JCEG ID |
JCEG224 |
Name |
gly-11
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:GALNT11
OMIM:
615130
615133
OrthoList :
GALNT11
GALNTL5
(Ensembl Compara)
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
ppGalNAcT |
Locus Tag |
Y75B8A.9
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
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Sequence Features |
|
Sequence |
CDS
atgctcctactttggaggcgaaaaacagtcggattaatatgccttttttc aattcttctcactatatatctctacgtctcaatgtatccagaagataacg agagagtatggaatagtggaaacgcagatattcagagaaaacatgaaaaa ctaaataatggaggacagggacgacacgattttgatgatgatgagggcgc ggaaaaggatgaagaggatgcggtcgagaaacagaacatcgccgctccac cacttccaaaatcattcacaacattcccggatcgttcaaaagaaattgag attgacacagatttgctggggaaaataaatggaaaagccgaagatgatct acaagttgaaggttataaaaagtatcagtttaacggattactaagtgatc gaattggatcaagaaggaagatcaaggactctagaaatgccagatgctct tctctaacatattccgacagcttaccagctgcctccatagttgtttgtta tttcaatgaatcaccttccgtgctaatccgaatggtgaattcaattttcg atcgtacaaaaccagaacatctccatgaaattctacttgtggatgattca agtgaatggtcgaatgcaactgatgaagctatcaagtacagagaaaaaca tattattcaatgggaaaaagtaaagtttttgaagactgacaagaatgagg gattgattagagcaaagatttttggagcaagaagggctaatggagaagtt ttggtattcctggatagtcactgtgaagtaaacgaagaatggcttccacc acttctcgatcaaatcaaacagaatcgccgtcgtgtcgtatgcccaatca ttgatataatcgatgcaatcactatgaaatacgtggaatctcctgtttgc acaggcggtgtcaattgggcaatgacattcaaatgggattacccccatcg atcctactttgaggatccgatgaattatgtgaacccgttgaaatcgccta caatggctggtggtctttttgcgattgataaagaatatttctttgaaatt ggaagttatgatgagggaatggatgtttggggagctgaaaatgtggaaat tagtgttaggatatggacctgcggtggagaacttctgattatgccgtgca gccgagttggccacattttccgccgccaacgcccatacggaataaaaacg gattcaatgggaaaaaattcagtccggctggcaagagtatggcttgatga atatcttgaaaatttcttcgaagctcgtccaaactaccgtacattcaccg actacggtgatcttacatcgagaatcagtctacgtaggaatttgcagtgt aaaccgttcaaatggtatttggaaaatatctatcctgaactattaccgga taacacaccaaatcagctgaataaccaaatacttgtcgctggaaagaaat atttgattaaaatggcaaatggaacacattgtttgagcgctgaaaactcg cagggaaggattgcaaatgggaatcgggtggaaatgagaaaatgtaatca tatggagagaatgcaacaatggaaatactcatcgacgaatgagctacgac cgatgggctcatcccgaatgtgcctagattccttacgagggattagtgtc attttgtgtcataatcaaggagcacatcaaatgtggcaagtttcgaacgc cggaaagctctacagtagatcagtgaataaatgtgcaactggatccaatg acgtcagtgcgctgagcactttaaaattctgctctcttgcgaatagcttc caattcgttgagctataa
atgctcctactttggaggcgaaaaacagtcggattaatatgccttttttc aattcttctcactatatatctctacgtctcaatgtatccagaagataacg agagagtatggaatagtggaaacgcagatattcagagaaaacatgaaaaa ctaaataatggaggacagggacgacacgattttgatgatgatgagggcgc ggaaaaggatgaagaggatgcggtcgagaaacagaacatcgccgctccac cacttccaaaatcattcacaacattcccggatcgttcaaaagaaattgag attgacacagatttgctggggaaaataaatggaaaagccgaagatgatct acaagttgaaggttataaaaagtatcagtttaacggattactaagtgatc gaattggatcaagaaggaagatcaaggactctagaaatgccagatgctct tctctaacatattccgacagcttaccagctgcctccatagttgtttgtta tttcaatgaatcaccttccgtgctaatccgaatggtgaattcaattttcg atcgtacaaaaccagaacatctccatgaaattctacttgtggatgattca agtgaatggtcgaatgcaactgatgaagctatcaagtacagagaaaaaca tattattcaatgggaaaaagtaaagtttttgaagactgacaagaatgagg gattgattagagcaaagatttttggagcaagaagggctaatggagaagtt ttggtattcctggatagtcactgtgaagtaaacgaagaatggcttccacc acttctcgatcaaatcaaacagaatcgccgtcgtgtcgtatgcccaatca ttgatataatcgatgcaatcactatgaaatacgtggaatctcctgtttgc acaggcggtgtcaattgggcaatgacattcaaatgggattacccccatcg atcctactttgaggatccgatgaattatgtgaacccgttgaaatcgccta caatggctggtggtctttttgcgattgataaagaatatttctttgaaatt ggaagttatgatgagggaatggatgtttggggagctgaaaatgtggaaat tagtgttaggatatggacctgcggtggagaacttctgattatgccgtgca gccgagttggccacattttccgccgccaacgcccatacggaataaaaacg gattcaatgggaaaaaattcagtccggctggcaagagtatggcttgatga atatcttgaaaatttcttcgaagctcgtccaaactaccgtacattcaccg actacgtgtaa
