JCEG ID JCEG161
Name hst-1      WormBase    NCBI Gene
Human Ortholog

GGDB:NDST1 

OMIM: 600853 603268 603950 615039

OrthoList :   NDST1   NDST2   NDST4   NDST3   ENSG00000175818  (Ensembl Compara)

GGDB Score E-val
NDST1 696 0.0
NDST3 693 0.0
NDST4 682 0.0
NDST2 680 0.0
HS3ST5 125 3e-30
HS3ST1 120 1e-28
HS3ST3B1 114 6e-27
HS3ST4 114 8e-27
HS3ST3A1 113 1e-26
HS3ST2 108 4e-25
Option tblastn : Query Worm Protein, Subject GGDB mRNA, E-val < 0.00001
Family Name Sulfotransferase and sulfation-related genes
Locus Tag F08B4.6
RNAi phenotype
phenotype Emb
Microscope observation (Image)
COPAS (Image)

Normal

hsp-4::GFP (Image)
Sequence Features
Sequence CDS
Protein
References

Berninsone PM WormBook (2006) :1-22 [PMID : 18050430] Carbohydrates and glycosylation.

Shaye DD, Greenwald I PLoS ONE (2011) 6 (5) :e20085 [PMID : 21647448] OrthoList: a compendium of C. elegans genes with human orthologs.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K Cell (2011) 145 (3) :470-82 [PMID : 21529718] A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Berninsone PM, Hirschberg CB Glycoconj. J. 19 (4-5) :325-30 [PMID : 12975612] The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans.

WormBase (WS254)

Functional Descriptions hst-1

hst-1 encodes the C. elegans ortholog of N-deacetylase/N-sulfotransferase (NDST), a bifunctional enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate; loss of hst-1 activity has been reported to result in embryonic lethality at various stages of development, defects in ventral neuroblast migrations during epidermal enclosure, and cessation of egg production in injected hermaphrodites.
Deletion Mutants tm626 ok1068
In Situ In Situ   
Expression Expression
db_name wbbt name def reliability expr_pattern paper WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00030839 : Embryo_Pan_Neuronal
WBPaper00030839 WormAtlas
WB WBbt:0003679

neuron "Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses." [ISBN:0140512888] Enriched WBPaper00031532 : Larva_Pan_Neuronal_Enriched
WBPaper00031532 WormAtlas
WB WBbt:0004740

I5 neuron "Neuron class of one pharyngeal interneuron, posterior sensory." [ISBN:0-87969-307-X] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005278

DA neuron "Neuron class of nine ventral cord motor neuron, innervates dorsal muscle." [WB:rynl] Enriched WBPaper00030839 : Embryo_A_Class
WBPaper00030839
WB WBbt:0005396

SAB "Neuron class of three interneurons, which send processes anteriorly up the sub-lateral cords in the head." [WB:Paper00000938] Enriched WBPaper00025141 : unc-4
WBPaper00025141
WB WBbt:0005656

retrovesicular ganglion "ganglion that lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore. It is open and continuous with the region containing the motoneurons of the ventral cord. In the early L1 this ganglion holds 12 neuron cell bodies plus one neuroblast (Sulston and Horvitz, 1977; White et al., 1986). In the adult animal, the ganglion holds 20 neuron cell bodies.\nReversal \n\n" [WBPaper:00038216] Enriched WBPaper00025141 : unc-4
WBPaper00025141 WormAtlas
WB WBbt:0005772

intestine "A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages." [WBPaper:00038216] Enriched WBPaper00040985 : AIN-2_L4_intestine
WBPaper00040985 WormAtlas
WB WBbt:0005784

germ line "cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes." [ISBN:0140512888] Enriched WBPaper00044760 : germline_specific
WBPaper00044760

WBGene00002028
Phenotype
Homology_paralog

Observed Observed and NOT Observed
Phenotype Definition RNAi / Allele
germ cell compartment morphology variant

"Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085699   WBPaper00038381   Observed
germ cell partition morphology variant

"Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. " [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085699   WBPaper00038381   Observed
germline nuclear positioning variant

"Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085699   WBPaper00038381   Observed
nuclear fallout

"Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085699   WBPaper00038381   Observed
oocyte accumulation

"An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. " [WB:WBPaper00006281, WB:WBPaper00030855]
RNAi: WBRNAi00085699   WBPaper00038381   Observed
rachis wide

"The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals." [WB:WBPaper00038381, WB:WBPerson557]
RNAi: WBRNAi00085699   WBPaper00038381   Observed


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