Name Definition IS_A
生殖細胞骸の蓄積
accumulated germline cell corpses
プログラム細胞死を受けたものの、吸収されなかった生殖細胞が多く存在している状態。 [WB:WBPerson712]
"Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712]
WBPhenotype:0000241:生殖細胞骸の蓄積
WBPhenotype:0000241:accumulated cell corpses
細胞骨格アクチンフィラメントの形態異常
actin cytoskeleton filament morphology variant
ほとんどの細胞で多量に存在する細胞骨格タンパク質で、しばしば細胞接合部や細胞膜に結合しているアクチンの形態や構造、組成、配置の変化がコントロールにくらべて見られる。 [WB:WBPerson2021, WB:WBPerson557]
"Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0001587:細胞骨格アクチンフィラメントの形態異常
WBPhenotype:0001587:actin organization biogenesis variant
活動度の異常
activity level variant
コントロールの線虫と比べて動きの程度になんらかの変化がみられる。 [WB:WBPerson48]
"Any variation in the degree of movement compared to control animals." [WB:cab]
WBPhenotype:0000643:活動度の異常
WBPhenotype:0000643:locomotion variant
加齢による蛍光増加
age associated fluorescence increased
コントロールに比べ、腸細胞における蛍光シグナル強度が加齢に伴いより増加する。 [WB:WBPaper00033040, WB:WBPerson2021]
"Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021]
WBPhenotype:0001009:加齢による蛍光増加
WBPhenotype:0001009:developmental pigmentation variant
amplitude of sinusoidal movement increased
"Animals exhibit an increase in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0004022:amplitude of sinusoidal movement variant
無酸素過敏
anoxia hypersensitive
微量酸素に対するストレス応答が、コントロールよりも短時間の曝露で見られる。 [WB:WBPerson2021]
"Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021]
WBPhenotype:0000464:無酸素過敏
WBPhenotype:0000464:oxygen response variant
アポトーシス機能の消失
apoptosis fails to occur
細胞がプログラムされた細胞死を受けない。ここでいうプログラム細胞死は、細胞が丸まったり、仮足の退化、細胞体積の削減(核濃縮)、染色体凝縮、核崩壊、細胞質小器官の超微細構造の修飾がほとんどないこと、細胞膜における小庖形成(但し最終過程に至るまで細胞膜は無傷に保たれる)、及び内在性食細胞による取り込みによって特徴付けられる。 [WB:WBPerson712]
"Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712]
WBPhenotype:0000182:アポトーシス機能の消失
WBPhenotype:0000182:apoptosis reduced
アポトーシスの減少
apoptosis reduced
何らかの不具合により、アポトーシスによる細胞死の頻度がコントロールと比べ減少している。 [GO:0043065, WB:WBPerson2021]
"Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021]
WBPhenotype:0000730:アポトーシスの減少
WBPhenotype:0000730:apoptosis variant
アポトーシスの変化
apoptosis variant
プログラム細胞死の経路に関与するなんらかの過程において変化が見られる。アポトーシス経路へと誘導されると、引き続く細胞崩壊を導くタンパク質分解酵素であるカスパーゼが活性化される。 [GO:0006915, WB:WBPerson2021]
"Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021]
WBPhenotype:0001172:アポトーシスの変化
WBPhenotype:0001172:programmed cell death variant
avoids bacterial lawn
"Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021]
WBPhenotype:0000659:feeding behavior variant
軸索分岐異常
axon branching variant
コントロールと比べ、神経細胞体から生じる軸索の個数やパターンに異常が見られる。 [GO:0048755, WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712]
"Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals." [GO:0048755, WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712]
WBPhenotype:0000180:軸索分岐異常
WBPhenotype:0001224:軸索分岐異常
WBPhenotype:0000180:axon morphology variant
WBPhenotype:0001224:axon outgrowth variant
軸索束状化の変化
axon fasciculation variant
軸索の収束能力や神経線維束の形成能力が損失している状態。 [GO:0007413,WB:WBPerson2021]
"The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised." [GO:0007413, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000880:軸索束状化の変化
WBPhenotype:0000880:axon development variant
軸索ガイダンスの異常
axon guidance variant
コントロールに比べ、特定の標的部位に向けた、キューによる定方向性をもった軸索の伸長に変化が見られる。 [GO:0048846, WB:WBPerson2021]
"Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021]
WBPhenotype:0001224:軸索ガイダンスの異常
WBPhenotype:0001224:axon outgrowth variant
軸索正中線の交差の変化
axon midline crossing variant
コントロールと比べ、制御をうけている軸索の腹側正中線の交差が交差の頻度または突起位置の発達に伴う維持様式に、変化が見られる。 [GO:0016199,WB:WBPaper00032007,WB:WBPerson712]
"Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control." [GO:0016199, WB:WBPaper00032007, WB:WBPerson712]
WBPhenotype:0000384:軸索正中線の交差の変化
WBPhenotype:0000384:axon guidance variant
軸索の形態変化
axon morphology variant
コントロールと比べて、細胞体からシグナルを放出する突起部の構造や構成、空間配置に変化が見られる。 [GO:0030424, WB:WBPaper00005236, WB:WBPerson712]
"Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712]
WBPhenotype:0001398:軸索の形態変化
WBPhenotype:0001398:neurite morphology variant
軸索の経路変化
axon trajectory variant
コントロールの神経系で軸索がたどる道筋と比べ、軸索のたどる方向付けられた道筋に変化が見られる。 [WB:WBPaper00001105, WB:WBPerson712]
"Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals." [WB:WBPaper00001105, WB:WBPerson712]
WBPhenotype:0000180:軸索の経路変化
WBPhenotype:0000180:axon morphology variant
バチルス・チューリンゲンシス菌毒素に対して過敏
Bacillus thuringiensis toxin hypersensitive
バチルス・チューリンゲンシス菌毒素(Btトキシン)に対し、コントロールよりも低濃度または短時間の曝露で反応する。 [WB:WBPerson557]
"Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
WBPhenotype:0000010:バチルス・チューリンゲンシス菌毒素に対して過敏
WBPhenotype:0000010:drug hypersensitive
バチルス・チューリンゲンシス菌耐毒素性
Bacillus thuringiensis toxin resistant
コントロールに比べて、バチルス・チューリンゲンシス菌毒素(Btトキシン)への耐性をもつ。 [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557]
"Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557]
WBPhenotype:0000011:バチルス・チューリンゲンシス菌耐毒素性
WBPhenotype:0000011:drug resistant
backing decreased
"Animals spend less time backing compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0001005:backward locomotion variant
backward point velocity decreased
"Animals exhibit decreased velocity of backward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002323:backward point velocity variant
細菌感染で非膨張
bacterially unswollen
マイクロバクテリウム菌などの病原性細菌に感染しても、コントロールでみられる尾部の膨張が見られない。 [WB:WBPerson48,WB:WBPaper00026735]
"Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control." [WB:cab, WB:WBPaper00026735]
WBPhenotype:0000073:細菌感染で非膨張
WBPhenotype:0001014:細菌感染で非膨張
WBPhenotype:0000073:tail morphology variant
WBPhenotype:0001014:pathogen resistance increased
頭部のバイオフィルム消失
biofilm absent head
体の先端に大量のバイオフィルムを蓄積させないで、細菌が生産したバイオフィルムの菌叢内を移動出来る。C. elegansがペスト菌などある種の細菌に曝されると、バイオフィルムが頭部に蓄積される。このバイオフィルムは線虫の摂食を妨げ、成長を阻害する。 [WB:WBPerson48,WB:WBPaper00005238]
"Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238]
WBPhenotype:0001415:頭部のバイオフィルム消失
WBPhenotype:0001415:pathogen adherence variant
双バルバ
bivulva
本来の産卵口(バルバ)よりも前部か後部に2つ目の産卵口陥入が見られる。これは産卵口(バルバ)の発達の際、前後軸に沿った娘細胞の誤配置による。 [WB:WBPaper00040151, WB:WBPerson712]
"Animals exhibit a secondary vulval invagination that is anterior or posterior to the primary opening depending on the the inappropriate placement of daughter cells along the anterior/posterior axis during vulval development." [WB:WBPaper00040151, WB:WBPerson712]
WBPhenotype:0000695:双バルバ
WBPhenotype:0000695:vulva morphology variant
ブリーチ過敏
bleach hypersensitive
コントロールよりも低濃度または短時間のブリーチ剤曝露に反応してしまう。 [WB:WBPerson557]
"Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
WBPhenotype:0000524:ブリーチ過敏
WBPhenotype:0000524:bleach response variant
膨満
bloated
子宮内に過剰の卵を持ち、体が腫れたり膨張している状態。 [WB:WBPerson557,WB:WBPerson2021]
"Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000545:膨満
WBPhenotype:0000545:egg retention
体の伸長の変化
body elongation variant
コントロールと比べ、胚の表皮細胞の伸長に変化が見られる。C. elegansにおいて、この伸長は豆粒型期の胚が線虫の形まで変化するのに必要とされ、前後軸に沿って起こる。 [WB:WBPerson2021, WB:WBPerson557]
"Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000749:体の伸長の変化
WBPhenotype:0000749:embryonic development variant
body morphology variant
"Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000582:organism segment morphology variant
body posture amplitude decreased
"Animals exhibit variations in body posture caused by a decrease in the extent of displacement measured from the mean position to an extreme position compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002291:body posture amplitude variant
body posture wavelength decreased
"Animals exhibit variations in body posture caused by a decrease in the distance between repeating units of a wave pattern compared to control animals. In C. elegans, characteristic sinusoidal body posture is sinusoidal." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002294:body posture wavelength variant
体サイズの変化
body size variant
同じ成長段階のコントロールに比べて体の物理的な大きさが変化している。 [WB:WBPerson712]
"Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage." [WB:WBPerson712]
WBPhenotype:0000072:体サイズの変化
WBPhenotype:0000072:body morphology variant
体壁筋の形態異常
body wall muscle morphology variant
コントロールと比べ、体壁筋の形態に何らかの変化が見られる。 [WB:WBPerson557]
"Any variation in the morphological appearance of the body wall muscle compared to control animals." [WB:WBPerson557]
WBPhenotype:0000924:体壁筋の形態異常
WBPhenotype:0000924:striated muscle morphology variant
体壁筋のミオシン配置欠陥
body wall muscle myosin organization defective
筋細胞内で特徴的なミオシンフィラメントの帯の形成が崩壊している。C. elegansにおいてミオシンフィラメントは、もはや筋肉の4分の1区を横切る垂直方向線維の線維にみえない。 [WB:WBPaper00001894, WB:WBPerson2021]
"The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021]
WBPhenotype:0000782:体壁筋のミオシン配置欠陥
WBPhenotype:0000782:body wall muscle thick filament variant
body wall muscle sarcomere morphology variant
"Any variation in the form, structure or composition of the repeating units of a myofibrils in a muscle cell that are composed of an array of overlapping thick and thin filaments, compared to control." [GO:0030017, WB:WBPerson557]
WBPhenotype:0000926:body wall muscle morphology variant
産仔数の変化
brood size variant
子孫の数がコントロールと異なる。 [WB:WBPerson557]
"The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557]
WBPhenotype:0000806:産仔数の変化
WBPhenotype:0000806:hermaphrodite fertility variant
糖質代謝の変化
carbohydrate metabolism variant
体内または細胞内に貯蔵された糖質の管理や生合成、蓄積といった過程のどこかにコントロールと比べて変化が見られる。 [WB:WBPerson557,WB:WBPaper00038233,WB:WBPerson712]
"Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control." [WB:WBPaper00038233, WB:WBPerson557, WB:WBPerson712]
WBPhenotype:0000027:糖質代謝の変化
WBPhenotype:0000027:organism metabolism processing variant
細胞分裂変化
cell division variant
細胞の娘細胞への物理的分割・分離においてコントロールと比べて変化が見られる。 [GO:0051301,WB:WBPerson2021]
"Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control." [GO:0051301, WB:WBPerson2021]
WBPhenotype:0000536:細胞分裂変化
WBPhenotype:0000536:cell physiology variant
