JCEG ID |
JCEG152 |
Name |
C15C7.7
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:POFUT1
OMIM:
607491
615327
OrthoList :
POFUT1
(Ensembl Compara)
GGDB |
Score |
E-val |
POFUT1
|
271 |
1e-74 |
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
POFUT |
Locus Tag |
C15C7.7
|
RNAi phenotype |
phenotype
|
WT
|
Microscope observation (Image)
|
|
COPAS (Image)
|
Normal
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
kr:Detected
tm:Detected
gg_motif:M1,M2,M3,M4,M5,M6
|
Sequence |
CDS
atgagagtgtcaaaagtattaacgttggctagtttcatatcagtctgctc gtattcagaagcaaaatccaacgaaactgatccgaatggatatattgtgt tttgtccgtgcatgggtagatttggcaaccaagttgaccaatttctcggt gttcttgcatttgcaaaagctctcgatagaacactagtactacccaattt catcgaattcaagcatcctgaaacgaagatgattccgtttgaattcttgt ttcaagtgggcacagtcgcaaagtacacccgagtagtcaccatgcaagaa ttcacaaaaaagatcatgccaacagtgtggcccccagaaaagcggaaagc attttgttggactccgcgtcaagcgatctacgataaatctgcagaaccag gatgccattcgaaagagggtaacccctttggaccttattgggatcaaatt gatgtttcatttgttggcgatgagtatttcggagatattcctggaggatt cgatttgaatcaaatgggaagcagaaagaaatggctagaaaagtttccgt cggaagagtaccccgttttggcattttccagtgctccagctccatttcct tccaaaggaaaagtctggtctattcagaaatatttaagatggtcctcacg aattaccgaacaagccaagaaattcatttcggccaacttggcaaaacctt ttgtcgctgttcatttaaggaatgacgctgattgggtacgagtttgtgag cacattgatacaactacgaatcggccattgtttgcctcggaacagtgtct tggcgaggggcatcatctgggcacacttaccaaagaaatatgctcaccga gcaaacaacaaattttagagcagatcgttgaaaaagtgggatcaattgga gcaaagtcggtgttcgtagcaagcgacaaagatcatatgatagatgaaat aaacgaggctttgaagccatatgagatcgaagctcatcgtcaagaacctg atgacatgtacacatcacttgccatcatgggaagggctgacttgtttgtt ggaaattgcgtctccacattttcacatattgtaaaacgagaacgagatca tgctggacaatctccaagaccttctgcattttttggaatccgggcggtca aaagacatatcgatttgtga
|
Protein
MRVSKVLTLASFISVCSYSEAKSNETDPNGYIVFCPCMGRFGNQVDQFLGVLAFAKALDR TLVLPNFIEFKHPETKMIPFEFLFQVGTVAKYTRVVTMQEFTKKIMPTVWPPEKRKAFCW TPRQAIYDKSAEPGCHSKEGNPFGPYWDQIDVSFVGDEYFGDIPGGFDLNQMGSRKKWLE KFPSEEYPVLAFSSAPAPFPSKGKVWSIQKYLRWSSRITEQAKKFISANLAKPFVAVHLR NDADWVRVCEHIDTTTNRPLFASEQCLGEGHHLGTLTKEICSPSKQQILEQIVEKVGSIG AKSVFVASDKDHMIDEINEALKPYEIEAHRQEPDDMYTSLAIMGRADLFVGNCVSTFSHI VKRERDHAGQSPRPSAFFGIRAVKRHIDL
|
References |
Wang H, Spang A, Sullivan MA, Hryhorenko J, Hagen FK
Mol. Biol. Cell
(2005)
16
(9)
:4202-13
[PMID : 15987734]
The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.
Kozma K, Keusch JJ, Hegemann B, Luther KB, Klein D, Hess D, Haltiwanger RS, Hofsteenge J
J. Biol. Chem.
(2006)
281
(48)
:36742-51
[PMID : 17032646]
Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats.
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
Lira-Navarrete E, Valero-Gonzalez J, Villanueva R, Martinez-Julvez M, Tejero T, Merino P, Panjikar S, Hurtado-Guerrero R
PLoS One
(2011)
6
(9)
:e25365
[PMID : 21966509]
Structural insights into the mechanism of protein O-fucosylation.
|
Functional Descriptions |
C15C7.7
C15C7.7 encodes a protein O-fucosyltransferase orthologous to the vertebrate POFUT1 family of proteins; the protein product of C15C7.7 exhibits protein O-fucosyltransferase activity in vitro, fucosylating the EGF12 repeat from the mouse Notch1 receptor; by sequence similarity, the product of C15C7.7 is predicted to localize to the endoplasmic reticulum.
|
Deletion Mutants |
|
In Situ |
In Situ
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Embryo_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0005751
|
coelomocyte |
"A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : coelomocytes_embryo_SelectivelyEnriched, coelomocytes_embryo_enriched
|
WBPaper00037950
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : intestine_larva_SelectivelyEnriched, intestine_larva_enriched
|
WBPaper00037950
|
WormAtlas
|
|
WBGene00015793
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|