JCEG ID |
JCEG060 |
Name |
F38E1.9
WormBase
|
Human Ortholog |
GGDB:MPDU1
OMIM:
604041
609180
OrthoList :
MPDU1
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
MAPPED |
0.29 |
0.00000001
(Testosterone)
|
|
0.28
(unit decrease)
|
[0.18-0.38] |
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
MAPPED |
0.29 |
0.0000000000000000005
(SHBG)
|
|
0.09
(unit decrease)
|
[0.070-0.110] |
24049095
|
|
Chen Z 2013-09-18 J Med Genet
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
|
MAPPED |
0.21 |
0.0000000004
|
1.23
|
|
[1.16-1.32] |
22197929
|
|
Yu XQ 2011-12-25 Nat Genet
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
|
|
Family Name |
GPI-anchor synthesis |
Locus Tag |
F38E1.9
|
RNAi phenotype |
phenotype
|
|
Microscope observation (Image)
|
|
COPAS (Image)
|
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
|
Sequence |
CDS
ATGTCAAAAATCATGAACGACATCATTCAAAGCCTCTTCCCAGGCAATTGTTTCGAAGAA CTCCTCATCAACTTTAATTTTTTCCATCCAACATGCCCTAAAGCAGTTCTTAGCCGGGGA CTTGGATTTGCTATCACTCTCGGATCTATTCTCCTTTTCGTTCCTCAAATTTTGAAAATT CAAGCTGCTCGCAGTGCACAGGGAATCTCTGCCGCTTCCCAACTTCTTGCTCTAGTCGGT GCCATCGGAACTGCTTCCTACAGTTATCGGTCAGGATTCGTGTTCAGTGGATGGGGAGAT TCATTCTTCGTAGCTGTTCAACTTGTTATCATTATTCTTCAAATCTTCCTGTTCTCAGGA CAAACGATGTTGTCCGTTGGATTTTTGGGAATTGTTTCCGCCGTGGCATATGGAGTTGTT AGCAAAAGTATTCCAATGCAGACTCTCACCGCAGTGCAAACCGCCGGAATTCCTATTGTT GTTGTGTCAAAACTTCTTCAAATCTCTCAAAACTATCGAGCTCAATCCACCGGTCAGCTT TCCCTGATCTCCGTTTTCCTTCAATTCGCCGGAACCTTAGCACGAGTTTTCACTTCAGTT CAAGATACTGGAGATATGCTTCTGATTGTCTCTTACTCAACAGCCGCTGTTCTCAATGGG CTCATCTTTGCACAATTCTTCATGTATTGGTCCCATTCAGAATCGGCTGCGAAAAAGAAG AGAAACTAA
|
Protein
MSKIMNDIIQSLFPGNCFEELLINFNFFHPTCPKAVLSRGLGFAITLGSILLFVPQILKI QAARSAQGISAASQLLALVGAIGTASYSYRSGFVFSGWGDSFFVAVQLVIIILQIFLFSG QTMLSVGFLGIVSAVAYGVVSKSIPMQTLTAVQTAGIPIVVVSKLLQISQNYRAQSTGQL SLISVFLQFAGTLARVFTSVQDTGDMLLIVSYSTAAVLNGLIFAQFFMYWSHSESAAKKK RN
|
References |
Lo MC, Gay F, Odom R, Shi Y, Lin R
Cell
(2004)
117
(1)
:95-106
[PMID : 15066285]
Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans.
|
Functional Descriptions |
F38E1.9
none available
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Embryo_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00031532 : Larva_Pan_Neuronal_Enriched
|
WBPaper00031532
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
|
WBGene00018181
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
cell fate transformation
|
"The cell takes on a different identity from which it was initially committed." [GO:0045165, WB:WBPaper00002924, WB:WBPerson712]
|
|
dauer lifespan extended
|
"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
protein subcellular localization variant
|
"Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557]
|
|
sister cell division timing asynchrony reduced
|
"Animals exhibit sister cells that have lost otherwise normal asynchrony of cell division timing, compared to control animals. This results in sister cells aberrantly dividing in synchrony." [WB:WBPaper00046953, WB:WBPerson2987]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|