CGGDB

> expression > OLL

Definition: "Neuron class of two neurons with ciliated endings in the lateral outer labial sensilla." [WB:Paper00000938]

JCEG ID

Family

Name

Locus Tag

Human Ortholog Name

OMIM

GWAS Catalog

JCEG007 ^* ⁼

Asparagine-linked glycosylation (ALG) genes

algn-7

Y60A3A.14

DPAGT1

191350
608093
614750

JCEG037 ^*

Fucosyltransferases

Y71H2AM.14

FUT2

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000002 (Conditioned on rs2303759)	1.08		[1.07-1.09]	21833088
	Sawcer S 2011-08-11 Nature Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
MAPPED		0.00000004	1.183432		[1.15-1.22]	25574825
	Baurecht H 2015-01-08 Am J Hum Genet Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
MAPPED		0.000000000000000000000000000000000004		70.21 (pg/ml increase)	[59.37-81.05]	22367966
	Lin X 2012-02-24 Hum Mol Genet Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
MAPPED		0.00000000000000000000000000000000000000000000000000000001				24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED	0.53	0.0000000000001 (DSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)		0.045 (unit increase)	[0.033-0.057]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.53	0.00000000000000000003 (vitamin B12)		49.77 (pg/ml increase)	[37.09-62.45]	19303062
	Tanaka T 2009-03-18 Am J Hum Genet Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
UPSTREAM	0.52	0.00000005 (Single Height-males)		0.07 (unit increase)	[0.043-0.097]	23449627
	Cousminer DL 2013-02-27 Hum Mol Genet Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
MAPPED	0.49	0.0000000002		1.27 (mg/dL increase)	[0.86-1.68]	20686565
	Teslovich TM 2010-08-05 Nature Biological, clinical and population relevance of 95 loci for blood lipids.
MAPPED	0.49	0.00000000000000005		0.09 (pg/ml decrease)	[0.07-0.11]	18776911
	Hazra A 2008-09-07 Nat Genet Common variants of FUT2 are associated with plasma vitamin B12 levels.
UPSTREAM	0.487	0.000000000007	1.07		[1.04-1.11]	21102463
	Franke A 2010-11-21 Nat Genet Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
MAPPED	0.483	0.000000000000001	1.107		[1.071-1.143]	23128233
	Jostins L 2012-11-01 Nature Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
MAPPED	0.482	0.0000002 (Vitamin B12)		0.143 (unit increase)	[NR]	25147783
	Keene KL 2014-08-06 Front Public Health Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
MAPPED	0.47	0.0000000008		2.3 (% increase)	[1.80-2.90]	22001757
	Chambers JC 2011-10-16 Nat Genet Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
MAPPED	0.47	0.0000000000000001		0.031 (unit increase)	[NR]	24097068
	Willer CJ 2013-10-06 Nat Genet Discovery and refinement of loci associated with lipid levels.
MAPPED	0.464	0.00000000000000000004 (SM-11 + 2 other traits)		0.129 (unit increase)	[NR]	21886157
	Suhre K 2011-08-31 Nature Human metabolic individuality in biomedical and pharmaceutical research.
MAPPED	0.46	(CA19-9)		0.444 (U/ml increase)	[0.41-0.48]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.46	(CEA)		0.238 (ng/ml increase)	[0.21-0.26]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.44	0.000000000000002 (Plasma Vitamin B12)		0.07 (unit decrease)	[0.050-0.090]	19744961
	Hazra A 2009-09-10 Hum Mol Genet Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
MAPPED	0.431	0.00000002				20570966
	McGovern DP 2010-06-22 Hum Mol Genet Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
MAPPED	0.43	0.000000006		0.04 (unit increase)	[0.026-0.054]	25028398
	Weiss FU 2014-07-15 Gut Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
MAPPED	0.43	0.00000000003 (ADpSGEGDFXAEGGGVR)		0.041 (unit increase)	[0.029-0.053]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.43	0.000000000000001		1.8 (% increase)	[0.80-2.80]	22001757
	Chambers JC 2011-10-16 Nat Genet Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
MAPPED	0.43	0.00000000000000000002 (ADSGEGDFXAEGGGVR/ADpSGEGDFXAEGGGVR)		0.055 (unit decrease)	[0.043-0.067]	24816252
	Shin SY 2014-05-11 Nat Genet An atlas of genetic influences on human blood metabolites.
MAPPED	0.272	0.000002 (Vitamin B12 )		0.03 (pmol/L increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