cell fate transformation
"The cell takes on a different identity from which it was initially committed." [GO:0045165, WB:WBPaper00002924, WB:WBPerson712]
WBPhenotype:0000216:cell fate specification variant
細胞恒常性代謝の変化
cell homeostasis metabolism variant
細胞レベルでの恒常性の維持に関わる化学反応や経路にコントロールと比べて変化が見られる。 [GO:0019725, WB:WBPerson2021]
"Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the cell compared to control." [GO:0019725, WB:WBPerson2021]
WBPhenotype:0000536:細胞恒常性代謝の変化
WBPhenotype:0000536:cell physiology variant
細胞膜組織の生合成異常
cell membrane organization biogenesis variant
細胞膜構造や成分の集合や輸送、配置、または分解に関する過程でコントロールと比べて変化が見られる。 [WB:WBPaper00038381, WB:WBPerson557]
"Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0010002:細胞膜組織の生合成異常
WBPhenotype:0010002:cell organization biogenesis variant
細胞の形態異常
cell morphology variant
全生物の基礎的な構造・機能的単位においてコントロールに比べ変化が見られる。細胞膜の他、細胞壁や細胞表層といった外部の被包構造がこれに含まれる。 [GO:0005623, WB:WBPerson2021, WB:WBPerson557]
"Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GO:0005623, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000520:細胞の形態異常
WBPhenotype:0000520:morphology variant
化学物質に対する反応の変化
chemical response variant
特定の化学物質に対する反応にコントロールに比べて変化が見られる。 [WB:WBPerson557]
"Animals exhibit variations in their response to a specific chemical compared to that observed in control animals." [WB:WBPerson557]
WBPhenotype:0000738:化学物質に対する反応の変化
WBPhenotype:0000738:organism environmental stimulus response variant
コンドロイチン生合成異常
chondroitin biosynthesis variant
コンドロイチン硫酸合成に関する化学反応や経路における異常。 [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712]
"Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712]
WBPhenotype:0001696:コンドロイチン生合成異常
WBPhenotype:0001696:biosynthesis variant
染色体凝縮異常
chromosome condensation variant
間期に分離している染色質を、糸状の染色体へと圧縮する過程―真核細胞において有糸分裂や減数分裂の前、あるいはアポトーシス中に起こる―こうした過程がコントロールと比べて変化している。 [GO:0030261, WB:WBPerson2021, WB:WBPerson557]
"Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0001743:染色体凝縮異常
WBPhenotype:0002012:染色体凝縮異常
WBPhenotype:0001743:mitosis variant
WBPhenotype:0002012:meiotic chromosome organization variant
体が透明
clear
コントロールと比べて体が異常に透明である。 [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654]
"Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654]
WBPhenotype:0000527:体が透明
WBPhenotype:0000527:organism pigmentation variant
coiling frequency increased
"Animals spend more time with their body posture in a coil or they increase the frequency with which they form coils compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002298:coiling frequency
コンマ期胚発生停止
comma arrest emb
線虫の胚形成中期に発生が停止する。この時期の胚は、卵殻内でわずかに折りたたまれている状態である。 [WB:WBPerson2021, WB:WBPerson557]
"Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000864:コンマ期胚発生停止
WBPhenotype:0000864:early elongation arrest
交連線維における左右性の欠損
commissure handedness defective
交連線維の伸長が、コントロールとは異なる体の側面で起こる。 [WB:WBPaper00032007,WB:WBPerson712]
"Outgrowth of the commissure occurs on the side of the body different from that observed in control animals." [WB:WBPaper00032007, WB:WBPerson712]
WBPhenotype:0000181:交連線維における左右性の欠損
WBPhenotype:0000384:交連線維における左右性の欠損
WBPhenotype:0000181:axon trajectory variant
WBPhenotype:0000384:axon guidance variant
交連線維がターゲットに到達しない
cord commissures fail to reach target
軸索が、神経束同士を完全に接続出来ていない状態。C. elegansにおいて軸索は、腹側と背側の神経束を接続しながら体の周りを取り囲むようにして成長する。 [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712]
"Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords." [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712]
WBPhenotype:0000014:交連線維がターゲットに到達しない
WBPhenotype:0000014:cord commissures variant
初期胚における表層動態の欠損
cortical dynamics defective early emb
皮質表層のラフリングや偽卵割溝がほとんど或いはまったく見られない。または、過剰な表層の活動がみられる。C. elegansでこの変化は、しばしば2細胞期に見られる。 [WB:cab, WB:cgc7141]
"Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141]
WBPhenotype:0000764:初期胚における表層動態の欠損
WBPhenotype:0001100:初期胚における表層動態の欠損
WBPhenotype:0000764:embryonic cell organization biogenesis variant
WBPhenotype:0001100:early embryonic lethal
クチクラの糖質表面の変化
cuticle carbohydrate surface variant
同じ成長段階のコントロールと比べて、グリコシル化タンパク質や脂質の発現変化あるいは、グリコシル化された部位への分子表面からのアクセスの変化がみられる。C. elegansでは、表面のグリコシル化の変化は、しばしばレクチン結合性が変化していることにより,明らかになる。 [WB:WBPaper00001576,WB:WBPerson712]
"Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals." [WB:WBPaper00001576, WB:WBPerson712]
WBPhenotype:0001210:クチクラの糖質表面の変化
WBPhenotype:0001210:pericellular component physiology variant
クチクラの発達変化
cuticle development variant
強固な外皮が徐々に形成されていく過程になんらかの変化がある。外皮は真皮やseam cell(上皮細胞の一種)、界面上皮細胞などから分泌される。 [WB:WBPerson2021, WB:WBPerson557]
"Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000200:クチクラの発達変化
WBPhenotype:0000200:pericellular component development variant
クチクラがもろい
cuticle fragile
表皮の強固さがコントロールに及ばない。C. elegansの表皮の強固さは、しばしばブリーチや他の化合物から体をどれだけ守れるかによって測定される。 [WB:WBPerson712]
"The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds." [WB:WBPerson712]
WBPhenotype:0001211:クチクラがもろい
WBPhenotype:0001211:cuticle integrity variant
クチクラの形態異常
cuticle morphology variant
強固な外皮の外見や構造に変化が見られる。外皮は真皮やseam cell(上皮細胞の一種)、他の上皮細胞から分泌される。 [WB:WBPerson557,WB:WBPerson2021]
"Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000912:クチクラの形態異常
WBPhenotype:0000912:pericellular component morphology variant
初期胚における細胞質分裂の欠損
cytokinesis defective early emb
細胞分裂の第一または第二段階におけるサイトカイネーシス(細胞質分裂)に異常が見られる。 [WB:cab, WB:cgc7141]
"Cytokinesis is abnormal in the first or second stages of cell division." [WB:cab, WB:cgc7141]
WBPhenotype:0001018:初期胚における細胞質分裂の欠損
WBPhenotype:0001100:初期胚における細胞質分裂の欠損
WBPhenotype:0001018:cytokinesis variant emb
WBPhenotype:0001100:early embryonic lethal
胚の細胞質分裂の変化
cytokinesis variant emb
胚発生において、何らかの異常により細胞質の分裂が撹乱される。 [GO:0000910, WB:WBPerson2021]
"Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control." [GO:0000910, WB:WBPerson2021]
WBPhenotype:0000050:胚の細胞質分裂の変化
WBPhenotype:0000746:胚の細胞質分裂の変化
WBPhenotype:0000050:embryonic lethal
WBPhenotype:0000746:cell division variant
細胞質のprocessing body (P-body)の変化
cytoplasmic processing body variant
コントロールと比較して、mRNAの翻訳抑制や分解機構を担う細胞質中の要素の集合からなる個別の集積体について、配置や集合形成に変化が見られたり、はっきりしなくなったりする。 [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712]
"Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control." [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712]
WBPhenotype:0001300:細胞質のprocessing body (P-body)の変化
WBPhenotype:0001300:germ cell cytoplasmic morphology variant
細胞骨格組織の生合成の変化
cytoskeleton organization biogenesis variant
コントロールと較べて、細胞内部の骨格を形作るさまざまな繊維状構成要素のいずれかについて、形態や構造、組成、配置に変化が見られる。これらの細胞骨格組織は、細胞の形状維持だけでなく、細胞の運動や細胞分裂、エンドサイトーシス、細胞小器官の運動といった機能にも関わっている。 [WB:WBPerson557,GO:0005856,WB:WBPerson2021]
"Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GO:0005856, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0001344:細胞骨格組織の生合成の変化
WBPhenotype:0001344:organelle organization biogenesis variant
dauer lifespan extended
"The life span of dauer-staged animals is longer than that observed in control dauer animals." [WB:WBPaper00032396, WB:WBPerson2987]
WBPhenotype:0001540:dauer lifespan variant
樹状突起発達の変化
dendrite development variant
コントロールと比較して細胞体へ向かって活動電位を伝導するニューロンの伸長になんらかの変化が見られる。 [GO:0016358, WB:WBPerson2021]
"Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control." [GO:0016358, WB:WBPerson2021]
WBPhenotype:0000944:樹状突起発達の変化
WBPhenotype:0000944:neurite development variant
発生遅延
developmental delay
個体の形成開始から成熟に至るまでの発生の進行がコントロールに比べ遅い。 [WB:WBPerson2021, WB:WBPerson557]
"The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000438:発生遅延
WBPhenotype:0000438:retarded heterochronic variations
卵母細胞形成におけるディアキネシス期進行変化
diakinesis progression during oogenesis variant
発達中の卵母細胞のディアキネシス期の開始や進行、終了にコントロールと比べて異常がある。ディアキネシス期とは、減数第一分裂前期の最終期、つまり減数第一分裂中期への移行期である。 [GO:0000241, WB:WBPaper00038381, WB:WBPerson557]
"Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GO:0000241, WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001824:卵母細胞形成におけるディアキネシス期進行変化
WBPhenotype:0001824:meiotic progression prophase variant
ディアキネシス期における組織異常
diakinesis region organization variant
コントロールに較べて、ディアキネシス期にある生殖巣で生殖細胞の核組織に異常が見られる。C. elegansの生殖巣ではディアキネシス期の細胞が存在する部域は、近位生殖管に存在し、ディプロテン期の部域の後に続いている。ディアキネシス期の領域では、卵母細胞は成熟するまでその段階で停止させられている。 [WB:WBPaper00038381, WB:WBPerson557]
"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001355:ディアキネシス期における組織異常
WBPhenotype:0001948:ディアキネシス期における組織異常
WBPhenotype:0001355:gonad morphology variant
WBPhenotype:0001948:diakinesis progression during oogenesis variant
卵母細胞形成におけるディプロテン期の消失
diplotene absent during oogenesis
発達中の卵母細胞においてディプロテン期が見られない。ディプロテン期は減数第一分裂前期の第4段階で、対合複合体が消失して相同染色体が分裂を開始する。 [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
"The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001947:卵母細胞形成におけるディプロテン期の消失
WBPhenotype:0001947:diplotene progression during oogenesis variant
卵母細胞形成におけるディプロテン進行変化
diplotene progression during oogenesis variant
発達中の卵母細胞のディプロテン期の開始や進行、終了にコントロールと比べて異常がある。ディプロテン期は減数第一分裂前期の第4段階で、相同染色体が分離を開始し、シナプトネマ構造が消失する。 [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
"Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001824:卵母細胞形成におけるディプロテン進行変化
WBPhenotype:0001824:meiotic progression prophase variant
ディプロテン期における組織異常
diplotene region organization variant
ディプロテン期にある生殖細胞の核の組織に異常が見られる。C. elegansでディプロテン期の領域は、パキテン期の領域に続いて位置しており、gonad armのループあるいはループ直前で起こる。ディプロテン期には、生殖細胞の区画が一つに統合される。 [WB:WBPaper00038381, WB:WBPerson557]
"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001355:ディプロテン期における組織異常
WBPhenotype:0001947:ディプロテン期における組織異常
WBPhenotype:0001355:gonad morphology variant
WBPhenotype:0001947:diplotene progression during oogenesis variant
distal tip 細胞(DTC)の遊走異常
distal tip cell migration variant
DTCの遊走パターンにコントロールと較べて変化が見られる。C. elegansでは、DTCは左右対称なU字型を形成しながら移動していく生殖腺原基の前端と後端に位置する。 Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern.
" Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern." [GO:0040039, WB:WBPaper00003598, WB:WBPerson2021]
WBPhenotype:0000594:distal tip 細胞(DTC)の遊走異常
WBPhenotype:0000594:cell migration variant
薬剤過敏
drug hypersensitive
特定の薬剤に対してコントロールよりも低濃度または短時間の曝露で反応する。 [WB:WBPerson557]
"Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
WBPhenotype:0000631:薬剤過敏
WBPhenotype:0000631:drug response variant
薬剤耐性
drug resistant
コントロールにおいては反応を誘発するような薬剤濃度に反応しない。あるいは、反応を誘発するためにはコントロールより高濃度または長時間薬剤に曝される必要がある。 [WB:WBPerson557]
"Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug." [WB:WBPerson557]
WBPhenotype:0000631:薬剤耐性
WBPhenotype:0000631:drug response variant
体が太く短い
dumpy
同じ成長段階にあるコントロールに比べ、体が太くて短い。 [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497]
"Worms are shorter and stouter than control animals at the same developmental stage." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497]
WBPhenotype:0001726:体が太く短い
WBPhenotype:0001727:体が太く短い
WBPhenotype:0001726:body length variant
WBPhenotype:0001727:body width variant
初期胚致死
early embryonic lethal
胚発生において原腸胚期に至るまでに死んでしまう。 [WB:WBPerson2021]
"Animal dies prior to the gastrulation stage of embryogenesis." [WB:WBPerson2021]
WBPhenotype:0000050:初期胚致死
WBPhenotype:0000050:embryonic lethal
幼虫早期発生停止
early larval arrest
幼虫の初期で成長が停止してしまう。C. elegansでこの表現型は、L1もしくはL2の幼虫発生期に起こる。 [WB:cab]
"Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development." [WB:cab]
WBPhenotype:0000059:幼虫早期発生停止
WBPhenotype:0000059:larval arrest
幼虫早期致死
early larval lethal
幼虫が初期の発生段階で死んでしまう。C. elegansでこの表現型は、L1からL2の幼虫期に起こる。 [WB:WBPerson2021]
"Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle." [WB:WBPerson2021]
WBPhenotype:0000054:幼虫早期致死
WBPhenotype:0000054:larval lethal
神経の異所伸長
ectopic neurite outgrowth
何らかの異常によって神経細胞(軸索や樹状突起)の増殖が過剰に起こり、神経突起の数が過剰に生成される。 [WB:WBPerson2021]
"Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated." [WB:WBPerson2021]
WBPhenotype:0000572:神経の異所伸長
WBPhenotype:0000572:neuronal outgrowth variant
egg laying defective
"Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPaper00025054]
WBPhenotype:0000640:egg laying variant
産卵における異常
egg laying variant
産みだされた卵や、産卵周期、産卵数、産卵の刺激による誘発などについて、コントロールに比べ変化が見られる。 Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control.
" Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control." [pmid:11813735, pmid:9697864, WB:cab]
WBPhenotype:0000525:産卵における異常
WBPhenotype:0000525:organism behavior variant
初期胚における浸透圧非侵襲性の欠損
embryo osmotic integrity defective early emb
胚の浸透圧調整能力に異常がある。この表現型をもつC. elegans胚の卵殻は浸透圧により溶けてしまう。 [WB:cab, WB:cgc7141]
"Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141]
WBPhenotype:0000041:初期胚における浸透圧非侵襲性の欠損
WBPhenotype:0001178:初期胚における浸透圧非侵襲性の欠損
WBPhenotype:0000041:osmotic integrity variant
WBPhenotype:0001178:egg integrity defective early emb
初期胚における浸透圧過敏
embryo osmotic pressure sensitive early emb
胚を2%アガーパッドに置き、カバーガラスをかけると破裂してしまう。 [WB:cab, WB:cgc5599]
"Embryos rupture when placed on a 2% agar pad and covered with a coverslip." [WB:cab, WB:cgc5599]
WBPhenotype:0001178:初期胚における浸透圧過敏
WBPhenotype:0001178:egg integrity defective early emb
胚発生停止
embryonic arrest
受精後から孵化するまでのいずれかの時期に発生が停止する。 [WB:WBPerson712]
"Cessation of development during any stage occurring after fertilization and until hatching compared to control." [WB:WBPerson712]
WBPhenotype:0000749:胚発生停止
WBPhenotype:0000749:embryonic development variant
胚致死
embryonic lethal
胚発生の途中で死んでしまう。C. elegansでは、しばしば屈折性の変化した卵 として観察される。大規模RNAiスクリーニングにおいては、10%以上の胚が死んでしまう場合。 [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
WBPhenotype:0000062:胚致死
WBPhenotype:0000749:胚致死
WBPhenotype:0000062:lethal
WBPhenotype:0000749:embryonic development variant
酵素活性低下
enzyme activity reduced
コントロールと比べ、酵素の触媒活性が低下してしまうようなすべての変化。触媒は、酵素として知られる天然に存在する高分子の物質である。酵素は基質に対して特異的な結合部位を持ち、しばしばタンパク質のみ、あるいは大部分がタンパク質(RNA成分を含むこともある)で構成されている。 [WB:WBPerson2021, WB:WBPerson557]
"Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000727:酵素活性低下
WBPhenotype:0000727:enzyme activity variant
上皮細胞形態の変化
epithelial cell morphology variant
コントロールと比べ、上皮細胞の外見になんらかの変化が見られる。 [WB:WBPerson557]
"Any variation in the morphological appearance of epithelial cells compared to control animals." [WB:WBPerson557]
WBPhenotype:0002108:上皮細胞形態の変化
WBPhenotype:0002108:cell type morphology variant
上皮形態の変化
epithelial morphology variant
個体の外表面を覆い、個体の組織や器官と外部環境を隔てる裏層を形成している細胞層の形態や組成、構造の変化がコントロールに比べて見られる。C. elegansの上皮細胞には、消化管上皮や腸細胞、皮下組織、界面細胞、体性生殖細胞が含まれる。 [WB:WBPerson2021, WB:WBPerson557]
"Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000600:上皮形態の変化
WBPhenotype:0000600:epithelial system morphology variant
バルバ(産卵口)が裏返し
everted vulva
最後の脱皮で、バルバ陥入が裏返しになる過程がうまく行われない。C.elegansでバルバの裏返しにおける変異は、主に体性生殖管(ときにバルバ)の発達異常による。 [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261]
"The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva)." [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261]
WBPhenotype:0000695:バルバ(産卵口)が裏返し
WBPhenotype:0000695:vulva morphology variant
初期胚における母性前核過剰
excess maternal pronucleus early emb
1細胞期の胚が2つ以上の母性前核をもつ。 [WB:cab, WB:cgc5599]
"One-cell embryos have two or more maternal pronuclei." [WB:cab, WB:cgc5599]
WBPhenotype:0001164:初期胚における母性前核過剰
WBPhenotype:0001164:excess pronucleus early emb
バルバの破裂
exploded through vulva
バルバ(産卵口)が破裂し、そこから体内の器官が飛び出している状態。 [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712]
"The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture." [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712]
WBPhenotype:0000619:バルバの破裂
WBPhenotype:0000619:epithelial system development variant
長寿
extended life span
成虫の生存期間がコントロールに比べて長い。 [GO:0008340, WB:WBPerson712]
"The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712]
WBPhenotype:0000039:長寿
WBPhenotype:0000039:life span variant
脂肪減少
fat content reduced
コントロールに比べて脂肪や脂質が少ない。 [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
"Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712]
WBPhenotype:0001182:脂肪減少
WBPhenotype:0001182:fat content variant
摂餌不足
feeding inefficient
コントロールと同程度の速度で栄養分摂取できない。 [WB:WBPaper00032342, WB:WBPerson712]
"Animals are unable to ingest nutrients at a rate similar to control animals." [WB:WBPaper00032342, WB:WBPerson712]
WBPhenotype:0000659:摂餌不足
WBPhenotype:0000659:feeding behavior variant
seam cell(上皮細胞)が少ない
fewer seam cells
seam cellとよばれる側翼(alae)形成上皮細胞の数がコントロールに比べ減少している。 [WB:WBPaper00034768]
"The population of the lateral, alae-producing epithelial cells (seam cells) is reduced compared to control animals." [WB:WBPaper00034768]
WBPhenotype:0000701:seam cell(上皮細胞)が少ない
WBPhenotype:0000701:epithelial development variant
WBPhenotype:0002174:cell number decreased
foraging behavior variant
"Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [GO:0060756, WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712]
WBPhenotype:0000525:organism behavior variant
forward locomotion decreased
"Animals spend less time in forward locomotion, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002345:forward locomotion variant
forward point velocity decreased
"Animals exhibit decreased velocity of forward translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0001716:forward point velocity variant
frequency body bend reduced
"Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712]
WBPhenotype:0001213:locomotion reduced
WBPhenotype:0004023:frequency of body bend variant
原腸陥入の変化
gastrulation variant
胚の内部に胚葉 が配置される過程になんらかの変化がコントロールと比べて見られる。原腸陥入では、細胞の小群が様々なタイミングで胞胚腔に移入する。 [WB:WBPaper00027251,WB:WBPerson2021]
"Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space." [WB:WBPaper00027251, WB:WBPerson2021]
WBPhenotype:0000749:原腸陥入の変化
WBPhenotype:0000749:embryonic development variant
生殖細胞区画が無核
germ cell compartment anucleate
区画に仕切られた生殖細胞が核を持たない。 [WB:WBPaper00038381, WB:WBPerson557]
"Germ cell compartments do not contain a nucleus." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001970:生殖細胞区画が無核
WBPhenotype:0001970:germ cell compartment nuclei number variant
生殖細胞区画拡張の欠損
germ cell compartment expansion absent
生殖細胞の区画の大きさが増加しない。 [WB:WBPaper00038381, WB:WBPerson557]
"The compartments of the germline do not increase in size." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001980:生殖細胞区画拡張の欠損
WBPhenotype:0001980:germ cell compartment expansion variant
生殖細胞区画拡張の変化
germ cell compartment expansion variant
生殖細胞区画の大きさの増加においてなんらかの変化が見られる。C. elegansの生殖細胞がループ部分に差し掛かかると、シンシチウムの区画が拡大し、完全に囲われた生殖細胞として切り離される。 [WB:WBPaper00038381, WB:WBPerson557]
"Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001969:生殖細胞区画拡張の変化
WBPhenotype:0001969:germ cell compartment morphology variant
生殖細胞区画が大きい
germ cell compartment large
生殖細胞の区画がコントロールに比べて大きい。 [WB:WBPaper00038381, WB:WBPerson557]
"Germ cell compartments are larger than that of control animals." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001973:生殖細胞区画が大きい
