JCGG-STR026436:JCGGDB ID

Glycan Information

Glyco Tree get Image

Composition

Descriptors Computed from Structure

Mass

Glycan Motifs

Motif ID	Structure / SubStructure Name	Note
JCGG-MOTIF3009	neolacto	Reducing Terminal
JCGG-MOTIF4062	Paragloboside	Reducing Terminal
JCGG-MOTIF4091	Terminal N-Acetyllactosamine	NON-Reducing Terminal

ID History Deleted Version

External Links

GlycoEpitope (Antiglycan Antibody)

Name:   Lacto-N-norhexaosylceramide
Alias Name:   i antigen
Description:   nLc₆Cer
Reducing terminal:   (b-1)Cer

GMDB (MSⁿ)

OLN-0000b4

JCGG	JCGG JGD-000336 JGD-000336 JCGG JGD-000390 JGD-000390 Reducing terminal: (b-1)Cer

LipidBank (Spectral Data)

GSG1174

Description: Galb1-4GlcNAcb1-3Galb1-4GlcNAcb1-3Galb1-4GlcCer
Reducing terminal: (b-)Cer

GlycomeDB (Structure)

5437

KEGG (Structure)

G00067

SGCAL (Mass Identification)

GSL-011

Description: Galb1-4GlcNAcb1-3Galb1-4GlcNAcb1-3Galb1-4Glc

CarbBank

CCSD : 994

Title : blood-group i and I activities of lacto-N-norhexaosylceramide and its analogues: the structural requirements for i-specificities

Authors : Niermann H; Watanabe K; Hakomori S; Childs RA; Feizi T

Info : Biochem Biophys Res Commun (1978) 81: 1286-1293

TAXID : 9913 Other Data : erythrocyte Other Data : 2010-12-17

CCSD : 995

Title : Structures of glycosphingolipids isolated from human granulocytes. The presence of a series of linear poly-N-acetyllactosaminylceramide and its significance in glycolipids of whole blood cells

Authors : Fukuda MN; Dell A; Oates JE; Wu P; Klock JC; Fukuda M

Info : J Biol Chem (1985) 260: 1067-1082

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : granulocyte Other Data : 2010-12-17

CCSD : 5376

Title : Specificity of fucose transfer to GlcNAc residues of extended chain neolacto-series glycolipids catalyzed by human .alpha.1-3fucosyltransferases: effect on the lipidic environment on the myeloid enzyme form

Authors : Holmes EH; Macher BA

Info : Arch Biochem Biophys (1993) 301: 190-199

Other Data : 2010-12-17

CCSD : 8586

Title : Glycosphingolipids in cellular interaction, differentiation, and oncogenesis

Authors : Hakomori SI

Info : Ann Rev Biochem (1981) 50: 733-764

Other Data : 2010-12-17

CCSD : 9294

Title : A multiplicity of erythrocyte glycolipids of the neolacto series revealed by immuno-thin-layer chromatography with monoclonal anti-I and anti-i antibodies

Authors : Uemura K; Childs RA; Hanfland P; Feizi T

Info : Biosci Rep (1983) 3: 577-588

Other Data : erythrocyte Other Data : 2010-12-17

CCSD : 9301

Title : Carbohydrate antigen profiles of human erythroleukemia cell lines HEL and K562

Authors : Kannagi R; Papayannopoulou T; Nakamoto B; Cochran NA; Yokochi T; Stamatoyannopoulos G; Hakomori S

Info : Blood (1983) 62: 1230-1241

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 11030

Title : Activation of the alternative complement pathway by natural antibody to glycolipids in guinea pig serum

Authors : Okada N; Yasuda T; Tsumita T; Okada H

Info : Immunology (1983) 50: 75-84

TAXID : 10141 Other Data : serum Other Data : 2010-12-17

CCSD : 11955

Title : Immunochemistry of I/i-active oligo- and polyglycosylceramides from rabbit erythrocyte membranes. II. Determination of branching patterns of a ceramide pentadecasaccharide by proton nuclear magnetic resonance

Authors : Dabrowski U; Hanfland P; Egge H; Kuhn S; Dabrowski J

Info : J Biol Chem (1984) 259: 7648-7651

TAXID : 9986 Other Data : erythrocyte Other Data : 2010-12-17

CCSD : 12351

Title : Glycolipid antigens with blood-group I and i specificities from human adult and umbilical cord erythrocytes

