JCEG ID | JCEG024 | |||||||||||||||||||||
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Name | bus-4 WormBase | |||||||||||||||||||||
Human Ortholog |
GGDB:C1GALT1 OMIM: OrthoList : C1GALT1C1 (Ensembl Compara)
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Family Name | Core 1 GalT | |||||||||||||||||||||
Locus Tag | T22B11.2 | |||||||||||||||||||||
RNAi phenotype |
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Sequence Features |
kr:Detected tm:Detected dxd:DDD gg_motif:M1,M3,M4,M6 |
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Sequence | CDS |
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Protein |
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References |
Gravato-Nobre MJ, Nicholas HR, Nijland R, O'Rourke D, Whittington DE, Yook KJ, Hodgkin J Genetics (2005) 171 (3) :1033-45 [PMID : 16079230] Multiple genes affect sensitivity of Caenorhabditis elegans to the bacterial pathogen Microbacterium nematophilum. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Darby C, Chakraborti A, Politz SM, Daniels CC, Tan L, Drace K Genetics (2007) 176 (1) :221-30 [PMID : 17339204] Caenorhabditis elegans mutants resistant to attachment of Yersinia biofilms. Samuelson AV, Carr CE, Ruvkun G Genes Dev. (2007) 21 (22) :2976-94 [PMID : 18006689] Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Drace K, Darby C Appl. Environ. Microbiol. (2008) 74 (14) :4509-15 [PMID : 18515487] The hmsHFRS operon of Xenorhabdus nematophila is required for biofilm attachment to Caenorhabditis elegans. Gravato-Nobre MJ, Stroud D, O'Rourke D, Darby C, Hodgkin J Genetics (2010) 187 (1) :141-55 [PMID : 20980242] Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. |
Functional Descriptions |
bus-4 bus-4 encodes a galactosyltransferase; bus-4 is required for bacterial infection, and for fully normal cuticle integrity and body size; specifically, bus-4 is needed both for colonization by Microbacterium nematophilum (and the tail-swelling response to M. nematophilum infection) and for attachment of Yersinia pseudotuberculosis biofilms. |
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Deletion Mutants | ||||||||||||||||||||||||||||||||||||||||||
In Situ | ||||||||||||||||||||||||||||||||||||||||||
Expression |
Expression
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WBGene00044620 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||||||||||||||||||
age associated fluorescence increased
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"Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021] |
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bacterially unswollen
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"Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control." [WB:cab, WB:WBPaper00026735] |
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biofilm absent head
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"Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238] |
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cuticle carbohydrate surface variant
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"Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals." [WB:WBPaper00001576, WB:WBPerson712] |
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cuticle fragile
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"The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds." [WB:WBPerson712] |
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dauer lifespan extended
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"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987] |
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organism hypersensitive desication
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"Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021] |
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organism pathogen response variant
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"Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack." [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712] |
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pathogen adherence defect
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"Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host." [WB:WBPaper00028877, WB:WBPerson2021] |
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pathogen resistance increased
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"Animals are less prone to infection compared to control." [WB:WBPerson2021, WB:WBPerson557] |
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post hermaphrodite contact variant
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"Males exhibit variations in mating behavior after contacting its mate compared to control." [WB:WBPerson557] |
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shortened life span
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"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712] |
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skiddy
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"Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735] |
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slow growth
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"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] |
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small
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"Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
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surface antigen negative
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"Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] |
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