WBPhenotype:0001973:germ cell compartment size variant
生殖細胞区画の形態変化
germ cell compartment morphology variant
コントロールと比較して、雌雄同体の生殖細胞区画の形態や組成になんらかの変化が見られる。C. elegansでは、これらの区画は核を一つ有し、共通細胞質(rachis)につながっている。これらの区画は後に細胞区画の形成を経てそれぞれ独立した卵母細胞となる。 [WB:WBPaper00038381, WB:WBPerson557]
"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0000900:生殖細胞区画の形態変化
WBPhenotype:0000900:germ cell morphology variant
生殖細胞区画が多核
germ cell compartment multinucleate
生殖細胞区画が複数の核を持っている。 [WB:WBPaper00038381, WB:WBPerson557]
"Germ cell compartments contain multiple nuclei." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001970:生殖細胞区画が多核
WBPhenotype:0001970:germ cell compartment nuclei number variant
生殖細胞区画サイズの変化
germ cell compartment size variant
コントロールと比較して、生殖細胞区画の大きさになんらかの変化が見られる。 [WB:WBPaper00038381, WB:WBPerson557]
"Any variation in germ cell compartment size compared to control." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001969:生殖細胞区画サイズの変化
WBPhenotype:0001969:germ cell compartment morphology variant
生殖細胞しきりの欠損
germ cell partition absent
生殖細胞のしきり(生殖細胞区画)が見られない。 [WB:WBPaper00038381, WB:WBPerson557]
"Animals lack germ cell partitions (germ cell compartments)." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001977:生殖細胞しきりの欠損
WBPhenotype:0001977:germ cell partition morphology variant
生殖細胞しきりの形態変化
germ cell partition morphology variant
雌雄同体や雌の生殖巣において、核が共通の細胞質(rachis)に結合したまま存在している時期に、区画のしきりの形態や組成に、コントロールと比べてなんらかの変化が見られる。 [WB:WBPaper00038381, WB:WBPerson557]
"Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. " [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001969:生殖細胞しきりの形態変化
WBPhenotype:0001969:germ cell compartment morphology variant
生殖巣における核の配置の変化
germline nuclear positioning variant
生殖巣区画内における方向性ももった運動や、核の定位置への配置にコントロールと比べて変化が見られる。 [WB:WBPaper00038381, WB:WBPerson557]
"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0000511:生殖巣における核の配置の変化
WBPhenotype:0000511:nuclear positioning variant
グリコーゲン量の変化
glycogen levels variant
グルコースが重合してできたグリコーゲンの量が、体全体を通してコントロールと比べ変化が見られる。 [WB:WBPaper00033086, WB:WBPerson2987]
"Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls." [WB:WBPaper00033086, WB:WBPerson2987]
WBPhenotype:0000027:グリコーゲン量の変化
WBPhenotype:0000027:organism metabolism processing variant
生殖腺の退化
gonad degenerate
もともと機能していた生殖腺が、その後機能を停止してしまうこと。これにより、雌雄同体や雌の子宮内には、しばしば新しい胚ではなく、古い胚や孵化した幼虫が存在する。 [WB:WBPaper00038381, WB:WBPerson557]
"Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001355:生殖腺の退化
WBPhenotype:0001355:gonad morphology variant
生殖巣の発達異常
gonad development variant
配偶子の産生を担う器官の発達に、コントロールに比べ異常が見られる。 [GO:0008406, WB:WBPerson2021]
"Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control." [GO:0008406, WB:WBPerson2021]
WBPhenotype:0000624:生殖巣の発達異常
WBPhenotype:0000624:reproductive system development variant
生殖巣の遊走異常
gonad migration variant
コントロールと比較して、生殖巣が全体的に、リーダー細胞の後ろの体壁に沿って、形成中のバルバから遠ざかるように移動する運動に異常が見られる。 [WB:WBPerson2021, WB:WBPerson557]
"Variations in the gross movement of the whole structure of the gonad along the body wall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000624:生殖巣の遊走異常
WBPhenotype:0000624:reproductive system development variant
生殖巣の形態の変化
gonad morphology variant
雄性配偶子や雌性配偶子を産生する生殖器官特有組織の形態や組成の変化がコントロールに比べて見られる。 [WB:WBPerson2021, WB:WBPerson557]
"Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000605:生殖巣の形態の変化
WBPhenotype:0000605:reproductive system morphology variant
生殖巣が小さい
gonad small
雄性配偶子や雌性配偶子を産生する生殖器官特有組織の大きさが、コントロールに比べ小さい。 [WB:WBPaper00038381, WB:WBPerson557]
"A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001355:生殖巣が小さい
WBPhenotype:0001355:gonad morphology variant
生殖巣の小胞化
gonad vesiculated
生殖巣内に、小さな、液体で満たされた無核で球状の、膜で囲まれた構造物が存在する。 [GO:0031982, WB:WBPaper00038381, WB:WBPerson557]
"Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad." [GO:0031982, WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001355:生殖巣の小胞化
WBPhenotype:0001355:gonad morphology variant
成長速度の変化
growth rate variant
個体の大きさや重さの増加の仕方が、生涯を通して、もしくは任意の成長段階において、コントロールと異なる。 [GO:0040007, WB:WBPerson712]
"The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals." [GO:0040007, WB:WBPerson712]
WBPhenotype:0000030:成長速度の変化
WBPhenotype:0000030:growth variant
成長の変化
growth variant
コントロールと比べ、細胞や組織、器官、個体のようなまとまった生命単位の大きさや質量の変化 (増加)を制御するなんらかの過程に異常が見られる。 [GO:0040007, WB:WBPerson2021]
"Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals." [GO:0040007, WB:WBPerson2021]
WBPhenotype:0000577:成長の変化
WBPhenotype:0000577:organism homeostasis metabolism variant
腸内顆粒の発達異常
gut granule development variant
複屈折性結晶体や他の暗色のエンドソームが含まれる腸細胞質内での異なる封入体の発達になんらかの変化がコントロールに比べて見られる。C. elegansではこれらの内容物には、グリコーゲン顆粒(多糖類の貯蔵)やrhabditin(炭水化物の貯蔵)、卵黄顆粒(脂質やタンパク質)、あるいは凝縮された排泄物が含まれる。 [WB:WBPerson2021, WB:WBPerson557]
"Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000705:腸内顆粒の発達異常
WBPhenotype:0000705:intestinal cell development variant
head bend angle variant
"Any variation in the extent of the maximum flex of the most anterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0001265:head movement variant
頭部の形態変化
head morphology variant
体の前部の任意の部分(神経環によって支配されている感覚子や咽頭、すべての筋肉などは代表例である)の形態や構造、組成におけるなんらかの変化がコントロールに比べて見られる。 [WB:WBPerson2021, WB:WBPerson557]
"Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000582:頭部の形態変化
WBPhenotype:0000582:organism segment morphology variant
ヘパラン硫酸生合成異常
heparan sulfate biosynthesis variant
ヘパラン硫酸プロテオグリカンを合成する化学反応や代謝経路になんらかの変化がコントロールに比べて見られる。 [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712]
"Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712]
WBPhenotype:0001696:ヘパラン硫酸生合成異常
WBPhenotype:0001696:biosynthesis variant
雌雄同体の稔性低下
hermaphrodite fertility reduced
雌雄同体における産仔数が、配偶子の応答能や機能の欠損により減少する。 [WB:WBPerson557,WB:WBPerson2021]
"Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000806:雌雄同体の稔性低下
WBPhenotype:0000806:hermaphrodite fertility variant
雌雄同体の自家不稔
hermaphrodite self sterile
雌雄同体において、自家受精で生きた仔を産生できない。ただし、野生型の雄と交配すると正常に生殖可能である。 [WB:WBPaper00001075,WB:WBPerson2021]
"Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males." [WB:WBPaper00001075, WB:WBPerson2021]
WBPhenotype:0000694:雌雄同体の自家不稔
WBPhenotype:0000694:hermaphrodite sterile
雌雄同体の不稔
hermaphrodite sterile
雌雄同体において、自家受精によっても交配によっても生きた仔を産生できない。 [WB:WBPerson557,WB:WBPerson2021]
"Hermaphrodites fail to generate viable self-progeny and/or cross-progeny." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000688:雌雄同体の不稔
WBPhenotype:0001259:雌雄同体の不稔
WBPhenotype:0000688:sterile
WBPhenotype:0001259:hermaphrodite fertility reduced
雄の発生頻度増加
high incidence male progeny
X染色体不分離の増加により、雄の子孫がコントロールよりも多く生まれる。 [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712]
"Higher numbers of male progeny occur in the population compared to control populations. In C. elegans, the high incidence of males phenotype in a self-fertilizing hermaphrodite population is a result of an increase in X chromosome nondisjunction." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712]
WBPhenotype:0001664:雄の発生頻度増加
WBPhenotype:0001664:X chromosome nondisjunction
HSN(雌雄同体特異的ニューロン)の遊走の変化
HSN migration variant
コントロールと比べ、HSN(雌雄同体特異的ニューロン)運動ニューロンが尾部で生じてから胚の中央付近まで前方に移動する運動になんらかの変化が見られる。 [WB:WBPaper00001836, WB:WBPerson2021]
"Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals." [WB:WBPaper00001836, WB:WBPerson2021]
WBPhenotype:0001229:HSN(雌雄同体特異的ニューロン)の遊走の変化
WBPhenotype:0001229:anterior neuron migration defective
皮下細胞の伸長の欠損
hypodermal cell elongation defective
表皮組織形成中、胚の伸長に必要な皮下細胞の特徴的な形の変化が、正常に行われない。 [WB:WBPaper00003991,WB:WBPerson712]
"During epidermal morphogenesis, hypodermal cells do not properly undergo the characteristic cell shape changes necessary for the embryo to elongate." [WB:WBPaper00003991, WB:WBPerson712]
WBPhenotype:0000701:皮下細胞の伸長の欠損
WBPhenotype:0000701:epithelial development variant
皮下組織構成の異常
hypodermis disorganized
皮下細胞がコントロールと同じように組織化されない。C. elegansでは、皮下細胞は通常それぞれ背側、側面、腹側に整列し、体全体を覆っている。 [WB:WBPaper00027006, WB:WBPerson2021]
"Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body." [WB:WBPaper00027006, WB:WBPerson2021]
WBPhenotype:0000703:皮下組織構成の異常
WBPhenotype:0000703:epithelial morphology variant
腸の蛍光強度増加
intestinal fluorescence increased
腸内で蛍光を発する生体色素や他の物質の蓄積や発現が増加している。 [WB:WBPerson557]
"Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson557]
WBPhenotype:0000293:腸の蛍光強度増加
WBPhenotype:0000293:alimentary system pigmentation variant
腸の形態異常
intestinal morphology variant
食物の通過を助ける微柔毛が並んだ内腔中枢を形成している立方状の細胞の形態や構造、組成の変化がコントロールに比べて見られる。食物は咽頭後部から腸へ流れて消化され、排泄物を排出する直腸へと入る。 [WB:WBPerson2021, WB:WBPerson557]
"Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000598:腸の形態異常
WBPhenotype:0000598:alimentary system morphology variant
L1致死
L1 lethal
L1幼虫期に死んでしまう。 [WB:WBPerson2021]
"Animals die at the L1 stage of the life cycle." [WB:WBPerson2021]
WBPhenotype:0000057:L1致死
WBPhenotype:0000057:early larval lethal
幼虫発育停止
larval arrest
