JCEG ID |
JCEG151 |
Name |
pps-1
WormBase
|
Human Ortholog |
GGDB:PAPSS1 PAPSS2
OMIM:
603005
603262
612847
OrthoList :
PAPSS2
PAPSS1
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.000004
|
1.32
|
|
[1.17-1.49] |
19727025
|
|
De Moor MH 2009-09-02 Med Sci Sports Exerc
Genome-wide association study of exercise behavior in Dutch and American adults.
|
DOWNSTREAM |
|
0.000002
(EA)
|
0.02742
|
|
(0.01614-0.03871) (mg/dl increase)] |
25886283
|
|
Chang X 2015-04-17 PLoS One
Genome-wide association study of serum minerals levels in children of different ethnic background.
|
DOWNSTREAM |
|
0.0000004
|
|
0.0243
(mg/dl increase)
|
[NR] |
25886283
|
|
Chang X 2015-04-17 PLoS One
Genome-wide association study of serum minerals levels in children of different ethnic background.
|
DOWNSTREAM |
0.029 |
0.00000005
|
|
|
[NR] |
24478790
|
|
Lee JH 2014-01-17 Front Genet
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
|
|
Family Name |
PAPS synthase and PAPS transporters |
Locus Tag |
T14G10.1
|
RNAi phenotype |
phenotype
|
|
Microscope observation (Image)
|
|
COPAS (Image)
|
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
|
Sequence |
CDS
ATGCTCACTCCACGGGATGAAAACAACGAAGGCGACGCCATGCCAATGTTAAAGAAGCCA AGATACTCGAGCCTCTCTGGTCAATCGACTAACATCACCTATCAAGAGCATACCATTAGT CGGGAAGAACGAGCTGCGGCAGTTGGAAGACATGAAGGTTTCCGTGGATGTACGATCTGG TTCACGGGACTTTCGGGTGCTGGAAAAACTACCATTTCTTTTGCGTTGGAGCGTACTTTA AACAAGCTCGGAATTCCTTGTTATGGGTTGGATGGAGACAACATTCGTCATGGATTATGT AAGAATCTCGGATTTTCCAAAGAAGATCGTCAAGAGAACATCCGTCGAGTTGCTGAAGTT GCTAAACTTTTTGCTGATTCTGGAATGATATGTCTTGCTGCATTCATTTCTCCTTTCCAA GAGGATCGTCTCGACGCTCGAAAGATCCATGAATCTGAAAATGTGAAATTCATTGAAGTT CATGTAAGCACTACTCTGGAAGTGTGTGAACAAAGAGATCCTAAGCAACTGTACAAGAAA GCTCGTGCTGGACAAATCCTCGGATTCACTGGAATTGACAGTGCCTACGAACCACCAGAG AATGCTGAAATTATTTTGGACGCTGGAAAGGATGGTGTTCAACAATGCGTTCAAAAAGTT CTGGATCATCTGGAATCCAAAGGATTGCTTCCAGAGCAGATCCCAGATGTTCCTGCTGTT CGAGAATTATTTGTGTCTGATGATTTGACCGTCGCTGAGCTGCTCAAGGAGAGTCAAAAT CTTCCAACTGTAGAGCTCACGAAAGTAGATCTTCAATGGCTTCAAGTTCTTGCTGAAGGA TGGGCAACTCCATTGTCTGGATTTATGCGCGAAAGACAATATCTTCAAAGCATGCATTTT GGACAACTTCTTGATTTGAAGCATAAAGTCGCATTTGTCGGAGAAAAAAGTGACGACAAA GAAGATTCGTGGCCAATGATGGATGATATTAACCAGTCTATTCCTATCGTTCTTCCAATC TCTGATGATGTCAAAAAGGGACTGGAAGGTGTTACAAGAATAGCTCTGAAATATAACGGA CAAGTCTATGCTATTCTTTCGGATCCTGAAATATTCGAACATCGAAAAGATGAACGTGTA TGTCGTCAATTTGGAACAAACGATCCACGTCATCCTGCAGTTGCTCAAGTTTTGGAATCT GGAAATTGGCTCCTAGGGGGTGATGTGGCAGTTGTACAGAAGATTCAGTTCAATGATGGA CTCGACAAATATCGTAAAACTCCAAATGAACTACGCGCAATTTTTGCTGAAAAGAATGCA GATGCCGTTTTCGCATTCCAACTTAGAAATCCGATTCATAACGGACATGCTCTTCTAATG AGAGATACCCGTGAAAAATTGCTCGCTGAGCACAAAAATCCAATTCTTTTATTGCACCCA CTTGGAGGATGGACAAAGGATGATGATGTACCCTTGGATATTAGAATAAAACAACACGAA GCAGTTATTGCTGAAAGAGTTTTGGATCCAGAATGGACTGTTCTCTCGATTTTCCCATCT CCAATGATGTATGCTGGTCCAACTGAAGTTCAGTGGCATGCCAGATCCAGAATAGCTGCT GGTATTCAACACTATATAGTGGGACGTGATCCTGCTGGAATTCAAAAACCAGGAAGTCCT GATGCTCTTTATGAAACTACACATGGAGCTAAAGTACTTTCAATGGCTCCAGGTCTTTCT GCTCTTCATATACTTCCATTCCGAGTTGCTGCATATGATAAAACAGCCAAGAAAATGTCA TTTTTCGATACATCAAGAAAAGAAGATTTTGAAAACATTAGTGGAACAAAGATGCGAGGA TTGGCACGAAATGGAGATACACCACCAGAGGGATTCATGGCTCCAACTGCATGGGAAGTT CTTGCTGGCTACTACAAATCACTACAAAACTCAAACTAA
|
Protein