Authors : Okada Y; Kannagi R; Levery SB; Hakomori SI

Info : J Immunol (1984) 133: 835-842

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : erythrocyte Other Data : 2010-12-17

CCSD : 14432

Title : Sialylation of lacto-N-neohexaosylceramide by sialyltransferase from embryonic chicken muscle

Authors : Dasgupta S; Chien JL; Hogan EL

Info : Biochim Biophys Acta (1986) 876: 363-370

Other Data : 2010-12-17

CCSD : 15276

Title : Proton NMR analysis of type-2 chain lactogangliosides. Confirmation of structure of a novel cancer-associated fucoganglioside, .alpha.-NeuAc-(2-6)- GlcpNAc-(1-3)-.beta.-D-Galp-(1-4)-.beta.-D-Glcp-(1-1)-Cer (VI6NeuAcIII3FucnLc6Cer)

Authors : Levery SB; Nudelman E; Kannagi R; Symington FW; Andersen NH; Clausen H; Baldwin M; Hakomori SI

Info : Carbohydr Res (1988) 178: 121-144

Other Data : 2010-12-17

CCSD : 16400

Title : Oncofetal expression of Lex carbohydrate antigens in human colonic adenocarcinomas. Regulation through type 2 core chain synthesis rather than fucosylation

Authors : Holmes EH; Ostrander GK; Clausen H; Graem N

Info : J Biol Chem (1987) 262: 11331-11338

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : colon Other Data : 2010-12-17

CCSD : 16464

Title : Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed .beta.1-3N-acetylglucosaminyltransferase

Authors : Holmes EH; Hakomori S; Ostrander GK

Info : J Biol Chem (1987) 262: 15649-15658

Other Data : 2010-12-17

CCSD : 16479

Title : The GDP-fucose:N-acetylglucosaminide 3-.alpha.-L-fucosyltransferases of LEC11 and LEC12 Chinese hamster ovary mutants exhibit novel specificities for glycolipid substrates

Authors : Howard DR; Fukuda M; Fukuda MN; Stanley P

Info : J Biol Chem (1987) 262: 16830-16837

TAXID : 10029 Other Data : CHO cells Other Data : 2010-12-17

CCSD : 16886

Title : Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunochemically similar to precursors of human blood-group antigens. Carbohydrate sequence specificity of the mouse monoclonal antibodies that recognize crossreacting antigens on LOS and human erythrocytes

Authors : Mandrell RE; Griffiss JML; Macher BA

Info : J Exp Med (1988) 168: 107-126

Other Data : 2010-12-17

CCSD : 16897

Title : Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum

Authors : Tsuji Y; Clausen H; Nudelman E; Kaizu T; Hakomori SI; Isojima S

Info : J Exp Med (1988) 168: 343-356

Other Data : 2010-12-17

CCSD : 16906

Authors : Mandrell RE; Griffiss JML; Macher BA

Info : J Exp Med (1988) 168: 1517

Other Data : 2010-12-17

CCSD : 17419

Title : A monoclonal antibody defining a binary N-acetyllactosaminyl structure in lactoisooctaosylceramide (IV6Gal.beta.1-4 GlcNAcnLc6): a useful probe for determining differential glycosylation patterns between normal and transformed human fibroblasts

Authors : Fenderson BA; Nichols EJ; Clausen H; Hakomori S

Info : Mol Immunol (1986) 23: 747-754

Other Data : 2010-12-17

CCSD : 18208

Title : High-performance liquid affinity chromatography and in situ fluorescent labeling on thin-layer chromatography of glycosphingolipids

Authors : Tomono Y; Abe K; Watanabe K

Info : Anal Biochem (1990) 184: 360-368

Other Data : 2010-12-17

CCSD : 18415

Title : Biosynthesis of fucose containing lacto-series glycolipids in human colonic adenocarcinoma Colo 205 cells

Authors : Holmes EH; Levery SB

Info : Arch Biochem Biophys (1989) 274: 633-647

Other Data : 2010-12-17

CCSD : 18426

Title : Characterization of two monoclonal antibodies specific for lacto- series type 1 chain Gal.beta.1-3GlcNAc-terminal structures