幼虫期のどこかで発生プログラムが停止してしまうため、成虫になれない。C. elegansのL1-L4のいずれでも起こりうる。 [WB:WBPaper00002958, WB:WBPerson2021]
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
WBPhenotype:0000750:幼虫発育停止
WBPhenotype:0001016:幼虫発育停止
WBPhenotype:0000750:larval development variant
WBPhenotype:0001016:larval growth variant
幼虫致死
larval lethal
孵化してから成虫になり始めるまでのどこかで死んでしまう。 [GO:0002119, WB:WBPerson712]
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
WBPhenotype:0000062:幼虫致死
WBPhenotype:0000062:lethal
後期胚発生停止
late embryonic arrest
胚発生の最終段階で発生が停止する。C. elegansでこの段階は、20℃では通常、最初の分裂の620-800分後、つまり伸長期のあとに起こる。 [WB:WBPerson101]
"Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation." [WB:WBPerson101]
WBPhenotype:0000867:後期胚発生停止
WBPhenotype:0000867:embryonic arrest
致死
lethal
ライフサイクルのいずれかの未熟な段階で死んでしまう。 [WB:WBPaper00001109, WB:WBPerson2021]
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
WBPhenotype:0000531:致死
WBPhenotype:0000531:organism development variant
寿命の変化
life span variant
コントロールと比べて寿命が延長、または短縮する。 [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557]
"Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557]
WBPhenotype:0000576:寿命の変化
WBPhenotype:0000576:organism physiology variant
移動行動の変化
locomotion variant
個体培地上での自己推進運動がコントロールと比べて異なっている。 [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
"Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712]
WBPhenotype:0001206:移動行動の変化
WBPhenotype:0001206:movement variant
体が長い
long
同じ発生段階のコントロールと比べて体が細長い。 [WB:cab, WB:cgc31]
"Animals are longer than control animals at the same developmental stage." [WB:cab, WB:cgc31]
WBPhenotype:0001726:体が長い
WBPhenotype:0001726:body length variant
腫瘤ができる
lumpy
コントロールでは見られない隆起や突起が体表面に見られる。 [WB:WBPerson557]
"Animals have protrusions or bumps on their exterior which are not characteristic of control animals." [WB:WBPerson557]
WBPhenotype:0000535:腫瘤ができる
WBPhenotype:0000535:organism morphology variant
リソソーム系細胞小器官の形態変化
lysosome-related organelle morphology variant
リソソームのように、内側が酸性で一般的に細胞を消化する特有の機能や構成、形態をもったリソソーム系細胞小器官(LROs)として知られる膜系小器官(リソソームとは、機能や組成、形態がはっきり異なっている)の形態や組成に、コントロールと比べてなんらかの変化が見られる。 [WB:WBPaper00041129, WB:WBPerson2987]
"Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987]
WBPhenotype:0002089:リソソーム系細胞小器官の形態変化
WBPhenotype:0002089:cell component morphology variant
母性不稔
maternal sterile
実験処理によって全く、もしくはごく僅かな数の胚しか産生できなくなる。これは遺伝的摂動による不稔(母性効果による不稔)と対照的である。 Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility).
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
WBPhenotype:0000694:母性不稔
WBPhenotype:0000694:hermaphrodite sterile
減数分裂における染色体分離の変化
meiotic chromosome segregation variant
減数分裂の際に遺伝子から染色体が構築されたのち物理的に分離し、2つ以上に配分される過程において、コントロールと比べてなんらかの変化が見られる。 [GO:0045132, WB:WBPerson2021, WB:WBPerson557]
"Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control." [GO:0045132, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000773:減数分裂における染色体分離の変化
WBPhenotype:0000773:chromosome segregation variant
膜輸送の変化
membrane trafficking variant
コントロールと比較して、細胞内で、膜の一方から他方への物質の定方向性移動の動きになんらかの変化が見られる。 [GO:0005215, WB:WBPaper00025137, WB:WBPerson2021]
"Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control." [GO:0005215, WB:WBPaper00025137, WB:WBPerson2021]
WBPhenotype:0000536:膜輸送の変化
WBPhenotype:0000536:cell physiology variant
代謝経路の変化
metabolic pathway variant
化学的変化を司る過程になんらかの変化がコントロールに比べて見られる。代謝過程では通常、低分子を変化させるが、それだけではなく、DNAの修復や複製、タンパク質の合成や分解といった高分子の処理もこれに含まれる。 [GO:0008152, WB:WBPerson712]
"Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GO:0008152, WB:WBPerson712]
WBPhenotype:0000027:代謝経路の変化
WBPhenotype:0000027:organism metabolism processing variant
mid larval lethal
"Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle." [WB:WBPerson2021]
WBPhenotype:0000054:larval lethal
脱皮の異常
molt defect
各幼虫期に起こるクチクラの交換において、クチクラの一部または全体の定期的な脱皮に欠陥がある。 [GO:0018996, WB:WBPerson712]
"Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage." [GO:0018996, WB:WBPerson712]
WBPhenotype:0002041:脱皮の異常
WBPhenotype:0002041:molt variant
脱皮の変化
molt variant
脱皮のタイミングあるいは脱皮能力に変化がみられる。 [WB:WBPaper00040467,WB:WBPerson712]
"Animals exhibit variation in timing or ability to molt." [WB:WBPaper00040467, WB:WBPerson712]
WBPhenotype:0000750:脱皮の変化
WBPhenotype:0000750:larval development variant
mRNA量増加
mRNA levels increased
コントロールに比べメッセンジャーRNAの量が多い。 [WB:WBPaper00033456, WB:WBPerson2021]
"Animals exhibit elevated levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021]
WBPhenotype:0000114:mRNA量増加
WBPhenotype:0000114:mRNA expression variant
mRNA量減少
mRNA levels reduced
コントロールに比べメッセンジャーRNAの量が少ない。 [WB:WBPaper00033456, WB:WBPerson2021]
"Animals exhibit decreased levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021]
WBPhenotype:0000114:mRNA量減少
WBPhenotype:0000114:mRNA expression variant
mRNAの監視機構の欠損
mRNA surveillance defective
mRNA分解に用いられる異常なmRNA(終止コドンや、スプライシングエラー、非翻訳領域の変化など)を標的して分解する機構に欠陥がある。C. elegansでこのような遺伝子の変異は、しばしば特定のアレル表現型のアレル特異的・遺伝子非特異的劣性サプレッサーとしてはたらき、雄や雌雄同体の生殖器官の形態形成に異常をきたす。 [WB:WBPaper00001192, WB:WBPaper00004926]
"Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926]
WBPhenotype:0000028:mRNAの監視機構の欠損
WBPhenotype:0000028:RNA processing variant
初期胚における複数の細胞質空洞
multiple cytoplasmic cavities early emb
胚発生初期に、複数の小胞や液胞、空洞が見られる。 [cgc:5599, WB:cab]
"Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab]
WBPhenotype:0001081:初期胚における複数の細胞質空洞
WBPhenotype:0001081:cytoplasmic morphology defective early emb
初期胚の多核
multiple nuclei early emb
1細胞期から4細胞期の1 つの細胞につき2つ以上の核をもっているため死んでしまう。 [WB:cab, WB:cgc5599]
"Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599]
WBPhenotype:0000746:初期胚の多核
WBPhenotype:0001142:初期胚の多核
WBPhenotype:0001894:初期胚の多核
WBPhenotype:0000746:cell division variant
WBPhenotype:0001142:nuclear number defective early emb
WBPhenotype:0001894:nuclear number variant
卵母細胞の多核
multiple nuclei oocyte
一倍体の雌性生殖細胞(卵母細胞)が2つ以上の核をもっている。 [WB:WBPaper00038381, WB:WBPerson557]
"Haploid female germ cells (oocytes) contain more than one nucleus." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0000186:卵母細胞の多核
WBPhenotype:0001260:卵母細胞の多核
WBPhenotype:0001894:卵母細胞の多核
WBPhenotype:0000186:oogenesis variant
WBPhenotype:0001260:oocyte morphology variant
WBPhenotype:0001894:nuclear number variant
神経系の形態変化
nervous system morphology variant
個体内や外部環境情報の検知や中継、協調を行ったり、エフェクターの応答や活動を開始・統合するはたらきをもつ器官の構成成分のどこかに、構造や組成の変化がコントロールに比べて見られる。 [WB:WBPerson712]
"Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson712]
WBPhenotype:0000534:神経系の形態変化
WBPhenotype:0000534:organ system morphology variant
neuron cell body absent misplaced
"The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced." [WB:WBPaper00000502, WB:WBPaper00000635, WB:WBPerson712]
WBPhenotype:0000816:neuron development variant
ニューロンの形態変化
neuron morphology variant
コントロールとべて、神経細胞の内部や細胞環境に関係した部分の構造や組成になんらかの変化が見られる。ニューロンは活動電位のパターンの形での情報伝達に特化した、神経組織の主要な細胞タイプである。 [WB:cab, WB:WBPerson712]
"Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses." [WB:cab, WB:WBPerson712]
WBPhenotype:0000604:ニューロンの形態変化
WBPhenotype:0002108:ニューロンの形態変化
WBPhenotype:0000604:nervous system morphology variant
WBPhenotype:0002108:cell type morphology variant
ニコチン過敏
nicotine hypersensitive
コントロールよりも低濃度または短時間のニコチン曝露に反応してしまう。ニコチンはコリン作動薬(アセチルコリン受容体刺激薬)である。 [WB:cab, WB:cgc7388, WB:WBPerson557]
"Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist." [WB:cab, WB:cgc7388, WB:WBPerson557]
WBPhenotype:0001573:ニコチン過敏
WBPhenotype:0001579:ニコチン過敏
WBPhenotype:0001573:nicotine response variant
WBPhenotype:0001579:cholinergic agonist hypersensitive
卵母細胞がない
no oocytes
雌雄同体が、受精可能な完全に分化した雌性配偶子をもたない。 [WB:WBPerson2021]
"Hermaphrodites lack fully specialized female gametes that are competent for fertilization." [WB:WBPerson2021]
WBPhenotype:0000395:卵母細胞がない
WBPhenotype:0000395:no differentiated gametes
ナンセンスmRNAの蓄積
nonsense mRNA accumulation
中途での終止コドンをもち、ポリAテイルをもたない3'末端へと変化したmRNA転写物の制御された分解が減少している。 [GO:0070478, WB:WBPerson2021, WB:WBPerson557]
"Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail." [GO:0070478, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000027:ナンセンスmRNAの蓄積
WBPhenotype:0000027:organism metabolism processing variant
nose movement increased
"Animals exhibit an increase in the movement of the extreme anterior portion of the body to a new location compared to control." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002301:nose movement variant
核の外見の変化
nuclear appearance variant
核の外見形態がコントロールと異なる。 [WB:cab]
"The morphological appearance of nuclei differs from control animals." [WB:cab]
WBPhenotype:0002089:核の外見の変化
WBPhenotype:0002089:cell component morphology variant
核の脱落
nuclear fallout
核が発生中の生殖細胞区画から共通細胞質(rachis)に脱落している。 [WB:WBPaper00038381, WB:WBPerson557]
"Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001952:核の脱落
WBPhenotype:0001952:germline nuclear positioning variant
核が小さい
nuclei small
特定の細胞の核がコントロールに比べて小さい。 [WB:WBPerson557]