MLTPRDENNEGDAMPMLKKPRYSSLSGQSTNITYQEHTISREERAAAVGRHEGFRGCTIW FTGLSGAGKTTISFALERTLNKLGIPCYGLDGDNIRHGLCKNLGFSKEDRQENIRRVAEV AKLFADSGMICLAAFISPFQEDRLDARKIHESENVKFIEVHVSTTLEVCEQRDPKQLYKK ARAGQILGFTGIDSAYEPPENAEIILDAGKDGVQQCVQKVLDHLESKGLLPEQIPDVPAV RELFVSDDLTVAELLKESQNLPTVELTKVDLQWLQVLAEGWATPLSGFMRERQYLQSMHF GQLLDLKHKVAFVGEKSDDKEDSWPMMDDINQSIPIVLPISDDVKKGLEGVTRIALKYNG QVYAILSDPEIFEHRKDERVCRQFGTNDPRHPAVAQVLESGNWLLGGDVAVVQKIQFNDG LDKYRKTPNELRAIFAEKNADAVFAFQLRNPIHNGHALLMRDTREKLLAEHKNPILLLHP LGGWTKDDDVPLDIRIKQHEAVIAERVLDPEWTVLSIFPSPMMYAGPTEVQWHARSRIAA GIQHYIVGRDPAGIQKPGSPDALYETTHGAKVLSMAPGLSALHILPFRVAAYDKTAKKMS FFDTSRKEDFENISGTKMRGLARNGDTPPEGFMAPTAWEVLAGYYKSLQNSN
|
References |
Dejima K, Seko A, Yamashita K, Gengyo-Ando K, Mitani S, Izumikawa T, Kitagawa H, Sugahara K, Mizuguchi S, Nomura K
J. Biol. Chem.
(2006)
281
(16)
:11431-40
[PMID : 16497669]
Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.
Samuelson AV, Carr CE, Ruvkun G
Genes Dev.
(2007)
21
(22)
:2976-94
[PMID : 18006689]
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
Ruzanov P, Jones SJ, Riddle DL
BMC Genomics
(2007)
8
:447
[PMID : 18053145]
Discovery of novel alternatively spliced C. elegans transcripts by computational analysis of SAGE data.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
van den Boom J, Heider D, Martin SR, Pastore A, Mueller JW
J. Biol. Chem.
(2012)
287
(21)
:17645-55
[PMID : 22451673]
3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthases, naturally fragile enzymes specifically stabilized by nucleotide binding.
|
Functional Descriptions |
pps-1
pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Larval_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0003933
|
AMshR |
"Embryonic cell of pedigree ABpraapaapp, amphid sheath cell, right." [ISBN:0-87969-307-X] |
Certain |
WB:Expr4395|WB:Expr4396
|
WBPaper00027123
|
WormAtlas
|
WB |
WBbt:0003935
|
AMshL |
"Embryonic cell of pedigree ABplaapaapp, amphid sheath cell, left." [ISBN:0-87969-307-X] |
Certain |
WB:Expr4395|WB:Expr4396
|
WBPaper00027123
|
WormAtlas
|
WB |
WBbt:0004679
|
hyp6 |
"Cylindrical hypodermal syncytium in head" [ISBN:0-87969-307-X] |
Certain |
WB:Expr4396
|
WBPaper00027123
|
|
WB |
WBbt:0004687
|
hyp4 |
"Cylindrical hypodermal syncytium in head" [ISBN:0-87969-307-X] |
Certain |
WB:Expr4396
|
WBPaper00027123
|
|
WB |
WBbt:0005734
|
hyp7 syncytium |
"entire syncytium of hyp7" [WB:pws] |
Certain |
WB:Expr4396
|
WBPaper00027123
|
|
WB |
WBbt:0005735
|
nervous system |
"Complement of nervous tissue (neurones, nerves, receptors and support cells) serving to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities." [ISBN:0-14-051288-8, WB:rynl] |
|
WB:Expr6696
|
WBPaper00006525
|
WormAtlas
|
WB |
WBbt:0005753
|
seam cell |
"a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail" [WB:rynl, WBPaper:00038216] |
Certain |
WB:Expr4395|WB:Expr4396
|
WBPaper00027123
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Certain |
WB:Expr4395|WB:Expr4396
|
WBPaper00027123
|
WormAtlas
|
WB |
WBbt:0005788
|
pharyngeal gland cell |
"secretory gland cell of the pharynx" [WB:rynl] |
Certain |
WB:Expr4395|WB:Expr4396
|
WBPaper00027123
|
WormAtlas
|
WB |
WBbt:0006751
|
head neuron |
"neuron with its cell body situated in the head, excluding the pharynx." [WB:rynl] |
|
WB:Expr6696
|
WBPaper00006525
|
|
|
WBGene00004091
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
age associated fluorescence increased
|
"Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021]
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
shortened life span
|
"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|