JCEG ID | JCEG160 | ||||||||||||
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Name | hst-6 WormBase NCBI Gene | ||||||||||||
Human Ortholog |
GGDB:HS6ST1 OMIM: 300545 604846 609401 614880 OrthoList : HS6ST1 HS6ST3 HS6ST2 (Ensembl Compara)
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Family Name | Sulfotransferase and sulfation-related genes | ||||||||||||
Locus Tag | Y34B4A.3 | ||||||||||||
RNAi phenotype |
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Sequence Features | |||||||||||||
Sequence | CDS |
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Protein |
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References |
Bulow HE, Berry KL, Topper LH, Peles E, Hobert O Proc. Natl. Acad. Sci. U.S.A. (2002) 99 (9) :6346-51 [PMID : 11983919] Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1. Bulow HE, Hobert O Neuron (2004) 41 (5) :723-36 [PMID : 15003172] Differential sulfations and epimerization define heparan sulfate specificity in nervous system development. Rhiner C, Gysi S, Frohli E, Hengartner MO, Hajnal A Development (2005) 132 (20) :4621-33 [PMID : 16176946] Syndecan regulates cell migration and axon guidance in C. elegans. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Hudson ML, Kinnunen T, Cinar HN, Chisholm AD Dev. Biol. (2006) 294 (2) :352-65 [PMID : 16677626] C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana JL, Padgett RW Curr. Biol. (2007) 17 (2) :159-64 [PMID : 17240342] Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Bulow HE, Tjoe N, Townley RA, Didiano D, van Kuppevelt TH, Hobert O Curr. Biol. (2008) 18 (24) :1978-85 [PMID : 19062279] Extracellular sugar modifications provide instructive and cell-specific information for axon-guidance choices. Bhattacharya R, Townley RA, Berry KL, Bulow HE J. Cell. Sci. (2009) 122 (Pt 24) :4492-504 [PMID : 19920077] The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans. Benard C, Tjoe N, Boulin T, Recio J, Hobert O Genetics (2009) 183 (3) :917-27 [PMID : 19737747] The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Townley RA, Bulow HE J. Biol. Chem. (2011) 286 (19) :16824-31 [PMID : 21454666] Genetic analysis of the heparan modification network in Caenorhabditis elegans. Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE, Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley WF, Habuchi H, Kimata K, Pitteloud N, Bulow HE Proc. Natl. Acad. Sci. U.S.A. (2011) 108 (28) :11524-9 [PMID : 21700882] Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism. Attreed M, Desbois M, van Kuppevelt TH, Bulow HE Nat. Methods (2012) 9 (5) :477-9 [PMID : 22466794] Direct visualization of specifically modified extracellular glycans in living animals. Berninsone PM, Hirschberg CB Glycoconj. J. 19 (4-5) :325-30 [PMID : 12975612] The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans. |
Functional Descriptions |
hst-6 hst-6 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme heparan 6O-sulfotransferase; by homology, HST-6 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying sulfation of the C6 hydroxyl group of the glucosamine subunits; during development, hst-6 activity is required for normal body size and nervous system development; an hst-6::gfp transcriptional reporter fusion is expressed beginning at early embryonic stages and continuing through adulthood; expression in embryos is nearly ubiquitous with later expression primarily restricted to neuronal tissues. |
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Deletion Mutants | ot17 ot19 ok273 | |||||||||||||||||||||||||
In Situ | ||||||||||||||||||||||||||
Expression |
Expression
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WBGene00002031 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||
axon guidance variant
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"Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021] |
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axon midline crossing variant
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"Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control." [GO:0016199, WB:WBPaper00032007, WB:WBPerson712] |
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axon morphology variant
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"Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712] |
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commissure handedness defective
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"Outgrowth of the commissure occurs on the side of the body different from that observed in control animals." [WB:WBPaper00032007, WB:WBPerson712] |
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small
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"Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] |
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