JCEG ID |
JCEG077 |
Name |
pigv-1
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:PIGV
OMIM:
239300
610274
OrthoList :
PIGV
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
0.09 |
0.000000001
|
|
0.037
(mg/dL increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
UPSTREAM |
0.09 |
0.000000000003
|
|
0.05
(unit increase)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
UPSTREAM |
0.09 |
0.000000000000001
|
|
0.051
(unit decrease)
|
[NR] |
24097068
|
|
Willer CJ 2013-10-06 Nat Genet
Discovery and refinement of loci associated with lipid levels.
|
|
Family Name |
GPI-anchor synthesis |
Locus Tag |
T09B4.1
|
RNAi phenotype |
phenotype
|
|
Microscope observation (Image)
|
|
COPAS (Image)
|
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
|
Sequence |
CDS
ATGCGTAGACGTGAGCCTGGGAGAGATGTTAAACGTGCAGCTGAGGAAGAATTTATCGAG TTAGAGAGACGTACGGATACGTACGAAGATGCCGTTCTCAACGAAGATCCACAGATGAAG GGATTCAGGTTTCCAAGCATCTTGTCGTTCCCGGTACCAAACAAGACTATTGAGACTGGT GTTACAGACGAGAATCCATTCTCTGCGAGGAAATCCGCGTTTTTCACAAATCGACTGATT GGAAGAGAGGAGAGCGATTCATCATCTTCCAGAGAAGACTCTCCTCTTGGTTCCACGGAA ACTGGAGAATCTTGTTCCACTACTGACGATGAAGAATCAAAGGAGAAAAGGATAGAGTAC CGTGATTCCCAAACGCAGCGGTGTCTTGGATTCTGTTTTCGACAGTTATTTTTCTCTCGG ATGTGGGTATTCATTCTCCAATTCATAGCCTCCTACTACGCTGGTGATCGGTTTCGGACA GATGGATTCAATTTAGTTGATAAACTGATCGAACCAGGACAATCAGTCTTTGGTGATGTC GTAGTTCGTCGTGGACTAATGGGACTTCGTCGTTGGGATGCTCAACAATTCTTGTTTATT GCTGAGCATCACTACATATTCGAGCATTCTCTTGCTTTCTTTGCTGGATTTCCAGAGACT GTGAACTACGTTCGAGTCGGAGTAAACAACGGAATGGAAAGTGTCTTCGGATGGACTTTC CCACCGTGGGTAACCATAACATTAGCCGCAGTGTTCGTCAATTTGTTCTGCTTTCTGCTT TGTGGAATGACTCTTTATCAAGTTGTACTAATCATGACCAGGAGTGTGAAAATATCTCTT CTGGCTGTTTCTATTTTCGCATTCAATCCAGCATCAATCTTCTTTTCCTCCGCTTACTCG GAATCGATGTTCTTCACAATGACTCTGACTGGTTTCGTCTTTATGCTTTTTGGTCTTCGT GGGAAAGGTTTTTGGCACCGAATGCTTAAAGGCTTCACCGGTACGATCTGTTTTGGGTTG ACCTTCGCTGTTCGATCGAACGGACTTCTCAATTTCCTTTACGTTGCATGGATCTGGTGT GGAACACTTCTTTGGGATGAGGAGATGCCAATTCCAGATTGTCACAAACTCATATCAACA CTTGCCGCTACAAAAAACGAACGTTATAAACAAGAATGGCAGGCAAAATTTTGGAGATTC CAGCAGAAGCGGAAACAAAATCGGAAAGTATTCAGATGGACGGATCCTAACTTTTCTCGC TGTGTTACTTTATTCATTGTAATCGTTTGTGCTATTAGTGCGACACTTCTCTTCTTCACT CCATACGTTTTTATGACGAATTTTACCGCCGACGAATTTTGCAAACCACAAGATTCTCAC AAACAAGCGGTTGAGACTATCGCCAAAACTGTTCGACTCTCTCCGAAGACTGTCAGTGTA AAGAATGCTTGGGAGAAAACGACTTGGTGCAAGAAACCGAAGCTATTTGGAATCATTGCT CGATACTACGGCGAGATTCAGACGAAATATTGGAGTGTCAAATTCTTCGGATACTGGAAG ATCAAGAAAATCCCATGCTTTTTGATGATGCTCCCTGCAGCGATTCTGACTGTGCTAGCA ATCAAGTCATCGTGGAATGATGTATTCTTAAATAAGCGATGGAACAATATATGGGTGCTC ACTGCTCGTTCAGACCACTCCCTACCAATGGCCATTCATTCTTCGGTTCTTCTTTTTGTT GCCATCTTCTACATAAACTCCGAAGTATTTACTCGCATCATCTTTTCTTCCAGTCCATTT ATCTACATTTACATTGCCACGTACATCGATAAGCTGACACAAGGGACCATTGCTGGAAAC CGCCTTTGGCAGTACTTTGAATCTCCAGGAATCTTGCCATTCTTCGTATTCAGACGTGTT TGGCAAGACGGATGGCGTGGAAAATTGCTCTACATCTACATCCTCGGTTACTTCGTTTTC GGAACAATGGCTCATTCTGCATGGCTGCCATTCACCTAA
|
Protein
