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I. Paschinger K, Rendic D, Lochnit G, Jantsch V, Wilson IB J. Biol. Chem. (2004) 279 (48) :49588-98 [PMID : 15364955] Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans. Shi H, Tan J, Schachter H Meth. Enzymol. (2006) 417 :359-89 [PMID : 17132514] N-glycans are involved in the response of Caenorhabditis elegans to bacterial pathogens. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Houston KM, Sutharsan R, Steiger CN, Schachter H, Harnett W Mol. Biochem. Parasitol. (2007) 157 (1) :88-91 [PMID : 17920136] Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis. Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Chen S, Spence AM, Schachter H Biochimie 85 (3-4) :391-401 [PMID : 12770777] Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity. |
Functional Descriptions |
gly-13 gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates; gly-13 is expressed throughout development in many cell types; a deletion allele of gly-13 is partially lethal with survivors displaying severe morphological and behavioral defects. |
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Deletion Mutants | ok712 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In Situ | In Situ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Expression |
Expression
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WBGene00001638 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organism pathogen response variant
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"Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack." [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712] |
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pathogen induced death increased
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"Animals are more prone to lethality as a result of infection compared to control." [WB:WBPerson2021, WB:WBPerson557] |
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