JCEG ID |
JCEG070 |
Name |
Y54E10BR.1
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:PIGN
OMIM:
606097
614080
OrthoList :
PIGN
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
|
0.000009
(phenotype 3)
|
3.57
|
|
[NR] |
25461247
|
|
Lehmann DS 2015-02-01 Pharmacogenet Genomics
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
|
MAPPED |
|
0.000009
(phenotype 1)
|
3.57
|
|
[NR] |
25461247
|
|
Lehmann DS 2015-02-01 Pharmacogenet Genomics
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
|
|
Family Name |
GPI-anchor synthesis |
Locus Tag |
Y54E10BR.1
|
RNAi phenotype |
phenotype
|
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Microscope observation (Image)
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COPAS (Image)
|
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hsp-4::GFP (Image)
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|
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Sequence Features |
|
Sequence |
CDS
ATGTCGTGGAAGTTTCTAATCGCCAGCATCACTGTGCACCTCGTCCTTATTTATTCAATT TTCGATGTCTACTACACAAGCCCCCTGGTTCATGGGATTCCTCCACAATTTATAAATAGT CAGGAGGCTCCTGCAAAACGGATTTTTATAATTTCAGCAGACGGCTTACGATATGACACA TTTAATAAATATCCCGACAAATCTCCATATTTACATTCAATTATGAATGAGAGAAAGGGA ATCTATGGACTATCCCGTTCTCATATCCCAACGGAATCCCGGCCGGGCCACGTGGCAATA TTCGCTGGAATTACTGAAGATATAAGTGCAGTTGCAAAAGGATGGAAAAAGAATCCAGTT CAATTCGATAGTGTATTCAATAGATCGTCGTATAGTTGGATGTGGGGAAGTCCGGATATT GTGAACCTTTTCGATGATCTTCCCAACGCTGAATCATTCTCATATTCTGCAGACGAGGAG GATTTCGCGTCGAAAGATGCTTCTAATTTGGATAAATGGGTTTTTGAGCATTTTGAGAAC TTCCTGGAAACTGCGAAAACCGATGAAGCATTGAACGATAAAATGCGGGAACAGAAAAGC ATATTTTTCTTGCATTTACTCGGAATCGACACGAATGGGCATGGGAATAAGCCAATGTCG AGGCAATATATTGATAATATCAAAGTAGTCGACTCGGGAATCGAGAAAGTTCAACACCTC GTCGACGCGTTCTTCGGAGATCACAAGACCGCGTGGCTTTTCACTTCAGATCACGGAATG ACTGATTGGGGATCGCATGGAGCTGGAAGTGATGATGAAGTGCTCACTCCATTTGTTGCA TGGGGTGCCGGAGTAAAGCAGGGTGGTCCAAAACTTGATCTTAATCAAATCGATTTGGCT CCACTGATTTCGGCGTTAATTGGATGTCCGATTCCTGTGAATTCAATGGGTATTCTTCCA GTTCAAATGATGAATTCAAAGGGCTCTAGTTATGAGTTTAAGGCGATTGAAGCAAATTTC AAACAGCTCAAAGAACAAATAATCTTTCTAAAAAACGCGAAATCCCGTCGTTTATGGTTT CGTCAATTCGAAAAATTCGGCGATAAAGCTATGGAATCTCTTCGTACAACATTGGCTCAA CTTGGAAGAGATCGAAGATTTTCAGTTGCCACGTCATTATTTGCAGATAATGCTCATTTA ATGAAAGAAGCTATCGTTTTTTATCATCGATATGATCGTCAGATGCTTGGAGCAGCGGTT AGCTGCAGTTTTGTTGCGTGGATTGCTCTAGTTGTCTCGTTTCTTCATAACTCAACATCA AAAGAAAATCTGTCACTTCTCGTGCCTCATCACCTATTCATCATTCCCCTCGCCTGCTCC CTGCTCTTCACAGCCTATTGCTCATTGAGCATGACACAAACCATTTATATAATCCTCCCA ATCTATCTGATCTCAATACTGGAAAATCATTCAAAATTGACACAACGAATCAGGGAACAC GTAAAAGCTTTGAGTGCACAACCGGATTGGCTCAACAAAGTTCTATCGGTGGAGGTTTTT GTGAAGCCGTTTTTGGGATTTGTAGGGTTTTCAATTACAATATGCATATTTGTTCTAACA TTTATGGATCGAGCATTTCTTGCGGCAGTTTTCGTTTTGCTGATGGCTTTACCGCAGTTT TATTCGCACCCGATTGTTTCATATTGGTCCAAAACCTGGCTAACCTTGTGCCTCGTTCTC