JCEG ID JCEG185
Name bre-4      WormBase    NCBI Gene
Human Ortholog

GGDB:B4GALT3 

OMIM: 604016 604017

OrthoList :   B4GALT3   B4GALT1   B4GALT2  (InParanoid)

GGDB Score E-val
B4GALT3 263 4e-72
B4GALT1 261 2e-71
B4GALT2 254 2e-69
B4GALT4 251 2e-68
B4GALT5 228 9e-62
B4GALT6 224 1e-60
B4GALT7 106 7e-25
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name b4GalT
Locus Tag Y73E7A.7
RNAi phenotype
phenotype WT
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features kr:Detected
tm:Detected
dxd:DVD
gg_motif:M1,M2,M3,M4,M5,M6
Sequence CDS
Protein
References

Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV Genetics (2000) 155 (4) :1693-9 [PMID : 10924467] Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.

Kawar ZS, Van Die I, Cummings RD J. Biol. Chem. (2002) 277 (38) :34924-32 [PMID : 12167666] Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.

Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Muller R, Brown JR, Hennet T, Esko JD, Aroian RV J. Biol. Chem. (2003) 278 (46) :45594-602 [PMID : 12944392] Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.

Darby C WormBook (2005) :1-15 [PMID : 18050390] Interactions with microbial pathogens.

Katic I, Vallier LG, Greenwald I Genetics (2005) 171 (4) :1605-15 [PMID : 16157663] New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme.

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV J. Biol. Chem. (2006) 282 (5) :3302-11 [PMID : 17135259] Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.

Ideo H, Fukushima K, Gengyo-Ando K, Mitani S, Dejima K, Nomura K, Yamashita K J. Biol. Chem. (2009) 284 (39) :26493-501 [PMID : 19635802] A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection.

Butschi A, Titz A, Walti MA, Olieric V, Paschinger K, Nobauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Kunzler M PLoS Pathog. (2010) 6 (1) :e1000717 [PMID : 20062796] Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Zhang H, Abraham N, Khan LA, Hall DH, Fleming JT, Gobel V Nat. Cell Biol. (2011) 13 (10) :1189-201 [PMID : 21926990] Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis.

WormBase (WS254)

Functional Descriptions bre-4

bre-4 encodes a beta-1,4-N-acetylgalactosaminyltransferase that is required for the toxicity of Bacillus thuringiensis Cry5B.
Deletion Mutants ok3167
In Situ
Expression Expression

WBGene00000269
Phenotype
Homology_paralog
Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
Bacillus thuringiensis toxin resistant

"Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557]
Allele: WBVar00275393   WBPaper00034766   Observed
brood size variant

"The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557]
Allele: WBVar00275389   WBPaper00004264   Observed
organism toxic chemical response variant

"Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557]
Allele: WBVar00275393   WBPaper00034766   Observed
pore forming toxin resistant

"Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557]
Allele: WBVar00275389   WBPaper00004264   Observed
Allele: WBVar00275390   WBPaper00004264   Observed
Allele: WBVar00275393   WBPaper00004264   Observed


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