"Nuclei of specific cells are smaller compared to control animals." [WB:WBPerson557]
WBPhenotype:0001028:核が小さい
WBPhenotype:0001028:nuclear appearance variant
初期胚1細胞期での発生停止
one cell arrest early emb
胚が分裂せずに1細胞期で発生を停止する。 [WB:WBPerson48,WB:WBPaper00005599]
"Embryos fail to divide and arrest as one-cell embryos." [WB:cab, WB:cgc5599]
WBPhenotype:0001100:初期胚1細胞期での発生停止
WBPhenotype:0001100:early embryonic lethal
卵母細胞の蓄積
oocyte accumulation
核内有糸分裂をせず生殖器内に蓄積している卵母細胞の数がコントロールと比べ増加している。 [WB:WBPaper00006281, WB:WBPaper00030855]
"An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. " [WB:WBPaper00006281, WB:WBPaper00030855]
WBPhenotype:0001260:卵母細胞の蓄積
WBPhenotype:0001260:oocyte morphology variant
卵母細胞の形態変化
oocyte morphology variant
コントロールと比較して、区画化されて細胞にわかれた一倍体の雌性生殖細胞(卵母細胞)の全体構造や外見、内容に変化が見られる。 [WB:WBPaper00001883, WB:WBPerson2021]
"Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021]
WBPhenotype:0000900:卵母細胞の形態変化
WBPhenotype:0000900:germ cell morphology variant
卵母細胞数減少
oocyte number decreased
生殖腺に存在する区画化されて細胞にわかれた一倍体の雌性生殖細胞(卵母細胞)の数がコントロールに比べて少ない。 [WB:WBPaper00038381, WB:WBPerson557]
"A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0000186:卵母細胞数減少
WBPhenotype:0001260:卵母細胞数減少
WBPhenotype:0000186:oogenesis variant
WBPhenotype:0001260:oocyte morphology variant
卵母細胞隔壁の形成異常
oocyte septum formation variant
卵母細胞どうしを仕切る隔壁に、コントロールと比べ変化が見られる。 [WB:WBPaper00028947]
"Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947]
WBPhenotype:0000399:卵母細胞隔壁の形成異常
WBPhenotype:0000399:somatic gonad development variant
卵母細胞の無核
oocytes lack nucleus
一倍体の雌性生殖細胞(卵母細胞)が核をもたない。 [WB:WBPaper00038381, WB:WBPerson557]
"Haploid female germ cells (oocytes) lack a nucleus." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0000186:卵母細胞の無核
WBPhenotype:0001260:卵母細胞の無核
WBPhenotype:0000186:oogenesis variant
WBPhenotype:0001260:oocyte morphology variant
卵母細胞が小さい
oocytes small
一倍体の雌性生殖細胞(卵母細胞)の大きさがコントロールと比べ極端に小さい。 [WB:WBPaper00038381, WB:WBPerson557]
"The size of haploid female germ cells (oocytes) are significantly smaller compared to control." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001260:卵母細胞が小さい
WBPhenotype:0001260:oocyte morphology variant
卵母細胞形成の変化
oogenesis variant
コントロールと比較して、卵母細胞の産生や成熟に関与する過程になんらかの変化が見られる。 [GO:0048477, WB:WBPerson2021]
"Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals." [GO:0048477, WB:WBPerson2021]
WBPhenotype:0000894:卵母細胞形成の変化
WBPhenotype:0000894:germ cell differentiation variant
個体発生の変化
organism development variant
受精から成虫になるまでのどこかで何らかの発生の変化が見られる。 [WB:cab]
"Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab]
WBPhenotype:0000518:個体発生の変化
WBPhenotype:0000518:development variant
organism heat hypersensitive
"Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557]
WBPhenotype:0001273:organism heat response variant
organism high sodium chloride hypersensitive
"Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab]
WBPhenotype:0000876:organism osmotic stress response variant
個体の恒常性代謝の変化
organism homeostasis metabolism variant
コントロールと比べ、個体の恒常状態維持に関わる化学反応や経路に変化が見られる。 [GO:0048871, WB:WBPerson2021, WB:WBPerson557]
"Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the organism compared to control." [GO:0048871, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000576:個体の恒常性代謝の変化
WBPhenotype:0000576:organism physiology variant
体の脱水に対して過敏
organism hypersensitive desication
コントロールよりも軽度の乾燥条件や短時間の曝露に反応する。 [WB:WBPerson2021]
"Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021]
WBPhenotype:0001417:体の脱水に対して過敏
WBPhenotype:0001417:organism desication response variant
個体の代謝機能の変化
organism metabolism processing variant
生物が化学物質を変換するための同化・異化作用を含む化学反応や経路に、コントロールと比べて変化が見られる。 [GO:0008152, WB:WBPerson2021, WB:WBPerson557]
"Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control." [GO:0008152, WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000577:個体の代謝機能の変化
WBPhenotype:0000577:organism homeostasis metabolism variant
個体の形態変化
organism morphology variant
個体の解剖学的構造のどこかの形態や構造、組成がコントロールと比べ変化している。 [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
WBPhenotype:0000520:個体の形態変化
WBPhenotype:0000520:morphology variant
酸化ストレス耐性
organism oxidative stress resistant
コントロールでは反応を誘発する活性酸素種の濃度に反応しない。 [WB:WBPerson2021]
"Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals." [WB:WBPerson2021]
WBPhenotype:0001620:酸化ストレス耐性
WBPhenotype:0001620:organism oxidative stress response variant
病原体応答の変化
organism pathogen response variant
コントロールと比べ、病気を引き起こす病原体に対する応答に変化が見られる。病原体応答には、攻撃によって引き起こされる感染の予防や損傷制御、回復が含まれる。 [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712]
"Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack." [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712]
WBPhenotype:0000738:病原体応答の変化
WBPhenotype:0000738:organism environmental stimulus response variant
個体のストレス応答の変化
organism stress response variant
ストレス刺激に対する応答にコントロールと比べ変化が見られる。 [GO:0006950, WB:WBPerson712]
"Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712]
WBPhenotype:0000738:個体のストレス応答の変化
WBPhenotype:0000738:organism environmental stimulus response variant
個体の有毒化学物質応答の変化
organism toxic chemical response variant
特定の有毒な化学物質に対する応答にコントロールと比べ変化が見られる。 [WB:WBPerson557]
"Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557]
WBPhenotype:0000523:個体の有毒化学物質応答の変化
WBPhenotype:0000523:chemical response variant
卵母細胞形成におけるパキテン期進行変化
pachytene progression during oogenesis variant
発達中の卵母細胞のパキテン期の開始や進行、終了にコントロールと比べて異常がある。パキテン期とは減数第一分裂前期の第三段階で、相同染色体の染色分体が互いに交差する。 [GO:0000239, WB:WBPaper00038381, WB:WBPerson557]
"Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GO:0000239, WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001824:卵母細胞形成におけるパキテン期進行変化
WBPhenotype:0001824:meiotic progression prophase variant
パキテン期部位の構造異常
pachytene region organization variant
コントロールに較べて、生殖巣のパキテン期部位にある生殖細胞の核の構成に異常が見られる。C. elegansの生殖巣ではパキテン領域の細胞は、transition zoneのすぐ直後の近位側から始まり、減数分裂前期からレプトテン期・ザイゴテン期に移行する。 [WB:WBPaper00038381, WB:WBPerson557]
"Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas)." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001355:パキテン期部位の構造異常
WBPhenotype:0001946:パキテン期部位の構造異常
WBPhenotype:0001355:gonad morphology variant
WBPhenotype:0001946:pachytene progression during oogenesis variant
体色が蒼白
pale
体色の彩度が不足し、透過性が増加している。 [WB:WBPerson2021, WB:WBPerson557]
"Animals show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000527:体色が蒼白
WBPhenotype:0000527:organism pigmentation variant
麻痺
paralyzed
動かず、外部からの機械的刺激に対して反応しない。 [WB:cab]
"Animals do not move and are not responsive to external mechanical stimulation." [WB:cab]
WBPhenotype:0001213:麻痺
WBPhenotype:0001213:locomotion reduced
麻痺による2つ折れ期の伸長停止
paralyzed arrested elongation two fold
2つ折れ期で動きや伸長が停止する。体壁筋細胞に存在する筋フィラメントの格子に変化がみとめられる。しかし胚内部での発生は継続する。胚が孵化した後、幼虫は生きることができない。 [WB:cab, WB:cgc1894]
"Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894]
WBPhenotype:0000050:麻痺による2つ折れ期の伸長停止
WBPhenotype:0000494:麻痺による2つ折れ期の伸長停止
WBPhenotype:0000050:embryonic lethal
WBPhenotype:0000494:two fold arrest
paraquat hypersensitive
"Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557]
WBPhenotype:0000460:paraquat response variant
paraquat resistant
"Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557]
WBPhenotype:0000460:paraquat response variant
斑状色分布
patchy coloration
生体色素や他の物質が不均一に分布しているため、透過性がコントロールと比較して、大変異なっている。 [WB:WBPerson2021, WB:WBPerson557]
"Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000527:斑状色分布
WBPhenotype:0000527:organism pigmentation variant
path curvature increased
"Animals exhibit increases in the extent to which the overall path of movement is curved, producing tighter and more frequent curves compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002335:path curvature variant
病原体付着性の変化
pathogen adherence defect
病原体が宿主表面に付着し接着/定着することが出来ない。これはしばしば宿主のクチクラ表面の性質の変化に起因する。 [WB:WBPaper00028877,WB:WBPerson2021]
"Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host." [WB:WBPaper00028877, WB:WBPerson2021]
WBPhenotype:0001014:病原体付着性の変化
WBPhenotype:0001415:病原体付着性の変化
WBPhenotype:0001014:pathogen resistance increased
WBPhenotype:0001415:pathogen adherence variant
病原体誘発性死亡の増加
pathogen induced death increased
コントロールと比べ、感染によってより死亡しやすい。 [WB:WBPerson2021, WB:WBPerson557]
"Animals are more prone to lethality as a result of infection compared to control." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0001013:病原体誘発性死亡の増加
WBPhenotype:0001013:pathogen susceptibility increased
病原体耐性増大
pathogen resistance increased
コントロールと比べ、より感染しにくい。 [WB:WBPerson2021, WB:WBPerson557]
"Animals are less prone to infection compared to control." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0001012:病原体耐性増大
WBPhenotype:0001012:organism pathogen response variant
導入遺伝子発現パターンの変化
pattern of transgene expression variant
コントロールと比較して、体内に導入された外来DNA由来の遺伝子産物の細胞/細胞内発現パターンに変化が見られる。 [WB:WBPerson557]
"Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