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Protein
MLLLWRRKTVGLICLFSILLTIYLYVSMYPEDNERVWNSGNADIQRKHEKLNNGGQGRHD FDDDEGAEKDEEDAVEKQNIAAPPLPKSFTTFPDRSKEIEIDTDLLGKINGKAEDDLQVE GYKKYQFNGLLSDRIGSRRKIKDSRNARCSSLTYSDSLPAASIVVCYFNESPSVLIRMVN SIFDRTKPEHLHEILLVDDSSEWSNATDEAIKYREKHIIQWEKVKFLKTDKNEGLIRAKI FGARRANGEVLVFLDSHCEVNEEWLPPLLDQIKQNRRRVVCPIIDIIDAITMKYVESPVC TGGVNWAMTFKWDYPHRSYFEDPMNYVNPLKSPTMAGGLFAIDKEYFFEIGSYDEGMDVW GAENVEISVRIWTCGGELLIMPCSRVGHIFRRQRPYGIKTDSMGKNSVRLARVWLDEYLE NFFEARPNYRTFTDYGDLTSRISLRRNLQCKPFKWYLENIYPELLPDNTPNQLNNQILVA GKKYLIKMANGTHCLSAENSQGRIANGNRVEMRKCNHMERMQQWKYSSTNELRPMGSSRM CLDSLRGISVILCHNQGAHQMWQVSNAGKLYSRSVNKCATGSNDVSALSTLKFCSLANSF QFVEL
MLLLWRRKTVGLICLFSILLTIYLYVSMYPEDNERVWNSGNADIQRKHEKLNNGGQGRHD FDDDEGAEKDEEDAVEKQNIAAPPLPKSFTTFPDRSKEIEIDTDLLGKINGKAEDDLQVE GYKKYQFNGLLSDRIGSRRKIKDSRNARCSSLTYSDSLPAASIVVCYFNESPSVLIRMVN SIFDRTKPEHLHEILLVDDSSEWSNATDEAIKYREKHIIQWEKVKFLKTDKNEGLIRAKI FGARRANGEVLVFLDSHCEVNEEWLPPLLDQIKQNRRRVVCPIIDIIDAITMKYVESPVC TGGVNWAMTFKWDYPHRSYFEDPMNYVNPLKSPTMAGGLFAIDKEYFFEIGSYDEGMDVW GAENVEISVRIWTCGGELLIMPCSRVGHIFRRQRPYGIKTDSMGKNSVRLARVWLDEYLE NFFEARPNYRTFTDYV
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References |
Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK
Mol. Biol. Cell
(2005)
16
(9)
:4202-13
[PMID : 15987734]
The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.
Berninsone PM
WormBook
(2006)
:1-22
[PMID : 18050430]
Carbohydrates and glycosylation.
Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G
Nat. Biotechnol.
(2008)
26
(9)
:1041-5
[PMID : 18711339]
Predicting PDZ domain-peptide interactions from primary sequences.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA
Glycobiology
(2012)
22
(6)
:736-56
[PMID : 22183981]
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.
|
Functional Descriptions |
gly-11
|
Deletion Mutants |
gk342
|
In Situ |
In Situ
|
Expression |
Expression
|
WBGene00001636
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic development variant
|
"Variations in the progression of an embryo over time, from zygote formation to hatching compared to control." [GO:0009790, WB:WBPerson2021]
|
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embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
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larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
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larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
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lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
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linker cell migration variant
|
"Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control." [WB:WBPaper00028966, WB:WBPerson2021]
|
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maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
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postembryonic development variant
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"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
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slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
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sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
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Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
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