| JCEG ID |
JCEG177 |
| Name |
F14B6.6
WormBase
NCBI Gene
|
| Human Ortholog |
GGDB:B3GALNT1
OMIM:
OrthoList :
B3GALT1
B3GALT2
B3GALT4
B3GALNT1
B3GALT5
(Ensembl Compara)
GWAS Catalog
| STREAM | RAF | p-value | OR | BETA | CI | Study |
| MAPPED |
0.43 |
0.000002
(AA)
|
|
4.21
(unit decrease)
|
[2.49-5.93] |
23599027
|
|
Demerath EW 2013-04-17 Hum Mol Genet
Genome-wide association study of age at menarche in African-American women.
|
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
|
| Family Name |
b3GalT1/b3GnT orthologs |
| Locus Tag |
F14B6.6
|
| RNAi phenotype |
|
phenotype
|
WT
|
|
Microscope observation (Image)
|
|
|
COPAS (Image)
|
|
|
hsp-4::GFP (Image)
|
|
|
| Sequence Features |
kr:N.D.
gg_motif:M1,M2,M3
tm:Detected
dxd:Detected
|
| Sequence |
CDS
atgaaagctcgtaaaattttaattaccgtagccattctggcttcactgct
tgcttaccgatattattctcagagaaccatggaatttttaattgaagaag
atcaaatgtgtctacagagggaatggtatgaaagctcccaaataaactca
accgccgattatggaaattcttatcaaatttcattttccgacgtccagag
cacattcaaatggatccatattccaaaaataagcggttctcctgaaatct
tattgatcgtcctatcgaggcctgacgacttttctagaagaaatgttata
aggcatacgtggatgagtcaggaaaatgagataaaatacttgtttctgat
tggattaggtgctaatatggacggaaaaattaaagaagttgtgatggcgg
aagcaaaattgtttggggacattgtagtgacatctatggaagatcggtat
tccaaattatcgtttaaaaccctgacgctgcttctcttcggggtctccaa
agtcccgtcagcccagctaattggaaaaattgacggagatgttctcttct
ttccgaatttattcttatcgactataaaaaacgaaaattctatgattaac
gtgacaagtgcaagtgtttatggaaaaattgccgaagctggagtgccgat
tgtgtccaactgctgcaaacgatttttaaagtacaatttcagacgaaatt
ctctgatttcgtttggatgcacgaggtacgctttctatcttgctggtcca
ttctacttggtgacaagaagtgctgctttacgattactagaagcttcaaa
acatagaaattttcacaagatcgaagataccctcatcactggagttctgg
ctgatgatactgatgtgagcagagtacagcttcaccggataaatttgggc
caagagaagggaactgatttggtttttgcatggcatagcccgctaaatga
tccggagtacaaagatctttactacaaaactatgagctcacagcagttta
aagaaaaattgcgattacaagaaataaatgtcacttga
|
Protein
MKARKILITVAILASLLAYRYYSQRTMEFLIEEDQMCLQREWYESSQINSTADYGNSYQI
SFSDVQSTFKWIHIPKISGSPEILLIVLSRPDDFSRRNVIRHTWMSQENEIKYLFLIGLG
ANMDGKIKEVVMAEAKLFGDIVVTSMEDRYSKLSFKTLTLLLFGVSKVPSAQLIGKIDGD
VLFFPNLFLSTIKNENSMINVTSASVYGKIAEAGVPIVSNCCKRFLKYNFRRNSLISFGC
TRYAFYLAGPFYLVTRSAALRLLEASKHRNFHKIEDTLITGVLADDTDVSRVQLHRINLG
QEKGTDLVFAWHSPLNDPEYKDLYYKTMSSQQFKEKLRLQEINVT
|
| References |
Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH
PLoS Biol.
(2003)
1
(1)
:E12
[PMID : 14551910]
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.
|
| Functional Descriptions |
F14B6.6
none available
|
| Deletion Mutants |
tm4667
|
| In Situ |
In Situ
|
| Expression |
Expression
| db_name |
wbbt |
name |
def |
reliability |
expr_pattern |
paper |
WormAtlas |
| WB |
WBbt:0005772
|
intestine |
"A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] |
Enriched |
WBPaper00037950 : intestine_embryo_SelectivelyEnriched, intestine_embryo_enriched
|
WBPaper00037950
|
WormAtlas
|
|
WBGene00008787
Phenotype
Homology_paralog
|
|
|
| Phenotype |
Definition |
RNAi / Allele |
|
adult lethal
|
"Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
embryonic lethal
|
"Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054]
|
|
|
larval arrest
|
"The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021]
|
|
|
larval lethal
|
"The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712]
|
|
|
lethal
|
"Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021]
|
|
|
maternal sterile
|
" Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557]
|
|
|
organism morphology variant
|
"Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395]
|
|
|
postembryonic development variant
|
"Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021]
|
|
slow growth
|
"Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557]
|
|
|
sterile progeny
|
"Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557]
|
|
|
Variant
|
"Animals exhibit variations compared to a given control." [WB:WBPerson557]
|
|