WBPhenotype:0000306:導入遺伝子発現パターンの変化
WBPhenotype:0000306:transgene expression variant
pausing variant
"Animals exhibit variations in the amount of time spent in a paused state, which is neither moving forward or backward, compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0001213:locomotion reduced
殺虫剤応答性の変化
pesticide response variant
コントロールに比べて、殺虫に使用されるあらゆる化学物質に対する反応に変化が見られる。 [WB:WBPerson557]
"Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals." [WB:WBPerson557]
WBPhenotype:0000738:殺虫剤応答性の変化
WBPhenotype:0000738:organism environmental stimulus response variant
咽頭発生の変化
pharyngeal development variant
咽頭(摂餌器官)の形成開始から成熟に至るまでの時間とともにおこる変化がコントロールと比べて変化している。C. elegansの咽頭は前部と後部に分かれている。前部は、corpusとよばれ前部corpusと後部corpusからなる一つ目の球状体bulbであり、後部は峡部(2つ目の球状体である末端球状体terminal bulb)を含む。 [GO:0043282,WB:WBPerson2021]
"Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb)." [GO:0043282, WB:WBPerson2021]
WBPhenotype:0000617:咽頭発生の変化
WBPhenotype:0000617:alimentary system development variant
咽頭ポンピング率の変化
pharyngeal pumping rate variant
咽頭の筋肉によって起きる協調的な収縮サイクル(ポンピング)の回数がコントロールと異なる。 [WB:WBPaper00001709, WB:WBPerson712]
"The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals." [WB:WBPaper00001709, WB:WBPerson712]
WBPhenotype:0000634:咽頭ポンピング率の変化
WBPhenotype:0000634:pharyngeal pumping variant
pharyngeal pumping reduced
"Pharyngeal pumping motion occurs at a slower rate than control animals." [WB:WBPaper00001709]
WBPhenotype:0001006:pharyngeal pumping rate variant
咽頭の非付着
pharynx unattached
咽頭が口から解離している。 [WB:WBPaper00031910,WB:WBPerson712]
"The pharynx or pharyngeal muscle does not form a functional connection to the mouth or buccal cavity." [WB:WBPaper00031910, WB:WBPerson712]
WBPhenotype:0000707:咽頭の非付着
WBPhenotype:0000707:pharyngeal development variant
フェロモン誘発性耐性幼虫形成欠損
pheromone induced dauer formation defective
コントロールではダウアー(耐性幼虫)形成を誘因することができる化学物質に曝されても、ダウアーにならない。 [WB:WBPerson2021, WB:WBPerson557]
"Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000013:フェロモン誘発性耐性幼虫形成欠損
WBPhenotype:0000132:フェロモン誘発性耐性幼虫形成欠損
WBPhenotype:0000013:dauer defective
WBPhenotype:0000132:pheromone induced dauer formation variant
初期胚における極体放出異常
polar body extrusion defective early emb
極体が放出されなかった、または吸収されたことにより、P0細胞に過剰のPN(前核)が形成されたり、AB細胞/P1細胞に過剰の染色体胞が生じる。 [WB:cab, WB:cgc7141]
"Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1." [WB:cab, WB:cgc7141]
WBPhenotype:0000775:初期胚における極体放出異常
WBPhenotype:0001147:初期胚における極体放出異常
WBPhenotype:0000775:meiosis variant
WBPhenotype:0001147:polar body defective early emb
膜孔形成毒素過敏
pore forming toxin hypersensitive
コントロールよりも低濃度や短時間の膜孔形成毒素への曝露で反応する。膜孔形成毒素(例:バチルス・チューリンゲンシス菌のCry5B)への感受性増大は、しばしば膜孔形成毒素存在下での生存率がコントロールよりも低いことによって明らかになる。 [WB:WBPerson2987, WB:WBPerson557]
"Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0000010:膜孔形成毒素過敏
WBPhenotype:0002058:膜孔形成毒素過敏
WBPhenotype:0000010:drug hypersensitive
WBPhenotype:0002058:pore forming toxin response variant
膜孔形成毒素耐性
pore forming toxin resistant
コントロールにおいては反応を誘発するような膜孔形成毒素濃度に反応しない。あるいは反応を誘発するためには、コントロールより高濃度または長時間膜孔形成毒素に曝される必要がある。 [WB:WBPerson557,WB:WBPerson2987]
"Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0000011:膜孔形成毒素耐性
WBPhenotype:0002058:膜孔形成毒素耐性
WBPhenotype:0000011:drug resistant
WBPhenotype:0002058:pore forming toxin response variant
雌雄同体への接触後の、雄の行動変化
post hermaphrodite contact variant
コントロールと比べて、雄が交配相手に接触した後の行動に変化が見られる。 [WB:WBPerson557]
"Males exhibit variations in mating behavior after contacting its mate compared to control." [WB:WBPerson557]
WBPhenotype:0000648:雌雄同体への接触後の、雄の行動変化
WBPhenotype:0000648:male mating variant
前シナプス部の形態変化
presynaptic region morphology variant
コントロールと比べ、シナプス小胞で満たされた結節状構造の構造や配置、分布、割合に変化が見られる。 [GO:0042734,WB:WBPaper00000938,WB:WBPaper00027305,WB:WBPaper00028886,WB:WBPerson712]
"Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control." [GO:0042734, WB:WBPaper00000938, WB:WBPaper00027305, WB:WBPaper00028886, WB:WBPerson712]
WBPhenotype:0000616:前シナプス部の形態変化
WBPhenotype:0000616:synapse morphology variant
初期胚における前核中心体の異常
pronucleus centrosomes defective early emb
生存できない胚の前核が異常。 [WB:cab, WB:WBPerson1815]
"Pronucleus is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815]
WBPhenotype:0001034:初期胚における前核中心体の異常
WBPhenotype:0001034:pronuclear nuclear appearance defective early emb
タンパク質凝集の変化
protein aggregation variant
特定の細胞や組織での可溶性または不溶性タンパク質凝集体の蓄積をもたらすような変化が、コントロールに比べて見られる。タンパク質凝集体は、しばしばミスフォールドタンパク質やフォールディング異常があるタンパク質の相互作用によって形成される。 [WB:WBPaper00034765, WB:WBPerson2021]
"Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021]
WBPhenotype:0001370:タンパク質凝集の変化
WBPhenotype:0001370:protein protein interaction variant
タンパク質の発現減少
protein expression reduced
タンパク質の発現が標準量より低下するなんらかの変化がコントロールに比べて見られる。 [WB:kmva]
"Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva]
WBPhenotype:0001400:タンパク質の発現減少
WBPhenotype:0001400:level of protein expression variant
タンパク質修飾の変化
protein modification variant
タンパク質やペプチド、新生ポリペプチド(翻訳時、翻訳後修飾)で起こっている1つ以上のアミノ酸の共有結合による修飾に、コントロールと比べ変化が見られる。これには、アミノアシルtRNAの修飾(翻訳前修飾)の結果ひきおこされるタンパク質の修飾も含まれる。 [GO:0006464,WB:WBPerson2021]
"Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021]
WBPhenotype:0000112:タンパク質修飾の変化
WBPhenotype:0000112:protein expression variant
タンパク質のリン酸化増加
protein phosphorylation increased
コントロールに比べてタンパク質のリン酸化が増加している。 [WB:WBPerson2021]
"Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021]
WBPhenotype:0001349:タンパク質のリン酸化増加
WBPhenotype:0001349:protein phosphorylation variant
タンパク質の細胞内局在に変化
protein subcellular localization variant
コントロールと比べて、細胞内、または細胞区画に存在するタンパク質の配置になんらかの変化が見られる。 [WB:WBPerson557]
"Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557]
WBPhenotype:0001408:タンパク質の細胞内局在に変化
WBPhenotype:0001408:pattern protein expression variant
バルバが突出
protruding vulva
バルバ(産卵口)の形成が不完全なため、バルバの位置には一つの突起が見られるだけである。 [WB:WBPaper00004408, WB:WBPerson2021]
"Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021]
WBPhenotype:0000695:バルバが突出
WBPhenotype:0000695:vulva morphology variant
初期胚における偽卵割溝の欠陥
pseudocleavage defective early emb
偽卵割溝が異型なため、胚が1細胞期で死んでしまう。 [WB:cab, WB:WBPerson1815]
"Pseudocleavage is atypical in the inviable one-cell embryo." [WB:cab, WB:WBPerson1815]
WBPhenotype:0001100:初期胚における偽卵割溝の欠陥
WBPhenotype:0001100:early embryonic lethal
Q neuroblast lineage migration variant
"The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals." [WB:WBPaper00001954, WB:WBPaper00031356, WB:WBPerson712]
WBPhenotype:0001140:neuron migration variant
RAB-11リサイクリングエンドソームの局在に変化
RAB-11 recycling endosome localization variant
RABタンパク質RAB-11陽性であるリサイクリングエンドソームとして知られる膜系小器官の細胞内局在になんらかの変化が見られる。このリサイクリングエンドソームは、初期エンドソームから細胞膜へと物質を逆輸送することにより、最近にエンドサイトーシスを受けた物質が細胞膜で再利用されるようにする。 [WB:WBPaper00041129, WB:WBPerson2987]
"Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
WBPhenotype:0002104:RAB-11リサイクリングエンドソームの局在に変化
WBPhenotype:0002104:recycling endosome localization variant
RAB-11リサイクリングエンドソームの形態変化
RAB-11 recycling endosome morphology variant
RABタンパク質RAB-11陽性であるリサイクリングエンドソームとして知られる膜系小器官の形態や組成になんらかの変化が見られる。このリサイクリングエンドソームは、初期エンドソームから細胞膜へと物質を逆輸送することにより、最近にエンドサイトーシスを受けた物質が細胞膜で再利用されるようにする。 [WB:WBPaper00041129, WB:WBPerson2987]
"Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987]
WBPhenotype:0002093:RAB-11リサイクリングエンドソームの形態変化
WBPhenotype:0002093:recycling endosome morphology variant
共通細胞質(rachis)がない
rachis absent
生殖巣のコア構造を形成する無核の細胞質であるrachisが存在しない。 [WB:WBPaper00038381, WB:WBPerson557]
"The nucleus-free core of germline cytoplasm in the gonad is missing." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001940:共通細胞質(rachis)がない
WBPhenotype:0001940:rachis morphology variant
共通細胞質(rachis)の形態変化
rachis morphology variant
生殖巣の細胞質のコア構造を形成する無核の細胞質(rachis)の形態や構造、組成に、コントロールと比べ変化が見られる。C. elegansの生殖腺では、有糸分裂を終えてそして減数分裂に突入した核は細胞膜に部分的に包まれた形で表層に沿って並んでおり、細胞質部分はrachisと呼ばれる無核の生殖腺細胞質を形成している。 [WB:WBPaper00031889, WB:WBPerson557]
"Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557]
WBPhenotype:0001355:共通細胞質(rachis)の形態変化
WBPhenotype:0001355:gonad morphology variant
共通細胞質(rachis)が狭い
rachis narrow
生殖巣にある無核の細胞質(rachis)がコントロールほど幅広くない。 [WB:WBPaper00038381, WB:WBPerson557]
"The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001940:共通細胞質(rachis)が狭い
WBPhenotype:0001940:rachis morphology variant
共通細胞質(rachis)が広い
rachis wide
生殖巣にある無核の細胞質(rachis)の幅がコントロールと比べて大きい。 [WB:WBPaper00038381, WB:WBPerson557]
"The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals." [WB:WBPaper00038381, WB:WBPerson557]
WBPhenotype:0001940:共通細胞質(rachis)が広い
WBPhenotype:0001940:rachis morphology variant
受容体媒介性エンドサイトーシスの異常
receptor mediated endocytosis defective
受容体活動を介した外部物質の細胞による取り込みに欠損が見られる。受容体媒介性エンドサイト―シスは輸送特異性を生み、通常クラスリン被覆小窩やクラスリン被覆小胞を介して起こる。C. elegansでは、しばしば卵母細胞が卵黄をうまく取り込めないことによって明らかになる。 [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021]
"Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes." [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021]