Authors : Holmes EH; Greene TG

Info : Arch Biochem Biophys (1990) 277: 181-188

Other Data : 2010-12-17

CCSD : 18484

Title : Isolation and fine-structure characterization of four monoclonal antibodies reactive with glycoconjugates containing terminal GlcNAc residues: application to aspects of lacto-series tumor antigen biosynthesis

Authors : Holmes EH; Greene TG

Info : Arch Biochem Biophys (1991) 288: 87-96

Other Data : 2010-12-17

CCSD : 18639

Title : Glycolipid glycosyltransferases in human embryonal carcinoma cells during retinoic acid induced differentiation

Authors : Chen C; Fenderson BA; Andrews PW; Hakomori S

Info : Biochemistry (1989) 28: 2229-2238

Other Data : 2010-12-17

CCSD : 18920

Title : Biosynthesis of GM1b and similar neolactoseries gangliosides by a partially purified chicken skeletal muscle sialyltransferase. Effect of sphingomyelin and acetylcholine

Authors : Dasgupta S; Chien JL; Hogan EL

Info : Biochim Biophys Acta (1990) 1036: 11-17

Other Data : 2010-12-17

CCSD : 19319

Title : Human IgG3 monoclonal antibody directed to an unbranched repeating type 2 chain (Gal.beta.1-4GlcNAc.beta.1-3Gal.beta.1-4GlcNAc.beta.1-3Gal.beta.1-R) which is highly expressed in colonic and hepatocellular carcinoma

Authors : Miyake M; Kohno N; Nudelman ED; Hakomori S

Info : Cancer Res (1989) 49: 5689-5695

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : liver Other Data : 2010-12-17

CCSD : 20740

Title : Bioorganic synthesis of dimeric Lex (difucosyl Y2 antigen; III3FucV3- FucnLc6Cer) and analogs thereof

Authors : Nudelman E; Sadozai K; Clausen H; Hakomori S; Stroud MR

Info : Eur Pat Appl (1990) : 1-26

Other Data : 2010-12-17

CCSD : 21104

Title : Specificity of glycosphingolipid recognition by Entamoeba histolytica trophozoites

Authors : Bailey GB; Nudelman ED; Day DB; Harper CF; Gilmour JR

Info : Infect Immun (1990) 58: 43-47

Other Data : 2010-12-17

CCSD : 21278

Title : Differential exposure of the major gangliosides in rabbit thymocytes to Vibrio cholerae neuraminidase

Authors : Iwamori M; Kawaguchi T; Nagai Y

Info : J Biochem (1989) 105: 723-727

Other Data : 2010-12-17

CCSD : 21744

Title : Extended type 1 chain glycosphingolipids: dimeric Lea (III4V4Fuc2Lc6) as human tumor-associated antigen

Authors : Stroud MR; Levery SB; Nudelman ED; Salyan MEK; Towell JA; Roberts CE; Watanabe M; Hakomori S

Info : J Biol Chem (1991) 266: 8439-8446

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 22115

Title : A disialoganglioside of the globo-series from chicken skeletal muscle

Authors : Dasgupta S; Chien JL; Hogan EL; van Halbeek H

Info : J Lipid Res (1991) 32: 499-506

TAXID : 9031 Other Data : muscle Other Data : 2010-12-17

CCSD : 25467

Title : Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3Fuc2nLc6) in human lung carcinoma PC9 cells

Authors : Holmes EH; Ostrander GK; Hakomori S

Info : J Biol Chem (1986) 261: 3737-3743

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : lung Other Data : 2010-12-17

CCSD : 25856

Title : Glycolipid antigens of human polymorphonuclear neutrophils and the inducible HL-60 myeloid leukemia line

Authors : Symington FW; Hedges DL; Hakomori S

Info : J Immunol (1985) 134: 2498-2506

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : 2010-12-17

CCSD : 26183

Title : ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex

Authors : Phillips ML; Nudelman E; Gaeta FCA; Perez M; Singhal AK; Hakomori SI; Paulson JC

Info : Science (1990) 250: 1130-1132

Other Data : 2010-12-17

CCSD : 26382

Title : Regulation of the expression of Gal.alpha.1-3Gal.beta.1-4GlcNAc glycosphingolipids in kidney