MRRREPGRDVKRAAEEEFIELERRTDTYEDAVLNEDPQMKGFRFPSILSFPVPNKTIETG VTDENPFSARKSAFFTNRLIGREESDSSSSREDSPLGSTETGESCSTTDDEESKEKRIEY RDSQTQRCLGFCFRQLFFSRMWVFILQFIASYYAGDRFRTDGFNLVDKLIEPGQSVFGDV VVRRGLMGLRRWDAQQFLFIAEHHYIFEHSLAFFAGFPETVNYVRVGVNNGMESVFGWTF PPWVTITLAAVFVNLFCFLLCGMTLYQVVLIMTRSVKISLLAVSIFAFNPASIFFSSAYS ESMFFTMTLTGFVFMLFGLRGKGFWHRMLKGFTGTICFGLTFAVRSNGLLNFLYVAWIWC GTLLWDEEMPIPDCHKLISTLAATKNERYKQEWQAKFWRFQQKRKQNRKVFRWTDPNFSR CVTLFIVIVCAISATLLFFTPYVFMTNFTADEFCKPQDSHKQAVETIAKTVRLSPKTVSV KNAWEKTTWCKKPKLFGIIARYYGEIQTKYWSVKFFGYWKIKKIPCFLMMLPAAILTVLA IKSSWNDVFLNKRWNNIWVLTARSDHSLPMAIHSSVLLFVAIFYINSEVFTRIIFSSSPF IYIYIATYIDKLTQGTIAGNRLWQYFESPGILPFFVFRRVWQDGWRGKLLYIYILGYFVF GTMAHSAWLPFT
|
References |
Hekimi S, Boutis P, Lakowski B
Genetics
(1995)
141
(4)
:1351-64
[PMID : 8601479]
Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans.
Ceron J, Rual JF, Chandra A, Dupuy D, Vidal M, van den Heuvel S
BMC Dev. Biol.
(2007)
7
:30
[PMID : 17417969]
Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.
Wang J, Farr GW, Hall DH, Li F, Furtak K, Dreier L, Horwich AL
PLoS Genet.
(2009)
5
(1)
:e1000350
[PMID : 19165329]
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
pigv-1
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003681
|
pharynx |
"the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine." [WB:rynl] |
Certain |
WB:Expr12350
|
WBPaper00046712
|
WormAtlas
|
WB |
WBbt:0004015
|
AB |
"Embryonic founder cell" [ISBN:0-87969-307-X] |
Enriched |
WBPaper00046691 : AB_enriched
|
WBPaper00046691
|
|
WB |
WBbt:0005733
|
hypodermis |
"epidermal layer" [WB:pws] |
Certain |
WB:Expr12350
|
WBPaper00046712
|
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Certain |
WB:Expr12350
|
WBPaper00046712
|
WormAtlas
|
WB |
WBbt:0005800
|
rectal epithelium |
"epithelium connecting intestine and anus." [WB:rynl] |
Certain |
WB:Expr12350
|
WBPaper00046712
|
WormAtlas
|
WB |
WBbt:0005812
|
excretory cell |
"H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] |
Certain |
WB:Expr12350
|
WBPaper00046712
|
WormAtlas
|
WB |
WBbt:0006849
|
germline precursor cell |
"member of a set of two cells that generate exclusively sperm and ovum." [WB:rynl] |
Enriched |
WBPaper00037950 : germline-precursors_embryo_SelectivelyEnriched, germline-precursors_embryo_enriched
|
WBPaper00037950
|
|
|
WBGene00020375
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
body morphology variant
|
"Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
head morphology variant
|
"Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
protein aggregation variant
|
"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
|
|
protruding vulva
|
"Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021]
|
|
reduced brood size
|
"The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile
|
"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
thin
|
"Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|