cgt-1 encodes a transmembrane protein that is one of three C. elegans ceramide glucosyltransferases; by homology, CGT-1 is predicted to localize to the Golgi membrane and catalyze the transfer of glucose from UDP-glucose to ceramide to synthesize glucosylceramide, a glycosphingolipid precursor; although cgt-1 mutant worms show no obvious defects, animals doubly mutant for cgt-1 and cgt-3 arrest development in the early L1 larval stage, showing impaired feeding ability; in addition, cgt-3;cgt-1 and cgt-3;cgt-1;cgt-2 mutant animals show reduced glucosylceramide levels; a CGT-1::GFP reporter fusion is expressed in pharyngeal tissues, the intestine, the pharyngeal-intestinal and intestinal-rectal valves, the rectal gland cells, unidentified head cells, and the excretory system; cgt-1 expression in the intestine is sufficient to rescue the defects of cgt-3;cgt-1 mutant animals.
| db_name | wbbt | name | def | reliability | expr_pattern | paper | WormAtlas |
|---|---|---|---|---|---|---|---|
| WB |
WBbt:0004510
 |
virR | "Intestino-rectal valve" [ISBN:0-87969-307-X] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0004511
|
virL | "Intestino-rectal valve" [ISBN:0-87969-307-X] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005190
|
GABAergic neuron | "neuron that uses GABA as a vesicular neurotransmitter." [WB:rynl] | Enriched |
WBPaper00037950 : GABAergic-motor-neurons_larva_SelectivelyEnriched |
WBPaper00037950 | |
| WB |
WBbt:0005451
|
pharyngeal muscle cell | "type of cells that make up muscle layers in the pharynx." [WB:rynl] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005751
|
coelomocyte | "A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] | Enriched |
WBPaper00037950 : coelomocytes_embryo_SelectivelyEnriched, coelomocytes_embryo_enriched |
WBPaper00037950 | WormAtlas |
| WB |
WBbt:0005758
|
hermaphrodite-specific | "cells or anatomical parts specific to the hermaphrodite sex" [WB:rynl] | Enriched |
WBPaper00048690 : gonad-hermaphrodite-biased |
WBPaper00048690 | |
| WB |
WBbt:0005767
|
pharyngeal-intestinal valve | "A group of six equivalent cells forms a tightly constructed 'valve' that links the posterior bulb of the pharynx to the anterior four cells of the intestine. These six cells comprise a small epithelial channel with a cuticular lining in continuity with the pharyngeal cuticle and link the lumen of the pharynx to the large lumen of the anterior intestine." [WBPaper:00038216] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005767
|
pharyngeal-intestinal valve | "A group of six equivalent cells forms a tightly constructed 'valve' that links the posterior bulb of the pharynx to the anterior four cells of the intestine. These six cells comprise a small epithelial channel with a cuticular lining in continuity with the pharyngeal cuticle and link the lumen of the pharynx to the large lumen of the anterior intestine." [WBPaper:00038216] | Certain | WB:Expr11537 | WBPaper00038174 | WormAtlas |
| WB |
WBbt:0005772
|
intestine | "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005772
|
intestine | "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] | Enriched |
WBPaper00037950 : intestine_embryo_SelectivelyEnriched, intestine_embryo_enriched |
WBPaper00037950 | WormAtlas |
| WB |
WBbt:0005772
|
intestine | "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] | Certain | WB:Expr11537 | WBPaper00038174 | WormAtlas |
| WB |
WBbt:0005775
|
excretory canal | "Four processes (canals) of the excretory canal cell each contain a central collecting lumen which feeds to a central lumenal canal in the cell body; the central canal forms a specialized membrane to release fluids into the excretory duct. These five canals form a continuous H-shaped channel which extends almost the full length of the body, generally in contact with the lateral hypodermis and the pseudocoelom." [WBPaper:00038216] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005775
|
excretory canal | "Four processes (canals) of the excretory canal cell each contain a central collecting lumen which feeds to a central lumenal canal in the cell body; the central canal forms a specialized membrane to release fluids into the excretory duct. These five canals form a continuous H-shaped channel which extends almost the full length of the body, generally in contact with the lateral hypodermis and the pseudocoelom." [WBPaper:00038216] | Certain | WB:Expr11537 | WBPaper00038174 | WormAtlas |
| WB |
WBbt:0005777
|
excretory duct | "The extracellular sinus formed by the excretory duct and pore cells." [WBPaper:00038216] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005778
|
excretory pore | "The outlet of the excretory sinus to the exterior environment through the cuticle, on the ventral side of the head, just behind the nerve ring." [WBPaper:00038216] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005797
|
rectal valve cell | "cell that forms intestinal-rectal valve." [WB:rynl] | Certain | WB:Expr11537 | WBPaper00038174 | WormAtlas |
| WB |
WBbt:0005799
|
rectal gland cell | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas | |
| WB |
WBbt:0005812
|
excretory cell | "H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] | Certain | WB:Expr8571 | WBPaper00032934 | WormAtlas |
| WB |
WBbt:0005812
|
excretory cell | "H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] | Enriched |
WBPaper00037950 : excretory-cell_larva_SelectivelyEnriched, excretory-cell_larva_enriched |
WBPaper00037950 | WormAtlas |
WBGene00011517
Phenotype
Homology_paralog
| Observed | Observed and NOT Observed |