JCEG ID | JCEG135 | ||||||||
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Name | ogt-1 WormBase NCBI Gene | ||||||||
Human Ortholog |
GGDB:OGT OMIM: 300255 OrthoList : OGT (Ensembl Compara)
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Family Name | O-GlcNAcT | ||||||||
Locus Tag | K04G7.3 | ||||||||
RNAi phenotype |
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Sequence Features |
tm:soluble dxd:Detected gg_motif:M1, M2, M3, M6 |
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Sequence | CDS |
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Protein |
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References |
Kreppel LK, Blomberg MA, Hart GW J. Biol. Chem. (1997) 272 (14) :9308-15 [PMID : 9083067] Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. Lubas WA, Frank DW, Krause M, Hanover JA J. Biol. Chem. (1997) 272 (14) :9316-24 [PMID : 9083068] O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. Hanover JA, Forsythe ME, Hennessey PT, Brodigan TM, Love DC, Ashwell G, Krause M Proc. Natl. Acad. Sci. U.S.A. (2005) 102 (32) :11266-71 [PMID : 16051707] A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout. Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation. Byrne AB, Weirauch MT, Wong V, Koeva M, Dixon SJ, Stuart JM, Roy PJ J. Biol. (2007) 6 (3) :8 [PMID : 17897480] A global analysis of genetic interactions in Caenorhabditis elegans. Nagy A, Hegyi H, Farkas K, Tordai H, Kozma E, Banyai L, Patthy L BMC Bioinformatics (2008) 9 :353 [PMID : 18752676] Identification and correction of abnormal, incomplete and mispredicted proteins in public databases. Kwon SI, Kim SH, Bhattacharjee S, Noh JJ, Gassmann W Plant J. (2008) 57 (1) :109-19 [PMID : 18774967] SRFR1, a suppressor of effector-triggered immunity, encodes a conserved tetratricopeptide repeat protein with similarity to transcriptional repressors. Lee J, Kim KY, Lee J, Paik YK J. Biol. Chem. (2009) 285 (5) :2930-9 [PMID : 19940149] Regulation of Dauer formation by O-GlcNAcylation in Caenorhabditis elegans. Rahman MM, Stuchlick O, El-Karim EG, Stuart R, Kipreos ET, Wells L Aging (Albany NY) (2010) 2 (10) :678-90 [PMID : 20952811] Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs. Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW Genetics (2011) 188 (2) :369-82 [PMID : 21441213] O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. |
Functional Descriptions |
ogt-1 ogt-1 encodes an ortholog of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT; OMIM:300255) with 12 N-terminal tetratricopeptide (TPR) domains (generally thought to enable protein-protein interactions) and a C-terminal putative catalytic domain; although loss of ogt-1 activity has no effect on overall viability or fertility, ogt-1 mutations result in alterations in macronutrient storage and can suppress constitutive dauer formation in daf-2 mutants suggesting that, in C. elegans, ogt-1 may play a regulatory role in nutrient sensing and insulin-like signaling pathways; OGT-1 is expressed in embryos, where it exhibits nuclear and punctate perinuclear localization. |
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Deletion Mutants | gk2567 tm1046 ok1474 ok430 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
In Situ | clone=46a1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Expression |
Expression
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WBGene00003858 Phenotype Homology_paralog |
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Phenotype | Definition | RNAi / Allele | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
carbohydrate metabolism variant
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"Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control." [WB:WBPaper00038233, WB:WBPerson557, WB:WBPerson712] |
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drug resistant
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"Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug." [WB:WBPerson557] |
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organism development variant
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"Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab] |
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organism heat hypersensitive
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"Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557] |
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organism stress response variant
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"Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712] |
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pheromone induced dauer formation defective
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"Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] |
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protein expression reduced
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"Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva] |
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protein modification variant
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"Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021] |
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