JCEG ID | JCEG173 | |||||||||||||||||||||||||||||||||
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Name | bre-2 WormBase NCBI Gene | |||||||||||||||||||||||||||||||||
Human Ortholog |
GGDB:B3GALT1 OMIM: 603018 OrthoList : B3GALT1 B3GALT2 B3GALT4 B3GALNT1 B3GALT5 (Ensembl Compara)
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Family Name | b3GalT1/b3GnT orthologs | |||||||||||||||||||||||||||||||||
Locus Tag | Y39E4B.9 | |||||||||||||||||||||||||||||||||
RNAi phenotype |
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Sequence Features |
kr:Detected gg_motif:M1,M2,M3 tm:Detected dxd:Detected |
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Sequence | CDS |
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Protein |
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References |
Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV Genetics (2000) 155 (4) :1693-9 [PMID : 10924467] Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Muller R, Brown JR, Hennet T, Esko JD, Aroian RV J. Biol. Chem. (2003) 278 (46) :45594-602 [PMID : 12944392] Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. Darby C WormBook (2005) :1-15 [PMID : 18050390] Interactions with microbial pathogens. Katic I, Vallier LG, Greenwald I Genetics (2005) 171 (4) :1605-15 [PMID : 16157663] New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV J. Biol. Chem. (2006) 282 (5) :3302-11 [PMID : 17135259] Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Ideo H, Fukushima K, Gengyo-Ando K, Mitani S, Dejima K, Nomura K, Yamashita K J. Biol. Chem. (2009) 284 (39) :26493-501 [PMID : 19635802] A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. |
Functional Descriptions |
bre-2 bre-2 is required for Cry5B toxicity. |
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Deletion Mutants | ||||||||||||||||||||||||||
In Situ | ||||||||||||||||||||||||||
Expression |
Expression
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WBGene00000267 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||
Bacillus thuringiensis toxin resistant
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"Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] |
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brood size variant
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"The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557] |
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organism toxic chemical response variant
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"Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557] |
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pore forming toxin resistant
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"Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557] |
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