JCEG ID |
JCEG096 |
Name |
glct-6
WormBase
NCBI Gene
|
Human Ortholog |
GGDB:B3GAT1
OMIM:
151290
245600
606374
607497
OrthoList :
B3GAT3
B3GAT2
B3GAT1
(Ensembl Compara)
GWAS Catalog
STREAM | RAF | p-value | OR | BETA | CI | Study |
UPSTREAM |
|
0.000008
|
4.35
|
|
[2.28-8.30] |
24172245
|
|
Haga S 2013-10-31 J Hum Genet
A genome-wide association study of third molar agenesis in Japanese and Korean populations.
|
MAPPED |
|
0.000003
|
0.701
|
|
(unit decrease)] |
24277619
|
|
Quillen EE 2013-11-26 Am J Med Genet B Neuropsychiatr Genet
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
|
UPSTREAM |
|
0.000002
|
|
0.64
(unit increase)
|
[0.39-0.89] |
25562672
|
|
Byrne EM 2014-12-09 J Clin Psychiatry
Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder.
|
UPSTREAM |
0.889723713 |
0.000009
(IGP36)
|
|
0.227
(unit decrease)
|
[0.13-0.33] |
23382691
|
|
Lauc G 2013-01-31 PLoS Genet
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
|
UPSTREAM |
0.871 |
0.000002
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
DOWNSTREAM |
0.53 |
0.000005
(CERAD-dr)
|
|
0.2826
(unit decrease)
|
[0.16-0.4] |
25648963
|
|
Debette S 2014-11-25 Biol Psychiatry
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
|
UPSTREAM |
0.143 |
0.0000007
|
|
|
[NR] |
23049088
|
|
Meng W 2012-10-09 Invest Ophthalmol Vis Sci
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
Family Name |
Glucuronyltransferase(GlcAT) |
Locus Tag |
W07G9.2
|
RNAi phenotype |
phenotype
|
|
Microscope observation (Image)
|
|
COPAS (Image)
|
|
hsp-4::GFP (Image)
|
|
|
Sequence Features |
tm:soluble
dxd:DDD
gg_motif:M4
|
Sequence |
CDS
atgcgaacaatgaacaagttgcgaaaatacggtatctacgtgctcttttg catgctgctcttcgccatggttttccagttttccgccgatttacggcagc cctcctatccagttttcaagctgtccgagggaaatatgacgaatcggatg attattgtggtgacgccgacgtataagaggatgacccggatacctgatat gttacgaatggcaaacaccctatcccacatcaaggatcttcactggatca tcgtagaagacggcaacaagaccgtgccagcagtccgtgatattctcgaa agaaccaaactcccttacacctacatgggtcacaaaaccattctggggta cccaagaagaggctggtatcaacggacgatggcgctgaagtacatccgat caaatacctcccaaatattgggaaaagatcatgaggaaggtgtcgtgtac tttggagatgacgataattcgtatgatacgcggctttttacggagtatat caggaatgtgaaaacgctcggaatttgggcagttggcctggtcggtggta ctgtagtcgaagcgccaaaagtggtgggcggcaaggtgacggcatttaac gtgaaatggaacccgaagcggcgatttgcggtggatatggccggttttgc agtcaacctgaaagtggtcctgaactctgatgcagtattcggtaccgctt gtaaacgcggcggtggtgccccggaaacatgtctgctggaggatatgggt ctagaacgagaggacattgagccattcggttatgagaaggataaagaccg tgaaatcctggtatggcatacaaaaaccagtacgccgaacatcgtgaaat ccaacaaaaattccacgaaaaaagcccctccgccagacaccttcgggtac tttgttgaagcgtga
|
Protein
MRTMNKLRKYGIYVLFCMLLFAMVFQFSADLRQPSYPVFKLSEGNMTNRMIIVVTPTYKR MTRIPDMLRMANTLSHIKDLHWIIVEDGNKTVPAVRDILERTKLPYTYMGHKTILGYPRR GWYQRTMALKYIRSNTSQILGKDHEEGVVYFGDDDNSYDTRLFTEYIRNVKTLGIWAVGL VGGTVVEAPKVVGGKVTAFNVKWNPKRRFAVDMAGFAVNLKVVLNSDAVFGTACKRGGGA PETCLLEDMGLEREDIEPFGYEKDKDREILVWHTKTSTPNIVKSNKNSTKKAPPPDTFGY FVEA
|
References |
Shaye DD, Greenwald I
PLoS ONE
(2011)
6
(5)
:e20085
[PMID : 21647448]
OrthoList: a compendium of C. elegans genes with human orthologs.
|
Functional Descriptions |
glct-6
|
Deletion Mutants |
|
In Situ |
|
Expression |
Expression
db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
WB |
WBbt:0003679
|
neuron |
"Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] |
Enriched |
WBPaper00030839 : Larval_Pan_Neuronal
|
WBPaper00030839
|
WormAtlas
|
WB |
WBbt:0005751
|
coelomocyte |
"A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : coelomocytes_embryo_enriched
|
WBPaper00037950
|
WormAtlas
|
WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00026980 : intestine_enriched
|
WBPaper00026980
|
WormAtlas
|
WB |
WBbt:0005812
|
excretory cell |
"H-shaped cell associated with the excretory system, largest cell in C. elegans." [WB:rynl] |
Enriched |
WBPaper00037950 : excretory-cell_larva_enriched
|
WBPaper00037950
|
WormAtlas
|
|
WBGene00019546
Phenotype
Homology_paralog
|
|
Phenotype |
Definition |
RNAi / Allele |
dauer lifespan extended
|
"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
extended life span
|
"The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712]
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
paraquat resistant
|
"Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|