JCEG ID | JCEG124 | ||||||||||||||
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Name | gsy-1 WormBase NCBI Gene | ||||||||||||||
Human Ortholog |
OMIM: 138570 138571 240600 611556 OrthoList : GYS1 GYS2 (Ensembl Compara)
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Family Name | Glycogen synthase | ||||||||||||||
Locus Tag | Y46G5A.31 | ||||||||||||||
RNAi phenotype |
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Sequence Features | |||||||||||||||
Sequence | CDS |
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Protein |
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References |
Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J Nature (2003) 421 (6920) :231-7 [PMID : 12529635] Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Roder M, Finell J, Hantsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gonczy P, Coulson A, Hyman AA, Echeverri CJ Nature (2005) 434 (7032) :462-9 [PMID : 15791247] Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Barberan-Soler S, Zahler AM PLoS Genet. (2008) 4 (2) :e1000001 [PMID : 18454200] Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. Frazier HN, Roth MB Curr. Biol. (2009) 19 (10) :859-63 [PMID : 19398339] Adaptive sugar provisioning controls survival of C. elegans embryos in adverse environments. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. LeGendre JB, Campbell ZT, Kroll-Conner P, Anderson P, Kimble J, Wickens M J. Biol. Chem. (2012) 288 (4) :2532-45 [PMID : 23195953] RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. |
Functional Descriptions |
gsy-1 gsy-1 is orthologous to the human gene GLYCOGEN SYNTHASE 1 (GYS1; OMIM:138570); deficiencies of GYS1 may be associated with susceptibility to type 2 diabetes. |
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Deletion Mutants | ||||||||||||||||||||||||||||||||||
In Situ | ||||||||||||||||||||||||||||||||||
Expression |
Expression
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WBGene00001793 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||||||||||
anoxia hypersensitive
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"Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021] |
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cortical dynamics defective early emb
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"Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141] |
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embryonic lethal
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"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] |
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glycogen levels variant
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"Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls." [WB:WBPaper00033086, WB:WBPerson2987] |
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larval lethal
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"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712] |
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locomotion variant
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"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712] |
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organism high sodium chloride hypersensitive
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"Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab] |
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organism morphology variant
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"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395] |
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slow embryonic development
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"The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712] |
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