TGCATCTTTCCATTCCTTCCGGCAGTCGGTGTCTCTACTCACATCCCACTTTGCATATTA TCTCCAATTATCACTGCATTCCTATGCCACCGACTGTCTCGTCGTTCCTGCTTGACAAGG ATCCAACGGATGCTTGAACTGATGATCTACGTGCAATCAGCCACAGCTTTTATGATTGCT GTAGTGAATTATGGATTTGAAAAGTTTGCAGCCACCGTCAATTGCTCGATGGATCTCCTG GACCTCAATCCCACTTTCTGTGATTGCTCCGTCGTTGCTCACGGGTCCATATCTTGTGGA TCGTCTAATTGCATACGCCTTATGCTTTTATGTGAGAAAATCGTCCCATACTCCCTGCTT TCAATATCTTACGAATCCCTCTTCATGCTCATCTTCCTCGTTCTCCTAACTCTATTCGTT CGCTTCGAATTCGGACATCTCTCTGACGTTGAGCTCTTGCAGCTGAAAGTTGATTCAACG AAAATTTCAACCGGAGAATACGTGGAGCTTCGCCGAACGGTCGTCTGCGTCTCCTTCGTC CTGTGCCCTCTCTTCGGCACCGGAAACTTTGCATCAATCAATTCATTCAATCCATCCACT TTGAATCTGTTCATTTCGGTGTTCAGCCCATTTACAATGGCTATTCTGTTGATCTTAAAA CTTCTTATTCCGATTCTTCTCGTCACATCGGCTTTTGCTTCCATAGTTCGATTTGATCAA GAATCCATTCAAAGACTCTGTTGTTTTTCGTTGATATTCACTGATTTTATGTCGATGTGT TTCTTCCACCAACTTCGAGATGAGGGTAGCTGGTTGGATATTGGTATGAGCATTTCTCAA TTCATCGTTTCAATGTGCATTTCTCTTGCTCTTCTGCTACTTCTCTCGATTTCCAGTCAT CTTATGGCATTTGAATTCCGAAAATTTCCTGGAAAAAGAAATCACCAGGAAATCGAATCG ATCTCTTCCCGGAAGTTATCCGACGACGAATCTGCTTAA
ATGTCGTGGAAGTTTCTAATCGCCAGCATCACTGTGCACCTCGTCCTTATTTATTCAATT TTCGATGTCTACTACACAAGCCCCCTGGTTCATGGGATTCCTCCACAATTTATAAATAGT CAGGAGGCTCCTGCAAAACGGATTTTTATAATTTCAGCAGACGGCTTACGATATGACACA TTTAATAAATATCCCGACAAATCTCCATATTTACATTCAATTATGAATGAGAGAAAGGGA ATCTATGGACTATCCCGTTCTCATATCCCAACGGAATCCCGGCCGGGCCACGTGGCAATA TTCGCTGGAATTACTGAAGATATAAGTGCAGTTGCAAAAGGATGGAAAAAGAATCCAGTT CAATTCGATAGTGTATTCAATAGATCGTCGTATAGTTGGATGTGGGGAAGTCCGGATATT GTGAACCTTTTCGATGATCTTCCCAACGCTGAATCATTCTCATATTCTGCAGACGAGGAG GATTTCGCGTCGAAAGATGCTTCTAATTTGGATAAATGGGTTTTTGAGCATTTTGAGAAC TTCCTGGAAACTGCGAAAACCGATGAAGCATTGAACGATAAAATGCGGGAACAGAAAAGC ATATTTTTCTTGCATTTACTCGGAATCGACACGAATGGGCATGGGAATAAGCCAATGTCG AGGCAATATATTGATAATATCAAAGTAGTCGACTCGGGAATCGAGAAAGTTCAACACCTC GTCGACGCGTTCTTCGGAGATCACAAGACCGCGTGGCTTTTCACTTCAGATCACGGAATG ACTGATTGGGGATCGCATGGAGCTGGAAGTGATGATGAAGTGCTCACTCCATTTGTTGCA TGGGGTGCCGGAGTAAAGCAGGGTGGTCCAAAACTTGATCTTAATCAAATCGATTTGGCT CCACTGATTTCGGCGTTAATTGGATGTCCGATTCCTGTGAATTCAATGGGTATTCTTCCA GTTCAAATGATGAATTCAAAGGGCTCTAGTTATGAGTTTAAGGCGATTGAAGCAAATTTC AAACAGCTCAAAGAACAAATAATCTTTCTAAAAAACGCGAAATCCCGTCGTTTATGGTTT CGTCAATTCGAAAAATTCGGCGATAAAGCTATGGAATCTCTTCGTACAACATTGGCTCAA CTTGGAAGAGATCGAAGATTTTCAGTTGCCACGTCATTATTTGCAGATAATGCTCATTTA ATGAAAGAAGCTATCGTTTTTTATCATCGATATGATCGTCAGATGCTTGGAGCAGCGGTT AGCTGCAGTTTTGTTGCGTGGATTGCTCTAGTTGTCTCGTTTCTTCATAACTCAACATCA AAAGAAAATCTGTCACTTCTCGTGCCTCATCACCTATTCATCATTCCCCTCGCCTGCTCC CTGCTCTTCACAGCCTATTGCTCATTGAGCATGACACAAACCATTTATATAATCCTCCCA ATCTATCTGATCTCAATACTGGAAAATCATTCAAAATTGACACAACGAATCAGGGAACAC GTAAAAGCTTTGAGTGCACAACCGGATTGGCTCAACAAAGTTCTATCGGTGGAGGTTTTT GTGAAGCCGTTTTTGGGATTTGTAGGGTTTTCAATTACAATATGCATATTTGTTCTAACA TTTATGGATCGAGCATTTCTTGCGGCAGTTTTCGTTTTGCTGATGGCTTTACCGCAGTTT TATTCGCACCCGATTGTTTCATATTGGTCCAAAACCTGGCTAACCTTGTGCCTCGTTCTC