Authors : Hendricks SP; He P; Stults CLM; Macher BA

Info : J Biol Chem (1990) 265: 17621-17626

Other Data : kidney Other Data : 2010-12-17

CCSD : 28510

Title : Rostrocaudal expression of antibody NHK-1-reactive glycolipids in mouse cerebellum: relationship to developmental compartments and leaner mutation

Authors : Nair SM; Prasadarao N; Tobet SA; Jungalwala FB

Info : J Comp Neurol (1993) 332: 282-292

Other Data : 2010-12-17

CCSD : 31754

Title : Characterization of binding of Gal.beta.4GlcNAc-specific lectins from Erythrina cristagalli and Erythrina corallodendron to glycosphingolipids. Detection, isolation and characterization of a novel glycosphingolipid of bovine buttermilk

Authors : Teneberg S; Aangstroem J; Jovall PA; Karlsson KA

Info : J Biol Chem (1994) 269: 8554-8563

TAXID : 9986 Other Data : thymus Other Data : 2010-12-17

CCSD : 33735

Title : Structure and function of sphingoglycolipids in transmembrane signalling and cell-cell interactions

Authors : Hakomori SI

Info : Biochem Soc Trans (1993) 21: 583-595

Other Data : 2010-12-17

CCSD : 37578

Title : Human tumor-associated Lea-Lex hybrid carbohydrate antigen IV3(Gal.beta.1- 3[Fuc.alpha.1-4]GlcNAc)III3FucnLc4 defined by monoclonal antibody 43-9F: Enzymatic synthesis, structural characterization, and comparative reactivity with various antibodies

Authors : Stroud MR; Levery SB; Martensson S; Salyan MEK; Clausen H; Hakomori SI

Info : Biochemistry (1994) 33: 10672-10680

Other Data : 2010-12-17

CCSD : 37844

Title : Studies of the binding specificity of the soluble 14000-dalton bovine heart muscle lectin using immobilised glycolipids and neoglycolipids

Authors : Solomon JC; Stoll MS; Penfold P; Abbott WM; Childs RA; Hanfland P; Feizi T

Info : Carbohydr Res (1991) 213: 293-307

Other Data : 2010-12-17

CCSD : 38291

Title : N-acetylglucosaminyltransferase regulates the expression of neolactoglycolipids including sulfoglucuronylglycolipids in the developing nervous system

Authors : Chou DKH; Jungalwala FB

Info : J Biol Chem (1993) 268: 21727-21733

Other Data : 2010-12-17

CCSD : 41775

Title : Analysis of glycosphingolipid glycosyltransferase products on TLC plates by combined storage phosphor and immunostaining techniques

Authors : Stults CLM; Sullivan MT; Macher BA; Johnston RF; Stack RJ

Info : Anal Biochem (1994) 219: 61-70

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : cell line:THP-1, HL-60 Other Data : 2010-12-17

CCSD : 43215

Title : Neolactoglycosphingolipids, potential mediators of corneal epithelial cell migration

Authors : Panjwani N; Zhao Z; Ahmad S; Yang Z; Jungalwala F; Baum J

Info : J Biol Chem (1995) 270: 14015-14023

TAXID : 9986 Other Data : cornea epithelial cells Other Data : 2010-12-17

CCSD : 44622

Title : Glycosphingolipids of rabbit, sheep, and pig thymus

Authors : He P; Hu J; Macher BA

Info : Arch Biochem Biophys (1993) 305: 350-361

TAXID : 9940 Other Data : thymus Other Data : 2010-12-17

CCSD : 45489

Title : Selective detection of terminally .alpha. 2-3 and .alpha. 2-6 sialylated neolacto- series gangliosides by immunostaining on thin layer chromatograms

Authors : Muthing J; Neumann U

Info : Biomed Chromatogr (1993) 7: 158-161

TAXID : 9606 Genus Species : man Scientific Name : Homo sapiens Other Data : granulocyte Other Data : 2010-12-17

CCSD : 50330

Title : Natural and pathologic human autoimmune responses to carbohydrate antigens on red blood cells

Authors : Silberstein LE

Info : Springer Semin Immunopathol (1993) 15: 139-153

Other Data : 2010-12-17

JCGGDB ID JCGG-STR026436

Glycan Information

External Links