WBPhenotype:0001422:受容体媒介性エンドサイトーシスの異常
WBPhenotype:0001424:受容体媒介性エンドサイトーシスの異常
WBPhenotype:0001422:endocytic transport defect
WBPhenotype:0001424:oocyte physiology variant
産仔数減少
reduced brood size
子孫の産生数がコントロールに比べて少ない。 [WB:WBPerson557]
"The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557]
WBPhenotype:0000673:産仔数減少
WBPhenotype:0000673:brood size variant
roaming reduced
"Animals exhibit a decrease in their high-speed movement in the forward direction with brief backward movement compared to control. In C. elegans, Animals do not move more than a few body lengths from their starting position and searches occur locally with pivoting behavior." [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557, WB:WBPerson712]
WBPhenotype:0000238:foraging reduced
WBPhenotype:0001213:locomotion reduced
WBPhenotype:0002315:roaming variant
seam cell(上皮細胞の一種)の融合変化
seam cell fusion variant
後期幼虫発生において、体壁に沿って連なったシンシチウムを形成するためのseam cellの融合能力(hyp 7シンシチウムの融合とは別)に、コントロールと比べて変化が見られる。皮下seam cellは体側壁に沿って存在し、側翼(alae)基底上皮細胞の縦縞を形成すると同時に側翼形成にも必要となる。 [WB:WBPerson2021, WB:WBPerson557]
"Variations in the ability of seam cells to fuse to form a continuous syncytium along the body wall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral body wall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000165:seam cell(上皮細胞の一種)の融合変化
WBPhenotype:0000165:cell fusion variant
short
"Animals exhibit a decreased body length compared to control animals of the same developmental stage." [WB:WBPerson712]
WBPhenotype:0001726:body length variant
短命
shortened life span
ライフサイクルにおける成虫期の生存期間がコントロールよりも短い。 [GO:0008340, WB:WBPerson712]
"The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712]
WBPhenotype:0000039:短命
WBPhenotype:0000039:life span variant
病気
sick
体サイズや運動、身体の完全性、色素沈着、生存力、稔性等に関する異常がいくつか組み合わさっている。 [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712]
"Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712]
WBPhenotype:0000030:病気
WBPhenotype:0000030:growth variant
sister cell division timing asynchrony reduced
"Animals exhibit sister cells that have lost otherwise normal asynchrony of cell division timing, compared to control animals. This results in sister cells aberrantly dividing in synchrony." [WB:WBPaper00046953, WB:WBPerson2987]
WBPhenotype:0000746:cell division variant
横滑り運動
skiddy
一見正常な正弦曲線運動を行うが、寒天培地の表面上への付着力が乏しいように見える。 [WB:WBPerson48,WB:WBPaper00026735]
"Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735]
WBPhenotype:0001701:横滑り運動
WBPhenotype:0001701:spastic locomotion
胚発生が遅い
slow embryonic development
受精から孵化するまでの期間の発生進行に遅延が見られる。 [WB:WBPerson712]
"The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712]
WBPhenotype:0000674:胚発生が遅い
WBPhenotype:0000749:胚発生が遅い
WBPhenotype:0000674:slow development
WBPhenotype:0000749:embryonic development variant
成長が遅い
slow growth
コントロールに比べて成長速度の低下をもたらすなんらかの変化が見られる。 [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
WBPhenotype:0000030:成長が遅い
WBPhenotype:0000043:成長が遅い
WBPhenotype:0000438:成長が遅い
WBPhenotype:0000030:growth variant
WBPhenotype:0000043:general pace of development variant
WBPhenotype:0000438:retarded heterochronic variations
体が小さい
small
同じ成長段階にあるコントロールよりも体が細く短い。 [WB:cab, WB:cgc31]
"Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31]
WBPhenotype:0001726:体が小さい
WBPhenotype:0001727:体が小さい
WBPhenotype:0001726:body length variant
WBPhenotype:0001727:body width variant
精子形成の変化
spermatogenesis variant
精子(運動性の精細胞)の産生や成熟に関与する過程になんらかの変化が見られる。 [GO:0007283, WB:WBPaper00027300, WB:WBPerson2021]
"Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control." [GO:0007283, WB:WBPaper00027300, WB:WBPerson2021]
WBPhenotype:0000894:精子形成の変化
WBPhenotype:0000894:germ cell differentiation variant
押しつぶされたバルバ
squashed vulva
バルバ陥入の部分的な崩壊が観察され、中央バルバ細胞の伸長により、しばしばバルバの外見が押しつぶされたように平らになる。 [WB:WBPaper00003405]
"The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance." [WB:WBPaper00003405]
WBPhenotype:0000510:押しつぶされたバルバ
WBPhenotype:0000510:vulval invagination variant L4
不稔
sterile
産生された配偶子が異常であったり、生殖ができないもしくはその子孫が生殖能力をもたない。 [GO:0000003, WB:WBPerson712]
"Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712]
WBPhenotype:0001384:不稔
WBPhenotype:0001384:fertility reduced
子孫の不稔
sterile progeny
子孫の生殖能力を損なう何らかの変化が見られる。 [WB:WBPerson2021, WB:WBPerson557]
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
WBPhenotype:0000069:子孫の不稔
WBPhenotype:0000688:子孫の不稔
WBPhenotype:0000069:progeny variant
WBPhenotype:0000688:sterile
表面抗原発現が陰性
surface antigen negative
同じ発生段階にあるブリストルN2に結合することができる抗体が、クチクラ表面やクチクラ抽出物に結合しない。 [WB:WBPaper00001280,WB:WBPerson712]
"Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712]
WBPhenotype:0001687:表面抗原発現が陰性
WBPhenotype:0001687:surface antigenicity variant
tail bend angle increased
"Animals exhibit an increase in the extent of the maximum flex of the most posterior portion of the animal compared to control animals." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002288:tail bend angle variant
体が細い
thin
同じ発生段階にあるコントロールと比べて胴囲が短い。 [WB:WBPerson712]
"Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712]
WBPhenotype:0001727:体が細い
WBPhenotype:0001727:body width variant
導入遺伝子発現の増加
transgene expression increased
コントロールと比較して、体内に導入された外来DNAによる遺伝子産物の発現強度に増加が見られる。 [WB:WBPerson557]
"Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
WBPhenotype:0000962:導入遺伝子発現の増加
WBPhenotype:0000962:level of transgene expression variant
導入遺伝子発現の減少
transgene expression reduced
コントロールと比較して、体内に導入された外来DNAによる遺伝子産物の発現強度に減少が見られる。 [WB:WBPerson557]
"Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
WBPhenotype:0000962:導入遺伝子発現の減少
WBPhenotype:0000962:level of transgene expression variant
導入遺伝子発現の変化
transgene expression variant
コントロールと比較して、体内に導入された外来DNAによる遺伝子産物の特徴的な発現になんらかの変化が見られる。 [WB:WBPerson557]
"Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals." [WB:WBPerson557]
WBPhenotype:0000717:導入遺伝子発現の変化
WBPhenotype:0000717:gene expression variant
導入遺伝子の細胞内局在変化
transgene subcellular localization variant
コントロールと比較して、体内に導入された外来遺伝物質をコードしているDNAによる遺伝子産物の細胞内局在になんらかの変化が見られる。 [WB:WBPerson557]
"Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557]
WBPhenotype:0000961:導入遺伝子の細胞内局在変化
WBPhenotype:0000961:pattern of transgene expression variant
ツニカマイシン(抗生物質)過敏
tunicamycin hypersensitive
コントロールよりも低濃度や短時間のツニカマイシンへの曝露に反応する。 [WB:WBPaper00030877, WB:WBPerson557]
"Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557]
WBPhenotype:0000359:ツニカマイシン(抗生物質)過敏
WBPhenotype:0000359:tunicamycin response variant
turning frequency variant
"Animals exhibit variations in the frequency of execution of the behavior by which the animal alters its trajectory of movement compared to control, excluding shifts from forward to backward movements (this is reversal)." [WB:WBPaper00043908, WB:WBPerson2987, WB:WBPerson557]
WBPhenotype:0002311:turning variant
ventral enclosure異常
ventral closure defective
ventral enclosureにおけるどれかの段階に異常があるため、胚が閉じられず、内部の細胞が外に突出している。 [WB:WBPaper00003991, WB:WBPerson712]
"The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo." [WB:WBPaper00003991, WB:WBPerson712]
WBPhenotype:0001566:ventral enclosure異常
WBPhenotype:0001566:ventral enclosure variant
ventral enclosureの変化
ventral enclosure variant
発生中の胚において、腹側上皮細胞の腹中線への遊走(上皮単層の下の細胞を包む働きをする)を制御している過程になんらかの変化がコントロールに比べて見られる。 [WB:WBPaper00027244,WB:WBPerson2021]
"Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control." [WB:WBPaper00027244, WB:WBPerson2021]
WBPhenotype:0000749:ventral enclosureの変化
WBPhenotype:0000749:embryonic development variant
腹側神経索の発生変化
ventral nerve cord development variant
腹側神経索の発生や維持に特異的ななんらかの過程に変化が見られる。 [WB:WBPerson557]
"Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord." [WB:WBPerson557]
WBPhenotype:0000945:腹側神経索の発生変化
WBPhenotype:0000945:neuropil development variant
バルバ細胞の運命決定変化
vulva cell fate specification variant
バルバ細胞への運命決定を支配する過程に、コントロールと比べてなんらかの変化が見られる。 [WB:WBPerson2021]
"Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals." [WB:WBPerson2021]
WBPhenotype:0000699:バルバ細胞の運命決定変化
WBPhenotype:0002017:バルバ細胞の運命決定変化
WBPhenotype:0000699:vulva development variant
WBPhenotype:0002017:VPC competence variant
バルバの形態変化
vulva morphology variant
コントロールと比較して、産卵や雄の配偶行動に影響する生殖器官の全体構造や構成に変化が見られる。 [WB:WBPerson712]
"Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control." [WB:WBPerson712]
WBPhenotype:0001335:バルバの形態変化
WBPhenotype:0001335:hermaphrodite reproductive system morphology variant
L4におけるバルバ陥入の変化
vulval invagination variant L4
L4幼虫期の中後期に最終バルバ細胞によって形成される特有のクリスマスツリー型の陥入が変化している。 [WB:WBPaper00001738, WB:WBPerson2021]
"The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered." [WB:WBPaper00001738, WB:WBPerson2021]
WBPhenotype:0000695:L4におけるバルバ陥入の変化
WBPhenotype:0000699:L4におけるバルバ陥入の変化
WBPhenotype:0000695:vulva morphology variant
WBPhenotype:0000699:vulva development variant





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