TGCATCTTTCCATTCCTTCCGGCAGTCGGTGTCTCTACTCACATCCCACTTTGCATATTA TCTCCAATTATCACTGCATTCCTATGCCACCGACTGTCTCGTCGTTCCTGCTTGACAAGG ATCCAACGGATGCTTGAACTGATGATCTACGTGCAATCAGCCACAGCTTTTATGATTGCT GTAGTGAATTATGGATTTGAAAAGCCACCGTCAATTGCTCGATGGATCTCCTGGACCTCA ATCCCACTTTCTGTGATTGCTCCGTCGTTGCTCACGGGTCCATATCTTGTGGATCGTCTA ATTGCATACGCCTTATGCTTTTATGTCCCATACTCCCTGCTTTCAATATCTTACGAATCC CTCTTCATGCTCATCTTCCTCGTTCTCCTAACTCTATTCGTTCGCTTCGAATTCGGACAT CTCTCTGACGTTGAGCTCTTGCAGCTGAAAGTTGATTCAACGAAAATTTCAACCGGAGAA TACGTGGAGCTTCGCCGAACGGTCGTCTGCGTCTCCTTCGTCCTGTGCCCTCTCTTCGGC ACCGGAAACTTTGCATCAATCAATTCATTCAATCCATCCACTTTGAATCTGTTCATTTCG GTGTTCAGCCCATTTACAATGGCTATTCTGTTGATCTTAAAACTTCTTATTCCGATTCTT CTCGTCACATCGGCTTTTGCTTCCATAGTTCGATTTGATCAAGAATCCATTCAAAGACTC TGTTGTTTTTCGTTGATATTCACTGATTTTATGTCGATGTGTTTCTTCCACCAACTTCGA GATGAGGGTAGCTGGTTGGATATTGGTATGAGCATTTCTCAATTCATCGTTTCAATGTGC ATTTCTCTTGCTCTTCTGCTACTTCTCTCGATTTCCAGTCATCTTATGGCATTTGAATTC CGAAAATTTCCTGGAAAAAGAAATCACCAGGAAATCGAATCGATCTCTTCCCGGAAGTTA TCCGACGACGAATCTGCTTAA
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Protein
MSWKFLIASITVHLVLIYSIFDVYYTSPLVHGIPPQFINSQEAPAKRIFIISADGLRYDT FNKYPDKSPYLHSIMNERKGIYGLSRSHIPTESRPGHVAIFAGITEDISAVAKGWKKNPV QFDSVFNRSSYSWMWGSPDIVNLFDDLPNAESFSYSADEEDFASKDASNLDKWVFEHFEN FLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVVDSGIEKVQHL VDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGVKQGGPKLDLNQIDLA PLISALIGCPIPVNSMGILPVQMMNSKGSSYEFKAIEANFKQLKEQIIFLKNAKSRRLWF RQFEKFGDKAMESLRTTLAQLGRDRRFSVATSLFADNAHLMKEAIVFYHRYDRQMLGAAV SCSFVAWIALVVSFLHNSTSKENLSLLVPHHLFIIPLACSLLFTAYCSLSMTQTIYIILP IYLISILENHSKLTQRIREHVKALSAQPDWLNKVLSVEVFVKPFLGFVGFSITICIFVLT FMDRAFLAAVFVLLMALPQFYSHPIVSYWSKTWLTLCLVLCIFPFLPAVGVSTHIPLCIL SPIITAFLCHRLSRRSCLTRIQRMLELMIYVQSATAFMIAVVNYGFEKFAATVNCSMDLL DLNPTFCDCSVVAHGSISCGSSNCIRLMLLCEKIVPYSLLSISYESLFMLIFLVLLTLFV RFEFGHLSDVELLQLKVDSTKISTGEYVELRRTVVCVSFVLCPLFGTGNFASINSFNPST LNLFISVFSPFTMAILLILKLLIPILLVTSAFASIVRFDQESIQRLCCFSLIFTDFMSMC FFHQLRDEGSWLDIGMSISQFIVSMCISLALLLLLSISSHLMAFEFRKFPGKRNHQEIES ISSRKLSDDESA
MSWKFLIASITVHLVLIYSIFDVYYTSPLVHGIPPQFINSQEAPAKRIFIISADGLRYDT FNKYPDKSPYLHSIMNERKGIYGLSRSHIPTESRPGHVAIFAGITEDISAVAKGWKKNPV QFDSVFNRSSYSWMWGSPDIVNLFDDLPNAESFSYSADEEDFASKDASNLDKWVFEHFEN FLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVVDSGIEKVQHL VDAFFGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGVKQGGPKLDLNQIDLA PLISALIGCPIPVNSMGILPVQMMNSKGSSYEFKAIEANFKQLKEQIIFLKNAKSRRLWF RQFEKFGDKAMESLRTTLAQLGRDRRFSVATSLFADNAHLMKEAIVFYHRYDRQMLGAAV SCSFVAWIALVVSFLHNSTSKENLSLLVPHHLFIIPLACSLLFTAYCSLSMTQTIYIILP IYLISILENHSKLTQRIREHVKALSAQPDWLNKVLSVEVFVKPFLGFVGFSITICIFVLT FMDRAFLAAVFVLLMALPQFYSHPIVSYWSKTWLTLCLVLCIFPFLPAVGVSTHIPLCIL SPIITAFLCHRLSRRSCLTRIQRMLELMIYVQSATAFMIAVVNYGFEKPPSIARWISWTS IPLSVIAPSLLTGPYLVDRLIAYALCFYVPYSLLSISYESLFMLIFLVLLTLFVRFEFGH LSDVELLQLKVDSTKISTGEYVELRRTVVCVSFVLCPLFGTGNFASINSFNPSTLNLFIS VFSPFTMAILLILKLLIPILLVTSAFASIVRFDQESIQRLCCFSLIFTDFMSMCFFHQLR DEGSWLDIGMSISQFIVSMCISLALLLLLSISSHLMAFEFRKFPGKRNHQEIESISSRKL SDDESA