JCEG050 ^* ⁼

Fucosyltransferases

fut-1

K08F8.3

FUT5 FUT3 FUT4 FUT6

104230
111100
111100
136835
136836
602030
606865
613852

STREAM	RAF	p-value	BETA	CI	Study
DOWNSTREAM		0.000004 (EA)			22566498
	Turner ST 2012-05-07 Hypertension Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
DOWNSTREAM		0.0000009 (EA)	1.4 (unit increase)	[0.79-2.01]	22566498
	Turner ST 2012-05-07 Hypertension Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
MAPPED		0.00000003			24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED		0.0000000000004	49.78 (pg/ml increase)	[36.41-63.15]	22367966
	Lin X 2012-02-24 Hum Mol Genet Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
MAPPED		0.0000000000000000008			24941225
	Liang Y 2014-06-18 PLoS One Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
MAPPED	0.38	(CA19-9)	0.282 (U/ml increase)	[0.20-0.37]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.33	0.00000000000000000000000000000000001 (CEA)	0.073 (ng/ml increase)	[0.048-0.098]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.33	(CA19-9)	0.481 (U/ml decrease)	[0.44-0.52]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.2	0.00000000000000000000000000000000000000000000000000000002 (CA19-9)	0.169 (U/ml decrease)	[0.11-0.22]	23300138
	He M 2013-01-07 Gut A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and Î± fetoprotein and their associations with cancer risk.
MAPPED	0.11	0.0000000009 (DG12)	0.3 (unit decrease)	[0.20-0.40]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.000000000003 (DG7)	0.34 (unit decrease)	[0.24-0.44]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.000000000001 (FUC-A)	0.34 (unit decrease)	[0.24-0.44]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
MAPPED	0.11	0.00000000000000004 (DG9)	0.41 (unit decrease)	[0.31-0.51]	21203500
	Lauc G 2010-12-23 PLoS Genet Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

JCEG054 ^* ⁼

Fukutin

T07D3.4

FCMD

253800
607440
611588
611615
613152

JCEG071 ^* ⁼

GPI-anchor synthesis

C27A12.9

PIGO

614730
614749

JCEG097 ^* ⁼

Glucuronyltransferase(GlcAT)

sqv-8

ZK1307.5

B3GAT3 B3GAT2

151290
245600
606374
607497

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000005	0.2918		(unit increase)]	23319000
	Luykx JJ 2013-01-15 Mol Psychiatry Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
MAPPED	0.219	0.000007 (ALT/AST)		0.03 (unit increase)	[NR]	23251661
	Comuzzie AG 2012-12-04 PLoS One Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
UPSTREAM	0.16	0.0000009		1.17 (unit decrease)	[0.70-1.64]	21326311
	Bhatnagar P 2011-02-17 J Hum Genet Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

JCEG118

Glyco_transf_92

T06A1.1

JCEG121

Glyco_transf_92

D1014.5

JCEG125 ^* ⁼

Glycosaminoglycan (GAG ) and Chitin synthesis genes

sqv-5

T24D1.1

CHSY1 CHPF CHSY3 CHPF2 CSGALNACT1 CSGALNACT2

605282
608183
609963

STREAM	RAF	p-value	OR	BETA	CI	Study
MAPPED		0.000007		0.226 (unit increase)	[NR]	23322567
	Lopes MC 2013-01-15 Invest Ophthalmol Vis Sci Identification of a candidate gene for astigmatism.
MAPPED		0.0000002	2.14		[1.53-2.99]	23726668
	Hunter AM 2013-05-30 J Psychiatr Res A genome-wide association study of a sustained pattern of antidepressant response.
MAPPED	0.66	0.000000002		0.08 (unit decrease)	[0.06-0.1]	23291589
	Lu Y 2013-01-06 Nat Genet Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
MAPPED	0.601	0.000001		0.022 (unit increase)	[NR]	25201988
	Rietveld CA 2014-09-08 Proc Natl Acad Sci U S A Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
UPSTREAM	0.31	0.000002 (ETV6-RUNX1 positive)	1.19		[1.07 - 1.33]	22076464
	Ellinghaus E 2011-11-11 Leukemia Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
UPSTREAM	0.31	0.000000006 (ETV6-RUNX1 positive, Northern European)				22076464
	Ellinghaus E 2011-11-11 Leukemia Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.

JCEG135 ^* ⁼

O-GlcNAcT

ogt-1

K04G7.3

OGT

300255

JCEG134 ^* ⁼

O-GlcNAcT

H12D21.10

EOGT

614789
615297

JCEG142

Oligosaccharyltransferase complex

T07A5.5

JCEG143 ^* ⁼

Other glycogenes

Y38C1AB.5

C1GALT1C1

STREAM	RAF	p-value	OR	BETA	CI	Study
UPSTREAM		0.000006 (Alpha peak frequency, occipital		0.051 (unit increase)	[0.029-0.073]	25387704
	Malone SM 2014-12-01 Psychophysiology Heritability and molecular-genetic basis of resting EEG activity: A genome-wide association study.
UPSTREAM		0.0000000000000000000000010000000000000001	1.28		[NR]	22808956
	Lyons PA 2012-07-19 N Engl J Med Genetically distinct subsets within ANCA-associated vasculitis.

JCEG149 ^* ⁼

PAPS synthase and PAPS transporters

pst-1

M03F8.2

SLC35B2

610788

JCEG158 ^* ⁼

Sulfotransferase and sulfation-related genes

hst-3.1

F40H3.5

HS3ST1

JCEG167 ^* ⁼

a-N-acetylglucosaminidase

K09E4.4

NAGLU

252920
609701

JCEG207 ^*

b6GnT

H41C03.1

GCNT2

JCEG199 ^* ⁼

b6GnT

Y51H4A.25

GCNT3

JCEG216 ^*

ppGalNAcT

gly-6

H38K22.5

GALNT1

JCEG224 ^* ⁼

ppGalNAcT

gly-11

Y75B8A.9

GALNT11

615130
615133

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