|
References |
Maeda I, Kohara Y, Yamamoto M, Sugimoto A
Curr. Biol.
(2001)
11
(3)
:171-6
[PMID : 11231151]
Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi.
Severson AF, Baillie DL, Bowerman B
Curr. Biol.
(2002)
12
(24)
:2066-75
[PMID : 12498681]
A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans.
Sawa M, Suetsugu S, Sugimoto A, Miki H, Yamamoto M, Takenawa T
J. Cell. Sci.
(2003)
116
(Pt 8)
:1505-18
[PMID : 12640035]
Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure.
Ackerman D, Gems D
PLoS Genet.
(2012)
8
(3)
:e1002498
[PMID : 22396654]
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.
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Functional Descriptions |
Y54E10BR.1
none available
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003675
|
muscle cell |
"contractile cell that makes up muscle tissue." [WB:rynl] |
Enriched |
WBPaper00031003 : 0hr_muscle_enriched, total_muscle_enriched
|
WBPaper00031003
|
WormAtlas
|
WB |
WBbt:0005751
|
coelomocyte |
"A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : coelomocytes_embryo_enriched
|
WBPaper00037950
|
WormAtlas
|
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WBGene00021840
Phenotype
Homology_paralog
|
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Phenotype |
Definition |
RNAi / Allele |
actin cytoskeleton filament morphology variant
|
"Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
|
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avoids bacterial lawn
|
"Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021]
|
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embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
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epithelial morphology variant
|
"Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
|
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larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
protein aggregation variant
|
"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
|
|
sick
|
"Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
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sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
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transgene expression increased
|
"Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
|
|
transgene subcellular localization variant
|
"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|
ventral closure defective
|
"The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo." [WB:WBPaper00003991, WB:WBPerson712]
|
|